Thematic 3: Endocrinology, signalling and cancer

Research thematic

The primary goal of our group is to understand and discriminate the respective roles of the lipid related nuclear receptors (namely LXR, FXR and SHP) in the control of the endocrine activity. For that purpose we use complementary as well as parallel approaches to answer these questions: new or already available mouse models and various cell models. The research project is focused on two complementary topics: 1) Control of the lipid homeostasis in the reproductive functions by studying the physiologic role of LXRs, FXR and TGR5 in the testis and the impact of bile acids on male reproductive functions. 2) Impact of lipids on prostate physiology and pathology (benign prostate hyperplasia and prostate cancer).