Dr. Bagora BAYALA, currently Assistant Professor at Koudougou Universty (Burkina Faso) has shown that essential oils extracted from Cymbopogon citratus, also known as citronella, has interesting anti-inflammatory and anti-proliferative properties on prostate cancer and glioblastoma cell lines. Gas chromatography coupled with mass spectrometry pointed out citral as the main molecule responsible for C. citratus effects.
Citral could thus become a lead for the synthesis of more efficient molecules.
Epidemiological studies show that the number of diagnosed cancers considerably increases every year. The question of the development of new treatments is thus asked. Up to date, more than 70% of the molecules used in therapy have been extracted from natural plants with a biological activity. It is thus of primary importance to cooperate with traditional practitioners in order to identify these plants used in folk medicine.
Essential oils have been extracted by water distillation from leaves of Cymbopogon citratus collected in the town of Gampela, located10 kms NE of Ouagadougou. These extracts have important anti-inflammatory and anti-proliferative properties on prostate cancer and glioblastoma cell lines. Gas chromatography coupled with mass spectrometry identified citral as the main molecule responsible for C. citratus effects. Interestingly citral shows the same cytotoxic effects as cisplatine, a molecule used for the treatment of aggressive prostate cancer.
Contact :Jean-Marc LOBACCARO
To know more:
Cymbopogon citratus and Cymbopogon giganteus essential oils have cytotoxic effects on tumor cell cultures. Identification of citral as a new putative anti-proliferative molecule. Bayala B, Bassole IHN, Maqdasy S, Baron S, Simpore J, Lobaccaro JA. Biochimie. 2018 Feb 28. pii: S0300-9084(18)30056-7. doi: 10.1016/j.biochi.2018.02.013.