Scientific & institutional news

Recrutement Assistant(e) Ingénieur(e) en biologie Moléculaire

L’activité s’exercera au sein de l’équipe «Diversification des cellules musculaires et cardiaques en conditions normales et pathologiques» L’Assistant(e) Ingénieur(e) sera en charge d ...

Recrutement Technicien(ne) en biologie Moléculaire

L’activité s’exercera au sein de l’équipe «Diversification des cellules musculaires et cardiaques en conditions normales et pathologiques» et la plateforme de transgénese et microinjection de Drosphile ...

Tumorigénèse testiculaire du Complexe de Carney : Identification de nouveaux circuits de prolifération

En développant des stratégies de génomique fonctionnelle sur des modèles murins, et en collaboration avec un réseau international de chercheurs et cliniciens, l’équipe Pathophysiologie moléculaire des tissus surrénaux et endocriniens a identifié les différents circuits moléculaires impliqués dans le développement de tumeurs testiculaires de patients atteints d’une maladie rare, le Complexe de Carney. Cette étude est publiée dans Journal Of Clinical Investigations (Djari et al., 2021)

Journée Portes Ouvertes

L’iGReD organise sa Journée Portes Ouvertes, dédiée aux étudiants de Licence et Master, le Mardi 7 décembre 2021, de 11h00 à 15h00.

Au cours de cette ...

L'iGReD répond présent à la Courstache 2021

Félicitations à la belle équipe de l'iGReD, ainsi qu'au 1700 sportifs de tout poil, qui ont participé à la 5^iémeCourstache (http://www.lacourstache.com/ ), course caricative ...

A new team joins the iGRED

Charléne GUILLOT, I-SITE CAP2025 call laureate , joined the i-GReD in september 2021 to set up her team " Dynamic regulation of body axis regulation".

To know more, it's here.

m6A methylation of mRNA promotes their transcription thought RNA polymerase II

This study, leads by G.Junion ( team Diversification of muscle and heart cells in normal and pathological conditions ), published in the journal Molecular Cell (Akhtar et al.) shows a new mechanism for regulating gene expression through modification of RNA. Using a combination of molecular biology and bioinformatics, they demonstrate that the enzymatic complex called m⁶A methyltransferase (MTC) enables RNA polymerase II to escape pausing and perform transcription, and thus precisely control the expression of genes responsible for the development of organisms.

iGReD goes green...

iGReD days 2021 (4th and 5th of october) will be held at the holiday village of Parent , near Clermont.

In the programme (here) : Science sand recreation...Quoi de plus ?!

Les stagiaires de 3iéme à la découverte du GReD.

Du 17 au 21 décembre 2018, six collégiens, tous désireux de découvrir les métiers de la recherche, ont rejoint le GReD. Les activés men ...

Stress & SUMO : le poids de SUMO dans la glande surrénale

La SUMOylation est un processus de modification post-traductionnelle conservé chez les eucaryotes, indispensable au maintien de l’intégrité des génomes, à la régulation des gènes et à la ...

GH1-HMGA1 : une protéine chromatinienne impliquée dans la stabilité des télomères et la réparation des cassures double brin de l’ADN

De par leur nature linéaire, les chromosomes des eucaryotes ont dû développer des mécanismes de protection de leurs extrémités appelés télomères. Si ...

TRAINING SCHOOL 3D-FisH & IMAGE ANALYSIS

October 15-19th, 2018

The Probst-Tatout’team organizes a training school in "3D-FiSH and Image Analysis" in the frame of INDEPTH. This first training school will also be supported at the ...

Weapons exchange in the battle between transposable elements and their host

The inactivation of transposable elements within genomes is insured by multiple epigenetic mechanisms. Olivier Mathieu's team has identified two genes required for repressing many transposable elements through a new ...

Adrenal differentiation: a key role for the epigenetic factor EZH2

The adrenal gland produces glucocorticoid and mineralocorticoid hormones that are essential for life. This hormone production depends on a complex process of recruitment and differentiation of progenitor cells. Using a ...

A key developmental stage for the targeting of transposable elements by piRNAs.

In few germline cells located at the anterior pole of the Drosophila ovariole, Piwi expression is weakened. This short time of germline development has been called the Piwiless pocket or ...

Les donateurs AFM-Téléthon à la rencontre des équipes de recherche du GReD

Le 8 octobre dernier le GReD organisait une journée Portes ouvertes aux donateurs de l’Association Française contre les Myopathies (AFM-Téléthon).

Recombination machinery compensates telomere loss in the absence of telomerase.

The chromosomes of most eukaryotic species are linear, consisting of a single DNA double-helix running from one end to the other. Each chromosome thus has two ends and these are ...

GENOME PLASTICITY: EXAMPLE OF 5S RIBOSOMAL RNA GENES

The genes coding 5S ribosomal RNAs (critical components of the ribosomes, the cellular machineries translating mRNA into proteins) are highly repeated in the genome, which allows the production of large ...

LINE fishing... with the new bioinformatics tool CLIFinder

Repeated elements represent 45% of the human genome. However, due to their large number and their high sequence homology, the contribution of those elements to the human genome transcriptome remains ...

EZH2, a novel therapeutic target in Adrenal Cortex Cancer

Adrenal cortex Cancer is one of the most aggressive cancers, for which there is no effective therapeutic approach. Research supervised by Pierre VAL at GReD laboratories, identified overexpression of EZH2 ...

