CALL for NEW RESEARCH GROUP LEADERS
We are opening two distinct calls for new research group leaders. We encourage both young and already established outstanding researchers to apply. The deadline for applications is July 1st 2017. Selected applicants will be interviewed in October 2017.
Soutenance de thése : Benjamin BERTIN
Benjamin BERTIN (Equipe « Diversification des cellules musculaires et cardiaques en conditions normales et pathologiques ») soutiendra sa thèse intitulée :
"Analyses moléculaires et fonctionnelles de la diversification musculaire par des approches génomiques cellules-spécifiques chez la drosophile."
Le vendredi 29 septembre à 14H.
Salle des actes, Faculté de médecine.
Prostate Cancer; LXRs strike back !
During his life, one in five men will be diagnosed for prostate cancer. Current therapeutics are based on androgen deprivation therapy to treat advanced cancer development. Unfortunately, although this strategy gives good results, efficiency remains transient. The NuReP team work's shows for the first time that receptors present in prostatic tissue, LXR for Liver X Receptors, are able to constrain the metastatic progression of prostate cancer. Like all receptors, these can be activated by natural or pharmacological molecules; therefore these results open up important prospects in the development of future treatments to fight the metastatic evolution of prostate cancer.
This work is published in Nature Communication (Alioui et al., 2017)
GReD meets Johan Swinnen during its 2400 km run for cancer patients
From the 21st of Auguts our colleague Johan Swinnen undertook a journey of a lifetime: running from Leuven to Santiago de Compostela with a backpack filled with hundreds of letters from cancer patients and from people who care about them.
He will run about two marathons each day, on average, to reach hus destinattion for end of september.
Near Perigueux, Jean-Marc Lobaccaro and Silvère Baron met him; A few kilometers of race to his side to support his run, the rain having invited on the course!
We wish a good race to Johan towards Santiago de Compostela with the GReD support's.
You can follow the event, send in letters and messages and support Johan via the dedicated website:
More info at:
Chaperoning histones and controlling genome function
Histone proteins are critical components of chromatin and the incorporation of different histone variants modulates nucleosome stability. Deposition of histones at the right time and the correct place in the genome is tightly controlled by specific histone chaperone complexes. In its last study , the team of Aline Probst and Christophe Tatout characterized the Arabidopsis ATRX (Alpha Thalassemia-mental Retardation X-linked) homologue. Using reverse genetic approaches along with genome wide analyses Duc et al show that loss of ATRX modulates the cellular balance between canonical H3.1 and its variant H3.3 and leads to reduced H3.3 deposition at set of genes with elevated H3.3 occupancy and high gene expression. This study further elucidates the network of histone chaperones in plants and reveals a specific role for ATRX in histone H3.3 deposition.
This work is published in The Plant Cell (Duc et al., 2017).
FXRα a new actor of germinal stem cells fate.
The FXRα nuclear receptor (Farnesoid-X-Receptor alpha) is a key factor controlling the male sex hormone synthesis within the testis. However, its roles in male germ cell homeostasis have not yet been studied. Using a phenotyping approach of Fxra deficient mice, the team of David Volle has characterized unexpected roles of FXRa with germ cell lineage. There, FXRa is involved in the establishment and the maintenance of undifferentiated germ cell pool and in turn, influences male fertility during aging.
This study is published in Stem Cell Reports (Martinot et al., 2017)
INDEPTH : The GReD, in collaboration with LIMOS laboratory, holds the first COST-Action coordinated by Clermont Auvergne University (UCA)
GReD and LIMOS laboratories are happy to inform you that their COST-action project entitled «Impact of Nuclear Domains on Gene Expression and Plant Traits » (INDEPTH) has been awarded. This pan-european project, coordinated by Pr Christophe Tatout (GReD) in collaboration with Pr Rémy Malgouyres (LIMOS), involves for the next 4 years more than 50 laboratories over 19 countries. INDEPTH will decipher how nuclear architecture, chromatin organization and gene expression are connected and modified in response to internal and external cues in plants. To address this challenge, the INDEPTH Action gathers a network bringing state-of-the-art technologies and fostering multidisciplinary approaches at research, training, education and industrial levels in high- and super-resolution microscopy, 3D image analysis and software development, chromatin domain mapping, genomics, bioinformatics and plant phenotyping. INDEPTH is the first cost-ation coordinated by UCA.
Les Doctorants du GReD à l’honneur lors des JED 2017.
Houda TABBAL, doctorante dans l’équipe « Pathophysiologie moléculaire des tissus surrénaux et endocriniens » et Alexandre CHAMPROUX, doctorant dans l’équipe « Mécanismes de l'infertilité mâle post-testiculaire », ont tous deux été primés lors des Journées de l’école Doctorale 2017.
Male infertility, toward new molecular causes .
Bile acids are molecules with endocrine activities controlling several physiological functions such as immunity and glucose homeostasis. Recently, they have also been shown to be involved in testicular physiology and as a cause of male fertility in experimental models. By the mean of mouse models and pharmacological approaches, the team of David Volle revealed the unexpected presence of alternative pathways, involving the Nuclear Receptor CAR (Constitutive-Androstane-Receptor ; NR1I3), to mediate bile acid functions in testis.
This study is published in Scientific Reports (Martinot et al., 2017).
Weapons exchange in the battle between transposable elements and their host
The inactivation of transposable elements within genomes is insured by multiple epigenetic mechanisms. Olivier Mathieu's team has identified two genes required for repressing many transposable elements through a new molecular pathway independent of the main epigenetic modifications. Surprisingly, these genes could themselves have derived from transposable elements. This reveals that domestication of transposable elements by flowering plants’ genomes would have allowed emergence of a new mechanism to control activity of these invasive sequences. This study is published in Nature Communications (Ikeda et al., 2017).
In a few words...
The GReD is a Research Center at Clermont-Ferrand, capital of the Auvergne region of central France. Created in 2008, the GReD is supported by the University of Auvergne, the University Blaise Pascal, the CNRS (UMR6293) and the INSERM (U1103). The center is composed of 10 research groups (totalling 130 people in April 2014) and is situated on the neighbouring campuses ...Read more