12H45 – 13H45
Faculté de médecine
Amphi Limagne (CRBC RdC)
Le GReD lance un appel à candidature pour recruter sa future directrice ou futur directeur, pour une prise de fonction en janvier 2021
The GReD wishes to recruit a new independent leader to form a group within the scientific spectrum of the GReD. The GReD will provide laboratory space (50m2) and free access to state-of-the-art technological platforms (cell/tissue culture, FACS, imaging/live imaging, histology). The successful candidates will have full access to transgenic plant and animal (mouse, drosophila, Arabidopsis) and bioinformatics facilities and will benefit of administrative support. Facilities for high-throughput sequencing, mass spectrometry, proteomics, electron microscopy and radiobiology are available on the multidisciplinary Medical School campus.
"Systems biology approach to early neuronal cell fate acquisition" Hinrich Gronemeyer, IGBMC, Illkirch
Thursday 20th of septembre 2018 ; 2:30 pm
Amphi VOLCAN, CRBC, Medical School.
Contact: Laurence Vandel ( email@example.com)
GH1-HMGA1 : une protéine chromatinienne impliquée dans la stabilité des télomères et la réparation des cassures double brin de l’ADN
De par leur nature linéaire, les chromosomes des eucaryotes ont dû développer des mécanismes de protection de leurs extrémités appelés télomères. Si ces mécanismes sont défaillant, les télomères sont reconnus par la cellule comme des cassures de l’ADN et vont donc être « réparés » de façon abusive et engendrer des dommages génomiques dramatiques pour la cellule. Chez l’homme, l’ADN télomérique est remodelé par un complexe protéique spécifique, qui constituent une « coiffe » qui a pour rôle principal d’assurer la protection du génome. Malgré d’intenses recherches, très peu de protéines impliquées dans l'homéostasie des télomères ont été identifiées chez les plantes.
Dans sa dernière étude (Charbonnel et al.), le groupe de Charles White décrit le rôle de la protéine GH1-HMGA1 dans l’homéostasie télomérique ainsi que dans la réparation de l’ADN chez la plante Arabidopsis thaliana.
Cecilia BASSALERT (Team “Molecular mechanisms of cell lineage differentiation in the early mouse embryo") will defend her thesis entitled:
"Influence des voies de signalisation IGF et MAPK sur la spécification des lignages de l'embryon de souris préimplantatoire."
Friday the 7th of September 2018 at 2 pm
Amphi 6B , Medical School
Chronic myeloid leukemia (CML), a cancer of the white blood cell, results from a translocation event that ultimately leads to the production of BCR-ABL1, a chimeric oncoprotein that promotes CML by aberrantly phosphorylating target proteins. Nonetheless, this event on its own, cannot account for an increasing number of clinical observation suggesting the involvement of other pathways, among which DNA methylation alteration emerges as a relevant candidate.
On that basis the teams of Marc BERGER (CHU, Clermont-Ferrand) and Philippe ARNAUD have characterized for the first time the DNA methylation patterns of CML cell subsets (immature and mature cells) isolated form the same clone during the early stage of the disease, before any treatment (Maupetit-Méhouas, Court, Bourgne et al.,). Altogether, this collaborative study demonstrated that DNA methylation abnormalities exist at early stages of CML and can affect the transcriptional landscape of malignant cells. These observations paved the way for new therapeutic strategies based on epigenetic drugs.
The genes coding 5S ribosomal RNAs (critical components of the ribosomes, the cellular machineries translating mRNA into proteins) are highly repeated in the genome, which allows the production of large quantities of these rRNAs.
In their last study (Simon et al., 2018), the team of Aline Probst and Christophe Tatout revealed an important variation in number and expression of 5S rRNA genes between different ecotypes of Arabidopsis thaliana.
Through a real bilateral collaboration, Drs. Silvère BARON’s et and Jean-Marc LOBACCARO’s team Nuclear Receptor and Prostate diseases and Pr. Jacques SIMPORE’s team (Laboratoire de Biologie Moléculaire et de Génétique, Université de Ouagadougou, Burkina Faso), have identified medicinal plants of the Burkina Faso pharmacopeia that could be used in the future in cancer treatment (Bayala et al., 2018).
The chromosomes of most eukaryotic species are linear, consisting of a single DNA double-helix running from one end to the other. Each chromosome thus has two ends and these are protected by specialized DNA-protein structures named telomeres. The importance of telomere structure is readily observed in the severe genetic instability and cell death that result from its absence.
