In a few words...
The GReD is a Research Center at Clermont-Ferrand, Auvergne Rhône Alpes region of France ...Read more
How does a begnihn tumor become cancerous?
While the evolution of cancer towards its most aggressive phases is largely studied, the mechanisms by which a benign tumour can become malignant remain poorly understood. Based on this observation, the "Nuclear Receptors and Prostate Diseases" team has developed a new model to study these early phases in Drosophila. Their work highlights the crucial role of growth factors in the transformation of the tumour. These results are published in Nature Communications (Rambur et al., 2020).
Relationship between transposable elements and their host genome: It is neither all black or all white...
In its last review article (Maupetit-Méhouas & Vaury), published in Cells, the team " Genetic instabilities and control by the host genome" presents the latest knwoledges on Germline reactivation of Transposable Elements
To access this review (Cells 2020, 9(5) 1172), it's here .
Post-doc position available "Environment-Metabolism-Spermatogenesis-Pathophysiology-&-Inheritance”.
A 2 to 3 years post-doc position, funded by the Plan Cancer-3R call, is available in the Volle’s team
In order to explore the questions of Testicular Germ Cell tumor (TGCT) biology and their sensitivity to chemo-drugs, the team has started...
The GReD , a player of the research to fight prostate cancer
Le projet collaboratif TransCAP réunit depuis 2014 les acteurs Auvergnats de la recherche sur le cancer de la prostate, dont l'équipe "Récepteurs nucléaires et maladies de la prostate". Cette collaboration fructueuse a abouti à la création d’une biobanque inédite en France, dont les détail sont à retrouver dans cet article de la Montagne
unexpected functions for the Dystrophin, the gene involved in Duchenne and Becker and muscular dystrophies
1st Spermatogenesis Conference. Male germ cells: from stem cells to diseases
For the organizing committee, the GReD institute invite you to attend the first Spermatogenesis Conference. Male germ cells: from stem cells to diseases in Lisbon (Portugal) from July 16 to 19th, 2021.
Muscular dystrophy and cardiac defects: the calcium lead
The majority of patients suffering from Myotonic Dystrophy Type I (DM1) exhibit cardiac conduction disturbance, reducing their life expectancy and causing sometimes sudden death. In their last study (Auxerre-Plantié et al., 2019), the team “Diversification of muscle and heart cells in normal and pathological conditions” used the fruitfly as a model system to reveal that this cardiac conduction defects are linked to gene expression alteration in cellular calcium regulation pathways, offering a new therapeutic lead for DM1 cardiac involvement.