News

Claire CHAZAUD received the VAN BENEDEN prize.

Claire CHAZAUD received the VAN BENEDEN prize.

This prize is awarded every three years by the Royal Academy of Sciences, Letters and Fine Arts of Belgium  to acknowledge a pioneer work in embryology or cytology .

 

Claire Chazaud has been awarded the 18th december 2017 for her work on the molecular mechanisms of epiblast and Primitive Endoderm specification in the early mouse embryo.

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Conference: « From fitness comparison to spatial constrains : the many roads of cell competition »

Conference: « From fitness comparison to spatial constrains : the many roads of cell competition »

By Romain levayer, Institut Pasteur, Paris.

Thursday the 11th of january. 11:00 am

Meeting room 003, CRBC  Building- Medical school campus

Contact: Vincent MIROUSE (vincent.mirouse@uca.fr)

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Les Mardis du GRed - Janvier 2018

Les Mardis du GRed - Janvier 2018

12H45 – 13H45
Faculté de médecine
Amphi limagne (CRBC RdC)

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Workshop "Mechanobiology and Physics of Life"

Workshop "Mechanobiology and Physics of Life"

After Lyon (2016) and Grenoble (2017), we are pleased to welcome you to the third workshop in Mechanobiology and Physics of Life to be held in Clermont-Ferrand on Tuesday January 30th 2018.

This workshop aims at strengthening the local community (Auvergne Rhône-Alpes area), and at fostering links between its members and with new members. 

This workshop will cover all aspects of mechanobiology and Physics of life, including development and cancer (with a special session supported by CLARA), but also plant mechanobiology, as well as approaches such as micromechanical measurements (including atomic force microscopy), microfluidics, advanced 3D microscopy, or modelling.

Our keynote speaker will be Yohanns Bellaiche, From Institut Curie, Paris, who will speak about “Mitotic geometrical and mechanical regulation during tissue morphogenesis”.


To consult the programm of the day, to submit your abstract as well as to register or ask questions, please connect to the following site:

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EMBO  Workshop "Plant Genome Stability and Change"

EMBO Workshop "Plant Genome Stability and Change"

This EMBO workshop represents the sixth International Meeting on molecular and cellular mechanisms underlying stability, variability and modification of plant genomes. It will be held at the IPK Gatersleben, Germany,  June 3-6, 2018.

For more details (programm, registration ) it's here.

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Amandine RAMBUR won the prize for the best poster at the 26th ARTP annual meeting

Amandine RAMBUR won the prize for the best poster at the 26th ARTP annual meeting

 Amandine RAMBUR (Team "Nuclear receptor and prostate diseases") won the prize for the best poster at the  ARTP (Asociation for research on prostate tumors) 26th annual meeting.

To know more, the awarded poster can be uploaded here.

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LINE fishing... with the new bioinformatics tool CLIFinder

LINE fishing... with the new bioinformatics tool CLIFinder

Repeated elements represent 45% of the human genome. However, due to their large number and their high sequence homology, the contribution of those elements to the human genome transcriptome remains difficult to study. Particularly, implication of recent LINE-1 (L1) elements to the transcriptional expression profile of cells and tissues is probably under-evaluated. Indeed, those L1 elements possess, in addition to their sense promoter, an antisense promoter (ASP) which allow the transcription of their adjacent sequences (which may include genes) in the form of LINE-1 chimeric transcripts (LCTs). Such LCTs have been already described in literature bur the question remains of the pangenomic extent of this transcriptional activity.

In a study conducted by Catherine Barrière (Pinson, Pogorelcnik et al., 2017), Philippe Arnaud’s team has developed and validated CLIFinder (Chimeric Line Finder), a new software dedicated to the identification of LCTs from stranded paired-end RNA-seq data. Thus, CLIFinder take advantage of the strong potential of next generation sequencing to unravel the complete transcriptome composition and allow the “fishing”, among all the transcriptome’s sequences, of numerous LCTs comprising a L1 sequence and a unique sequence of the genome. The CLIFinder tool is today available for the scientific community to realize extensive analyses in normal and pathological tissues. Indeed, many LCTs have been identified specifically in tumors and are supposed to play a functional role in tumorigenesis.

This software has been published in Bioinformatics (Pinson, Pogorelcnik et al., 2017)

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GReD meets Johan Swinnen during its 2400 km run for cancer patients

GReD meets Johan Swinnen during its 2400 km run for cancer patients

From the 21st of Auguts our colleague Johan Swinnen undertook  a journey of a lifetime: running from Leuven to Santiago de Compostela with a backpack filled with hundreds of letters from cancer patients and from people who care about them.

He will run about two marathons each day, on average, to reach hus destinattion for end of september.

Near Perigueux, Jean-Marc Lobaccaro and Silvère Baron met him;  A few kilometers of race to his side to support his run, the rain having invited on the course!

We wish a good race to Johan towards Santiago de Compostela with the GReD support's.

 You can follow the event, send in letters and messages  and support Johan via the dedicated  website: 

http://www.post-voor-compostela.be/en/johans-journey/2400-km-run

More info at:

http://www.flanderstoday.eu/living/cancer-researcher-runs-2400km-compostela-tribute-son

 

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Chaperoning histones and controlling genome function

Chaperoning histones and controlling genome function

Histone proteins are critical components of chromatin and the incorporation of different histone variants modulates nucleosome stability. Deposition of histones at the right time and the correct place in the genome is tightly controlled by specific histone chaperone complexes. In its last study  , the team of Aline Probst and Christophe Tatout characterized the Arabidopsis ATRX (Alpha Thalassemia-mental Retardation X-linked) homologue. Using reverse genetic approaches along with genome wide analyses Duc et al show that loss of ATRX modulates the cellular balance between canonical H3.1 and its variant H3.3 and leads to reduced H3.3 deposition at set of genes with elevated H3.3 occupancy and high gene expression. This study further elucidates the network of histone chaperones in plants and reveals a specific role for ATRX in histone H3.3 deposition.

 

This work is published in The Plant Cell (Duc et al., 2017).

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FXRα  a new actor  of germinal stem cells fate.

FXRα a new actor of germinal stem cells fate.

The FXRα nuclear receptor (Farnesoid-X-Receptor alpha) is a key factor controlling the male sex hormone synthesis within the testis. However, its roles in male germ cell homeostasis have not yet been studied. Using a phenotyping approach of Fxra deficient mice, the team of David Volle has characterized unexpected roles of FXRa with germ cell lineage. There, FXRa is involved in the establishment and the maintenance of undifferentiated germ cell pool and in turn, influences male fertility during aging.

This study is  published  in  Stem Cell Reports (Martinot et al., 2017)

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In a few words...

GReD

The GReD is a Research Center at Clermont-Ferrand, Auvergne Rhône Alpes region of France. Created in 2008, the GReD is supported by the University Clermont Auvergne (UCA), the CNRS (UMR6293) and the INSERM (U1103). The center is composed of 14 research groups (totalling 147 people in December 2017) based at the Centre de Recherche Bio-Clinique (CRBC) on the campus ...

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