Scientific & institutional news
Post-doctoral position in Epigenetics
An ANR funded postdoctoral position is available in our research group “ Genetic instabilities and control by the host genome ” . We are looking for an enthusiastic and highly motivated post-doc to ...
Read moreL’iGReD à l’assaut du Géant
Dignes successeurs de Florin Périer et de son expérience du Puy de Dôme sur la pression atmosphérique , Christophe, Adrien, Franck et Claude, membres de la « Team ...
Read morem6A methylation of mRNA promotes their transcription thought RNA polymerase II
This study, leads by G.Junion ( team Diversification of muscle and heart cells in normal and pathological conditions ), published in the journal Molecular Cell (Akhtar et al.) shows a new mechanism for regulating gene expression through modification of RNA. Using a combination of molecular biology and bioinformatics, they demonstrate that the enzymatic complex called m6A methyltransferase (MTC) enables RNA polymerase II to escape pausing and perform transcription, and thus precisely control the expression of genes responsible for the development of organisms.
James WILMOUTH s’illustre lors des JED 2021
James WILMOUTH , doctorant dans l’équipe Pathophysiologie moléculaire des tissus surrénaux et endocriniens, a reçu le prix Cancéropole CLARA de la meilleure communication orale dans le domaine du Cancer.
Ce prix, attribué par un jury de chercheurs du public et du privé, lui permettra d'exercer ses talents d’orateur dans un congrès International. Félicitations à lui.
Accessing the inaccessible
The heterochromatic regions of eukaryotic genomes are enriched in repeated sequences and poorly accessible due to a high level of compaction. Nevertheless, heterochromatin has to retain a certain degree of accessibility to allow important DNA-related biological processes to occur, including DNA replication, DNA damage repair, maintenance of DNA methylation and transcription for small RNA production. In a new study published in Nature Communications (Bourguet et al., ), the SILENT team now shows that the histone variant H2A.W cooperates with linker histone H1 to maintain optimal accessibility of heterochromatin in Arabidopsis.
JED 2021
The JED SVSAE 2021 are coming up May 27-28th! You can find all the information here: https://svsae.ed.uca.fr/inscription-obligations/obligations/journee-scientifique-de-led-svsae-1
Here is a teaser of what's to come! https://www.youtube.com/watch?v=lRNUEz1CRqE
Diversity matters
Blood cell progenitors play an essential role in the cellular immune response to infection but the importance of their heterogeneity remains elusive. In collaboration with the team of Pr M. Inamdar (JNCASR- Bangalore), the team “Epigenetic regulation and hematopoiesis” revealed that Drosophila larval blood cell progenitors exhibit an unforeseen degree of diversity, which underlies a proper immune response. This study has beeen published (Rodriguez et al., 2021) in elife.
This study has been higlighted on the INSB CNRS website
fixed-term contract for Research Engineer "Towards the development of better tools for the evaluation and conservation of male gametes".
Research Engineer position ( fixed-term contract 24 months) is available from june 2021 in the team "Mechanisms of mammalian post-testicular infertility"
Form more details an dapply , it's here
Read moreWhen LXR plays firefighters….
Chronic inflammation is a precursor mechanism supporting cancer development. Regarding the prostate, although hormone deprivation therapy significantly slows down cancer development, it triggers deep alterations in the tumor microenvironment. In ...
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Replicate to repress
Heterochromatin, which states for highly condensed genomics regions, is mainly constituted of transcriptionally repressed repeated elements. In its last study, published in Genome Biology (Bourguet et al., 2020), the SILENT team shows that DNA polymerase epsilon, which is involved in DNA replication, plays a crucial role in maintaining both the structure and the function of heterochromatin.
Post-doc available : “Identification of natural extracts targeting LXR nuclear receptors activity involved in skin wound healing”
A 2 years post-doc position, shared between the GRed and GREENTECH company, is available in the "Nuclear receptors and prostate diseases" from august 2021
For more details and to apply ...
Read moreTRAINING SCHOOL 3D-FisH & IMAGE ANALYSIS
October 15-19th, 2018
The Probst-Tatout’team organizes a training school in "3D-FiSH and Image Analysis" in the frame of INDEPTH. This first training school will also be supported at the ...
Read moreWeapons exchange in the battle between transposable elements and their host
The inactivation of transposable elements within genomes is insured by multiple epigenetic mechanisms. Olivier Mathieu's team has identified two genes required for repressing many transposable elements through a new ...
Read moreAdrenal differentiation: a key role for the epigenetic factor EZH2
The adrenal gland produces glucocorticoid and mineralocorticoid hormones that are essential for life. This hormone production depends on a complex process of recruitment and differentiation of progenitor cells. Using a ...
