Based on our respective background and preliminary data on prostate cancer, environmental disrupting chemicals (EDCs) and nuclear receptor networking, we have hypothesized that exposure to EDCs could affect prostate epithelium homeostasis and enhance the transformation of normal epithelium to cancer and ultimately to metastasis. This effect would be mediated through alterations of the metabolism and/or a modification in the nuclear receptor network. The bulk of this collaborative project funded by the French NCI is to understand how EDCs could provoke prostate cancer and whether and how they induce a higher risk of prostate cancer metastasis. The objective of the program is thus to decipher how EDCs affect prostate homeostasis and could induce prostate cancer metastasis and castration resistant state. This will be done using animal models and new cell systems developed in our lab.
Pommier et al. Liver X Receptor downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells. Oncogene. 2010; 29(18):2712-23. (here)
Dufour et al. Lack of liver X receptors leads to cell proliferation in a model of mouse dorsal prostate epithelial cell. PLoS One. 2013;8(3):e58876. (here)
Pommier et al. Liver x receptors protect from development of prostatic intra-epithelial neoplasia in mice. PLoS Genet. 2013 May;9(5):e1003483. (here)
Maqdasy et al. Once and for all, LXRα and LXRβ are gatekeepers of the endocrine system. Mol Aspects Med. 2016;49:31-46. (here)
The position is funded by University of Clermont-Ferrand for 1 year renewable twice (max length 3 years).
The candidate should:
- have a PhD, a MD or a post-doctoral experience. We are looking for highly motivated researcher, with experience in the field of molecular pharmacology, cell culture and transfection, western blot, animal handling. Knowledges on metabolism, immunohistochemistry and qPCR will be appreciated.
- have a good knowledge of animal experimentation (routes of administration, graft, removal of organs ...). To have the diploma of animal experimentation or equivalent will be a plus.
- be rigorous, dynamic, organized and to have a good adaptability. The candidate will have to analyze the results, to draft technical protocols and study reports, to present the results and to participate in the management of the lab and orders.
Applicant should send a CV with list of publications, a description of their research activities and 2 to 3 recommendation letters addressed to: