CALL for NEW RESEARCH GROUP LEADERS
We are opening two distinct calls for new research group leaders. We encourage both young and already established outstanding researchers to apply. The deadline for applications is July 1st 2017. Selected applicants will be interviewed in October 2017.
Pint of Science "Le Gras c'est la vie !" par L. Bousset & S. Baron-Lundi 15 mai
Et si on démystifiait la recherche scientifique autour d’une petite bière…
LE GRAS C’EST LA VIE !
Mon médecin m’a dit : « Trop de cholestérol… le fromage et le beurre, c’est fini ! » Et pourtant le gras, on en a besoin ! Le cholestérol n’est pas uniquement mauvais pour la santé.
Conférenciers : Laura BOUSSET (Doctorante)
CHOLESTEROL JE T’AIME …
Silvère BARON (Maître de Conférences)
… MOI NON PLUS !
Lundi 15 Mai
19h-22h - Le Régent - 33 Boulevard Lafayette Clermont-Ferrand
Pour plus de détails : https://pintofscience.fr/event/le-gras-cest-la-vie
Weapons exchange in the battle between transposable elements and their host
The inactivation of transposable elements within genomes is insured by multiple epigenetic mechanisms. Olivier Mathieu's team has identified two genes required for repressing many transposable elements through a new molecular pathway independent of the main epigenetic modifications. Surprisingly, these genes could themselves have derived from transposable elements. This reveals that domestication of transposable elements by flowering plants’ genomes would have allowed emergence of a new mechanism to control activity of these invasive sequences. This study is published in Nature Communications (Ikeda et al., 2017).
Les Mardis du GRed - Mai 2017
12H30 – 13H30
Faculté de médecine
Amphi 1 (1èR étage, R1
EXCEPTIONNELLEMENT! Mercredi 03 Mai : Andrea CERASE, European Molecular Biology Laboratory (EMBL), Monterotondo, Italy
Understanding Xist-mediated gene silencing
09 Mai : Cyrielle GASC, MEDIS, UMR 0454 INRA / UCA
Capture de gènes par hybridation pour découvrir l'inconnu
16 Mai : Thomas STANISLAS, Laboratoire de Reproduction et Développement des Plantes, ENS Lyon
Contact : email@example.com
Interface Membrane-Cytoskeleton during mechanical stress
23 Mai : Maxime VOISIN, GReD, INSERM U1103, CNRS 6293, UCA
Rôle des protéines KAKU4 et CRWN dans l'architecture nucléaire chez Arabidopsis thaliana
30 Mai : Fabiana CERQUEIRA-CAMPOS, GReD, INSERM U1103, CNRS 6293, UCA
How to sculpt an organ: Dystrophin and Dystroglycan organize F-actin and extra-cellular matrix
3 years post-doctoral position, available from June 2017
The team "Nuclear receptors and protate diseases" is recruiting a post-doctoral researcher.
Project: “Effects of environmental disrupting chemicals in metastatic development of prostate cancer and evolution in castration resistant cancer”
Key words: Prostate cancer, environmental disrupting chemicals, nuclear receptors, metastasis, castration resistant prostate cancer.
Male infertility, toward new molecular causes .
Bile acids are molecules with endocrine activities controlling several physiological functions such as immunity and glucose homeostasis. Recently, they have also been shown to be involved in testicular physiology and as a cause of male fertility in experimental models. By the mean of mouse models and pharmacological approaches, the team of David Volle revealed the unexpected presence of alternative pathways, involving the Nuclear Receptor CAR (Constitutive-Androstane-Receptor ; NR1I3), to mediate bile acid functions in testis.
This study is published in Scientific Reports (Martinot et al., 2017).
The LINC complex contributes to heterochromatin organisation and transcriptional gene silencing in plants
The linker of nucleoskeleton and cytoskeleton (LINC) complex is an evolutionarily well-conserved protein bridge connecting the cytoplasmic and nuclear compartments across the nuclear membrane. Recent investigations have highlighted its function in nuclear morphology and meiosis. The new study performed by the team of Aline Probst and Christophe Tatout brings new insights into LINC complex function in plants. Using 3D imaging and molecular techniques the authors reveal that plants carrying mutations in this complex show release of transcriptional silencing as well as a decompaction of heterochromatic sequences. Therefore, the plant LINC complex contributes to proper heterochromatin organisation and positioning at the nuclear periphery, illustrating the important function of the nuclear envelope in the regulation of genome expression.
This study has been published in Journal of Cell Science (Poulet et al., 2017)
The journey of a thousand piRNAs begins with a single Dot
Among the several kinds of non-coding small RNAs, piRNAs (Piwi-interacting RNAs) are the ‘transposon-silencers’. They occur within the gonads of animals, protecting the cellular genome from transposable elements. One of the most mysterious question is how piRNAs are transcribed and processed inside the cell. Now Chantal Vaury’s lab brings new data into the biosynthesis of piRNAs. Their study, published recently in Nature Comm (Dennis & al., Nat Commun, 2016 Dec 8;7:13739. doi: 10.1038/ncomms13739), shows that the precursor transcripts of piRNAs are exported out of the nucleus by specific exporter proteins-Nxt1,Nxf1 and that the export itself directs the assembly of Yb bodies which are the cytoplasmic maturation centres of piRNAs. Chantal’s lab has been actively studying piRNA production for the past years, using the ovarian tissue of the fruit fly Drosophila melanogaster as a model. In 2013, they discovered ‘Dot COM’ – a single bright spot within the nuclei of ovarian follicular cells where piRNA precursor transcripts accumulate before to be processed. This year their new study has revealed that the precursors travel away from the site of transcription in the DNA to DOT COM, with the help of exportins and exon-junction complex (EJC) proteins. The study opens new possibilities of research in the piRNA and transposable element regulation fields.
Marie-Elisa PINSON won the prize for the best poster at the Auvergne-Rhône-Alpes forum on cancer research
To know more, the awarded poster can be uploaded here.
In a few words...
The GReD is a Research Center at Clermont-Ferrand, capital of the Auvergne region of central France. Created in 2008, the GReD is supported by the University of Auvergne, the University Blaise Pascal, the CNRS (UMR6293) and the INSERM (U1103). The center is composed of 10 research groups (totalling 130 people in April 2014) and is situated on the neighbouring campuses ...Read more