Read moreA key developmental stage for the targeting of transposable elements by piRNAs.
In few germline cells located at the anterior pole of the Drosophila ovariole, Piwi expression is weakened. This short time of germline development has been called the Piwiless pocket or ...
Read moreLes donateurs AFM-Téléthon à la rencontre des équipes de recherche du GReD
Le 8 octobre dernier le GReD organisait une journée Portes ouvertes aux donateurs de l’Association Française contre les Myopathies (AFM-Téléthon).
Read moreRecombination machinery compensates telomere loss in the absence of telomerase.
The chromosomes of most eukaryotic species are linear, consisting of a single DNA double-helix running from one end to the other. Each chromosome thus has two ends and these are ...
Read moreGENOME PLASTICITY: EXAMPLE OF 5S RIBOSOMAL RNA GENES
The genes coding 5S ribosomal RNAs (critical components of the ribosomes, the cellular machineries translating mRNA into proteins) are highly repeated in the genome, which allows the production of large ...
Read moreLINE fishing... with the new bioinformatics tool CLIFinder
Repeated elements represent 45% of the human genome. However, due to their large number and their high sequence homology, the contribution of those elements to the human genome transcriptome remains ...
Read moreEZH2, a novel therapeutic target in Adrenal Cortex Cancer
Adrenal cortex Cancer is one of the most aggressive cancers, for which there is no effective therapeutic approach. Research supervised by Pierre VAL at GReD laboratories, identified overexpression of EZH2 ...
Read moreAdrenal gland differentiation: positive antagonism
Endocrine activity of the adrenal glands is essential for body homeostasis and depends on the differentiation of two concentric cellular zones. Using transgenic mouse models, Pierre Val’s team has ...
Read moreRecrutement chargé(e) de mission scientifique
La filière Maladies Rares Endocriniennes (FIRENDO http://www.firendo.fr/accueil-filiere-firendo/) recherche :
Un(e) chargé(e) de mission scientifique, affecté(e) à l'équipe "Pathophysiologie moléculaire des tissus surr ...
Read moreWhat if honeybees could help fighting prostate cancer?
Prostate cancer is one of the most frequent and deadly tumors in man for which it is necessary to expand the portfolio of therapeutic strategies.
Based on an ethnobotany screening ...
Read moreInauguration du Centre de Recherche BioClinique de l’Université Clermont Auvergne
Depuis l’été 2018, les équipes du GReD sont hébergées au CRBC, Centre de Recherche BioClinique.
Ce nouveau bâtiment a été inauguré le lundi 10 décembre ...
Read moreMême confiné le GReD reste actif et solidaire
Solidaire tout d’abord de nos membres aussi praticiens hospitaliers, ainsi que de nos collègues clermontois, qui sont directement impliqués dans la lutte contre le virus : courage à vous ...
Read moreClaire CHAZAUD received the VAN BENEDEN prize.
This prize is awarded every three years by the Royal Academy of Sciences, Letters and Fine Arts of Belgium to acknowledge a pioneer work in embryology or cytology .
Claire Chazaud ...
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Le GReD partie prenante dans le projet VitAbeilles
Quatre laboratoires de l’Université Clermont Auvergne, dont le GReD, viennent de mettre en évidence un extrait végétal capable de soigner la nosémose, une maladie qui d ...
Read moreHow to turn a football into a rugby ball?
Tissue elongation is part of the repertoire of processes that allow an organ to acquire its shape (morphogenesis). In the last years, the elongation of the ovarian follicle of Drosophila ...
Read moreCymbopogon citratus and cancer: when citronella is a repellent not only for mosquitoes…
Through a real bilateral collaboration, Drs. Silvère BARON’s et and Jean-Marc LOBACCARO’s team Nuclear Receptor and Prostate diseases and Pr. Jacques SIMPORE’s team (Laboratoire de Biologie ...
Read moresRNAPipe: a Galaxy-based pipeline for bioinformatic in-depth exploration of small RNAseq data
Les recherches menées au cours de cette dernière décennie ont révélé que la quasi-totalité des génomes est transcrite et que la plupart des mol ...
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Souvenirs ( pas si lointain) d'un GReD confiné
La mosaique du GReD confiné, en attendant le 22 juin, date à laquelle nous pourrons enfin tous nous retrouver dans nos locaux,tout en respectant les gestes barriéres.
Les d ...
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Muscular dystrophy and cardiac defects: the calcium lead
The majority of patients suffering from Myotonic Dystrophy Type I (DM1) exhibit cardiac conduction disturbance, reducing their life expectancy and causing sometimes sudden death. In their last study (Auxerre-Plantié et ...
