Research Thematics
News
Appel à candidature pour la future direction du GReD
Le GReD lance un appel à candidature pour recruter sa future directrice ou futur directeur, pour une prise de fonction en janvier 2021
CALL for a NEW RESEARCH GROUP LEADER
The GReD wishes to recruit a new independent leader to form a group within the scientific spectrum of the GReD. The GReD will provide laboratory space (50m2) and free access to state-of-the-art technological platforms (cell/tissue culture, FACS, imaging/live imaging, histology). The successful candidates will have full access to transgenic plant and animal (mouse, drosophila, Arabidopsis) and bioinformatics facilities and will benefit of administrative support. Facilities for high-throughput sequencing, mass spectrometry, proteomics, electron microscopy and radiobiology are available on the multidisciplinary Medical School campus.
CNET 2018: Registration is open
The 21st annual meeting organized by the French research community working on transposable elements (CNET 2018), organized this year by the GReD, will be held in Clermont-Ferrand on 2-4 July 2018.
This conference will cover all aspects of transposable element biology, including molecular mechanisms, cellular defense pathways, physiological impact on organisms, evolution of genomes and populations, and ecology.
For more details (programm, registration ) it's here.
EMBO Workshop "Plant Genome Stability and Change"
This EMBO workshop represents the sixth International Meeting on molecular and cellular mechanisms underlying stability, variability and modification of plant genomes. It will be held at the IPK Gatersleben, Germany, June 3-6, 2018.
For more details (programm, registration ) it's here.
DNA methylation : a new actor in CML biology
Chronic myeloid leukemia (CML), a cancer of the white blood cell, results from a translocation event that ultimately leads to the production of BCR-ABL1, a chimeric oncoprotein that promotes CML by aberrantly phosphorylating target proteins. Nonetheless, this event on its own, cannot account for an increasing number of clinical observation suggesting the involvement of other pathways, among which DNA methylation alteration emerges as a relevant candidate.
On that basis the teams of Marc BERGER (CHU, Clermont-Ferrand) and Philippe ARNAUD have characterized for the first time the DNA methylation patterns of CML cell subsets (immature and mature cells) isolated form the same clone during the early stage of the disease, before any treatment (Maupetit-Méhouas, Court, Bourgne et al.,). Altogether, this collaborative study demonstrated that DNA methylation abnormalities exist at early stages of CML and can affect the transcriptional landscape of malignant cells. These observations paved the way for new therapeutic strategies based on epigenetic drugs.
GENOME PLASTICITY: EXAMPLE OF 5S RIBOSOMAL RNA GENES
The genes coding 5S ribosomal RNAs (critical components of the ribosomes, the cellular machineries translating mRNA into proteins) are highly repeated in the genome, which allows the production of large quantities of these rRNAs.
In their last study (Simon et al., 2018), the team of Aline Probst and Christophe Tatout revealed an important variation in number and expression of 5S rRNA genes between different ecotypes of Arabidopsis thaliana.
Cymbopogon citratus and cancer: when citronella is a repellent not only for mosquitoes…
Through a real bilateral collaboration, Drs. Silvère BARON’s et and Jean-Marc LOBACCARO’s team Nuclear Receptor and Prostate diseases and Pr. Jacques SIMPORE’s team (Laboratoire de Biologie Moléculaire et de Génétique, Université de Ouagadougou, Burkina Faso), have identified medicinal plants of the Burkina Faso pharmacopeia that could be used in the future in cancer treatment (Bayala et al., 2018).
GReD Symposium : "Les surpises du Vivant"
the wednesday 16th of May, the GReD organizes its symposium
"Les surprises du vivant".
Amphitheater Limagne, CRBC Building , Faculté de Médecine
To the Programm click on "read more "....
Recombination machinery compensates telomere loss in the absence of telomerase.
The chromosomes of most eukaryotic species are linear, consisting of a single DNA double-helix running from one end to the other. Each chromosome thus has two ends and these are protected by specialized DNA-protein structures named telomeres. The importance of telomere structure is readily observed in the severe genetic instability and cell death that result from its absence.
In its last study ( Olivier et al., 2018), the team of Charles White and Maria Gallego unveiled mechanisms by which recombination machinery contributes to protect the telomeres from replicative failure, ensuring their stability.
In a few words...
The GReD is a Research Center at Clermont-Ferrand, Auvergne Rhône Alpes region of France. Created in 2008, the GReD is supported by the University Clermont Auvergne (UCA), the CNRS (UMR6293) and the INSERM (U1103). The center is composed of 14 research groups (totalling 147 people in December 2017) based at the Centre de Recherche Bio-Clinique (CRBC) on the campus ...
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