Nous sommes toutes et tous issu(e)s d'une cellule unique qui se multiplie d'abord en cellules identiques, et qui ensuite se différencient les unes des autres ...

Avec pas moins de quatre premiers prix ...

Guerric GILBERT (Equipe ERO) : Prix de l'ED SVSAE récompensant la meilleure communication orale, toute catégorie confondue

Fanny HENRIOUX (Equipe Approche ...

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David MANGESDORF,  University of Texas Southwestern, Dallas, USA

Friday 24 of June 12:15- Amphithéatre Michel de l'Hospital, école de Droit

Inserm is opening 12 junior professorships across France, one  is at the iGRed with a research project on "Dynamic regulation of the body axis morphogenesis".

Detail on the research project ...

The team "Diversification of muscle and heart cells in normal and pathological conditions"  is seeking postdoctoral candidates to investigate the function of Hox proteins in Drosophila and mouse muscle development ...

L’infertilité est un problème de santé publique affectant des millions de couples en France. Parmi les causes possibles, la chimiothérapie a été pointée du doigt comme ...

Dans sa dernière revue, publié dans Biology (Yoth et al., 2022)  l’équipe « Instabilités génétiques et contrôle par le génome hôte » décrit ...

A review written in the CODED team in collaboration with the Pascal Institute and Oxford Brookes University explains why neural network learning methods are still not widely used in our ...

The GReD internal meeting 2017 will be held thursday the 9th and friday the 10th of february  at "amplhi de Physique" on Cézeaux Campus.

Please,click  here to download ...

The next  "Mercredis de la Science" ”, organized by the university Blaise Pascal, will be dedicated to the Epigenetics. All are welcome to listen our two researchers, Aline Probst and Christophe ...

Sous l’impulsion de l’équipe « Pathophysiologie moléculaire des tissus surrénaux et endocriniens », les maladies rares de la surrénale ont été à l’honneur du 25 au 28 ...

Puberty is a key event for the development of male reproductive functions. It depends on the increase of testosterone produced by the testis, under the control of the activity of ...

the wednesday 16th of May, the GReD organizes its symposium

"Les surprises du vivant".

Amphitheater Limagne, CRBC Building , Faculté de Médecine

To the  Programm click on "read more "....

The chromosomes of most eukaryotic species are linear, consisting of a single DNA double-helix running from one end to the other. Each chromosome thus has two ends and these are ...

After Lyon (2016) and Grenoble (2017), we are pleased to welcome you to the third workshop in Mechanobiology and Physics of Life to be held in Clermont-Ferrand on Tuesday January ...

Repeated elements represent 45% of the human genome. However, due to their large number and their high sequence homology, the contribution of those elements to the human genome transcriptome remains ...

Among the several kinds of non-coding small RNAs, piRNAs (Piwi-interacting RNAs) are the ‘transposon-silencers’. They occur within the gonads of animals, protecting the cellular genome from transposable elements. One of ...

Adrenal cortex Cancer is one of the most aggressive cancers, for which there is no effective therapeutic approach. Research supervised by Pierre VAL at GReD laboratories, identified overexpression of EZH2 ...

The telomeric CST complex contributes to maintain genome stability through chromosome end protection and telomere length regulation. In its last study conducted on the yeast model (Calvo, Grandin et al ...

Depuis l’été 2018, les équipes du GReD sont hébergées au CRBC, Centre de Recherche BioClinique.

Ce nouveau bâtiment a été inauguré le lundi 10 décembre ...

From the 21st of Auguts our colleague Johan Swinnen undertook  a journey of a lifetime: running from Leuven to Santiago de Compostela with a backpack filled with hundreds of letters ...

The linker of nucleoskeleton and cytoskeleton (LINC) complex is an evolutionarily well-conserved protein bridge connecting the cytoplasmic and nuclear compartments across the nuclear membrane. Recent investigations have highlighted its function ...

Histone proteins are critical components of chromatin and the incorporation of different histone variants modulates nucleosome stability. Deposition of histones at the right time and the correct place in the ...

The FXRα nuclear receptor (Farnesoid-X-Receptor alpha) is a key factor controlling the male sex hormone synthesis within the testis. However, its roles in male germ cell homeostasis have not yet ...

