Scientific & institutional news

CALL for a NEW RESEARCH GROUP LEADER,

The GReD Institute opens a position of Independent Group Leader in human mobility related fields.

As part of the CAP20-25 initiative , the successful candidate will benefit from a 400 k€ start-up package and the GReD Institute will provide office, appropriate lab space and access to in-house facilities.

The final deadline for applications is noon, January 31st 2021.

For more details and apply , it's here

Replicate to repress

Heterochromatin, which states for highly condensed genomics regions, is mainly constituted of transcriptionally repressed repeated elements. In its last study, published in Genome Biology (Bourguet et al., 2020), the SILENT team shows that DNA polymerase epsilon, which is involved in DNA replication, plays a crucial role in maintaining both the structure and the function of heterochromatin.

Post-doc available : “Identification of natural extracts targeting LXR nuclear receptors activity involved in skin wound healing”

A 2 years post-doc position, shared between the GRed and GREENTECH company, is available in the "Nuclear receptors and prostate diseases" from august 2021

For more details and to apply ...

Post-doc available to valorize a treatment Strategy by sevoflurane of the Acute Respiratory Distress Syndrome COVID-19

A 30 months post-doc position is available in the "Translational approach to epithelial injury and repair" team to work on the ASTRA project: "Biomedical and industrial valorization of a Treatment ...

Three new young CNRS/INSERM researchers at the GReD in 2020...what else ?!

2020 Competitive Examinations for CNRS and INSERM Researchers has been a great vintage for the GReD as all its three candidates have been appointed.

We are thus happy and proud ...

4ème Colloque Recherche de la filière FIRENDO

Le 4ème Colloque Recherche de la filière FIRENDO , co-organisé par l'équipe "Pathophysiologie moléculaire des tissus surrénaux et endocriniens", aura lieu le Mardi 8 décembre ...

Les Doctorantes du GReD s’illustrent lors des JED 2020.

Amy HESKETH (Equipe “SILENT”), Marianne YOTH (Equipe “Instabilités génétiques et contrôle par le génome hôte”) et Manon BOULET (“Régulation épigénétique et ...

A new research group has joined the GReD

Awarded in 2020 by the FRM "Young Investigator " programm, Antoine Molaro has joined the GRed this summer to develop its thematic on Evolutionary Epigenomics and Genetic Conflicts.

He his supported in this journey by Marine Fraisse and both they can count on their trusty companions "Steeve" and "Brian" .

To know more, it's here

Discovering how plant adapt to climate changes : INDEPTH meets the challenge!

A better understanding of the mechanisms whereby 3D organisation of chromatin would influence plant growth is a prerequisite to discover how plant can adapt to climate changes.

The COST-Action INDEPTH ...

Everything you wanted to know on the impact of nuclear organization on plant traits....

The Team "Histone variants and the nuclear envelope in heterochromatin dynamics" have co-edited the Special issue of the Journal of Experimental Botany on 'Impact of Chromatin Domains on Plant Phenotypes' in collaboration with the Society of Experimental Biology and the COST Action CA16212.

The team contributed a review article (Probst et al,) presenting up-to-date knowledge on histone variants that you can access here.

1st Spermatogenesis Conference. Male germ cells: from stem cells to diseases

For the organizing committee, the GReD institute invite you to attend the first Spermatogenesis Conference. Male germ cells: from stem cells to diseases in Lisbon (Portugal) from July 16 to 19th, 2021.

https://www.fusion-conferences.com/conference/129

Stress & SUMO : le poids de SUMO dans la glande surrénale

La SUMOylation est un processus de modification post-traductionnelle conservé chez les eucaryotes, indispensable au maintien de l’intégrité des génomes, à la régulation des gènes et à la ...

GH1-HMGA1 : une protéine chromatinienne impliquée dans la stabilité des télomères et la réparation des cassures double brin de l’ADN

De par leur nature linéaire, les chromosomes des eucaryotes ont dû développer des mécanismes de protection de leurs extrémités appelés télomères. Si ...

TRAINING SCHOOL 3D-FisH & IMAGE ANALYSIS

October 15-19th, 2018

The Probst-Tatout’team organizes a training school in "3D-FiSH and Image Analysis" in the frame of INDEPTH. This first training school will also be supported at the ...

Weapons exchange in the battle between transposable elements and their host

The inactivation of transposable elements within genomes is insured by multiple epigenetic mechanisms. Olivier Mathieu's team has identified two genes required for repressing many transposable elements through a new ...

