News

PhD defense: Elisa LE BOITEUX

PhD defense: Elisa LE BOITEUX

Elisa Le Boiteux (Team “Genomic Imprinting and the epigenetic control of cell fate determination”) will defend her thesis entitled:

"Altération du contrôle de H3K27me3 et dérégulation transcriptionnelle dans les gliomes : Etude des clusters HOX"

Tuesday the 3rd of December 2019  at 1:30 pm

Salle des Thése, Medical School

Viva examiners : Mary CALLANAN (CHU, Dijon), Marie-Pierre JUNIER (IBPS, Paris), Samir MERABET (IGFL, Lyon) ; Pierre VERRELLE (Institut Curie, Paris & UCA), Anne Fogli (GReD), Philippe ARNAUD (GReD)

Recrutement chargé(e) de mission scientifique

Recrutement chargé(e) de mission scientifique

La filière Maladies Rares Endocriniennes (FIRENDO http://www.firendo.fr/accueil-filiere-firendo/) recherche :

Un(e) chargé(e) de mission scientifique, affecté(e)  à l'équipe  "Pathophysiologie moléculaire des tissus surrénaux et endocriniens" au GReD

CDD de 1 an renouvelable 

Missions: accompagner, conseiller, soutenir et coordonner les acteurs recherche de la filière dans le but de recenser, faciliter et optimiser la mise en place des projets de recherche.

Diplômes: minimum BAC+5 scientifique ou ingénierie des systèmes de santé ou Bac+8 Doctorat en Biologie. Une formation en recherche clinique est un plus, mais n’est pas indispensable.

Contact: Antoine Martinez   email: antoine.martinez@uca.fr

Le profil détaillé du poste est disponible ici

1ere Automnale du Groupe Cancer Clermont Auvergne

1ere Automnale du Groupe Cancer Clermont Auvergne

Le mardi 26 Novembre, de 9h à 17h, se tiendra la 1éreAutomnale du Groupe Cancer Clermont Auvergne

Cette journée permettra d’avoir un panorama de la recherche en cancérologie du site, alliant ses aspects fondamentaux (biologiques et sciences humaines), translationnelles et cliniques.

International congress on transposable elements (ICTE)

International congress on transposable elements (ICTE)

For the organizing committee, the GReD institute invite you to attend the next international congress on transposable elements (ICTE) in Saint Malo from April 25 to 29th, 2020.

http://icte2020 ...

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Looking for pERK !

Looking for pERK !

In its last study, published in Development (Azami et al., ),   the team "Molecular mechanisms of cell lineage differentiation in the early mouse embryo" identified the phosporylation of ERK as a key event in the specification of epiblast (Epi) and Primitive Endoderm (PrE).

GReD Seminar

GReD Seminar

Faculté de médecine
CRBC AMPHI LIMAGNE

12h45 - 13h45

Transcriptional alterations in Glioma: DNA methylation is the tip of the “epigenetic” iceberg

Transcriptional alterations in Glioma:  DNA methylation is the tip of the “epigenetic” iceberg

In cancer cells, aberrant DNA methylation is commonly associated with transcriptional alterations, including silencing of tumor suppressor genes. However, multiple epigenetic mechanisms, including polycomb repressive marks, contribute to gene deregulation in cancer. In its last study  (Court et al.,  2019) the team " Genomic Imprinting and the epigenetic control of cell fate determination" used glioma, one the most widespread type of brain tumor, to evaluate for the first time the relative contribution of DNA methylation-independent mechanisms on transcriptional alteration at CpG-island (CGI)/promoter-associated genes in cancer cells. They found that most transcriptional alterations in tumor samples were DNA methylation-independent. Instead, altered histone H3 trimethylation at lysine 27 (H3K27me3) was the predominant molecular defect at deregulated genes.

