Research Thematics
News
Appel à candidature pour la future direction du GReD
Le GReD lance un appel à candidature pour recruter sa future directrice ou futur directeur, pour une prise de fonction en janvier 2021
CNET 2018: Registration is open
The 21st annual meeting organized by the French research community working on transposable elements (CNET 2018), organized this year by the GReD, will be held in Clermont-Ferrand on 2-4 July 2018.
This conference will cover all aspects of transposable element biology, including molecular mechanisms, cellular defense pathways, physiological impact on organisms, evolution of genomes and populations, and ecology.
For more details (programm, registration ) it's here.
PhD Defense: Lilia Laddada
Lilia LADDADA (Team “Diversification of muscle and heart cells in normal and pathological conditions”) will defend her thesis entitled:
"Étude du développement des tendons et de leur interaction avec les précurseurs de muscles lors de la myogenèse appendiculaire chez la drosophile"
Friday the 4th of May 2018 at 2 pm
Salle des Théses , Medical School
EMBO Workshop "Plant Genome Stability and Change"
This EMBO workshop represents the sixth International Meeting on molecular and cellular mechanisms underlying stability, variability and modification of plant genomes. It will be held at the IPK Gatersleben, Germany, June 3-6, 2018.
For more details (programm, registration ) it's here.
Les Mardis du GRed - Avril 2018
12H45 – 13H45
Faculté de médecine
Amphi limagne (CRBC RdC)
GENOME PLASTICITY: EXAMPLE OF 5S RIBOSOMAL RNA GENES
The genes coding 5S ribosomal RNAs (critical components of the ribosomes, the cellular machineries translating mRNA into proteins) are highly repeated in the genome, which allows the production of large quantities of these rRNAs.
In their last study (Simon et al., 2018), the team of Aline Probst and Christophe Tatout revealed an important variation in number and expression of 5S rRNA genes between different ecotypes of Arabidopsis thaliana.
Cymbopogon citratus and cancer: when citronella is a repellent not only for mosquitoes…
Through a real bilateral collaboration, Drs. Silvère BARON’s et and Jean-Marc LOBACCARO’s team Nuclear Receptor and Prostate diseases and Pr. Jacques SIMPORE’s team (Laboratoire de Biologie Moléculaire et de Génétique, Université de Ouagadougou, Burkina Faso), have identified medicinal plants of the Burkina Faso pharmacopeia that could be used in the future in cancer treatment (Bayala et al., 2018).
Recombination machinery compensates telomere loss in the absence of telomerase.
The chromosomes of most eukaryotic species are linear, consisting of a single DNA double-helix running from one end to the other. Each chromosome thus has two ends and these are protected by specialized DNA-protein structures named telomeres. The importance of telomere structure is readily observed in the severe genetic instability and cell death that result from its absence.
In its last study ( Olivier et al., 2018), the team of Charles White and Maria Gallego unveiled mechanisms by which recombination machinery contributes to protect the telomeres from replicative failure, ensuring their stability.
How to turn a football into a rugby ball?
Tissue elongation is part of the repertoire of processes that allow an organ to acquire its shape (morphogenesis). In the last years, the elongation of the ovarian follicle of Drosophila has emerged as a model of choice for the study of tissue elongation mechanisms. During its development the initially spherical follicle becomes ovoid and this elongation is controlled by the epithelial cells surrounding each follicle. However, so far, all studies on the subject have focused on the basal domain of these cells.
In its last study (Alegot et al.,) , the group of Vincent Mirouse has shown that the apical domain of the epithelial cells also contributed to this elongation.
LINE fishing... with the new bioinformatics tool CLIFinder
Repeated elements represent 45% of the human genome. However, due to their large number and their high sequence homology, the contribution of those elements to the human genome transcriptome remains difficult to study. Particularly, implication of recent LINE-1 (L1) elements to the transcriptional expression profile of cells and tissues is probably under-evaluated. Indeed, those L1 elements possess, in addition to their sense promoter, an antisense promoter (ASP) which allow the transcription of their adjacent sequences (which may include genes) in the form of LINE-1 chimeric transcripts (LCTs). Such LCTs have been already described in literature bur the question remains of the pangenomic extent of this transcriptional activity.
In a study conducted by Catherine Barrière (Pinson, Pogorelcnik et al., 2017), Philippe Arnaud’s team has developed and validated CLIFinder (Chimeric Line Finder), a new software dedicated to the identification of LCTs from stranded paired-end RNA-seq data. Thus, CLIFinder take advantage of the strong potential of next generation sequencing to unravel the complete transcriptome composition and allow the “fishing”, among all the transcriptome’s sequences, of numerous LCTs comprising a L1 sequence and a unique sequence of the genome. The CLIFinder tool is today available for the scientific community to realize extensive analyses in normal and pathological tissues. Indeed, many LCTs have been identified specifically in tumors and are supposed to play a functional role in tumorigenesis.
This software has been published in Bioinformatics (Pinson, Pogorelcnik et al., 2017)
In a few words...
The GReD is a Research Center at Clermont-Ferrand, Auvergne Rhône Alpes region of France. Created in 2008, the GReD is supported by the University Clermont Auvergne (UCA), the CNRS (UMR6293) and the INSERM (U1103). The center is composed of 14 research groups (totalling 147 people in December 2017) based at the Centre de Recherche Bio-Clinique (CRBC) on the campus ...
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