In its last study ( Olivier et al., 2018), the team of Charles White and Maria Gallego unveiled mechanisms by which recombination machinery contributes to protect the telomeres from replicative failure, ensuring their stability.
Tissue elongation is part of the repertoire of processes that allow an organ to acquire its shape (morphogenesis). In the last years, the elongation of the ovarian follicle of Drosophila has emerged as a model of choice for the study of tissue elongation mechanisms. During its development the initially spherical follicle becomes ovoid and this elongation is controlled by the epithelial cells surrounding each follicle. However, so far, all studies on the subject have focused on the basal domain of these cells.
Repeated elements represent 45% of the human genome. However, due to their large number and their high sequence homology, the contribution of those elements to the human genome transcriptome remains difficult to study. Particularly, implication of recent LINE-1 (L1) elements to the transcriptional expression profile of cells and tissues is probably under-evaluated. Indeed, those L1 elements possess, in addition to their sense promoter, an antisense promoter (ASP) which allow the transcription of their adjacent sequences (which may include genes) in the form of LINE-1 chimeric transcripts (LCTs). Such LCTs have been already described in literature bur the question remains of the pangenomic extent of this transcriptional activity.
In a study conducted by Catherine Barrière (Pinson, Pogorelcnik et al., 2017), Philippe Arnaud’s team has developed and validated CLIFinder (Chimeric Line Finder), a new software dedicated to the identification of LCTs from stranded paired-end RNA-seq data. Thus, CLIFinder take advantage of the strong potential of next generation sequencing to unravel the complete transcriptome composition and allow the “fishing”, among all the transcriptome’s sequences, of numerous LCTs comprising a L1 sequence and a unique sequence of the genome. The CLIFinder tool is today available for the scientific community to realize extensive analyses in normal and pathological tissues. Indeed, many LCTs have been identified specifically in tumors and are supposed to play a functional role in tumorigenesis.
This software has been published in Bioinformatics (Pinson, Pogorelcnik et al., 2017)
The EDC-CaP project- Environmental chemical disrupter and metastasic potential of prostate cancer- leads by Jean-Marc Lobacarro et Sylvére Baron is among the 8 selected projects from the national call ...Read more
Puberty is a key event for the development of male reproductive functions. It depends on the increase of testosterone produced by the testis, under the control of the activity of ...Read more
From May 25th to May 28th, PhD students from the GReD lab held a booth at Polydôme (Clermont-Ferrand) to present their work to children and young adults.Read more
Adrenal cortex Cancer is one of the most aggressive cancers, for which there is no effective therapeutic approach. Research supervised by Pierre VAL at GReD laboratories, identified overexpression of EZH2 ...Read more
Alexandre CHAMPROUX ( team : "Mechanisms of mammalian post-testicular infertility") will defend his thesis entitled:
"L'impact du stress oxydant sur l'épigénome spermatique murin. "
Wednesday the 11 of April 2018 ...Read more
SVSAE doctoral School conference
‘Epigenetic regulatory complexes in development and cancer’.
Peter MULLIGAN - Centre de Recherche en Cancérologie de Lyon (CRCL)- Centre Léon Bérard, Lyon
Friday, 12th ...Read more
Et si on démystifiait la recherche scientifique autour d’une petite bière…
LE GRAS C’EST LA VIE !
Mon médecin m’a dit : « Trop de cholestérol ...Read more
Benjamin BERTIN (Equipe « Diversification des cellules musculaires et cardiaques en conditions normales et pathologiques ») soutiendra sa thèse intitulée :
"Analyses moléculaires et fonctionnelles de la diversification musculaire par ...Read more
Lilia LADDADA (Team “Diversification of muscle and heart cells in normal and pathological conditions”) will defend her thesis entitled:
"Étude du développement des tendons et de leur interaction avec ...Read more
Hematopoiesis and immune response: insight from Drosophila
Michèle Crozatier (CBD Toulouse)
Friday Sept 29 at 11h, CBRC room 003
This prize is awarded every three years by the Royal Academy of Sciences, Letters and Fine Arts of Belgium to acknowledge a pioneer work in embryology or cytology .