Les Chercheurs du GReD accueillent les malades

Les Chercheurs du GReD accueillent les malades

Sous l''égide de l'INSERM, le GReD et M2iSH accueillent les malades sur le théme "Santé et environnement" ,  le mercredi 13 novembre .

Au programme (13h30-16h30, salle de réunion 003, batiment CRBC):

- La Recherche à l'Inserm avec et pour les Associations de Malades : C. Lemercier, Inserm

- Présentation générale des deux laboratoires GReD et M2ISH

- Effets des perturbateurs endocriniens sur la reproduction, le cancer : D. Volle, Inserm U1103

- Environnement, Microbiote Intestinal, Inflammation : N. Barnich, directeur du laboratoire M2ISH.·

- Visite du GReD

Pour en savoir plus cliquez  ici

Sewing workshop in GReD

Sewing workshop in GReD

Everyone has been involved, from the doctoral students to the director, to contribute to the "Pink October" and to make "heart cushions" for patients who have had breast cancer. They were given to the Jean Perrin Center in Clermont-Ferrand on October 22, 2019

GReD goes green...

GReD goes green...

GReD days 2019  (10th and 11th of october) will be held  at the holiday village of Parent , near Clermont.

In the programme (here) : Science sand recreation...Quoi de plus ?!

Les piARNs contre attaquent

Les piARNs contre attaquent

Dans sa dernière étude, publiée dans Genome Biology (Duc, Yoth et al., 2019) , l’équipe « Instabilités génétiques et contrôle par le génome hôte » montre qu’à la suite d’une réactivation d’un élément transposable (ET = séquence d’ADN mobile) dans un tissu adjacent aux cellules germinales, cet élément est capable d’infecter et d’envahir le génome de la lignée germinale comme le ferait un virus. En retour, la lignée germinale apprend à se défendre de cette attaque en piégeant cet élément dans son ADN de façon à garder la mémoire de cette infection. Une « auto-immunisation » du génome se met ainsi en place et « vaccine » la lignée germinale de l’individu et de sa descendance contre des futures invasions.

Les experts mondiaux des maladies de la surrénale se sont réunis au GReD

 Les experts mondiaux des maladies de la surrénale se sont réunis au GReD

Sous l’impulsion de l’équipe « Pathophysiologie moléculaire des tissus surrénaux et endocriniens », les maladies rares de la surrénale ont été à l’honneur du 25 au 28 ...

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PhD defense: Quentin Laurichesse

PhD defense: Quentin Laurichesse

Quentin LAURICHESSE  (Team “ Diversification of muscle and heart cells in normal and pathological conditions”) will defend his thesis entitled:

" Caractérisation génétique des précurseurs de tendons appendiculaires ...

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When the liver controls male puberty....

When the liver controls male puberty....

Puberty is a key event for the development of male reproductive functions. It depends on the increase of testosterone produced by the testis, under the control of the activity of ...

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Conference : " The connection between nervous and immune system in Drosophila melanogaster "

Conference :  " The connection between nervous and immune system in Drosophila melanogaster "

The connection between nervous and immune system in Drosophila melanogaster

Angela Giangrande- IGBMC à Strasbourg

Frdiday 10th of  may,   11 am

Amphi Limagne. CRBC Building  - Medical school

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La recherche contre le cancer au GReD : De la paillasse… à la Courstache !

La recherche contre le cancer au GReD : De la paillasse… à la Courstache !

L’équipe NuReP mise en lumière dans un article de La Montagne de l’édition du Vendredi 2 Novembre dans le cadre du mois « MOVEMBER » de soutien aux patients ...

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Conference: "The unique mechanisms for the nuclear dynamics in Arabidopsis" Dr. Tamura - Kyoto University, Japan

"The unique mechanisms for the nuclear dynamics in Arabidopsis"

By Dr. Kentaro Tamura, from Kyoto University, Japan

Friday the 3rd of February. 2:30pm

Meeting room, Vegetal Biology Building- Campus ...

