In a few words...

GReD

The GReD is a Research Center at Clermont-Ferrand, capital of the Auvergne region of central France. Created in 2008, the GReD is supported by the University of Auvergne, the University Blaise Pascal, the CNRS (UMR6293) and the INSERM (U1103). The center is composed of 10 research groups (totalling 130 people in April 2014) and is situated on the neighbouring campuses ...

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News

EZH2, a novel therapeutic target in Adrenal Cortex Cancer

EZH2, a novel therapeutic target in Adrenal Cortex Cancer

Adrenal cortex Cancer is one of the most aggressive cancers, for which there is no effective therapeutic approach. Research supervised by Pierre VAL at GReD laboratories, identified overexpression of EZH2 as a novel alteration involved in malignant progression of this cancer. These data show that targeting EZH2 with pharmacological inhibitors blocks proliferation of cancer cells and induces cell death. This suggests that EZH2 could be an interesting target for treatment of adrenal cancer. This article is published in Human Molecular Genetics (Drelon et al., 2016)

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 When it comes to DNA methylation, 1 + 1 = 3.

When it comes to DNA methylation, 1 + 1 = 3.

Variation in DNA methylation, which decorates DNA of most living organisms, can impact gene transcription, just like does DNA sequence. How distinct DNA methylation states of genes and transposons, called epialleles, emerge is not well understood. A collaborative work by the groups of Olivier Mathieu (CNRS/Laboratory GReD) and Detlef Weigel (Max Planck Institute for Developmental Biology, Germany) published in PNAS now highlights the rapid and massive creation of novel epialleles following an epigenomic shock. The epigenomic shock is triggered by combining identical genomes with different DNA methylation patterns in the same individual, and is characterized by widespread changes in DNA methylation and gene expression. Many novel epialleles not found in the parents emerge at protein-coding genes. On the other hand, transposons generally undergo decrease in DNA methylation associated with transcriptional activation, which can translate into transposon mobilization in the progeny. Hence, in addition to providing a scenario for the rapid and broad-scale emergence of epigenetic variation, this work may have implications for transposon dynamics within populations.

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When the liver controls male puberty....

When the liver controls male puberty....

Puberty is a key event for the development of male reproductive functions. It depends on the increase of testosterone produced by the testis, under the control of the activity of the hypothalamic-pituitary axis. Ultimately, this leads to the maturation of secondary sexual characteristics, to the establishment and maintenance of spermatogenesis and fertility. In a study published in Oncotarget (Baptisard et al., 2016), David Volle and Coll. reveal that he nuclear receptor for bile acids, FXRa, play a key role in this process. 

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A focus on sperm DNA oxidative damage : a putative new trail to improve some male infertile situations

A focus on sperm DNA oxidative damage : a putative new trail to improve some male infertile situations

Oxidative alterations of the sperm nucleus are causative of reproductive failures and increase the risk of transmitting paternal inherited mutations to the next generation. With the goal to explore new therapeutic approaches, two new reports from the GReD research team « Mechanisms of Post-testicular Infertility » headed by Joël Drevet, have focused on one of the most common sperm DNA alterations, which is sperm DNA oxidation.

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Les Mardis du GRed - Mai 2016

Les Mardis du GRed - Mai 2016

12H30 – 13H30
Faculté de médecine
Amphi 1 (1èR étage, R1)

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