How to turn a football into a rugby ball?
Tissue elongation is part of the repertoire of processes that allow an organ to acquire its shape (morphogenesis). In the last years, the elongation of the ovarian follicle of Drosophila has emerged as a model of choice for the study of tissue elongation mechanisms. During its development the initially spherical follicle becomes ovoid and this elongation is controlled by the epithelial cells surrounding each follicle. However, so far, all studies on the subject have focused on the basal domain of these cells.
EMBO Workshop "Plant Genome Stability and Change"
This EMBO workshop represents the sixth International Meeting on molecular and cellular mechanisms underlying stability, variability and modification of plant genomes. It will be held at the IPK Gatersleben, Germany, June 3-6, 2018.
For more details (programm, registration ) it's here.
Claire CHAZAUD received the VAN BENEDEN prize.
This prize is awarded every three years by the Royal Academy of Sciences, Letters and Fine Arts of Belgium to acknowledge a pioneer work in embryology or cytology .
Claire Chazaud has been awarded the 18th december 2017 for her work on the molecular mechanisms of epiblast and Primitive Endoderm specification in the early mouse embryo.
Amandine RAMBUR won the prize for the best poster at the 26th ARTP annual meeting
To know more, the awarded poster can be uploaded here.
LINE fishing... with the new bioinformatics tool CLIFinder
Repeated elements represent 45% of the human genome. However, due to their large number and their high sequence homology, the contribution of those elements to the human genome transcriptome remains difficult to study. Particularly, implication of recent LINE-1 (L1) elements to the transcriptional expression profile of cells and tissues is probably under-evaluated. Indeed, those L1 elements possess, in addition to their sense promoter, an antisense promoter (ASP) which allow the transcription of their adjacent sequences (which may include genes) in the form of LINE-1 chimeric transcripts (LCTs). Such LCTs have been already described in literature bur the question remains of the pangenomic extent of this transcriptional activity.
In a study conducted by Catherine Barrière (Pinson, Pogorelcnik et al., 2017), Philippe Arnaud’s team has developed and validated CLIFinder (Chimeric Line Finder), a new software dedicated to the identification of LCTs from stranded paired-end RNA-seq data. Thus, CLIFinder take advantage of the strong potential of next generation sequencing to unravel the complete transcriptome composition and allow the “fishing”, among all the transcriptome’s sequences, of numerous LCTs comprising a L1 sequence and a unique sequence of the genome. The CLIFinder tool is today available for the scientific community to realize extensive analyses in normal and pathological tissues. Indeed, many LCTs have been identified specifically in tumors and are supposed to play a functional role in tumorigenesis.
This software has been published in Bioinformatics (Pinson, Pogorelcnik et al., 2017)
GReD meets Johan Swinnen during its 2400 km run for cancer patients
From the 21st of Auguts our colleague Johan Swinnen undertook a journey of a lifetime: running from Leuven to Santiago de Compostela with a backpack filled with hundreds of letters from cancer patients and from people who care about them.
He will run about two marathons each day, on average, to reach hus destinattion for end of september.
Near Perigueux, Jean-Marc Lobaccaro and Silvère Baron met him; A few kilometers of race to his side to support his run, the rain having invited on the course!
We wish a good race to Johan towards Santiago de Compostela with the GReD support's.
You can follow the event, send in letters and messages and support Johan via the dedicated website:
More info at:
Chaperoning histones and controlling genome function
Histone proteins are critical components of chromatin and the incorporation of different histone variants modulates nucleosome stability. Deposition of histones at the right time and the correct place in the genome is tightly controlled by specific histone chaperone complexes. In its last study , the team of Aline Probst and Christophe Tatout characterized the Arabidopsis ATRX (Alpha Thalassemia-mental Retardation X-linked) homologue. Using reverse genetic approaches along with genome wide analyses Duc et al show that loss of ATRX modulates the cellular balance between canonical H3.1 and its variant H3.3 and leads to reduced H3.3 deposition at set of genes with elevated H3.3 occupancy and high gene expression. This study further elucidates the network of histone chaperones in plants and reveals a specific role for ATRX in histone H3.3 deposition.
This work is published in The Plant Cell (Duc et al., 2017).
FXRα a new actor of germinal stem cells fate.
The FXRα nuclear receptor (Farnesoid-X-Receptor alpha) is a key factor controlling the male sex hormone synthesis within the testis. However, its roles in male germ cell homeostasis have not yet been studied. Using a phenotyping approach of Fxra deficient mice, the team of David Volle has characterized unexpected roles of FXRa with germ cell lineage. There, FXRa is involved in the establishment and the maintenance of undifferentiated germ cell pool and in turn, influences male fertility during aging.
This study is published in Stem Cell Reports (Martinot et al., 2017)
INDEPTH : The GReD, in collaboration with LIMOS laboratory, holds the first COST-Action coordinated by Clermont Auvergne University (UCA)
GReD and LIMOS laboratories are happy to inform you that their COST-action project entitled «Impact of Nuclear Domains on Gene Expression and Plant Traits » (INDEPTH) has been awarded. This pan-european project, coordinated by Pr Christophe Tatout (GReD) in collaboration with Pr Rémy Malgouyres (LIMOS), involves for the next 4 years more than 50 laboratories over 19 countries. INDEPTH will decipher how nuclear architecture, chromatin organization and gene expression are connected and modified in response to internal and external cues in plants. To address this challenge, the INDEPTH Action gathers a network bringing state-of-the-art technologies and fostering multidisciplinary approaches at research, training, education and industrial levels in high- and super-resolution microscopy, 3D image analysis and software development, chromatin domain mapping, genomics, bioinformatics and plant phenotyping. INDEPTH is the first cost-ation coordinated by UCA.
Weapons exchange in the battle between transposable elements and their host
The inactivation of transposable elements within genomes is insured by multiple epigenetic mechanisms. Olivier Mathieu's team has identified two genes required for repressing many transposable elements through a new molecular pathway independent of the main epigenetic modifications. Surprisingly, these genes could themselves have derived from transposable elements. This reveals that domestication of transposable elements by flowering plants’ genomes would have allowed emergence of a new mechanism to control activity of these invasive sequences. This study is published in Nature Communications (Ikeda et al., 2017).
In a few words...
The GReD is a Research Center at Clermont-Ferrand, Auvergne Rhône Alpes region of France. Created in 2008, the GReD is supported by the University Clermont Auvergne (UCA), the CNRS (UMR6293) and the INSERM (U1103). The center is composed of 14 research groups (totalling 147 people in December 2017) based at the Centre de Recherche Bio-Clinique (CRBC) on the campus ...Read more