Adrenal differentiation: a key role for the epigenetic factor EZH2

The adrenal gland produces glucocorticoid and mineralocorticoid hormones that are essential for life. This hormone production depends on a complex process of recruitment and differentiation of progenitor cells. Using a ...

A key developmental stage for the targeting of transposable elements by piRNAs.

In few germline cells located at the anterior pole of the Drosophila ovariole, Piwi expression is weakened. This short time of germline development has been called the Piwiless pocket or ...

Les donateurs AFM-Téléthon à la rencontre des équipes de recherche du GReD

Le 8 octobre dernier le GReD organisait une journée Portes ouvertes aux donateurs de l’Association Française contre les Myopathies (AFM-Téléthon).

Recombination machinery compensates telomere loss in the absence of telomerase.

The chromosomes of most eukaryotic species are linear, consisting of a single DNA double-helix running from one end to the other. Each chromosome thus has two ends and these are ...

GENOME PLASTICITY: EXAMPLE OF 5S RIBOSOMAL RNA GENES

The genes coding 5S ribosomal RNAs (critical components of the ribosomes, the cellular machineries translating mRNA into proteins) are highly repeated in the genome, which allows the production of large ...

LINE fishing... with the new bioinformatics tool CLIFinder

Repeated elements represent 45% of the human genome. However, due to their large number and their high sequence homology, the contribution of those elements to the human genome transcriptome remains ...

EZH2, a novel therapeutic target in Adrenal Cortex Cancer

Adrenal cortex Cancer is one of the most aggressive cancers, for which there is no effective therapeutic approach. Research supervised by Pierre VAL at GReD laboratories, identified overexpression of EZH2 ...

Adrenal gland differentiation: positive antagonism

Endocrine activity of the adrenal glands is essential for body homeostasis and depends on the differentiation of two concentric cellular zones. Using transgenic mouse models, Pierre Val’s team has ...

Recrutement chargé(e) de mission scientifique

La filière Maladies Rares Endocriniennes (FIRENDO http://www.firendo.fr/accueil-filiere-firendo/) recherche :

Un(e) chargé(e) de mission scientifique, affecté(e) à l'équipe "Pathophysiologie moléculaire des tissus surr ...

What if honeybees could help fighting prostate cancer?

Prostate cancer is one of the most frequent and deadly tumors in man for which it is necessary to expand the portfolio of therapeutic strategies.

Based on an ethnobotany screening ...

Inauguration du Centre de Recherche BioClinique de l’Université Clermont Auvergne

Depuis l’été 2018, les équipes du GReD sont hébergées au CRBC, Centre de Recherche BioClinique.

Ce nouveau bâtiment a été inauguré le lundi 10 décembre ...

Même confiné le GReD reste actif et solidaire

Solidaire tout d’abord de nos membres aussi praticiens hospitaliers, ainsi que de nos collègues clermontois, qui sont directement impliqués dans la lutte contre le virus : courage à vous ...

Claire CHAZAUD received the VAN BENEDEN prize.

This prize is awarded every three years by the Royal Academy of Sciences, Letters and Fine Arts of Belgium to acknowledge a pioneer work in embryology or cytology .

Claire Chazaud ...

GReD confined : The mosaic ....team 13

Mosaic Team 13

GReD confined : The mosaic ....team 3

Team 3

How to turn a football into a rugby ball?

Tissue elongation is part of the repertoire of processes that allow an organ to acquire its shape (morphogenesis). In the last years, the elongation of the ovarian follicle of Drosophila ...

Le GReD partie prenante dans le projet VitAbeilles

Quatre laboratoires de l’Université Clermont Auvergne, dont le GReD, viennent de mettre en évidence un extrait végétal capable de soigner la nosémose, une maladie qui d ...

sRNAPipe: a Galaxy-based pipeline for bioinformatic in-depth exploration of small RNAseq data

Les recherches menées au cours de cette dernière décennie ont révélé que la quasi-totalité des génomes est transcrite et que la plupart des mol ...

GReD confined : The mosaic ....team 1

Team 1: Behind the screen...each has its own containment

more details : here

Souvenirs ( pas si lointain) d'un GReD confiné

La mosaique du GReD confiné, en attendant le 22 juin, date à laquelle nous pourrons enfin tous nous retrouver dans nos locaux,tout en respectant les gestes barriéres.

Les d ...

GReD confined : The mosaic ....team "Muscle"

Team "Muscle"

Muscular dystrophy and cardiac defects: the calcium lead

The majority of patients suffering from Myotonic Dystrophy Type I (DM1) exhibit cardiac conduction disturbance, reducing their life expectancy and causing sometimes sudden death. In their last study (Auxerre-Plantié et ...

