GReD - News

Muscular dystrophy and cardiac defects: the calcium lead

The majority of patients suffering from Myotonic Dystrophy Type I (DM1) exhibit cardiac conduction disturbance, reducing their life expectancy and causing sometimes sudden death. In their last study (Auxerre-Plantié et al., 2019), the team “Diversification of muscle and heart cells in normal and pathological conditions” used the fruitfly as a model system to reveal that this cardiac conduction defects are linked to gene expression alteration in cellular calcium regulation pathways, offering a new therapeutic lead for DM1 cardiac involvement.

Looking for pERK !

In its last study, published in Development (Azami et al., ), the team "Molecular mechanisms of cell lineage differentiation in the early mouse embryo" identified the phosporylation of ERK as a key event in the specification of epiblast (Epi) and Primitive Endoderm (PrE).

Les Mardis du GReD January 2020

Faculté de médecine
CRBC AMPHI LIMAGNE

12h45 - 13h45

Transcriptional alterations in Glioma: DNA methylation is the tip of the “epigenetic” iceberg

In cancer cells, aberrant DNA methylation is commonly associated with transcriptional alterations, including silencing of tumor suppressor genes. However, multiple epigenetic mechanisms, including polycomb repressive marks, contribute to gene deregulation in cancer. In its last study (Court et al., 2019) the team " Genomic Imprinting and the epigenetic control of cell fate determination" used glioma, one the most widespread type of brain tumor, to evaluate for the first time the relative contribution of DNA methylation-independent mechanisms on transcriptional alteration at CpG-island (CGI)/promoter-associated genes in cancer cells. They found that most transcriptional alterations in tumor samples were DNA methylation-independent. Instead, altered histone H3 trimethylation at lysine 27 (H3K27me3) was the predominant molecular defect at deregulated genes.

La recherche contre les myopathies au GReD : La drosophile un modéle précieux

Grâce aux dons du téléthon, L' AFM soutient deux équipes de recherche au GReD.

En tirant partie du modéle drosophile, les équipes "Diversification des cellules musculaires ...

Le GReD soutient la création du Groupe Cancer Clermont Auvergne

Plusieurs équipes du GReD sont partie prenante dans ce réseau, dont l’une des premières actions a été l’organisation de la 1ére Automnale du Groupe Cancer Clermont Auvergne, le 26 novembre dernier. Dans la lignée du succès de cette première rencontre, la création du groupe a fait l’objet de plusieurs retombées dans la presse.

Article dans la Montagne

Article dans 7 jours à Clermont

International congress on transposable elements (ICTE)

For the organizing committee, the GReD institute invite you to attend the next international congress on transposable elements (ICTE) in Saint Malo from April 25 to 29th, 2020.

http://icte2020.sciencesconf.org

Chercheuses en herbe

Chaque année, la semaine précédant noël, le GReD accueille des collégiens désireux de découvrir les métiers de la recherche. Cette année, c’est une promotion 100% féminine qui nous a rejoints du 16 au 20 décembre 2019, avec Inés (Collège Lizinat, St Germain Lembron), Jane (Collège Michel de l’Hospital, Riom), Lou (Collège Jean de Prades, Castelsarrasin, Tarn et Garonne) et Mélanie (Collège Molière, Beaumont).

GReD Christmas 2019 is coming ....

Brace yourself for Christmas, FortGReD ( prepared by the phD students) is coming !

To know more , it's here

See you friday 20th of decembre ....

Docteur et Médecin du GReD lauréats du Prix Bettencourt.

Deux anciens doctorants du GReD, Salwan MAQDASY et Mickaël MATHIEU ont reçu, le 20 Novembre 2019, le prix Bettencourt dans le cadre de leur activité de recherche.

Après une thèse en médecine, Salwan a réalisé son doctorat en science, soutenu en 2016, dans l’équipe « Récepteurs nucléaires et maladies de la prostate ». Mickaël, quant à lui, a réalisé sa thèse , soutenue en 2018, dans l’équipe « Pathophysiologie moléculaire des tissus surrénaux et endocriniens ».

Ils sont maintenant respectivement en stage postdoctoral au Karolinska Institut à Stockholm, Suède et au Memorial Sloane Kettering Cancer Center à New York, Etats-Unis.