Adrenal gland differentiation: positive antagonism

Endocrine activity of the adrenal glands is essential for body homeostasis and depends on the differentiation of two concentric cellular zones. Using transgenic mouse models, Pierre Val’s team has ...

What if honeybees could help fighting prostate cancer?

Prostate cancer is one of the most frequent and deadly tumors in man for which it is necessary to expand the portfolio of therapeutic strategies.

Based on an ethnobotany screening ...

Inauguration du Centre de Recherche BioClinique de l’Université Clermont Auvergne

Depuis l’été 2018, les équipes du GReD sont hébergées au CRBC, Centre de Recherche BioClinique.

Ce nouveau bâtiment a été inauguré le lundi 10 décembre ...

Même confiné le GReD reste actif et solidaire

Solidaire tout d’abord de nos membres aussi praticiens hospitaliers, ainsi que de nos collègues clermontois, qui sont directement impliqués dans la lutte contre le virus : courage à vous ...

Claire CHAZAUD received the VAN BENEDEN prize.

This prize is awarded every three years by the Royal Academy of Sciences, Letters and Fine Arts of Belgium to acknowledge a pioneer work in embryology or cytology .

Claire Chazaud ...

GReD confined : The mosaic ....team 13

Mosaic Team 13

GReD confined : The mosaic ....team 3

Team 3

How to turn a football into a rugby ball?

Tissue elongation is part of the repertoire of processes that allow an organ to acquire its shape (morphogenesis). In the last years, the elongation of the ovarian follicle of Drosophila ...

Cymbopogon citratus and cancer: when citronella is a repellent not only for mosquitoes…

Through a real bilateral collaboration, Drs. Silvère BARON’s et and Jean-Marc LOBACCARO’s team Nuclear Receptor and Prostate diseases and Pr. Jacques SIMPORE’s team (Laboratoire de Biologie ...

sRNAPipe: a Galaxy-based pipeline for bioinformatic in-depth exploration of small RNAseq data

Les recherches menées au cours de cette dernière décennie ont révélé que la quasi-totalité des génomes est transcrite et que la plupart des mol ...

GReD confined : The mosaic ....team 1

Team 1: Behind the screen...each has its own containment

more details : here

GReD confined : The mosaic ....team "Muscle"

Team "Muscle"

Muscular dystrophy and cardiac defects: the calcium lead

The majority of patients suffering from Myotonic Dystrophy Type I (DM1) exhibit cardiac conduction disturbance, reducing their life expectancy and causing sometimes sudden death. In their last study (Auxerre-Plantié et ...

La recherche contre les myopathies au GReD : La drosophile un modéle précieux

Grâce aux dons du téléthon, L' AFM soutient deux équipes de recherche au GReD.

En tirant partie du modéle drosophile, les équipes "Diversification des cellules musculaires ...

GReD confined : The mosaic ....team 4

Team 4: "100 years of shared solitude"

GReD confined : The mosaic ....team "MePTI"

Team "MePTI"

Transcriptional alterations in Glioma: DNA methylation is the tip of the “epigenetic” iceberg

In cancer cells, aberrant DNA methylation is commonly associated with transcriptional alterations, including silencing of tumor suppressor genes. However, multiple epigenetic mechanisms, including polycomb repressive marks, contribute to gene deregulation ...

1st Spermatogenesis Conference. Male germ cells: from stem cells to diseases

For the organizing committee, the GReD institute invite you to attend the first Spermatogenesis Conference. Male germ cells: from stem cells to diseases in Lisbon (Portugal) from July 16 to 19th, 2021.

https://www.fusion-conferences.com/conference/129

The GReD , a player of the research to fight prostate cancer

Le projet collaboratif TransCAP réunit depuis 2014 les acteurs Auvergnats de la recherche sur le cancer de la prostate, dont l'équipe "Récepteurs nucléaires et maladies de ...

unexpected functions for the Dystrophin, the gene involved in Duchenne and Becker and muscular dystrophies

Résultat de recherche d'images pour "petit chapeau"

GReD confiné : La mosaïque .... Team Nurep

Team NuReP: "COVID or not COVID? This is not the question… show must go on :)"

More here

Le GReD partie prenante dans le projet VitAbeilles

Quatre laboratoires de l’Université Clermont Auvergne, dont le GReD, viennent de mettre en évidence un extrait végétal capable de soigner la nosémose, une maladie qui d ...

GReD confiné : The mosaic .... Team Reclab

Team Reclab

Looking for pERK !

In its last study, published in Development (Azami et al., ), the team "Molecular mechanisms of cell lineage differentiation in the early mouse embryo" identified the phosporylation of ERK as a ...

GReD confined : The mosaic ....team AKR

team AKR

GReD confined : The mosaic ....team 14

Team 14

GReD confined : The mosaic ....Administrative team

Administrative team

GReD confiné : The mosaic ....team 10

"A défaut d'être ensemble, la team 10 Zoom!!"

The conserved yeast telomeric CST complex also functions in the regulation of RNA polymerase II transcription

The telomeric CST complex contributes to maintain genome stability through chromosome end protection and telomere length regulation. In its last study conducted on the yeast model (Calvo, Grandin et al ...

DNA methylation : a new actor in CML biology

Chronic myeloid leukemia (CML), a cancer of the white blood cell, results from a translocation event that ultimately leads to the production of BCR-ABL1, a chimeric oncoprotein that promotes CML ...