GReD and LIMOS laboratories are happy to inform you that their COST-action project entitled «Impact of Nuclear Domains on Gene Expression and Plant Traits »  (INDEPTH) has been awarded.  This pan-european ...

Bile acids are molecules with endocrine activities controlling several physiological functions such as immunity and glucose homeostasis. Recently, they have also been shown to be involved in testicular physiology and ...

Houda TABBAL, doctorante dans l’équipe « Pathophysiologie moléculaire des tissus surrénaux et endocriniens » et Alexandre CHAMPROUX, doctorant dans l’équipe « Mécanismes de l'infertilité mâle post-testiculaire ...

Prostate cancer is one of the most frequent and deadly tumors in man for which it is necessary to expand the portfolio of therapeutic strategies.

Based on an ethnobotany screening ...

Dans sa dernière étude, publiée dans Genome Biology (Duc, Yoth et al., 2019) , l’équipe « Instabilités génétiques et contrôle par le génome h ...

Le mardi 26 Novembre, de 9h à 17h, se tiendra la 1^éreAutomnale du Groupe Cancer Clermont Auvergne

Cette journée permettra d’avoir un panorama de la recherche en ...

Chronic myeloid leukemia (CML), a cancer of the white blood cell, results from a translocation event that ultimately leads to the production of BCR-ABL1, a chimeric oncoprotein that promotes CML ...

The adrenal gland produces glucocorticoid and mineralocorticoid hormones that are essential for life. This hormone production depends on a complex process of recruitment and differentiation of progenitor cells. Using a ...

Le 8 octobre dernier le GReD organisait une journée Portes ouvertes aux donateurs de l’Association Française contre les Myopathies (AFM-Téléthon).

The genes coding 5S ribosomal RNAs (critical components of the ribosomes, the cellular machineries translating mRNA into proteins) are highly repeated in the genome, which allows the production of large ...

Through a real bilateral collaboration, Drs. Silvère BARON’s et and Jean-Marc LOBACCARO’s team Nuclear Receptor and Prostate diseases and Pr. Jacques SIMPORE’s team (Laboratoire de Biologie ...

The inactivation of transposable elements within genomes is insured by multiple epigenetic mechanisms. Olivier Mathieu's team has identified two genes required for repressing many transposable elements through a new ...

Endocrine activity of the adrenal glands is essential for body homeostasis and depends on the differentiation of two concentric cellular zones. Using transgenic mouse models, Pierre Val’s team has ...

Quatre laboratoires de l’Université Clermont Auvergne, dont le GReD, viennent de mettre en évidence un extrait végétal capable de soigner la nosémose, une maladie qui d ...

In few germline cells located at the anterior pole of the Drosophila ovariole, Piwi expression is weakened. This short time of germline development has been called the Piwiless pocket or ...

La SUMOylation est un processus de modification post-traductionnelle conservé chez les eucaryotes, indispensable au maintien de l’intégrité des génomes, à la régulation des gènes et à la ...

Du 17 au 21 décembre 2018, six collégiens, tous désireux de découvrir les métiers de la recherche, ont rejoint le GReD.  Les activés men ...

Les recherches menées au cours de cette dernière décennie ont révélé que la quasi-totalité des génomes est transcrite et que la plupart des mol ...

Le projet collaboratif TransCAP réunit depuis 2014 les acteurs Auvergnats de la recherche sur le cancer de la prostate, dont l'équipe "Récepteurs nucléaires et maladies de ...

The majority of patients suffering from Myotonic Dystrophy Type I (DM1) exhibit cardiac conduction disturbance, reducing their life expectancy and causing sometimes sudden death. In their last study (Auxerre-Plantié et ...

In its last study, published in Development (Azami et al., ),   the team "Molecular mechanisms of cell lineage differentiation in the early mouse embryo" identified the phosporylation of ERK as a ...

Grâce aux dons du téléthon, L' AFM soutient deux équipes de recherche au GReD.

En tirant partie du modéle drosophile, les équipes "Diversification des cellules musculaires ...