The journey of a thousand piRNAs begins with a single Dot

Among the several kinds of non-coding small RNAs, piRNAs (Piwi-interacting RNAs) are the ‘transposon-silencers’. They occur within the gonads of animals, protecting the cellular genome from transposable elements. One of ...

When the liver controls male puberty....

Puberty is a key event for the development of male reproductive functions. It depends on the increase of testosterone produced by the testis, under the control of the activity of ...

Les piARNs contre attaquent

Dans sa dernière étude, publiée dans Genome Biology (Duc, Yoth et al., 2019) , l’équipe « Instabilités génétiques et contrôle par le génome h ...

Epigénétique: the revenge of Lamarck?

The next "Mercredis de la Science" ”, organized by the university Blaise Pascal, will be dedicated to the Epigenetics. All are welcome to listen our two researchers, Aline Probst and Christophe ...

A focus on sperm DNA oxidative damage : a putative new trail to improve some male infertile situations

Oxidative alterations of the sperm nucleus are causative of reproductive failures and increase the risk of transmitting paternal inherited mutations to the next generation. With the goal to explore new ...

Les stagiaires de 3iéme à la découverte du GReD.

Du 17 au 21 décembre 2018, six collégiens, tous désireux de découvrir les métiers de la recherche, ont rejoint le GReD. Les activés men ...

When it comes to DNA methylation, 1 + 1 = 3.

Variation in DNA methylation, which decorates DNA of most living organisms, can impact gene transcription, just like does DNA sequence. How distinct DNA methylation states of genes and transposons, called ...

Benjamin Bertin : prix du Jury des JED 2016

Benjamin BERTIN, doctorant dans l'équipe de Krzysztof Jagla , a reçu le prix du Jury lors des 'Journées de l'Ecole Doctorale 2016".

Axel POULET thesis works highlighted on the Oxford Brooke University website.

The 6^th of June, Axel Poulet, student in Christophe Tatout and Aline Probst’s team, successfully defended his thesis performed under a co-tutelle arrangement between Oxford Brooked and Blaise ...

Stress & SUMO : le poids de SUMO dans la glande surrénale

La SUMOylation est un processus de modification post-traductionnelle conservé chez les eucaryotes, indispensable au maintien de l’intégrité des génomes, à la régulation des gènes et à la ...

GH1-HMGA1 : une protéine chromatinienne impliquée dans la stabilité des télomères et la réparation des cassures double brin de l’ADN

De par leur nature linéaire, les chromosomes des eucaryotes ont dû développer des mécanismes de protection de leurs extrémités appelés télomères. Si ...

Les Chercheurs du GReD accueillent les malades

Sous l''égide de l'INSERM, le GReD et M2iSH accueillent les malades sur le théme "Santé et environnement" , le mercredi 13 novembre .

Au programme (13h30-16h30, salle de r ...

Weapons exchange in the battle between transposable elements and their host

The inactivation of transposable elements within genomes is insured by multiple epigenetic mechanisms. Olivier Mathieu's team has identified two genes required for repressing many transposable elements through a new ...

Adrenal differentiation: a key role for the epigenetic factor EZH2

The adrenal gland produces glucocorticoid and mineralocorticoid hormones that are essential for life. This hormone production depends on a complex process of recruitment and differentiation of progenitor cells. Using a ...

A key developmental stage for the targeting of transposable elements by piRNAs.

In few germline cells located at the anterior pole of the Drosophila ovariole, Piwi expression is weakened. This short time of germline development has been called the Piwiless pocket or ...

Les donateurs AFM-Téléthon à la rencontre des équipes de recherche du GReD

Le 8 octobre dernier le GReD organisait une journée Portes ouvertes aux donateurs de l’Association Française contre les Myopathies (AFM-Téléthon).

Chaperoning histones and controlling genome function

Histone proteins are critical components of chromatin and the incorporation of different histone variants modulates nucleosome stability. Deposition of histones at the right time and the correct place in the ...

INDEPTH : The GReD, in collaboration with LIMOS laboratory, holds the first COST-Action coordinated by Clermont Auvergne University (UCA)

GReD and LIMOS laboratories are happy to inform you that their COST-action project entitled «Impact of Nuclear Domains on Gene Expression and Plant Traits » (INDEPTH) has been awarded. This pan-european ...

Recombination machinery compensates telomere loss in the absence of telomerase.

