The LINC complex contributes to heterochromatin organisation and transcriptional gene silencing in plants
The linker of nucleoskeleton and cytoskeleton (LINC) complex is an evolutionarily well-conserved protein bridge connecting the cytoplasmic and nuclear compartments across the nuclear membrane. Recent investigations have highlighted its function in nuclear morphology and meiosis. The new study performed by the team of Aline Probst and Christophe Tatout brings new insights into LINC complex function in plants. Using 3D imaging and molecular techniques the authors reveal that plants carrying mutations in this complex show release of transcriptional silencing as well as a decompaction of heterochromatic sequences. Therefore, the plant LINC complex contributes to proper heterochromatin organisation and positioning at the nuclear periphery, illustrating the important function of the nuclear envelope in the regulation of genome expression.
This study has been published in Journal of Cell Science (Poulet et al., 2017)
Poulet A, Duc C, Voisin M, Desset S, Tutois S, Vanrobays E, Benoit M, Evans DE, Probst AV, Tatout C. The LINC complex contributes to heterochromatin organisation and transcriptional gene silencing in plants. J Cell Sci. 2017, 130(3):590-601. doi: 10.1242/jcs.194712.
Last modified: 02/28/2017