La recherche contre les myopathies au GReD : La drosophile un modéle précieux

Grâce aux dons du téléthon, L' AFM soutient deux équipes de recherche au GReD.

En tirant partie du modéle drosophile, les équipes "Diversification des cellules musculaires ...

GReD confined : The mosaic ....team 4

Team 4: "100 years of shared solitude"

GReD confined : The mosaic ....team "MePTI"

Team "MePTI"

Transcriptional alterations in Glioma: DNA methylation is the tip of the “epigenetic” iceberg

In cancer cells, aberrant DNA methylation is commonly associated with transcriptional alterations, including silencing of tumor suppressor genes. However, multiple epigenetic mechanisms, including polycomb repressive marks, contribute to gene deregulation ...

Les polyphénols, l’alternative « gagnant/gagnant » aux pesticides pour protéger à la fois les plantes et les abeilles.

Dans les cinquante dernières années, la protection des espèces végétales a consisté à utiliser massivement les produits phytopharmaceutiques ou pesticides. Cependant, ces composés de synthèse sont devenus délétères pour l’ensemble des organismes vivants dont les abeilles.

Une étude impliquant quatre unités clermontoises, LMGE-PIAF-SIGMA et le GReD, fait précisément émerger un nouveau concept technologique consistant à extraire les polyphénols des plantes et les réintroduire dans l’environnement pour protéger les plantes et les abeilles. Ce procédé phytosanitaire a fait l’objet d’un dépôt de brevet.

Pour en savoir plus, retrouvez ici l’article dédié sur le site de la minute recherche de l’UCA.

Contact au GReD : Ayhan Kocer

L'Art s'affiche au GReD

Dans le cadre de la fête de la science l'artiste peinte /plasticien Lionel Chantillon (http://lionel.chantillon.overblog.com/page/2) expose une partie de ses oeuvres dans ...

Relationship between transposable elements and their host genome: It is neither all black or all white...

In its last review article (Maupetit-Méhouas & Vaury), published in Cells, the team " Genetic instabilities and control by the host genome" presents the latest knwoledges on Germline reactivation of Transposable ...

The GReD , a player of the research to fight prostate cancer

Le projet collaboratif TransCAP réunit depuis 2014 les acteurs Auvergnats de la recherche sur le cancer de la prostate, dont l'équipe "Récepteurs nucléaires et maladies de ...

How does a begnin tumor become cancerous?

While the evolution of cancer towards its most aggressive phases is largely studied, the mechanisms by which a benign tumour can become malignant remain poorly understood. Based on this observation, the "Nuclear Receptors and Prostate Diseases" team has developed a new model to study these early phases in Drosophila. Their work highlights the crucial role of growth factors in the transformation of the tumour. These results are published in Nature Communications (Rambur et al., 2020).

unexpected functions for the Dystrophin, the gene involved in Duchenne and Becker and muscular dystrophies

Résultat de recherche d'images pour "petit chapeau"

GReD confiné : La mosaïque .... Team Nurep

Team NuReP: "COVID or not COVID? This is not the question… show must go on :)"

More here

GReD confiné : The mosaic ....team 10

"A défaut d'être ensemble, la team 10 Zoom!!"

GReD confiné : The mosaic .... Team Reclab

Team Reclab

Looking for pERK !

In its last study, published in Development (Azami et al., ), the team "Molecular mechanisms of cell lineage differentiation in the early mouse embryo" identified the phosporylation of ERK as a ...

GReD confined : The mosaic ....team AKR

team AKR

GReD confined : The mosaic ....team 14

Team 14

GReD confined : The mosaic ....Administrative team

Administrative team

Cymbopogon citratus and cancer: when citronella is a repellent not only for mosquitoes…

Through a real bilateral collaboration, Drs. Silvère BARON’s et and Jean-Marc LOBACCARO’s team Nuclear Receptor and Prostate diseases and Pr. Jacques SIMPORE’s team (Laboratoire de Biologie ...

The conserved yeast telomeric CST complex also functions in the regulation of RNA polymerase II transcription

The telomeric CST complex contributes to maintain genome stability through chromosome end protection and telomere length regulation. In its last study conducted on the yeast model (Calvo, Grandin et al ...

DNA methylation : a new actor in CML biology

Chronic myeloid leukemia (CML), a cancer of the white blood cell, results from a translocation event that ultimately leads to the production of BCR-ABL1, a chimeric oncoprotein that promotes CML ...