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A focus on sperm DNA oxidative damage : a putative new trail to improve some male infertile situations

A focus on sperm DNA oxidative damage : a putative new trail to improve some male infertile situations

Oxidative alterations of the sperm nucleus are causative of reproductive failures and increase the risk of transmitting paternal inherited mutations to the next generation. With the goal to explore new ...

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Epigénétique: the revenge of Lamarck?

Epigénétique: the revenge of Lamarck?

The next  "Mercredis de la Science" ”, organized by the university Blaise Pascal, will be dedicated to the Epigenetics. All are welcome to listen our two researchers, Aline Probst and Christophe ...

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Les stagiaires de 3iéme à la découverte du GReD.

Les stagiaires de 3iéme à la découverte du GReD.

Du 17 au 21 décembre 2018, six collégiens, tous désireux de découvrir les métiers de la recherche, ont rejoint le GReD.  Les activés men ...

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When it comes to DNA methylation, 1 + 1 = 3.

 When it comes to DNA methylation, 1 + 1 = 3.

Variation in DNA methylation, which decorates DNA of most living organisms, can impact gene transcription, just like does DNA sequence. How distinct DNA methylation states of genes and transposons, called ...

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Benjamin Bertin : prix du Jury des JED 2016

Benjamin Bertin :  prix du Jury des JED 2016

Benjamin BERTIN, doctorant dans l'équipe de Krzysztof Jagla , a reçu le prix du Jury lors  des 'Journées de l'Ecole Doctorale 2016".

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Axel POULET thesis works highlighted on the Oxford Brooke University website.

 Axel POULET thesis works highlighted on the Oxford Brooke University website.

The 6th of June, Axel Poulet, student in Christophe Tatout and Aline Probst’s team,   successfully defended his thesis performed under a co-tutelle arrangement between Oxford Brooked and Blaise ...

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Stress & SUMO : le poids de SUMO dans la glande surrénale

Stress & SUMO : le poids de SUMO dans la glande surrénale

La SUMOylation est un processus de modification post-traductionnelle conservé chez les eucaryotes, indispensable au maintien de l’intégrité des génomes, à la régulation des gènes et à la ...

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GH1-HMGA1 : une protéine chromatinienne impliquée dans la stabilité des télomères et la réparation des cassures double brin de l’ADN

GH1-HMGA1 : une protéine chromatinienne impliquée dans la stabilité des télomères et la réparation des cassures double brin de l’ADN

De par leur nature linéaire, les chromosomes des eucaryotes ont dû développer des mécanismes de protection de leurs extrémités appelés télomères. Si ...

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A new recognition for the GReD research againts cancer

A new recognition for the GReD  research againts cancer

The EDC-CaP project- Environmental chemical disrupter and metastasic potential of prostate cancer- leads by Jean-Marc Lobacarro et Sylvére Baron is among the 8 selected projects from the national call ...

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Nutrition and Cancer Congress - June 22 -23, 2017

Nutrition and Cancer Congress - June 22 -23, 2017

The 4th  International Congress of Translational Research in Human Nutrition – Theme: Nutrition and Cancer , will be held in Clermont-Ferrand  on 22 and 23 of june.

To know more about ...

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Weapons exchange in the battle between transposable elements and their host

Weapons exchange in the battle between transposable elements and their host

The inactivation of transposable elements within genomes is insured by multiple epigenetic mechanisms. Olivier Mathieu's team has identified two genes required for repressing many transposable elements through a new ...

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Adrenal differentiation: a key role for the epigenetic factor EZH2

Adrenal differentiation: a key role for the epigenetic factor EZH2

The adrenal gland produces glucocorticoid and mineralocorticoid hormones that are essential for life. This hormone production depends on a complex process of recruitment and differentiation of progenitor cells. Using a ...

