GReD - News

CALL for NEW RESEARCH GROUP LEADERS

The GReD wishes to recruit a new independent leader to establish a group within the scientific spectrum of the GReD. The project must be focused on the scientific field covered by the UCA CAP 20-25 project – challenge 3: « Personalized human mobility for a better health » (Muscle development, metabolic response to exercise, impact of nutrition on mobility, pathologies affecting locomotion... see annexe).

As part of the CAP20-25 initiative, the successful candidate will benefit from a start-up package of €300,000 to €340,000 (salaries and operating budget for 24 to 30 months).

PhD defense: Nolwenn MOUNIEE

Nolwenn MOUNIEE (Team “Genetic instabilities and control by the host genome”) will defend her thesis entitled:

"Etude de la biologie des clusters de piRNAs chez Drosophila melanogaster en utilisant comme modèle le locus flamenco"

Tuesday the 16^th of July 2019 at 2 pm

Salle des thèses , Medical School

Viva examiners : Sandra DUHARCOURT (Institut Jacques Monod, Paris), Clément CARRE, (Institut de biologie Paris Seine, Paris) Clément GILBERT, (Laboratoire Evolution, Génomes, Comportement, Ecologie, Gif sur Yvette), Maria Eugenia GALLEGO, (GReD), Philippe ARNAUD (GReD), Emilie BRASSET, (GReD).

Les piARNs contre attaquent

Dans sa dernière étude, publiée dans Genome Biology (Duc, Yoth et al., 2019) , l’équipe « Instabilités génétiques et contrôle par le génome hôte » montre qu’à la suite d’une réactivation d’un élément transposable (ET = séquence d’ADN mobile) dans un tissu adjacent aux cellules germinales, cet élément est capable d’infecter et d’envahir le génome de la lignée germinale comme le ferait un virus. En retour, la lignée germinale apprend à se défendre de cette attaque en piégeant cet élément dans son ADN de façon à garder la mémoire de cette infection. Une « auto-immunisation » du génome se met ainsi en place et « vaccine » la lignée germinale de l’individu et de sa descendance contre des futures invasions.

Stress & SUMO : le poids de SUMO dans la glande surrénale

La SUMOylation est un processus de modification post-traductionnelle conservé chez les eucaryotes, indispensable au maintien de l’intégrité des génomes, à la régulation des gènes et à la signalisation intracellulaire. Essentielle aux processus cellulaires fondamentaux, son implication dans l’édification et la fonction des organes, reste cependant, mal comprise. Cette question centrale est l’objet de l’étude récemment publié dans FASEB (Dumontet et al. 2019) par l’équipe Pathophysiologie moléculaire des tissus surrénaux et endocriniens.

Les résultats, obtenus chez la souris et les patients, révèlent que la glande surrénale présente un patron tissulaire de SUMOylation unique, sensible aux conditions de stress et altéré en cas de tumeurs ou d’hyperactivité, suggérant son implication dans l’organogenèse et la physiopathologie de la glande.

Les Doctorants du GReD à l’honneur lors des JED 2019.

Laura BOUSSET, doctorante dans l’équipe « Récepteurs nucléaires et maladies de la prostate» et Laura THIROUARD, doctorante dans l’équipe « Environnement, spermatogénèse, pathophysiologie et hérédité», ont toutes deux été primées lors des Journées de l’école Doctorale 2019. Elles ont respectivement reçu le prix de la meilleure communication orale du Cancéropôle CLARA et celui du meilleur poster.

Le GReD partie prenante dans le projet VitAbeilles

Quatre laboratoires de l’Université Clermont Auvergne, dont le GReD, viennent de mettre en évidence un extrait végétal capable de soigner la nosémose, une maladie qui décime les colonies d’abeilles. Le projet VitAbeilles, vise à développer et commercialiser cette découverte.

Ayhan Kocer ( équipe « récepteur nucléaire et maladie de la prostate » ainsi que Stéphanie Hermite ( ex-doctorante du GReD) représentent le GReD au sein de ce projet collaboratif Clermontois innovant.

The conserved yeast telomeric CST complex also functions in the regulation of RNA polymerase II transcription

The telomeric CST complex contributes to maintain genome stability through chromosome end protection and telomere length regulation. In its last study conducted on the yeast model (Calvo, Grandin et al. 2019), the team “Recombination and maintenance of genome integrity” revealed that this complex exhibited also specific genetic interactions with several genes coding for transcription regulators. This original observation suggests that CST could also stimulate transcription.

What if honeybees could help fighting prostate cancer?