The chromosomes of most eukaryotic species are linear, consisting of a single DNA double-helix running from one end to the other. Each chromosome thus has two ends and these are ...

Male infertility, toward new molecular causes .

Bile acids are molecules with endocrine activities controlling several physiological functions such as immunity and glucose homeostasis. Recently, they have also been shown to be involved in testicular physiology and ...

GENOME PLASTICITY: EXAMPLE OF 5S RIBOSOMAL RNA GENES

The genes coding 5S ribosomal RNAs (critical components of the ribosomes, the cellular machineries translating mRNA into proteins) are highly repeated in the genome, which allows the production of large ...

LINE fishing... with the new bioinformatics tool CLIFinder

Repeated elements represent 45% of the human genome. However, due to their large number and their high sequence homology, the contribution of those elements to the human genome transcriptome remains ...

EZH2, a novel therapeutic target in Adrenal Cortex Cancer

Adrenal cortex Cancer is one of the most aggressive cancers, for which there is no effective therapeutic approach. Research supervised by Pierre VAL at GReD laboratories, identified overexpression of EZH2 ...

A new research group has joined the GReD

The team « Epigenetic Regulation and Hematopoiesis », headed by Lucas Waltzer, has joined the GReD.

The team: Manon Boulet ( PhD Student)- Lucas Waltzer (DR2 CNRS, Team leader)- Laurence Vandel (DR2 CNRS ...

The LINC complex contributes to heterochromatin organisation and transcriptional gene silencing in plants

The linker of nucleoskeleton and cytoskeleton (LINC) complex is an evolutionarily well-conserved protein bridge connecting the cytoplasmic and nuclear compartments across the nuclear membrane. Recent investigations have highlighted its function ...

Adrenal gland differentiation: positive antagonism

Endocrine activity of the adrenal glands is essential for body homeostasis and depends on the differentiation of two concentric cellular zones. Using transgenic mouse models, Pierre Val’s team has ...

GReD meets Johan Swinnen during its 2400 km run for cancer patients

From the 21st of Auguts our colleague Johan Swinnen undertook a journey of a lifetime: running from Leuven to Santiago de Compostela with a backpack filled with hundreds of letters ...

FXRα a new actor of germinal stem cells fate.

The FXRα nuclear receptor (Farnesoid-X-Receptor alpha) is a key factor controlling the male sex hormone synthesis within the testis. However, its roles in male germ cell homeostasis have not yet ...

What if honeybees could help fighting prostate cancer?

Prostate cancer is one of the most frequent and deadly tumors in man for which it is necessary to expand the portfolio of therapeutic strategies.

Based on an ethnobotany screening ...

Workshop "Mechanobiology and Physics of Life"

After Lyon (2016) and Grenoble (2017), we are pleased to welcome you to the third workshop in Mechanobiology and Physics of Life to be held in Clermont-Ferrand on Tuesday January ...

Inauguration du Centre de Recherche BioClinique de l’Université Clermont Auvergne

Depuis l’été 2018, les équipes du GReD sont hébergées au CRBC, Centre de Recherche BioClinique.

Ce nouveau bâtiment a été inauguré le lundi 10 décembre ...

GReD goes green...

GReD days 2019 (10th and 11th of october) will be held at the holiday village of Parent , near Clermont.

In the programme (here) : Science sand recreation...Quoi de plus ?!

Les Doctorants du GReD à l’honneur lors des JED 2017.

Houda TABBAL, doctorante dans l’équipe « Pathophysiologie moléculaire des tissus surrénaux et endocriniens » et Alexandre CHAMPROUX, doctorant dans l’équipe « Mécanismes de l'infertilité mâle post-testiculaire ...

Sewing workshop in GReD

Everyone has been involved, from the doctoral students to the director, to contribute to the "Pink October" and to make "heart cushions" for patients who have had breast cancer. They ...

How to turn a football into a rugby ball?

Tissue elongation is part of the repertoire of processes that allow an organ to acquire its shape (morphogenesis). In the last years, the elongation of the ovarian follicle of Drosophila ...

GReD Symposium : "Les surpises du Vivant"

the wednesday 16th of May, the GReD organizes its symposium

"Les surprises du vivant".

Amphitheater Limagne, CRBC Building , Faculté de Médecine

To the Programm click on "read more "....