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Marie-Elisa PINSON won the prize for the best poster at the Auvergne-Rhône-Alpes forum on cancer research

Marie-Elisa PINSON won the prize for the best poster at the Auvergne-Rhône-Alpes forum on cancer research

Marie-Elisa PINSON won the prize for the best poster, section "Bioinformatics and modelisation" at the Auvergne-Rhône-Alpes forum on cancer research.

To know more, the awarded poster can be uploaded ...

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A key developmental stage for the targeting of transposable elements by piRNAs.

A key developmental stage for the targeting of transposable elements by piRNAs.

In few germline cells located at the anterior pole of the Drosophila ovariole, Piwi expression is weakened. This short time of germline development has been called the Piwiless pocket or ...

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Les donateurs AFM-Téléthon à la rencontre des équipes de recherche du GReD

Les donateurs AFM-Téléthon à la rencontre des équipes de recherche du GReD

Le 8 octobre dernier le GReD organisait une journée Portes ouvertes aux donateurs de l’Association Française contre les Myopathies (AFM-Téléthon).

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Chaperoning histones and controlling genome function

Chaperoning histones and controlling genome function

Histone proteins are critical components of chromatin and the incorporation of different histone variants modulates nucleosome stability. Deposition of histones at the right time and the correct place in the ...

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Recombination machinery compensates telomere loss in the absence of telomerase.

Recombination machinery compensates telomere loss in the absence of telomerase.

The chromosomes of most eukaryotic species are linear, consisting of a single DNA double-helix running from one end to the other. Each chromosome thus has two ends and these are ...

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Male infertility, toward new molecular causes .

Male infertility, toward new molecular causes .

Bile acids are molecules with endocrine activities controlling several physiological functions such as immunity and glucose homeostasis. Recently, they have also been shown to be involved in testicular physiology and ...

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Amandine RAMBUR won the prize for the best poster at the 26th ARTP annual meeting

Amandine RAMBUR won the prize for the best poster at the 26th ARTP annual meeting

 Amandine RAMBUR (Team "Nuclear receptor and prostate diseases") won the prize for the best poster at the  ARTP (Asociation for research on prostate tumors) 26th annual meeting.

To know more ...

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GENOME PLASTICITY: EXAMPLE OF 5S RIBOSOMAL RNA GENES

GENOME PLASTICITY: EXAMPLE OF 5S RIBOSOMAL RNA GENES

The genes coding 5S ribosomal RNAs (critical components of the ribosomes, the cellular machineries translating mRNA into proteins) are highly repeated in the genome, which allows the production of large ...

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LINE fishing... with the new bioinformatics tool CLIFinder

LINE fishing... with the new bioinformatics tool CLIFinder

Repeated elements represent 45% of the human genome. However, due to their large number and their high sequence homology, the contribution of those elements to the human genome transcriptome remains ...

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EZH2, a novel therapeutic target in Adrenal Cortex Cancer

EZH2, a novel therapeutic target in Adrenal Cortex Cancer

Adrenal cortex Cancer is one of the most aggressive cancers, for which there is no effective therapeutic approach. Research supervised by Pierre VAL at GReD laboratories, identified overexpression of EZH2 ...

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A new research group has joined the GReD

The team « Epigenetic Regulation and Hematopoiesis », headed by Lucas Waltzer, has joined the GReD.

The team: Manon Boulet ( PhD Student)- Lucas Waltzer (DR2 CNRS, Team leader)- Laurence Vandel (DR2 CNRS ...

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The LINC complex contributes to heterochromatin organisation and transcriptional gene silencing in plants

The LINC complex contributes to heterochromatin organisation and transcriptional gene silencing in plants

The linker of nucleoskeleton and cytoskeleton (LINC) complex is an evolutionarily well-conserved protein bridge connecting the cytoplasmic and nuclear compartments across the nuclear membrane. Recent investigations have highlighted its function ...

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Adrenal gland differentiation: positive antagonism

Adrenal gland differentiation: positive antagonism

Endocrine activity of the adrenal glands is essential for body homeostasis and depends on the differentiation of two concentric cellular zones. Using transgenic mouse models, Pierre Val’s team has ...