Prostate cancer is one of the most frequent and deadly tumors in man for which it is necessary to expand the portfolio of therapeutic strategies.

Based on an ethnobotany screening, the teams of J.M Lobaccaro/S. Baron & V. Sapin/L. Blanchon have developed a collaborative study with Jijel and Oum El Bouaghi Universities (Algeria) and the CHU Clermont-Ferrand, to evaluate the effects of ethanolic extract of propolis from Jijel (Algeria) on human prostate cancer cells.

This work, published in the Journal of Steroid Biochemistry and Molecular Biology shows for the first time that propolis reduces the survival of LNCaP cells with high efficacy by the induction of the apoptosis as well as blocking the cell cycle.

Inauguration du Centre de Recherche BioClinique de l’Université Clermont Auvergne

Depuis l’été 2018, les équipes du GReD sont hébergées au CRBC, Centre de Recherche BioClinique.

Ce nouveau bâtiment a été inauguré le lundi 10 décembre dernier en présence de M. Mathias BERNARD, président de l’Université Clermont Auvergne, M. Jean-Pierre BRENNAS, conseiller régional Auvergne-Rhône-Alpes, M. Jean-Marc MORVAN, vice-président de Clermont Auvergne Métropole, Mme Claire GIRY, présidente par intérim de l’Inserm, M. Hervé Moreau, représentant de l’Institut des Sciences biologiques du CNRS, M Pierre Clavelou, Doyen de la faculté de médecine de Clermont-Ferrand, Mme Chantal VAURY, directrice du GReD et de Mme Anne-Françoise JUMEAU, architecte à l’agence PERIPHERIQUES.

Outre le GReD , dont les équipes sont réparties sur 4 étages du bâtiment, le CRBC accueille, en rez de chaussée, un pôle enseignement avec des salles de cours et 2 amphithéâtres et, au premier étage, un pôle valorisation, géré par l’UCA accélérateur Biotech.

Les stagiaires de 3iéme à la découverte du GReD.

Du 17 au 21 décembre 2018, six collégiens, tous désireux de découvrir les métiers de la recherche, ont rejoint le GReD. Les activés menées tant dans les équipes d’accueil qu' en commun ont permis à Natacha & Noa (Collège Henri-Pourrat, Ceyrat); Lucas (Collège La Ribeyre, Cournon d’Auvergne); Sam (Collège Françoise Sagan, Bornel, Oise); Florian (Collège Louisa Paulin, Réalmont, Haute-Garonne) et Swann (Collège Emile Beaussire, Luçon, Vendée) de découvrir l’ensemble des métiers pratiqués au GReD, les services offerts par les plateformes et les services communs et de réaliser diverses approches expérimentales. Sans conteste ce sont ces dernières qui ont eu leur préférence ! Parmi ce qui les a le plus surpris : « Le nombre de métiers au sein d’un laboratoire » ; « La taille et le prix des microscopes ! » « …que l’on puisse travailler sur des mouches » ; « qu’il y ait autant de bureaux dans un laboratoire de recherche » ou encore « rien ». Et pour tous, cette semaine passée au GReD les a confortés dans leur désir de travailler plus tard dans la recherche " ...car on peut faire des découvertes tous les jours, voir ses résultats tous les jours, en plus c'est fabuleux de travailler ici car on a toujours envie d'y aller et on a l'impression que le temps défile à toute allure."…what else ?!

When the liver controls male puberty....

Puberty is a key event for the development of male reproductive functions. It depends on the increase of testosterone produced by the testis, under the control of the activity of ...

Conference : " The connection between nervous and immune system in Drosophila melanogaster "

The connection between nervous and immune system in Drosophila melanogaster

Angela Giangrande- IGBMC à Strasbourg

Frdiday 10th of may, 11 am

Amphi Limagne. CRBC Building - Medical school

La recherche contre le cancer au GReD : De la paillasse… à la Courstache !

L’équipe NuReP mise en lumière dans un article de La Montagne de l’édition du Vendredi 2 Novembre dans le cadre du mois « MOVEMBER » de soutien aux patients ...

Conference: "The unique mechanisms for the nuclear dynamics in Arabidopsis" Dr. Tamura - Kyoto University, Japan

"The unique mechanisms for the nuclear dynamics in Arabidopsis"

By Dr. Kentaro Tamura, from Kyoto University, Japan

Friday the 3rd of February. 2:30pm

Meeting room, Vegetal Biology Building- Campus ...

A focus on sperm DNA oxidative damage : a putative new trail to improve some male infertile situations

Oxidative alterations of the sperm nucleus are causative of reproductive failures and increase the risk of transmitting paternal inherited mutations to the next generation. With the goal to explore new ...

