When it comes to DNA methylation, 1 + 1 = 3.
Variation in DNA methylation, which decorates DNA of most living organisms, can impact gene transcription, just like does DNA sequence. How distinct DNA methylation states of genes and transposons, called epialleles, emerge is not well understood. A collaborative work by the groups of Olivier Mathieu (CNRS/Laboratory GReD) and Detlef Weigel (Max Planck Institute for Developmental Biology, Germany) published in PNAS now highlights the rapid and massive creation of novel epialleles following an epigenomic shock. The epigenomic shock is triggered by combining identical genomes with different DNA methylation patterns in the same individual, and is characterized by widespread changes in DNA methylation and gene expression. Many novel epialleles not found in the parents emerge at protein-coding genes. On the other hand, transposons generally undergo decrease in DNA methylation associated with transcriptional activation, which can translate into transposon mobilization in the progeny. Hence, in addition to providing a scenario for the rapid and broad-scale emergence of epigenetic variation, this work may have implications for transposon dynamics within populations.
This work has been highlighted on the CNRS website (in French) http://www.cnrs.fr/insb/recherche/parutions/articles2016/o-mathieu.html
For more informations ….
Mélanie Rigal, Claude Becker, Thierry Pélissier, Romain Pogorelcnik, Jane Devos, Yoko Ikeda,,Detlef Weigel, and Olivier Mathieu
Epigenome confrontation triggers immediatereprogramming of DNA methylation and transposon silencing in Arabidopsis thaliana F1 epihybrids.
published ahead of print March 21, 2016 PNAS. doi/10.1073/pnas.1600672113.
Olivier Mathieu Email : firstname.lastname@example.org
Last modified: 06/24/2016