CALL for NEW RESEARCH GROUP LEADERS
We are opening two distinct calls for new research group leaders. We encourage both young and already established outstanding researchers to apply. The deadline for applications is July 1st 2017. Selected applicants will be interviewed in October 2017.
Male infertility, toward new molecular causes .
Bile acids are molecules with endocrine activities controlling several physiological functions such as immunity and glucose homeostasis. Recently, they have also been shown to be involved in testicular physiology and as a cause of male fertility in experimental models. By the mean of mouse models and pharmacological approaches, the team of David Volle revealed the unexpected presence of alternative pathways, involving the Nuclear Receptor CAR (Constitutive-Androstane-Receptor ; NR1I3), to mediate bile acid functions in testis.
This study is published in Scientific Reports (Martinot et al., 2017).
Phd Defense : Marjorie WHITFIELD
Marjorie WHITFIELD ( Team "Mechanisms of mammalian post-testicular infertility" ) will defend her thesis
"Modèle murin invalidé pour les LXRs : dyslipidémie et impact sur la maturation post-testiculaire des gamètes."
Thursday 16th of March at 2 pm
"Pôle Physique " Amphitheater, Campus des Cézeaux
The LINC complex contributes to heterochromatin organisation and transcriptional gene silencing in plants
The linker of nucleoskeleton and cytoskeleton (LINC) complex is an evolutionarily well-conserved protein bridge connecting the cytoplasmic and nuclear compartments across the nuclear membrane. Recent investigations have highlighted its function in nuclear morphology and meiosis. The new study performed by the team of Aline Probst and Christophe Tatout brings new insights into LINC complex function in plants. Using 3D imaging and molecular techniques the authors reveal that plants carrying mutations in this complex show release of transcriptional silencing as well as a decompaction of heterochromatic sequences. Therefore, the plant LINC complex contributes to proper heterochromatin organisation and positioning at the nuclear periphery, illustrating the important function of the nuclear envelope in the regulation of genome expression.
This study has been published in Journal of Cell Science (Poulet et al., 2017)
Les Mardis du GRed - Mars 2017
12H30 – 13H30
Faculté de médecine
Amphi 1 (1er étage, R1)
07 Mars : Séminaires Etudiants M2R GReD
DOUET Jérémie Étude du rôle des protéines TRBs dans la protection télomérique.
HESKETH Amy Origins and consequences of DNA hypermethylation in Pol epsilon-depleted plants.
THIROUARD Laura Etude du rôle de TGR5 dans l'altération de la spermatogenèse induite par le busulfan.
14 Mars : Séminaires Etudiants M2R GReD
EXCEPTIONNELLEMENT !!! AMPHI 3 !!! (5ème R1)
BAUDET Laura Régulation épigénétique des éléments transposables dans la lignée germinale.
FOURNET Marianne Régulation par RAGE de l'activation macrophagique via l'inflammasome NLRP3 au cours de l'agression alvéolaire aiguë.
21 Mars : Denis TAGU, Gaël LE TRIONNAIRE & Fabrice LEGEAI
INRA Rennes, UMR Igepp (Institut de Génétique, Environnement et Protection des Plantes), & INRIA Rennes, Irisa
Contact : email@example.com
Integrative genomics and gene networks for studying phenotypic plasticity in the pea aphid.
28 Mars : Séminaires Etudiants M2R GReD
LELONG Emeline Etude et caractérisation du mutant related to VRN1 (rtv1) et de ses partenaires chez Arabidopsis thaliana.
SAINTE-CATHERINE David Rôle du complexe PRC2 dans la physiopathologie surrénalienne.
GARCIA Manon Caractérisation des rôles de FXRα dans l'initiation et le développement des cancers germino-testiculaires.
The journey of a thousand piRNAs begins with a single Dot
Among the several kinds of non-coding small RNAs, piRNAs (Piwi-interacting RNAs) are the ‘transposon-silencers’. They occur within the gonads of animals, protecting the cellular genome from transposable elements. One of the most mysterious question is how piRNAs are transcribed and processed inside the cell. Now Chantal Vaury’s lab brings new data into the biosynthesis of piRNAs. Their study, published recently in Nature Comm (Dennis & al., Nat Commun, 2016 Dec 8;7:13739. doi: 10.1038/ncomms13739), shows that the precursor transcripts of piRNAs are exported out of the nucleus by specific exporter proteins-Nxt1,Nxf1 and that the export itself directs the assembly of Yb bodies which are the cytoplasmic maturation centres of piRNAs. Chantal’s lab has been actively studying piRNA production for the past years, using the ovarian tissue of the fruit fly Drosophila melanogaster as a model. In 2013, they discovered ‘Dot COM’ – a single bright spot within the nuclei of ovarian follicular cells where piRNA precursor transcripts accumulate before to be processed. This year their new study has revealed that the precursors travel away from the site of transcription in the DNA to DOT COM, with the help of exportins and exon-junction complex (EJC) proteins. The study opens new possibilities of research in the piRNA and transposable element regulation fields.
Adrenal gland differentiation: positive antagonism
Endocrine activity of the adrenal glands is essential for body homeostasis and depends on the differentiation of two concentric cellular zones. Using transgenic mouse models, Pierre Val’s team has shown that this zonal differentiation relies on a double antagonistic interaction between two signalling pathways. They further show that this antagonism inhibits development of aggressive tumours in mouse models and patients. This study is published in Nature Communications (Drelon et al., 2016) .
A new recognition for the GReD research againts cancer
The EDC-CaP project- Environmental chemical disrupter and metastasic potential of prostate cancer- leads by Jean-Marc Lobacarro et Sylvére Baron is among the 8 selected projects from the national call "effects of the exposure to environmental risk factors on cancer". This success highlights the capabilities of the GReD teams to design and coordinate demanding and original research projects to fight cancer.
When the liver controls male puberty....
Puberty is a key event for the development of male reproductive functions. It depends on the increase of testosterone produced by the testis, under the control of the activity of the hypothalamic-pituitary axis. Ultimately, this leads to the maturation of secondary sexual characteristics, to the establishment and maintenance of spermatogenesis and fertility. In a study published in Oncotarget (Baptisard et al., 2016), David Volle and Coll. reveal that he nuclear receptor for bile acids, FXRa, play a key role in this process.
In a few words...
The GReD is a Research Center at Clermont-Ferrand, capital of the Auvergne region of central France. Created in 2008, the GReD is supported by the University of Auvergne, the University Blaise Pascal, the CNRS (UMR6293) and the INSERM (U1103). The center is composed of 10 research groups (totalling 130 people in April 2014) and is situated on the neighbouring campuses ...Read more