Cymbopogon citratus and cancer: when citronella is a repellent not only for mosquitoes…

Through a real bilateral collaboration, Drs. Silvère BARON’s et and Jean-Marc LOBACCARO’s team Nuclear Receptor and Prostate diseases and Pr. Jacques SIMPORE’s team (Laboratoire de Biologie ...

sRNAPipe: a Galaxy-based pipeline for bioinformatic in-depth exploration of small RNAseq data

Les recherches menées au cours de cette dernière décennie ont révélé que la quasi-totalité des génomes est transcrite et que la plupart des mol ...

PhD defense: Jil CERCY

Jil Cercy (Team “Genomic Imprinting and the epigenetic control of cell fate determination”) will defend her thesis entitled:

"Vers l'identification des facteurs impliqués dans la régulation concert ...

Conference : "Molecular control of DNA methylation in mammalian genomes" CANCELED

Michael WEBER -BSC, UMR7242 CNRS/Université de Strasbourg

Friday the 13 December at 10 am ANNULEE

Amphi Limagne, CRBC

Contact: philippe.arnaud@uca.fr

PhD defense: Elisa LE BOITEUX

Elisa Le Boiteux (Team “Genomic Imprinting and the epigenetic control of cell fate determination”) will defend her thesis entitled:

"Altération du contrôle de H3K27me3 et dérégulation ...

PhD defense: Laura BOUSSET

Laura Bousset (Team “ Nuclear receptors and prostate diseases”) will defend her thesis entitled:

" Cancer de la prostate et mécanismes de résistance à la castration : Etude du rôle des récepteurs nucléaires LXR "

Tuesday the 17^th of December 2019 at 2 pm

Amphithéâtre Limagne, CRBC, Medical School

Viva examiners : Olivier Cuvillier ( IPBS Toulouse); Catherine Muller (IPBS, Toulouse) ; Virginie Vlaeminck-Guillem ( Hospices Civils, Lyon) ; Elisabeth Billard (M2iSH, Clermont-Ferrand), Laurent Morel (GReD), Silvere Baron (GReD)

Recrutement chargé(e) de mission scientifique

La filière Maladies Rares Endocriniennes (FIRENDO http://www.firendo.fr/accueil-filiere-firendo/) recherche :

Un(e) chargé(e) de mission scientifique, affecté(e) à l'équipe "Pathophysiologie moléculaire des tissus surrénaux et endocriniens" au GReD

CDD de 1 an renouvelable

Missions: accompagner, conseiller, soutenir et coordonner les acteurs recherche de la filière dans le but de recenser, faciliter et optimiser la mise en place des projets de recherche.

Diplômes: minimum BAC+5 scientifique ou ingénierie des systèmes de santé ou Bac+8 Doctorat en Biologie. Une formation en recherche clinique est un plus, mais n’est pas indispensable.

Contact: Antoine Martinez email: antoine.martinez@uca.fr

Le profil détaillé du poste est disponible ici

Imaris Open Day

Georgia Golfis, de Bitplane, viendra présenter le logiciel Imaris le 11 février 2014.
Cette présentation sera suivie d'une formation pratique l'après-midi.

The conserved yeast telomeric CST complex also functions in the regulation of RNA polymerase II transcription

The telomeric CST complex contributes to maintain genome stability through chromosome end protection and telomere length regulation. In its last study conducted on the yeast model (Calvo, Grandin et al ...

DNA methylation : a new actor in CML biology

Chronic myeloid leukemia (CML), a cancer of the white blood cell, results from a translocation event that ultimately leads to the production of BCR-ABL1, a chimeric oncoprotein that promotes CML ...

ARIOL

1ere Automnale du Groupe Cancer Clermont Auvergne

Le mardi 26 Novembre, de 9h à 17h, se tiendra la 1^éreAutomnale du Groupe Cancer Clermont Auvergne

Cette journée permettra d’avoir un panorama de la recherche en ...

Budding Researchers

The pupils ,aged 6 years old, of the school Nestor Perret in Clermont-Ferrand spent Tuesday, May 30^th, morning together with the researchers of the GReD in a real course ...

Les experts mondiaux des maladies de la surrénale se sont réunis au GReD

Sous l’impulsion de l’équipe « Pathophysiologie moléculaire des tissus surrénaux et endocriniens », les maladies rares de la surrénale ont été à l’honneur du 25 au 28 ...