Scientific & institutional news

Recrutement d’un-e préparateur-trice en biologie et SVT

Un poste d’agent technique- préparateur-trice en biologie et SVT- est ouvert au GReD. Ce CDD Université d’Auvergne d’une durée de 11 mois est à pourvoir au 1^er Octobre 2020.

Pour en savoir plus et postuler, c’est ici.

Everything you wanted to know on the impact of nuclear organization on plant traits....

The Team "Histone variants and the nuclear envelope in heterochromatin dynamics" have co-edited the Special issue of the Journal of Experimental Botany on 'Impact of Chromatin Domains on Plant Phenotypes' in collaboration with the Society of Experimental Biology and the COST Action CA16212.

The team contributed a review article (Probst et al,) presenting up-to-date knowledge on histone variants that you can access here.

Recrutement Assistant(e)-Ingénieur(e): Biologie Moléculaire/Culture Cellulaire/Génétique et développment de la souris

L'équipe Epigénomique évolutive et conflits génétiques (A. Molaro) recherche un(e) assistant(e)-ingénieur(e).

L’équipe utilise des approches expérimentales (culture cellulaire et ...

Les polyphénols, l’alternative « gagnant/gagnant » aux pesticides pour protéger à la fois les plantes et les abeilles.

Dans les cinquante dernières années, la protection des espèces végétales a consisté à utiliser massivement les produits phytopharmaceutiques ou pesticides. Cependant, ces composés de synthèse sont devenus délétères pour l’ensemble des organismes vivants dont les abeilles.

Une étude impliquant quatre unités clermontoises, LMGE-PIAF-SIGMA et le GReD, fait précisément émerger un nouveau concept technologique consistant à extraire les polyphénols des plantes et les réintroduire dans l’environnement pour protéger les plantes et les abeilles. Ce procédé phytosanitaire a fait l’objet d’un dépôt de brevet.

Pour en savoir plus, retrouvez ici l’article dédié sur le site de la minute recherche de l’UCA.

Contact au GReD : Ayhan Kocer

Discovering how plant adapt to climate changes : INDEPTH meets the challenge!

A better understanding of the mechanisms whereby 3D organisation of chromatin would influence plant growth is a prerequisite to discover how plant can adapt to climate changes.

The COST-Action INDEPTH ...

How does a begnin tumor become cancerous?

While the evolution of cancer towards its most aggressive phases is largely studied, the mechanisms by which a benign tumour can become malignant remain poorly understood. Based on this observation, the "Nuclear Receptors and Prostate Diseases" team has developed a new model to study these early phases in Drosophila. Their work highlights the crucial role of growth factors in the transformation of the tumour. These results are published in Nature Communications (Rambur et al., 2020).

Relationship between transposable elements and their host genome: It is neither all black or all white...

In its last review article (Maupetit-Méhouas & Vaury), published in Cells, the team " Genetic instabilities and control by the host genome" presents the latest knwoledges on Germline reactivation of Transposable ...

1st Spermatogenesis Conference. Male germ cells: from stem cells to diseases

For the organizing committee, the GReD institute invite you to attend the first Spermatogenesis Conference. Male germ cells: from stem cells to diseases in Lisbon (Portugal) from July 16 to 19th, 2021.

https://www.fusion-conferences.com/conference/129

Focus sur le Groupe Cancer Clermont Auvergne

Focus sur le Groupe Cancer Clermont Auvergne dans le LAB#7 de l’UCA.

Retrouvez ici l’interview de Silvere Baron ( équipe : Récepteurs nucléaires et maladies de la ...

Les stagiaires de 3iéme à la découverte du GReD.

Du 17 au 21 décembre 2018, six collégiens, tous désireux de découvrir les métiers de la recherche, ont rejoint le GReD. Les activés men ...

Stress & SUMO : le poids de SUMO dans la glande surrénale

La SUMOylation est un processus de modification post-traductionnelle conservé chez les eucaryotes, indispensable au maintien de l’intégrité des génomes, à la régulation des gènes et à la ...

GH1-HMGA1 : une protéine chromatinienne impliquée dans la stabilité des télomères et la réparation des cassures double brin de l’ADN

De par leur nature linéaire, les chromosomes des eucaryotes ont dû développer des mécanismes de protection de leurs extrémités appelés télomères. Si ...

TRAINING SCHOOL 3D-FisH & IMAGE ANALYSIS

October 15-19th, 2018

The Probst-Tatout’team organizes a training school in "3D-FiSH and Image Analysis" in the frame of INDEPTH. This first training school will also be supported at the ...

Weapons exchange in the battle between transposable elements and their host

The inactivation of transposable elements within genomes is insured by multiple epigenetic mechanisms. Olivier Mathieu's team has identified two genes required for repressing many transposable elements through a new ...

Adrenal differentiation: a key role for the epigenetic factor EZH2

The adrenal gland produces glucocorticoid and mineralocorticoid hormones that are essential for life. This hormone production depends on a complex process of recruitment and differentiation of progenitor cells. Using a ...

A key developmental stage for the targeting of transposable elements by piRNAs.

In few germline cells located at the anterior pole of the Drosophila ovariole, Piwi expression is weakened. This short time of germline development has been called the Piwiless pocket or ...

Les donateurs AFM-Téléthon à la rencontre des équipes de recherche du GReD

Le 8 octobre dernier le GReD organisait une journée Portes ouvertes aux donateurs de l’Association Française contre les Myopathies (AFM-Téléthon).

