FXRα a new actor of germinal stem cells fate.
The FXRα nuclear receptor (Farnesoid-X-Receptor alpha) is a key factor controlling the male sex hormone synthesis within the testis. However, its roles in male germ cell homeostasis have not yet been studied. Using a phenotyping approach of Fxra deficient mice, the team of David Volle has characterized unexpected roles of FXRa with germ cell lineage. There, FXRa is involved in the establishment and the maintenance of undifferentiated germ cell pool and in turn, influences male fertility during aging.
This study is published in Stem Cell Reports (Martinot et al., 2017)
Figure legend : Undifferentiated germ cells identified byPLZF immunolabelling.
To know more:
Martinot E, Sèdes L, Baptissart M, Holota H, Rouaisnel B, Damon-Soubeyrand C, De Haze A, Saru JP, Thibault-Carpentier C, Keime C, Lobaccaro JA, Baron S, Benoit G, Caira F, Beaudoin C, Volle DH.The Bile Acid Nuclear Receptor FXRα Is a Critical Regulator of Mouse Germ Cell Fate. Stem Cell Reports. 2017 Jul 11;9(1):315-328. doi: 10.1016/j.stemcr.2017.05.036. Epub 2017 Jun 29. PMID: 28669602
David Volle: email@example.com
Last modified: 12/11/2017