unexpected functions for the Dystrophin, the gene involved in Duchenne and Becker and muscular dystrophies

unexpected functions for the Dystrophin, the gene involved in Duchenne and Becker and muscular dystrophies

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strophin human gene is very famous because its mutation is causal for Duchenne and Becker muscular dystrophies. In collaboration with a team of the University of Chicago, the team "Epithlial Growth and Morphogenesis"  studied Dystrophin role in Drosophila non-muscle cells. Their results, pubished in Development (Cerqueira Campos et al.,) shine a new light on what could be Dystrophin functions at molecular and cellular scales, and open interesting prospects to get a better understanding of its involvement in dystrophies.

Especially, we have shown that Dystrophin is request for tissue morphogenesis, promoting follicle elongation. This role requires two distinct functions of the Dystrophin, one in the secretion of matrix fibrill and the other in the polarisation of the actin cytoskeleton.

Last modified: 05/22/2020