Solidaire tout d’abord de nos membres aussi praticiens hospitaliers, ainsi que de nos collègues clermontois, qui sont directement impliqués dans la lutte contre le virus : courage  à vous ...

iGReD days 2021  (4th and 5th of october) will be held  at the holiday village of Parent , near Clermont.

In the programme (here) : Science sand recreation...Quoi de plus ?!

L’iGReD organise sa Journée Portes Ouvertes, dédiée aux étudiants de Licence et Master,  le Mardi 7 décembre 2021, de 11h00 à 15h00.

Au cours de cette ...

Plusieurs équipes du GReD sont partie prenante dans ce réseau, dont l’une des premières actions a été l’organisation de la 1ére Automnale du Groupe Cancer ...

Mosaic Team 13

team AKR

In cancer cells, aberrant DNA methylation is commonly associated with transcriptional alterations, including silencing of tumor suppressor genes. However, multiple epigenetic mechanisms, including polycomb repressive marks, contribute to gene deregulation ...

Team 14

Team Reclab

Team NuReP: "COVID or not COVID? This is not the question… show must go on :)"

More here

"A défaut d'être ensemble, la team 10 Zoom!!"

Charléne GUILLOT, I-SITE CAP2025 call laureate , joined the i-GReD in september 2021 to set up her team " Dynamic regulation of body axis regulation".

To know more, it's here.

Pour la fête de la science, le GReD partage avec vous les émotions de la découverte grâce à Guillaume, doctorant.

Pour voir les autres vidéos "Eureka! que ...

This study, leads by G.Junion ( team  Diversification of muscle and heart cells in normal and pathological conditions ),  published in the journal Molecular Cell (Akhtar et al.) shows a new ...

Team "Muscle"

Team 3

Team 1: Behind the screen...each has its own containment

more details : here

Les membranes fœtales également appelées « poche des eaux  » sont nécessaires pour un développement harmonieux du bébé durant les 9 mois de la grossesse.

Dans sa ...

Team 4: "100 years of shared solitude"

Georgia Golfis, de Bitplane, viendra présenter le logiciel Imaris le 11 février 2014.
Cette présentation sera suivie d'une formation pratique l'après-midi.

Administrative team

En développant des stratégies de génomique fonctionnelle sur des modèles murins, et en collaboration avec un réseau international de chercheurs et cliniciens, l’équipe Pathophysiologie ...

Team "MePTI"

Tissue elongation is part of the repertoire of processes that allow an organ to acquire its shape (morphogenesis). In the last years, the elongation of the ovarian follicle of Drosophila ...

De par leur nature linéaire, les chromosomes des eucaryotes ont dû développer des mécanismes de protection de leurs extrémités appelés télomères. Si ...

The pupils ,aged 6 years old, of the school Nestor Perret in Clermont-Ferrand spent Tuesday, May 30^th, morning together with the researchers of the GReD in a real course ...

The team « Epigenetic Regulation and Hematopoiesis », headed by Lucas Waltzer, has joined the GReD.

The team: Manon Boulet ( PhD Student)- Lucas Waltzer (DR2 CNRS, Team leader)- Laurence Vandel (DR2 CNRS ...

Oxidative alterations of the sperm nucleus are causative of reproductive failures and increase the risk of transmitting paternal inherited mutations to the next generation. With the goal to explore new ...

Variation in DNA methylation, which decorates DNA of most living organisms, can impact gene transcription, just like does DNA sequence. How distinct DNA methylation states of genes and transposons, called ...

Benjamin BERTIN, doctorant dans l'équipe de Krzysztof Jagla , a reçu le prix du Jury lors  des 'Journées de l'Ecole Doctorale 2016".

The 6^th of June, Axel Poulet, student in Christophe Tatout and Aline Probst’s team,   successfully defended his thesis performed under a co-tutelle arrangement between Oxford Brooked and Blaise ...

Heidi Serra received the young researcher award 2015 from the Bettencourt-Schueller foundation.

Spring 2017 is going to be a landmark for the GReD with the Research Unit being united in the brand-new building CRBC.
This large research facility is part of the ...

Pour prolonger les journées du GReD 2015...