News

CALL for NEW RESEARCH GROUP LEADERS

CALL for NEW RESEARCH GROUP LEADERS

We are opening  two distinct calls for new research group leaders. We encourage both young and already established outstanding researchers to apply. The deadline for applications is July 1st 2017. Selected applicants will be interviewed in October 2017.

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3 years post-doctoral position, available from June 2017

3 years post-doctoral position, available from June 2017

The team "Nuclear receptors and protate diseases"  is recruiting a post-doctoral researcher.

 Project: “Effects of environmental disrupting chemicals in metastatic development of prostate cancer and evolution in castration resistant cancer”

Key words: Prostate cancer, environmental disrupting chemicals, nuclear receptors, metastasis, castration resistant prostate cancer.

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Nutrition and Cancer Congress - June 22 -23, 2017

Nutrition and Cancer Congress - June 22 -23, 2017

The 4th  International Congress of Translational Research in Human Nutrition – Theme: Nutrition and Cancer , will be held in Clermont-Ferrand  on 22 and 23 of june.

To know more about it ( registration, program...), it's here.

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Marie-Elisa PINSON won the prize for the best poster at the Auvergne-Rhône-Alpes forum on cancer research

Marie-Elisa PINSON won the prize for the best poster at the Auvergne-Rhône-Alpes forum on cancer research

Marie-Elisa PINSON won the prize for the best poster, section "Bioinformatics and modelisation" at the Auvergne-Rhône-Alpes forum on cancer research.

To know more, the awarded poster can be uploaded here.

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Les Mardis du GRed - Avril 2017

12H30 – 13H30
Faculté de médecine
Amphi 1 (1èR étage, R1)

04 Avril  !!! AMPHI 3 !!! (5ème R1)     :     Mubeen GOOLAM   
University of Cambridge, Department of Physiology, Development & Neuroscience, UK
Contact: claire.chazaud@uca.fr

Identification of Novel Molecular Regulators of Cell Fate during Mouse Preimplantation Development.

11 Avril      :     Pas de séminaire

18 Avril      :     Lauriane SEDES  
GReD, INSERM U1103, CNRS 6293, UCA

FXRalpha as a new sensor of environmental molecules.

25 Avril      :     Marc PIECHACZYK  
UMR5535, Institut de Génétique Moléculaire Montpellier (IGMM)
Contact: philippe.arnaud@uca.fr

The ROS/SUMO axis in chemosensitivity versus chemoresistance of acute myeloid leukemia (and other transcriptional studies).

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Male infertility, toward new molecular causes .

Male infertility, toward new molecular causes .

Bile acids are molecules with endocrine activities controlling several physiological functions such as immunity and glucose homeostasis. Recently, they have also been shown to be involved in testicular physiology and as a cause of male fertility in experimental models. By the mean of mouse models and pharmacological approaches, the team of David Volle revealed the unexpected presence of alternative pathways, involving the Nuclear Receptor CAR (Constitutive-Androstane-Receptor ; NR1I3), to mediate bile acid functions in testis.

This study is published in Scientific Reports (Martinot et al., 2017).

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The LINC complex contributes to heterochromatin organisation and transcriptional gene silencing in plants

The LINC complex contributes to heterochromatin organisation and transcriptional gene silencing in plants

The linker of nucleoskeleton and cytoskeleton (LINC) complex is an evolutionarily well-conserved protein bridge connecting the cytoplasmic and nuclear compartments across the nuclear membrane. Recent investigations have highlighted its function in nuclear morphology and meiosis. The new study performed by the team of Aline Probst and Christophe Tatout brings new insights into LINC complex function in plants. Using 3D imaging and molecular techniques the authors reveal that plants carrying mutations in this complex show release of transcriptional silencing as well as a decompaction of heterochromatic sequences. Therefore, the plant LINC complex contributes to proper heterochromatin organisation and positioning at the nuclear periphery, illustrating the important function of the nuclear envelope in the regulation of genome expression.

This study has been published in Journal of Cell Science (Poulet et al., 2017)

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The journey of a thousand piRNAs begins with a single Dot

The journey of a thousand piRNAs begins with a single Dot

Among the several kinds of non-coding small RNAs, piRNAs (Piwi-interacting RNAs) are the ‘transposon-silencers’. They occur within the gonads of animals, protecting the cellular genome from transposable elements. One of the most mysterious question is how piRNAs are transcribed and processed inside the cell. Now  Chantal Vaury’s lab brings new data into the biosynthesis of piRNAs. Their study, published recently in Nature Comm (Dennis & al., Nat Commun, 2016 Dec 8;7:13739. doi: 10.1038/ncomms13739), shows that the precursor transcripts of piRNAs are exported out of the nucleus by specific exporter proteins-Nxt1,Nxf1 and that the export itself directs the assembly of Yb bodies which are the cytoplasmic maturation centres of piRNAs. Chantal’s lab has been actively studying piRNA production for the past years, using the ovarian tissue of the fruit fly Drosophila melanogaster as a model. In 2013, they discovered ‘Dot COM’ – a single bright spot within the nuclei of ovarian follicular cells where piRNA precursor transcripts accumulate before to be processed. This year their new study has revealed that the precursors travel away from the site of transcription in the DNA to DOT COM, with the help of exportins and exon-junction complex (EJC) proteins. The study opens new possibilities of research in the piRNA and transposable element regulation fields.

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Adrenal gland differentiation: positive antagonism

Adrenal gland differentiation: positive antagonism

Endocrine activity of the adrenal glands is essential for body homeostasis and depends on the differentiation of two concentric cellular zones. Using transgenic mouse models, Pierre Val’s team has shown that this zonal differentiation relies on a double antagonistic interaction between two signalling pathways. They further show that this antagonism inhibits development of aggressive tumours in mouse models and patients. This study is published in Nature Communications (Drelon et al., 2016) .

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EZH2, a novel therapeutic target in Adrenal Cortex Cancer

EZH2, a novel therapeutic target in Adrenal Cortex Cancer

Adrenal cortex Cancer is one of the most aggressive cancers, for which there is no effective therapeutic approach. Research supervised by Pierre VAL at GReD laboratories, identified overexpression of EZH2 as a novel alteration involved in malignant progression of this cancer. These data show that targeting EZH2 with pharmacological inhibitors blocks proliferation of cancer cells and induces cell death. This suggests that EZH2 could be an interesting target for treatment of adrenal cancer. This article is published in Human Molecular Genetics (Drelon et al., 2016)

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In a few words...

GReD

The GReD is a Research Center at Clermont-Ferrand, capital of the Auvergne region of central France. Created in 2008, the GReD is supported by the University of Auvergne, the University Blaise Pascal, the CNRS (UMR6293) and the INSERM (U1103). The center is composed of 10 research groups (totalling 130 people in April 2014) and is situated on the neighbouring campuses ...

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