Epigénétique: the revenge of Lamarck?

The next "Mercredis de la Science" ”, organized by the university Blaise Pascal, will be dedicated to the Epigenetics. All are welcome to listen our two researchers, Aline Probst and Christophe ...

When it comes to DNA methylation, 1 + 1 = 3.

Variation in DNA methylation, which decorates DNA of most living organisms, can impact gene transcription, just like does DNA sequence. How distinct DNA methylation states of genes and transposons, called ...

Benjamin Bertin : prix du Jury des JED 2016

Benjamin BERTIN, doctorant dans l'équipe de Krzysztof Jagla , a reçu le prix du Jury lors des 'Journées de l'Ecole Doctorale 2016".

Axel POULET thesis works highlighted on the Oxford Brooke University website.

The 6^th of June, Axel Poulet, student in Christophe Tatout and Aline Probst’s team, successfully defended his thesis performed under a co-tutelle arrangement between Oxford Brooked and Blaise ...

GH1-HMGA1 : une protéine chromatinienne impliquée dans la stabilité des télomères et la réparation des cassures double brin de l’ADN

De par leur nature linéaire, les chromosomes des eucaryotes ont dû développer des mécanismes de protection de leurs extrémités appelés télomères. Si ...

A new recognition for the GReD research againts cancer

The EDC-CaP project- Environmental chemical disrupter and metastasic potential of prostate cancer- leads by Jean-Marc Lobacarro et Sylvére Baron is among the 8 selected projects from the national call ...

Nutrition and Cancer Congress - June 22 -23, 2017

The 4^th International Congress of Translational Research in Human Nutrition – Theme: Nutrition and Cancer , will be held in Clermont-Ferrand on 22 and 23 of june.

To know more about ...

Weapons exchange in the battle between transposable elements and their host

The inactivation of transposable elements within genomes is insured by multiple epigenetic mechanisms. Olivier Mathieu's team has identified two genes required for repressing many transposable elements through a new ...

Adrenal differentiation: a key role for the epigenetic factor EZH2

The adrenal gland produces glucocorticoid and mineralocorticoid hormones that are essential for life. This hormone production depends on a complex process of recruitment and differentiation of progenitor cells. Using a ...

Marie-Elisa PINSON won the prize for the best poster at the Auvergne-Rhône-Alpes forum on cancer research

Marie-Elisa PINSON won the prize for the best poster, section "Bioinformatics and modelisation" at the Auvergne-Rhône-Alpes forum on cancer research.

To know more, the awarded poster can be uploaded ...

A key developmental stage for the targeting of transposable elements by piRNAs.

In few germline cells located at the anterior pole of the Drosophila ovariole, Piwi expression is weakened. This short time of germline development has been called the Piwiless pocket or ...

Les donateurs AFM-Téléthon à la rencontre des équipes de recherche du GReD

Le 8 octobre dernier le GReD organisait une journée Portes ouvertes aux donateurs de l’Association Française contre les Myopathies (AFM-Téléthon).

Chaperoning histones and controlling genome function

Histone proteins are critical components of chromatin and the incorporation of different histone variants modulates nucleosome stability. Deposition of histones at the right time and the correct place in the ...

INDEPTH : The GReD, in collaboration with LIMOS laboratory, holds the first COST-Action coordinated by Clermont Auvergne University (UCA)

GReD and LIMOS laboratories are happy to inform you that their COST-action project entitled «Impact of Nuclear Domains on Gene Expression and Plant Traits » (INDEPTH) has been awarded. This pan-european ...

Recombination machinery compensates telomere loss in the absence of telomerase.

The chromosomes of most eukaryotic species are linear, consisting of a single DNA double-helix running from one end to the other. Each chromosome thus has two ends and these are ...

Male infertility, toward new molecular causes .

Bile acids are molecules with endocrine activities controlling several physiological functions such as immunity and glucose homeostasis. Recently, they have also been shown to be involved in testicular physiology and ...

Amandine RAMBUR won the prize for the best poster at the 26th ARTP annual meeting

Amandine RAMBUR (Team "Nuclear receptor and prostate diseases") won the prize for the best poster at the ARTP (Asociation for research on prostate tumors) 26th annual meeting.

To know more ...

GENOME PLASTICITY: EXAMPLE OF 5S RIBOSOMAL RNA GENES

The genes coding 5S ribosomal RNAs (critical components of the ribosomes, the cellular machineries translating mRNA into proteins) are highly repeated in the genome, which allows the production of large ...