Read moreLa recherche contre les myopathies au GReD : La drosophile un modéle précieux
Grâce aux dons du téléthon, L' AFM soutient deux équipes de recherche au GReD.
En tirant partie du modéle drosophile, les équipes "Diversification des cellules musculaires ...
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Transcriptional alterations in Glioma: DNA methylation is the tip of the “epigenetic” iceberg
In cancer cells, aberrant DNA methylation is commonly associated with transcriptional alterations, including silencing of tumor suppressor genes. However, multiple epigenetic mechanisms, including polycomb repressive marks, contribute to gene deregulation ...
Read more1st Spermatogenesis Conference. Male germ cells: from stem cells to diseases
For the organizing committee, the GReD institute invite you to attend the first Spermatogenesis Conference. Male germ cells: from stem cells to diseases in Lisbon (Portugal) from July 16 to 19th, 2021.
https://www.fusion-conferences.com/conference/129
Relationship between transposable elements and their host genome: It is neither all black or all white...
In its last review article (Maupetit-Méhouas & Vaury), published in Cells, the team " Genetic instabilities and control by the host genome" presents the latest knwoledges on Germline reactivation of Transposable ...
Read moreThe GReD , a player of the research to fight prostate cancer
Le projet collaboratif TransCAP réunit depuis 2014 les acteurs Auvergnats de la recherche sur le cancer de la prostate, dont l'équipe "Récepteurs nucléaires et maladies de ...
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Looking for pERK !
In its last study, published in Development (Azami et al., ), the team "Molecular mechanisms of cell lineage differentiation in the early mouse embryo" identified the phosporylation of ERK as a ...
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The conserved yeast telomeric CST complex also functions in the regulation of RNA polymerase II transcription
The telomeric CST complex contributes to maintain genome stability through chromosome end protection and telomere length regulation. In its last study conducted on the yeast model (Calvo, Grandin et al ...
Read moreDNA methylation : a new actor in CML biology
Chronic myeloid leukemia (CML), a cancer of the white blood cell, results from a translocation event that ultimately leads to the production of BCR-ABL1, a chimeric oncoprotein that promotes CML ...
Read more1ere Automnale du Groupe Cancer Clermont Auvergne
Le mardi 26 Novembre, de 9h à 17h, se tiendra la 1éreAutomnale du Groupe Cancer Clermont Auvergne
Cette journée permettra d’avoir un panorama de la recherche en ...
Read moreFocus sur le Groupe Cancer Clermont Auvergne
Focus sur le Groupe Cancer Clermont Auvergne dans le LAB#7 de l’UCA.
Retrouvez ici l’interview de Silvere Baron ( équipe : Récepteurs nucléaires et maladies de la ...
Read moreLes experts mondiaux des maladies de la surrénale se sont réunis au GReD
Sous l’impulsion de l’équipe « Pathophysiologie moléculaire des tissus surrénaux et endocriniens », les maladies rares de la surrénale ont été à l’honneur du 25 au 28 ...
Read moreThe journey of a thousand piRNAs begins with a single Dot
Among the several kinds of non-coding small RNAs, piRNAs (Piwi-interacting RNAs) are the ‘transposon-silencers’. They occur within the gonads of animals, protecting the cellular genome from transposable elements. One of ...
Read moreLes piARNs contre attaquent
Dans sa dernière étude, publiée dans Genome Biology (Duc, Yoth et al., 2019) , l’équipe « Instabilités génétiques et contrôle par le génome h ...
Read moreLe GReD soutient la création du Groupe Cancer Clermont Auvergne
Plusieurs équipes du GReD sont partie prenante dans ce réseau, dont l’une des premières actions a été l’organisation de la 1ére Automnale du Groupe Cancer ...
Read moreLes stagiaires de 3iéme à la découverte du GReD.
Du 17 au 21 décembre 2018, six collégiens, tous désireux de découvrir les métiers de la recherche, ont rejoint le GReD. Les activés men ...
Read moreStress & SUMO : le poids de SUMO dans la glande surrénale
La SUMOylation est un processus de modification post-traductionnelle conservé chez les eucaryotes, indispensable au maintien de l’intégrité des génomes, à la régulation des gènes et à la ...
Read moreGH1-HMGA1 : une protéine chromatinienne impliquée dans la stabilité des télomères et la réparation des cassures double brin de l’ADN
De par leur nature linéaire, les chromosomes des eucaryotes ont dû développer des mécanismes de protection de leurs extrémités appelés télomères. Si ...
Read moreGRED’s people in the spotlight
Heidi Serra received the young researcher award 2015 from the Bettencourt-Schueller foundation.
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