Oxidative alterations of the sperm nucleus are causative of reproductive failures and increase the risk of transmitting paternal inherited mutations to the next generation. With the goal to explore new therapeutic approaches, two new reports from the GReD research team « Mechanisms of Post-testicular Infertility » headed by Joël Drevet, have focused on one of the most common sperm DNA alterations, which is sperm DNA oxidation.
The first report published in Free Radic. Biol. Med. (Kocer et al., dec2015) describes the extent of oxidative DNA damage on mouse sperm chromosomes. It reveals that chromosomes do not show an equal susceptibility to DNA oxidation and that this may be related to their positions in the sperm nucleus.
In a more therapeutic perspective, Drevet’s team in collaboration with a spanish (Dr. A. Gutiérez-Adan, Madrid) and an Australian (Prof RJ Aitken, Newcastle) research groups as well as a US biotech company (Celloxess Inc., Princeton, NJ; Dr. P. Gharagozloo) collectively show in a second report (Gharagozloo et al., 2016) that a properly designed antioxidant oral supplementation is able to correct the sperm nucleus oxidative alterations. The treatment also improves reproductive success in situations of sperm oxidative DNA damage. This article was just released this month in Human Reproduction. If successfully translated to human, it opens the road for the development of alternative, non-invasive and economical therapeutic strategies that may improve some male infertile situations.
These two reports have been highlighted on the CNRS INSB and Blaise Pascal University websites respectively at (http://www.cnrs.fr/insb/recherche/parutions/ parutions.htm) and (http://www.univ-bpclermont.fr/article3202.html). (both in french)
For more informations… :
Kocer A, Henry-Berger J, Noblanc A, Champroux A, Pogorelcnik R, Guiton R, Janny L, Pons-Rejraji H, Saez F, Johnson GD, Krawetz SA, Alvarez JG, Aitken RJ, Drevet JR. Oxidative DNA damage in mouse sperm chromosomes: Size matters. Free Radic Biol Med. 2015 Dec;89:993-1002. doi: 10.1016/j.freeradbiomed.2015.10.419.
Gharagozloo P, Gutiérrez-Adán A, Champroux A, Noblanc A, Kocer A, Calle A, Pérez-Cerezales S, Pericuesta E, Polhemus A, Moazamian A, Drevet JR, Aitken RJ. A novel antioxidant formulation designed to treat male infertility associated with oxidative stress: promising preclinical evidence from animal models. Hum Reprod.2016 Feb;31(2):252-62. doi: 10.1093/humrep/dev302.