Recombination machinery compensates telomere loss in the absence of telomerase.

The chromosomes of most eukaryotic species are linear, consisting of a single DNA double-helix running from one end to the other. Each chromosome thus has two ends and these are ...

GENOME PLASTICITY: EXAMPLE OF 5S RIBOSOMAL RNA GENES

The genes coding 5S ribosomal RNAs (critical components of the ribosomes, the cellular machineries translating mRNA into proteins) are highly repeated in the genome, which allows the production of large ...

LINE fishing... with the new bioinformatics tool CLIFinder

Repeated elements represent 45% of the human genome. However, due to their large number and their high sequence homology, the contribution of those elements to the human genome transcriptome remains ...

EZH2, a novel therapeutic target in Adrenal Cortex Cancer

Adrenal cortex Cancer is one of the most aggressive cancers, for which there is no effective therapeutic approach. Research supervised by Pierre VAL at GReD laboratories, identified overexpression of EZH2 ...

Adrenal gland differentiation: positive antagonism

Endocrine activity of the adrenal glands is essential for body homeostasis and depends on the differentiation of two concentric cellular zones. Using transgenic mouse models, Pierre Val’s team has ...

Recrutement chargé(e) de mission scientifique

La filière Maladies Rares Endocriniennes (FIRENDO http://www.firendo.fr/accueil-filiere-firendo/) recherche :

Un(e) chargé(e) de mission scientifique, affecté(e) à l'équipe "Pathophysiologie moléculaire des tissus surr ...

What if honeybees could help fighting prostate cancer?

Prostate cancer is one of the most frequent and deadly tumors in man for which it is necessary to expand the portfolio of therapeutic strategies.

Based on an ethnobotany screening ...

Inauguration du Centre de Recherche BioClinique de l’Université Clermont Auvergne

Depuis l’été 2018, les équipes du GReD sont hébergées au CRBC, Centre de Recherche BioClinique.

Ce nouveau bâtiment a été inauguré le lundi 10 décembre ...

Même confiné le GReD reste actif et solidaire

Solidaire tout d’abord de nos membres aussi praticiens hospitaliers, ainsi que de nos collègues clermontois, qui sont directement impliqués dans la lutte contre le virus : courage à vous ...

Claire CHAZAUD received the VAN BENEDEN prize.

This prize is awarded every three years by the Royal Academy of Sciences, Letters and Fine Arts of Belgium to acknowledge a pioneer work in embryology or cytology .

Claire Chazaud ...

GReD confined : The mosaic ....team 13

Mosaic Team 13

GReD confined : The mosaic ....team 3

Team 3

How to turn a football into a rugby ball?

Tissue elongation is part of the repertoire of processes that allow an organ to acquire its shape (morphogenesis). In the last years, the elongation of the ovarian follicle of Drosophila ...

Cymbopogon citratus and cancer: when citronella is a repellent not only for mosquitoes…

Through a real bilateral collaboration, Drs. Silvère BARON’s et and Jean-Marc LOBACCARO’s team Nuclear Receptor and Prostate diseases and Pr. Jacques SIMPORE’s team (Laboratoire de Biologie ...

sRNAPipe: a Galaxy-based pipeline for bioinformatic in-depth exploration of small RNAseq data

Les recherches menées au cours de cette dernière décennie ont révélé que la quasi-totalité des génomes est transcrite et que la plupart des mol ...

GReD confined : The mosaic ....team 1

Team 1: Behind the screen...each has its own containment

more details : here

Souvenirs ( pas si lointain) d'un GReD confiné

La mosaique du GReD confiné, en attendant le 22 juin, date à laquelle nous pourrons enfin tous nous retrouver dans nos locaux,tout en respectant les gestes barriéres.

Les d ...

GReD confined : The mosaic ....team "Muscle"

Team "Muscle"

Muscular dystrophy and cardiac defects: the calcium lead

The majority of patients suffering from Myotonic Dystrophy Type I (DM1) exhibit cardiac conduction disturbance, reducing their life expectancy and causing sometimes sudden death. In their last study (Auxerre-Plantié et ...

La recherche contre les myopathies au GReD : La drosophile un modéle précieux

Grâce aux dons du téléthon, L' AFM soutient deux équipes de recherche au GReD.

En tirant partie du modéle drosophile, les équipes "Diversification des cellules musculaires ...

GReD confined : The mosaic ....team 4

Team 4: "100 years of shared solitude"

GReD confined : The mosaic ....team "MePTI"

Team "MePTI"

Transcriptional alterations in Glioma: DNA methylation is the tip of the “epigenetic” iceberg

In cancer cells, aberrant DNA methylation is commonly associated with transcriptional alterations, including silencing of tumor suppressor genes. However, multiple epigenetic mechanisms, including polycomb repressive marks, contribute to gene deregulation ...

GReD confined : The mosaic ....Administrative team

Administrative team

The conserved yeast telomeric CST complex also functions in the regulation of RNA polymerase II transcription

The telomeric CST complex contributes to maintain genome stability through chromosome end protection and telomere length regulation. In its last study conducted on the yeast model (Calvo, Grandin et al ...

DNA methylation : a new actor in CML biology

Chronic myeloid leukemia (CML), a cancer of the white blood cell, results from a translocation event that ultimately leads to the production of BCR-ABL1, a chimeric oncoprotein that promotes CML ...