News

CALL for NEW RESEARCH GROUP LEADERS

CALL for NEW RESEARCH GROUP LEADERS

We are opening  two distinct calls for new research group leaders. We encourage both young and already established outstanding researchers to apply. The deadline for applications is July 1st 2017. Selected applicants will be interviewed in October 2017.

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Conference: "Ontogeny and function of muscle interstitial progenitor cells" Sigmar Stricker -Freie Universitaet of Berlin

"Ontogeny and function of muscle interstitial progenitor cells" Sigmar Stricker - Freie Universitaet of Berlin

Friday the 27th of January. 3pm

Meeting room, Vegetal Biology Building- Campus des Cézeaux

Contact: Cédric Soler (Cedric.SOLER@udamail.fr)

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Les Mardis du GRed - Janvier 2017

Les Mardis du GRed - Janvier 2017

12H30 – 13H30
Faculté de médecine
Amphi 1 (1èR étage, R1)

10 Janvier  :     Frédérick ARNAUD, UMR 754 - IVPC - Infections Virales et Pathologie Comparée, Lyon
Contact : chantal.vaury@udamail.fr
Arthropod-Borne Viruses: the case of Bluetongue virus.

17 Janvier  :     Cyril CHARBONNEL, GReD, INSERM U1103, CNRS 6293, Clermont Universités
HMGA-like proteins involved in DNA Repair and Genome Stability in A. thaliana.

24 Janvier  :     Junaid AKHTAR, Institute of Molecular Biology,Mainz, Germany
Contact: guillaume.junion@udamail.fr
EJC controls exon definition by facilitating promoter proximal pausing of RNA Pol II.

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The GReD wishes you the best for 2017

The GReD wishes you the best for 2017

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The journey of a thousand piRNAs begins with a single Dot

The journey of a thousand piRNAs begins with a single Dot

Among the several kinds of non-coding small RNAs, piRNAs (Piwi-interacting RNAs) are the ‘transposon-silencers’. They occur within the gonads of animals, protecting the cellular genome from transposable elements. One of the most mysterious question is how piRNAs are transcribed and processed inside the cell. Now  Chantal Vaury’s lab brings new data into the biosynthesis of piRNAs. Their study, published recently in Nature Comm (Dennis & al., Nat Commun, 2016 Dec 8;7:13739. doi: 10.1038/ncomms13739), shows that the precursor transcripts of piRNAs are exported out of the nucleus by specific exporter proteins-Nxt1,Nxf1 and that the export itself directs the assembly of Yb bodies which are the cytoplasmic maturation centres of piRNAs. Chantal’s lab has been actively studying piRNA production for the past years, using the ovarian tissue of the fruit fly Drosophila melanogaster as a model. In 2013, they discovered ‘Dot COM’ – a single bright spot within the nuclei of ovarian follicular cells where piRNA precursor transcripts accumulate before to be processed. This year their new study has revealed that the precursors travel away from the site of transcription in the DNA to DOT COM, with the help of exportins and exon-junction complex (EJC) proteins. The study opens new possibilities of research in the piRNA and transposable element regulation fields.

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Adrenal gland differentiation: positive antagonism

Adrenal gland differentiation: positive antagonism

Endocrine activity of the adrenal glands is essential for body homeostasis and depends on the differentiation of two concentric cellular zones. Using transgenic mouse models, Pierre Val’s team has shown that this zonal differentiation relies on a double antagonistic interaction between two signalling pathways. They further show that this antagonism inhibits development of aggressive tumours in mouse models and patients. This study is published in Nature Communications (Drelon et al., 2016) .

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A new recognition for the GReD  research againts cancer

A new recognition for the GReD research againts cancer

The EDC-CaP project- Environmental chemical disrupter and metastasic potential of prostate cancer- leads by Jean-Marc Lobacarro et Sylvére Baron is among the 8 selected projects from the national call "effects of the exposure to environmental risk factors on cancer".  This success highlights the capabilities of the GReD teams to design and coordinate demanding and original research projects to fight cancer.

 

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GReD's PhD students stimulate scientific career interest at Exposciences

GReD's PhD students stimulate scientific career interest at Exposciences

From May 25th to May 28th, PhD students from the GReD lab held a booth at Polydôme (Clermont-Ferrand) to present their work  to children and young adults.

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Benjamin Bertin :  prix du Jury des JED 2016

Benjamin Bertin : prix du Jury des JED 2016

Benjamin BERTIN, doctorant dans l'équipe de Krzysztof Jagla , a reçu le prix du Jury lors  des 'Journées de l'Ecole Doctorale 2016".

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Epigénétique: the revenge of Lamarck?

Epigénétique: the revenge of Lamarck?

The next  "Mercredis de la Science" ”, organized by the university Blaise Pascal, will be dedicated to the Epigenetics. All are welcome to listen our two researchers, Aline Probst and Christophe Tatout, presenting this fascinating field Wednesday, June 15th, 2016 at 3:30 pm in the"Amphithéâtre de recherche du Pôle Physique" on the Cézeaux campus.

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In a few words...

GReD

The GReD is a Research Center at Clermont-Ferrand, capital of the Auvergne region of central France. Created in 2008, the GReD is supported by the University of Auvergne, the University Blaise Pascal, the CNRS (UMR6293) and the INSERM (U1103). The center is composed of 10 research groups (totalling 130 people in April 2014) and is situated on the neighbouring campuses ...

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