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GReD meets Johan Swinnen during its 2400 km run for cancer patients

GReD meets Johan Swinnen during its 2400 km run for cancer patients

From the 21st of Auguts our colleague Johan Swinnen undertook  a journey of a lifetime: running from Leuven to Santiago de Compostela with a backpack filled with hundreds of letters ...

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FXRα a new actor of germinal stem cells fate.

FXRα  a new actor  of germinal stem cells fate.

The FXRα nuclear receptor (Farnesoid-X-Receptor alpha) is a key factor controlling the male sex hormone synthesis within the testis. However, its roles in male germ cell homeostasis have not yet ...

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Portes ouvertes aux étudiants de Licence et Master 1 et 2; Jeudi 14 mars 2019

 Portes ouvertes aux étudiants de Licence et Master 1 et 2; Jeudi  14 mars 2019

Le jeudi 14 mars 2019 le GReD organise une journée portes ouvertes spécialement dédiée aux étudiants de Licence et Master 1 et 2.

Ce sera l ...

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PhD defense: Colin Niarfeix

PhD defense: Colin Niarfeix

Colin NIARFEIX  (Team “ Epithelial Growth and Morphogenesis”) will defend his thesis entitled:

"Impact des signaux germinaux sur la croissance et la prolifération des cellules somatiques et leurs cellules souches ...

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What if honeybees could help fighting prostate cancer?

What if honeybees could help fighting prostate cancer?

Prostate cancer is one of the most frequent and deadly tumors in man for which it is necessary to expand the portfolio of therapeutic strategies.

Based on an ethnobotany screening ...

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Workshop "Mechanobiology and Physics of Life"

Workshop "Mechanobiology and Physics of Life"

After Lyon (2016) and Grenoble (2017), we are pleased to welcome you to the third workshop in Mechanobiology and Physics of Life to be held in Clermont-Ferrand on Tuesday January ...

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Inauguration du Centre de Recherche BioClinique de l’Université Clermont Auvergne

Inauguration du Centre de Recherche BioClinique de l’Université Clermont Auvergne

Depuis l’été 2018, les équipes du GReD sont hébergées au CRBC, Centre de Recherche BioClinique.

Ce nouveau bâtiment a été inauguré le lundi 10 décembre ...

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Conference : " Interaction of light and circadian clock signaling networks in Arabidopsis "

Conference :  " Interaction of light and circadian clock signaling networks in Arabidopsis "

 Laszlo Kozma-Bogna ,

Institute of Plant Biology, Szeged, Hungary

Frdiay  12th of  april,  11 am

Amphi 2B    Medical School, R1  4th floor

Contact : Aline Probst (aline.probst@uca.fr)

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The conserved yeast telomeric CST complex also functions in the regulation of RNA polymerase II transcription

The conserved yeast telomeric CST complex also functions in the regulation of RNA polymerase II transcription

The telomeric CST complex contributes to maintain genome stability through chromosome end protection and telomere length regulation. In its last study conducted on the yeast model (Calvo, Grandin et al ...

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DNA methylation : a new actor in CML biology

DNA methylation : a new actor in CML biology

Chronic myeloid leukemia (CML), a cancer of the white blood cell, results from a translocation event that ultimately leads to the production of BCR-ABL1, a chimeric oncoprotein that promotes CML ...

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Conference: "Epigenetic regulatory complexes in development and cancer. "

SVSAE doctoral School conference

‘Epigenetic regulatory complexes in development and cancer’. 

Peter MULLIGAN - Centre de Recherche en Cancérologie de Lyon (CRCL)- Centre Léon Bérard, Lyon

Friday, 12th ...

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Budding Researchers

Budding Researchers

The pupils ,aged 6 years old, of the school Nestor Perret in Clermont-Ferrand spent Tuesday, May 30th, morning together with the researchers of the GReD in a real course ...

