In a few words...
The GReD is a Research Center at Clermont-Ferrand, Auvergne Rhône Alpes region of France ...
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PhD defense: Elisa LE BOITEUX
Elisa Le Boiteux (Team “Genomic Imprinting and the epigenetic control of cell fate determination”) will defend her thesis entitled:
"Altération du contrôle de H3K27me3 et dérégulation transcriptionnelle dans les gliomes : Etude des clusters HOX"
Tuesday the 3rd of December 2019 at 1:30 pm
Salle des Thése, Medical School
Viva examiners : Mary CALLANAN (CHU, Dijon), Marie-Pierre JUNIER (IBPS, Paris), Samir MERABET (IGFL, Lyon) ; Pierre VERRELLE (Institut Curie, Paris & UCA), Anne Fogli (GReD), Philippe ARNAUD (GReD)
Recrutement chargé(e) de mission scientifique
La filière Maladies Rares Endocriniennes (FIRENDO http://www.firendo.fr/accueil-filiere-firendo/) recherche :
Un(e) chargé(e) de mission scientifique, affecté(e) à l'équipe "Pathophysiologie moléculaire des tissus surrénaux et endocriniens" au GReD
CDD de 1 an renouvelable
Missions: accompagner, conseiller, soutenir et coordonner les acteurs recherche de la filière dans le but de recenser, faciliter et optimiser la mise en place des projets de recherche.
Diplômes: minimum BAC+5 scientifique ou ingénierie des systèmes de santé ou Bac+8 Doctorat en Biologie. Une formation en recherche clinique est un plus, mais n’est pas indispensable.
Contact: Antoine Martinez email: antoine.martinez@uca.fr
Le profil détaillé du poste est disponible ici
1ere Automnale du Groupe Cancer Clermont Auvergne
Le mardi 26 Novembre, de 9h à 17h, se tiendra la 1éreAutomnale du Groupe Cancer Clermont Auvergne
Cette journée permettra d’avoir un panorama de la recherche en cancérologie du site, alliant ses aspects fondamentaux (biologiques et sciences humaines), translationnelles et cliniques.
International congress on transposable elements (ICTE)
For the organizing committee, the GReD institute invite you to attend the next international congress on transposable elements (ICTE) in Saint Malo from April 25 to 29th, 2020.
Looking for pERK !
In its last study, published in Development (Azami et al., ), the team "Molecular mechanisms of cell lineage differentiation in the early mouse embryo" identified the phosporylation of ERK as a key event in the specification of epiblast (Epi) and Primitive Endoderm (PrE).
Transcriptional alterations in Glioma: DNA methylation is the tip of the “epigenetic” iceberg
In cancer cells, aberrant DNA methylation is commonly associated with transcriptional alterations, including silencing of tumor suppressor genes. However, multiple epigenetic mechanisms, including polycomb repressive marks, contribute to gene deregulation in cancer. In its last study (Court et al., 2019) the team " Genomic Imprinting and the epigenetic control of cell fate determination" used glioma, one the most widespread type of brain tumor, to evaluate for the first time the relative contribution of DNA methylation-independent mechanisms on transcriptional alteration at CpG-island (CGI)/promoter-associated genes in cancer cells. They found that most transcriptional alterations in tumor samples were DNA methylation-independent. Instead, altered histone H3 trimethylation at lysine 27 (H3K27me3) was the predominant molecular defect at deregulated genes.
Les Chercheurs du GReD accueillent les malades
Sous l''égide de l'INSERM, le GReD et M2iSH accueillent les malades sur le théme "Santé et environnement" , le mercredi 13 novembre .
Au programme (13h30-16h30, salle de réunion 003, batiment CRBC):
- La Recherche à l'Inserm avec et pour les Associations de Malades : C. Lemercier, Inserm
- Présentation générale des deux laboratoires GReD et M2ISH
- Effets des perturbateurs endocriniens sur la reproduction, le cancer : D. Volle, Inserm U1103
- Environnement, Microbiote Intestinal, Inflammation : N. Barnich, directeur du laboratoire M2ISH.·
- Visite du GReD
Pour en savoir plus cliquez ici
Sewing workshop in GReD
Everyone has been involved, from the doctoral students to the director, to contribute to the "Pink October" and to make "heart cushions" for patients who have had breast cancer. They were given to the Jean Perrin Center in Clermont-Ferrand on October 22, 2019
