News

CALL for NEW RESEARCH GROUP LEADERS

CALL for NEW RESEARCH GROUP LEADERS

We are opening  two distinct calls for new research group leaders. We encourage both young and already established outstanding researchers to apply. The deadline for applications is July 1st 2017. Selected applicants will be interviewed in October 2017.

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GReD internal meeting 2017

The GReD internal meeting 2017 will be held thursday the 9th and friday the 10th of february  at "amplhi de Physique" on Cézeaux Campus.

Please,click  here to download the program.

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Les Mardis du GRed - Février 2017

12H30 – 13H30
Faculté de médecine
Amphi 1 (1èR étage, R1)

07 Février   :            Pas de séminaire - Journées du GReD - 9-10 Février - Amphi Physique Cézeaux

14 Février   :    Julien MAUPETIT, Président, co-fondateur de TailorDev SAS
Contact : chantal.vaury@udamail.fr
OPEN SCIENCE 101
Depuis quelques années, grâce au développement d'Internet mais également des réseaux sociaux, le mouvement Open Science a pris de l'ampleur. Je vous propose une définition de ce que regroupe le terme Open Science, une présentation des outils du moment facilitant l'ouverture de vos travaux de recherche et un échange pragmatico-pratique sur la réalité du terrain et les questions que soulève l'adoption de ces pratiques dans votre recherche.

21 Février   :     Pas de séminaire

28 Février   :     Romain GUIEZE, EA CHELTER UCA
Genomic basis of resistance to BCL2 inhibition in lymphoid malignancies

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The journey of a thousand piRNAs begins with a single Dot

The journey of a thousand piRNAs begins with a single Dot

Among the several kinds of non-coding small RNAs, piRNAs (Piwi-interacting RNAs) are the ‘transposon-silencers’. They occur within the gonads of animals, protecting the cellular genome from transposable elements. One of the most mysterious question is how piRNAs are transcribed and processed inside the cell. Now  Chantal Vaury’s lab brings new data into the biosynthesis of piRNAs. Their study, published recently in Nature Comm (Dennis & al., Nat Commun, 2016 Dec 8;7:13739. doi: 10.1038/ncomms13739), shows that the precursor transcripts of piRNAs are exported out of the nucleus by specific exporter proteins-Nxt1,Nxf1 and that the export itself directs the assembly of Yb bodies which are the cytoplasmic maturation centres of piRNAs. Chantal’s lab has been actively studying piRNA production for the past years, using the ovarian tissue of the fruit fly Drosophila melanogaster as a model. In 2013, they discovered ‘Dot COM’ – a single bright spot within the nuclei of ovarian follicular cells where piRNA precursor transcripts accumulate before to be processed. This year their new study has revealed that the precursors travel away from the site of transcription in the DNA to DOT COM, with the help of exportins and exon-junction complex (EJC) proteins. The study opens new possibilities of research in the piRNA and transposable element regulation fields.

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Adrenal gland differentiation: positive antagonism

Adrenal gland differentiation: positive antagonism

Endocrine activity of the adrenal glands is essential for body homeostasis and depends on the differentiation of two concentric cellular zones. Using transgenic mouse models, Pierre Val’s team has shown that this zonal differentiation relies on a double antagonistic interaction between two signalling pathways. They further show that this antagonism inhibits development of aggressive tumours in mouse models and patients. This study is published in Nature Communications (Drelon et al., 2016) .

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A new recognition for the GReD  research againts cancer

A new recognition for the GReD research againts cancer

The EDC-CaP project- Environmental chemical disrupter and metastasic potential of prostate cancer- leads by Jean-Marc Lobacarro et Sylvére Baron is among the 8 selected projects from the national call "effects of the exposure to environmental risk factors on cancer".  This success highlights the capabilities of the GReD teams to design and coordinate demanding and original research projects to fight cancer.

 

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A focus on sperm DNA oxidative damage : a putative new trail to improve some male infertile situations

A focus on sperm DNA oxidative damage : a putative new trail to improve some male infertile situations

Oxidative alterations of the sperm nucleus are causative of reproductive failures and increase the risk of transmitting paternal inherited mutations to the next generation. With the goal to explore new therapeutic approaches, two new reports from the GReD research team « Mechanisms of Post-testicular Infertility » headed by Joël Drevet, have focused on one of the most common sperm DNA alterations, which is sperm DNA oxidation.

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 When it comes to DNA methylation, 1 + 1 = 3.

When it comes to DNA methylation, 1 + 1 = 3.

Variation in DNA methylation, which decorates DNA of most living organisms, can impact gene transcription, just like does DNA sequence. How distinct DNA methylation states of genes and transposons, called epialleles, emerge is not well understood. A collaborative work by the groups of Olivier Mathieu (CNRS/Laboratory GReD) and Detlef Weigel (Max Planck Institute for Developmental Biology, Germany) published in PNAS now highlights the rapid and massive creation of novel epialleles following an epigenomic shock. The epigenomic shock is triggered by combining identical genomes with different DNA methylation patterns in the same individual, and is characterized by widespread changes in DNA methylation and gene expression. Many novel epialleles not found in the parents emerge at protein-coding genes. On the other hand, transposons generally undergo decrease in DNA methylation associated with transcriptional activation, which can translate into transposon mobilization in the progeny. Hence, in addition to providing a scenario for the rapid and broad-scale emergence of epigenetic variation, this work may have implications for transposon dynamics within populations.

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Les Mardis du GRed - Janvier 2017

Les Mardis du GRed - Janvier 2017

12H30 – 13H30
Faculté de médecine
Amphi 1 (1èR étage, R1)

10 Janvier  :     Frédérick ARNAUD, UMR 754 - IVPC - Infections Virales et Pathologie Comparée, Lyon
Contact : chantal.vaury@udamail.fr
Arthropod-Borne Viruses: the case of Bluetongue virus.

17 Janvier  :     Cyril CHARBONNEL, GReD, INSERM U1103, CNRS 6293, Clermont Universités
HMGA-like proteins involved in DNA Repair and Genome Stability in A. thaliana.

24 Janvier  :     Junaid AKHTAR, Institute of Molecular Biology,Mainz, Germany
Contact: guillaume.junion@udamail.fr
EJC controls exon definition by facilitating promoter proximal pausing of RNA Pol II.

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The GReD wishes you the best for 2017

The GReD wishes you the best for 2017

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In a few words...

GReD

The GReD is a Research Center at Clermont-Ferrand, capital of the Auvergne region of central France. Created in 2008, the GReD is supported by the University of Auvergne, the University Blaise Pascal, the CNRS (UMR6293) and the INSERM (U1103). The center is composed of 10 research groups (totalling 130 people in April 2014) and is situated on the neighbouring campuses ...

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