Research Thematics
News
Appel à candidature pour la future direction du GReD
Le GReD lance un appel à candidature pour recruter sa future directrice ou futur directeur, pour une prise de fonction en janvier 2021
Les Mardis du GRed - Avril 2018
12H45 – 13H45
Faculté de médecine
Amphi limagne (CRBC RdC)
GENOME PLASTICITY: EXAMPLE OF 5S RIBOSOMAL RNA GENES
The genes coding 5S ribosomal RNAs (critical components of the ribosomes, the cellular machineries translating mRNA into proteins) are highly repeated in the genome, which allows the production of large quantities of these rRNAs.
In their last study (Simon et al., 2018), the team of Aline Probst and Christophe Tatout revealed an important variation in number and expression of 5S rRNA genes between different ecotypes of Arabidopsis thaliana.
PhD Defense: Alexandre CHAMPROUX
Alexandre CHAMPROUX ( team : "Mechanisms of mammalian post-testicular infertility") will defend his thesis entitled:
"L'impact du stress oxydant sur l'épigénome spermatique murin. "
Wednesday the 11 of April 2018, at 2 pm
Amphitheatre Volcan, CRBC building , Medical School
Cymbopogon citratus and cancer: when citronella is a repellent not only for mosquitoes…
Through a real bilateral collaboration, Drs. Silvère BARON’s et and Jean-Marc LOBACCARO’s team Nuclear Receptor and Prostate diseases and Pr. Jacques SIMPORE’s team (Laboratoire de Biologie Moléculaire et de Génétique, Université de Ouagadougou, Burkina Faso), have identified medicinal plants of the Burkina Faso pharmacopeia that could be used in the future in cancer treatment (Bayala et al., 2018).
Recombination machinery compensates telomere loss in the absence of telomerase.
The chromosomes of most eukaryotic species are linear, consisting of a single DNA double-helix running from one end to the other. Each chromosome thus has two ends and these are protected by specialized DNA-protein structures named telomeres. The importance of telomere structure is readily observed in the severe genetic instability and cell death that result from its absence.
In its last study ( Olivier et al., 2018), the team of Charles White and Maria Gallego unveiled mechanisms by which recombination machinery contributes to protect the telomeres from replicative failure, ensuring their stability.
Les mardis du GReD: Mars 2018
12H45 – 13H45
Faculté de médecine
CRBC Amphi Limagne (CRBC RdC)
How to turn a football into a rugby ball?
Tissue elongation is part of the repertoire of processes that allow an organ to acquire its shape (morphogenesis). In the last years, the elongation of the ovarian follicle of Drosophila has emerged as a model of choice for the study of tissue elongation mechanisms. During its development the initially spherical follicle becomes ovoid and this elongation is controlled by the epithelial cells surrounding each follicle. However, so far, all studies on the subject have focused on the basal domain of these cells.
In its last study (Alegot et al.,) , the group of Vincent Mirouse has shown that the apical domain of the epithelial cells also contributed to this elongation.
EMBO Workshop "Plant Genome Stability and Change"
This EMBO workshop represents the sixth International Meeting on molecular and cellular mechanisms underlying stability, variability and modification of plant genomes. It will be held at the IPK Gatersleben, Germany, June 3-6, 2018.
For more details (programm, registration ) it's here.
Claire CHAZAUD received the VAN BENEDEN prize.
This prize is awarded every three years by the Royal Academy of Sciences, Letters and Fine Arts of Belgium to acknowledge a pioneer work in embryology or cytology .
Claire Chazaud has been awarded the 18th december 2017 for her work on the molecular mechanisms of epiblast and Primitive Endoderm specification in the early mouse embryo.
In a few words...
The GReD is a Research Center at Clermont-Ferrand, Auvergne Rhône Alpes region of France. Created in 2008, the GReD is supported by the University Clermont Auvergne (UCA), the CNRS (UMR6293) and the INSERM (U1103). The center is composed of 14 research groups (totalling 147 people in December 2017) based at the Centre de Recherche Bio-Clinique (CRBC) on the campus ...
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