LINE fishing... with the new bioinformatics tool CLIFinder

Repeated elements represent 45% of the human genome. However, due to their large number and their high sequence homology, the contribution of those elements to the human genome transcriptome remains ...

EZH2, a novel therapeutic target in Adrenal Cortex Cancer

Adrenal cortex Cancer is one of the most aggressive cancers, for which there is no effective therapeutic approach. Research supervised by Pierre VAL at GReD laboratories, identified overexpression of EZH2 ...

A new research group has joined the GReD

The team « Epigenetic Regulation and Hematopoiesis », headed by Lucas Waltzer, has joined the GReD.

The team: Manon Boulet ( PhD Student)- Lucas Waltzer (DR2 CNRS, Team leader)- Laurence Vandel (DR2 CNRS ...

The LINC complex contributes to heterochromatin organisation and transcriptional gene silencing in plants

The linker of nucleoskeleton and cytoskeleton (LINC) complex is an evolutionarily well-conserved protein bridge connecting the cytoplasmic and nuclear compartments across the nuclear membrane. Recent investigations have highlighted its function ...

Adrenal gland differentiation: positive antagonism

Endocrine activity of the adrenal glands is essential for body homeostasis and depends on the differentiation of two concentric cellular zones. Using transgenic mouse models, Pierre Val’s team has ...

GReD meets Johan Swinnen during its 2400 km run for cancer patients

From the 21st of Auguts our colleague Johan Swinnen undertook a journey of a lifetime: running from Leuven to Santiago de Compostela with a backpack filled with hundreds of letters ...

FXRα a new actor of germinal stem cells fate.

The FXRα nuclear receptor (Farnesoid-X-Receptor alpha) is a key factor controlling the male sex hormone synthesis within the testis. However, its roles in male germ cell homeostasis have not yet ...

Cymbopogon citratus and cancer: when citronella is a repellent not only for mosquitoes…

Through a real bilateral collaboration, Drs. Silvère BARON’s et and Jean-Marc LOBACCARO’s team Nuclear Receptor and Prostate diseases and Pr. Jacques SIMPORE’s team (Laboratoire de Biologie ...

DNA methylation : a new actor in CML biology

Chronic myeloid leukemia (CML), a cancer of the white blood cell, results from a translocation event that ultimately leads to the production of BCR-ABL1, a chimeric oncoprotein that promotes CML ...

Conference: "Epigenetic regulatory complexes in development and cancer. "

SVSAE doctoral School conference

‘Epigenetic regulatory complexes in development and cancer’.

Peter MULLIGAN - Centre de Recherche en Cancérologie de Lyon (CRCL)- Centre Léon Bérard, Lyon

Friday, 12th ...

Budding Researchers

The pupils ,aged 6 years old, of the school Nestor Perret in Clermont-Ferrand spent Tuesday, May 30^th, morning together with the researchers of the GReD in a real course ...

GReD internal meeting 2017

The GReD internal meeting 2017 will be held thursday the 9th and friday the 10th of february at "amplhi de Physique" on Cézeaux Campus.

Please,click here to download ...

The GReD wishes you the best for 2017

Pint of Science "Le Gras c'est la vie !" par L. Bousset & S. Baron-Lundi 15 mai

Et si on démystifiait la recherche scientifique autour d’une petite bière…

LE GRAS C’EST LA VIE !

Mon médecin m’a dit : « Trop de cholestérol ...

Conference : "Preserving Heart Function despite Obesity, Aging and Parental Diet"

"Preserving Heart Function despite Obesity, Aging and Parental Diet"

Rolf Bodmer (Sanford Burnham Prebys, San-Diego)

Monday 24th of June, 2pm

Amphi Volcan. CRBC Building - Medical school

Contact : Krzysztof JAGLA (christophe ...

The journey of a thousand piRNAs begins with a single Dot

Among the several kinds of non-coding small RNAs, piRNAs (Piwi-interacting RNAs) are the ‘transposon-silencers’. They occur within the gonads of animals, protecting the cellular genome from transposable elements. One of ...

PhD defense: Quentin Laurichesse

Quentin LAURICHESSE (Team “ Diversification of muscle and heart cells in normal and pathological conditions”) will defend his thesis entitled:

" Caractérisation génétique des précurseurs de tendons appendiculaires ...

EMBO Workshop "Plant Genome Stability and Change"

This EMBO workshop represents the sixth International Meeting on molecular and cellular mechanisms underlying stability, variability and modification of plant genomes. It will be held at the IPK Gatersleben, Germany ...