Claire Chazaud ...Read more
On Friday, july 7th, in the CRBC Amphi "Volcan", Thyphanie DUMONTET will defend her thesis entitled:"Rôle de la signalisation PKA dans la zonation de la glande surrénale ...Read more
12H30 – 13H30
Faculté de médecine
Amphi 1 (1èR étage, R1)
06 Juin : Damien BOUVIER GReD, INSERM U1103, CNRS 6293, UCA
Biomarkers of Fetal Alcohol Syndrome in amniotic fluid ...Read more
By Romain levayer, Institut Pasteur, Paris.
Thursday the 11th of january. 11:00 am
Meeting room 003, CRBC Building- Medical school campus
Contact: Vincent MIROUSE (firstname.lastname@example.org)Read more
From the 21st of Auguts our colleague Johan Swinnen undertook a journey of a lifetime: running from Leuven to Santiago de Compostela with a backpack filled with hundreds of letters ...Read more
The 4th International Congress of Translational Research in Human Nutrition – Theme: Nutrition and Cancer , will be held in Clermont-Ferrand on 22 and 23 of june.
To know more about ...Read more
After Lyon (2016) and Grenoble (2017), we are pleased to welcome you to the third workshop in Mechanobiology and Physics of Life to be held in Clermont-Ferrand on Tuesday January ...Read more
The LINC complex contributes to heterochromatin organisation and transcriptional gene silencing in plants
The linker of nucleoskeleton and cytoskeleton (LINC) complex is an evolutionarily well-conserved protein bridge connecting the cytoplasmic and nuclear compartments across the nuclear membrane. Recent investigations have highlighted its function ...Read more
We are pleased to announce the first main meeting of the COST-Action CA16212 “Impact of Nuclear Domains in Gene Expression and Plant Traits” (INDEPTH). The meeting will take place from ...Read more
Marie-Elisa PINSON won the prize for the best poster at the Auvergne-Rhône-Alpes forum on cancer research
Histone proteins are critical components of chromatin and the incorporation of different histone variants modulates nucleosome stability. Deposition of histones at the right time and the correct place in the ...Read more
The FXRα nuclear receptor (Farnesoid-X-Receptor alpha) is a key factor controlling the male sex hormone synthesis within the testis. However, its roles in male germ cell homeostasis have not yet ...Read more
INDEPTH : The GReD, in collaboration with LIMOS laboratory, holds the first COST-Action coordinated by Clermont Auvergne University (UCA)
GReD and LIMOS laboratories are happy to inform you that their COST-action project entitled «Impact of Nuclear Domains on Gene Expression and Plant Traits » (INDEPTH) has been awarded. This pan-european ...Read more
SVSAE doctoral School conference
‘Biomechanics of Muscle Morphogenesis’
Franck Schnorrer, IBDM (Institut de Biologie du Développement) - Marseille
Friday, 5th of May; 2:30pm
Meeting room, Vegetal Biology Building- Campus ...Read more
Marie-Elisa Pinson (Team “Genomic Imprinting and the epigenetic control of cell fate determination”) will defend her thesis entitled:
"Etude de l'impact de la dérégulation transcriptionnelle liée ...Read more
We are opening two distinct calls for new research group leaders. We encourage both young and already established outstanding researchers to apply. The deadline for applications is July 1st 2017 ...Read more
Multi-scale mathematical model of Epi/PrE specification.