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GReD internal meeting 2017

The GReD internal meeting 2017 will be held thursday the 9th and friday the 10th of february  at "amplhi de Physique" on Cézeaux Campus.

Please,click  here to download ...

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Pint of Science "Le Gras c'est la vie !" par L. Bousset & S. Baron-Lundi 15 mai

Pint of Science "Le Gras c'est la vie !"  par L. Bousset & S. Baron-Lundi 15 mai

Et si on démystifiait la recherche scientifique autour d’une petite bière…

LE GRAS C’EST LA VIE !

Mon médecin m’a dit : « Trop de cholestérol ...

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Conference : "Preserving Heart Function despite Obesity, Aging and Parental Diet"

Conference :  "Preserving Heart Function despite Obesity, Aging and Parental Diet"

"Preserving Heart Function despite Obesity, Aging and Parental Diet"

Rolf Bodmer  (Sanford Burnham Prebys, San-Diego)

Monday 24th of June, 2pm

Amphi Volcan. CRBC Building  - Medical school

Contact : Krzysztof JAGLA  (christophe ...

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The journey of a thousand piRNAs begins with a single Dot

The journey of a thousand piRNAs begins with a single Dot

Among the several kinds of non-coding small RNAs, piRNAs (Piwi-interacting RNAs) are the ‘transposon-silencers’. They occur within the gonads of animals, protecting the cellular genome from transposable elements. One of ...

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EMBO Workshop "Plant Genome Stability and Change"

EMBO  Workshop "Plant Genome Stability and Change"

This EMBO workshop represents the sixth International Meeting on molecular and cellular mechanisms underlying stability, variability and modification of plant genomes. It will be held at the IPK Gatersleben, Germany ...

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GReD Symposium : "Les surpises du Vivant"

GReD Symposium :  "Les surpises du Vivant"

the wednesday 16th of May, the GReD organizes its symposium

"Les surprises du vivant".

Amphitheater Limagne, CRBC Building , Faculté de Médecine

To the  Programm click on "read more "....

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Le GReD partie prenante dans le projet VitAbeilles

 Le GReD partie prenante dans le projet VitAbeilles

Quatre laboratoires de l’Université Clermont Auvergne, dont le GReD, viennent de mettre en évidence un extrait végétal capable de soigner la nosémose, une maladie qui d ...

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sRNAPipe: a Galaxy-based pipeline for bioinformatic in-depth exploration of small RNAseq data

sRNAPipe: a Galaxy-based pipeline for bioinformatic in-depth exploration of small RNAseq data

Les recherches menées au cours de cette dernière décennie ont révélé que la quasi-totalité des génomes est transcrite et que la plupart des mol ...

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How to turn a football into a rugby ball?

How to turn a football into a rugby ball?

Tissue elongation is part of the repertoire of processes that allow an organ to acquire its shape (morphogenesis). In the last years, the elongation of the ovarian follicle of Drosophila ...

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PhD defense: Marilyne LAVERGNE

PhD defense: Marilyne LAVERGNE

Marilyne LAVERGNE (Team “Translational approach to epithelial injury and repair”) will defend her thesis entitled:

" Rôle des protéines NLRP dans la physiopathologie des membranes fœtales humaines ...

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GRED’s people in the spotlight

GRED’s people in the spotlight

 

Heidi Serra received the young researcher award 2015 from the Bettencourt-Schueller foundation.

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Ceremony for the foundation stone of the new building CRBC (Centre for Research in Clinical Biology).

Ceremony for the foundation stone of the new building CRBC (Centre for Research in Clinical Biology).

Spring 2017 is going to be a landmark for the GReD with the Research Unit being united in the brand-new building CRBC.
This large research facility is part of the ...

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Les Journées du Gred 2015 en images

Les Journées du Gred 2015 en images

Pour prolonger les journées du GReD 2015...

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