In a few words...

The GReD is a Research Center at Clermont-Ferrand, Auvergne Rhône Alpes region of France ...

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News

Post-doctoral position in Epigenetics

Post-doctoral position in Epigenetics

An  ANR funded  postdoctoral position is available in our research group “ Genetic instabilities and control  by the host genome ” . We are looking for an enthusiastic and highly motivated post-doc to investigate the relationship between  transposable elements and their host genome.

Funded for 30 months; Reviewing applications until November 2021 for a start date as early as possible.

More information and details to apply are provided here

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m6A methylation of mRNA  promotes their transcription thought RNA polymerase II

m6A methylation of mRNA promotes their transcription thought RNA polymerase II

This study, leads by G.Junion ( team  Diversification of muscle and heart cells in normal and pathological conditions ),  published in the journal Molecular Cell (Akhtar et al.) shows a new mechanism for regulating gene expression through modification of RNA. Using a combination of molecular biology and bioinformatics, they demonstrate that the enzymatic complex called m6A methyltransferase (MTC) enables RNA polymerase II to escape pausing and perform transcription, and thus precisely control the expression of genes responsible for the development of organisms.

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L’iGReD à l’assaut du Géant

L’iGReD à l’assaut du Géant

Dignes successeurs de Florin Périer et de son expérience du Puy de Dôme  sur la pression atmosphérique ,  Christophe, Adrien, Franck et Claude, membres de la « Team UCA-CNRS »,  illustrent que la recherche c’est la tête et les jambes.

Même le soleil était (un peu trop) au rendez-vous de cette 46iéme édition de La Montée du Puy de Dôme FSCT,  jumelée cette année avec les 150 ans de l’Observatoire de Physique du Globe (UCA-CNRS).

Félicitations à tous les « finishers »

Pour en savoir plus : https://fsgtpuydedome.wixsite.com/fsgt

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PhD thesis defense: Amy HESKETH

PhD thesis defense: Amy HESKETH

Amy HESKETH, PhD student in SILENT team,  will defend her Thesis  entitled:

"Silencing transcriptionnel et methylation de l’ADN chez Arabidopsis thalia

Friday    the 2nd of  July  2021  at 2 pm-  online (link to come )

Viva examiners :Cécile Raynaud (IPS2-Paris Saclay), Jean Molinier (IBMP,Strasbourg), Thierry Lagrange (LGDP, Perpignan), Emilie Brasset (iGReD), Maria-Eugenia Gallego (iGReD)

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 James WILMOUTH s’illustre lors des JED 2021

James WILMOUTH s’illustre lors des JED 2021

James WILMOUTH , doctorant dans l’équipe Pathophysiologie moléculaire des tissus surrénaux et endocriniens, a reçu le prix Cancéropole CLARA  de la meilleure communication orale dans le domaine du Cancer.

Ce prix, attribué par un jury de chercheurs du public et du privé, lui permettra d'exercer ses talents d’orateur dans un congrès International. Félicitations à lui.

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Accessing the inaccessible

Accessing the inaccessible

The heterochromatic regions of eukaryotic genomes are enriched in repeated sequences and poorly accessible due to a high level of compaction. Nevertheless, heterochromatin has to retain a certain degree of accessibility to allow important DNA-related biological processes to occur, including DNA replication, DNA damage repair, maintenance of DNA methylation and transcription for small RNA production. In a new study published in Nature Communications (Bourguet et al., ), the SILENT team now shows that the histone variant H2A.W cooperates with linker histone H1 to maintain optimal accessibility of heterochromatin in Arabidopsis.

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JED 2021

JED 2021

The JED SVSAE 2021 are coming up May 27-28th! You can find all the information here: https://svsae.ed.uca.fr/inscription-obligations/obligations/journee-scientifique-de-led-svsae-1

Here is a teaser of what's to come!  https://www.youtube.com/watch?v=lRNUEz1CRqE

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 Diversity matters

Diversity matters

Blood cell progenitors play an essential role in the cellular immune response to infection but the importance of their heterogeneity remains elusive. In collaboration with the team of Pr M. Inamdar (JNCASR- Bangalore), the team “Epigenetic regulation and hematopoiesis” revealed that Drosophila larval blood cell progenitors exhibit an unforeseen degree of diversity, which underlies a proper immune response. This study has beeen published  (Rodriguez et al., 2021) in elife.

 This study has been higlighted on the  INSB CNRS website

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fixed-term contract for Research Engineer "Towards the development of better tools for the evaluation and conservation of male gametes".

fixed-term contract for Research Engineer "Towards the development of better tools for the evaluation and conservation of male gametes".

Research Engineer position ( fixed-term contract 24 months) is available from june 2021 in the team "Mechanisms of mammalian post-testicular infertility"

Form more details an dapply , it's here

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When LXR plays firefighters….

When LXR plays firefighters….

Chronic inflammation is a precursor mechanism supporting cancer development. Regarding the prostate, although hormone deprivation therapy significantly slows down cancer development, it triggers deep alterations in the tumor microenvironment. In its last studi, published in Genome Biology ( Bousset et al.) the NuReP team shows that the absence of nuclear receptors LXR leads to reprogramming of the tumor microenvironment, in particular the immune landscape.

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