Alen TOSENBERGER- Unit of Theoretical Chronobiology, ULB, Brussels
Tuesday September 26th at 12h45, amphi LIMAGNE (Ground floor CRBC building)
Contact : claire.chazaud@uca ...Read more
Endocrine activity of the adrenal glands is essential for body homeostasis and depends on the differentiation of two concentric cellular zones. Using transgenic mouse models, Pierre Val’s team has ...Read more
Among the several kinds of non-coding small RNAs, piRNAs (Piwi-interacting RNAs) are the ‘transposon-silencers’. They occur within the gonads of animals, protecting the cellular genome from transposable elements. One of ...Read more
Houda TABBAL, doctorante dans l’équipe « Pathophysiologie moléculaire des tissus surrénaux et endocriniens » et Alexandre CHAMPROUX, doctorant dans l’équipe « Mécanismes de l'infertilité mâle post-testiculaire ...Read more
Stéphanie HERMITTE (Team “Molecular mechanisms of cell lineage differentiation in the early mouse embryo”) will defend her thesis entitled:
"Caractérisation de la différenciation de l'endoderme primitif ...Read more
Maxime Voisin (Team “Histone variants and the nuclear envelope in heterochromatin organization”) will defend his thesis entitled:
"Fonction des protéines de l’enveloppe et de la périphérie ...Read more
"Chromatin alterations in cancers"
Raphaël Margueron- Institut Curie Paris
Friday 23rd of March; 11am
Amphi 6A- Medical School- Main Building R3 3rd floor
Contact :email@example.comRead more
Mickael MATHIEU ( équipe : "Pathophysiologie moléculaire des tissus surrénaux et endocriniens") will defend his thesis entitled:
"Rôle de EZH2 et du complexe PRC2 dans l'homéostasie du ...Read more
12H30 – 13H30
Faculté de médecine
Amphi 1 (1er étage, R1)
07 Mars : Séminaires Etudiants M2R GReD
DOUET Jérémie Étude du rôle des protéines TRBs ...Read more
Cristiana DONDI (Team “Diversification of muscle and heart cells in normal and pathological conditions”) will defend her thesis entitled:
"Molecular and functional analysis of cardiac diversification by cell specific translatomic approaches in Drosophila melanogaster"
Friday the 8th of June 2018 at 1.30 pm
Amphi 2A , Medical School
This EMBO workshop represents the sixth International Meeting on molecular and cellular mechanisms underlying stability, variability and modification of plant genomes. It will be held at the IPK Gatersleben, Germany ...Read more
the wednesday 16th of May, the GReD organizes its symposium
"Les surprises du vivant".
Amphitheater Limagne, CRBC Building , Faculté de Médecine
To the Programm click on "read more "....
Bile acids are molecules with endocrine activities controlling several physiological functions such as immunity and glucose homeostasis. Recently, they have also been shown to be involved in testicular physiology and ...Read more
The pupils ,aged 6 years old, of the school Nestor Perret in Clermont-Ferrand spent Tuesday, May 30th, morning together with the researchers of the GReD in a real course ...Read more
A focus on sperm DNA oxidative damage : a putative new trail to improve some male infertile situations
Oxidative alterations of the sperm nucleus are causative of reproductive failures and increase the risk of transmitting paternal inherited mutations to the next generation. With the goal to explore new ...Read more
Conference: "Revisiting cell lineage specification during male sex determination with single cell RNA sequencing ", Serge NEF, University of Geneva
SVSAE doctoral School conference
"Revisiting cell lineage specification during male sex determination with single cell RNA sequencing ", Serge NEF, University of Geneva, Medical School
Friday, 14th of April; 2pm
Meeting ...Read more
Variation in DNA methylation, which decorates DNA of most living organisms, can impact gene transcription, just like does DNA sequence. How distinct DNA methylation states of genes and transposons, called ...Read more
Marjorie WHITFIELD ( Team "Mechanisms of mammalian post-testicular infertility" ) will defend her thesis
"Modèle murin invalidé pour les LXRs : dyslipidémie et impact sur la maturation post-testiculaire des gamètes ...Read more
Benjamin BERTIN, doctorant dans l'équipe de Krzysztof Jagla , a reçu le prix du Jury lors des 'Journées de l'Ecole Doctorale 2016".Read more
The 6th of June, Axel Poulet, student in Christophe Tatout and Aline Probst’s team, successfully defended his thesis performed under a co-tutelle arrangement between Oxford Brooked and Blaise ...Read more
Conference: "The unique mechanisms for the nuclear dynamics in Arabidopsis" Dr. Tamura - Kyoto University, Japan
"The unique mechanisms for the nuclear dynamics in Arabidopsis"
By Dr. Kentaro Tamura, from Kyoto University, Japan
Friday the 3rd of February. 2:30pm
Meeting room, Vegetal Biology Building- Campus ...Read more
Conference: "Ontogeny and function of muscle interstitial progenitor cells" Sigmar Stricker -Freie Universitaet of Berlin
"Ontogeny and function of muscle interstitial progenitor cells" Sigmar Stricker - Freie Universitaet of Berlin
Friday the 27th of January. 3pm
Meeting room, Vegetal Biology Building- Campus des Cézeaux
Contact ...Read more
Ceremony for the foundation stone of the new building CRBC (Centre for Research in Clinical Biology).
Spring 2017 is going to be a landmark for the GReD with the Research Unit being united in the brand-new building CRBC.
This large research facility is part of the ...
Heidi Serra received the young researcher award 2015 from the Bettencourt-Schueller foundation.Read more