News
Appel à candidature pour la future direction du GReD
Le GReD lance un appel à candidature pour recruter sa future directrice ou futur directeur, pour une prise de fonction en janvier 2021
CALL for a NEW RESEARCH GROUP LEADER
The GReD wishes to recruit a new independent leader to form a group within the scientific spectrum of the GReD. The GReD will provide laboratory space (50m2) and free access to state-of-the-art technological platforms (cell/tissue culture, FACS, imaging/live imaging, histology). The successful candidates will have full access to transgenic plant and animal (mouse, drosophila, Arabidopsis) and bioinformatics facilities and will benefit of administrative support. Facilities for high-throughput sequencing, mass spectrometry, proteomics, electron microscopy and radiobiology are available on the multidisciplinary Medical School campus.
Conference : "Systems biology approach to early neuronal cell fate acquisition"
"Systems biology approach to early neuronal cell fate acquisition" Hinrich Gronemeyer, IGBMC, Illkirch
Thursday 20th of septembre 2018 ; 2:30 pm
Amphi VOLCAN, CRBC, Medical School.
Contact: Laurence Vandel ( laurence.vandel@uca.fr)
GH1-HMGA1 : une protéine chromatinienne impliquée dans la stabilité des télomères et la réparation des cassures double brin de l’ADN
De par leur nature linéaire, les chromosomes des eucaryotes ont dû développer des mécanismes de protection de leurs extrémités appelés télomères. Si ces mécanismes sont défaillant, les télomères sont reconnus par la cellule comme des cassures de l’ADN et vont donc être « réparés » de façon abusive et engendrer des dommages génomiques dramatiques pour la cellule. Chez l’homme, l’ADN télomérique est remodelé par un complexe protéique spécifique, qui constituent une « coiffe » qui a pour rôle principal d’assurer la protection du génome. Malgré d’intenses recherches, très peu de protéines impliquées dans l'homéostasie des télomères ont été identifiées chez les plantes.
Dans sa dernière étude (Charbonnel et al.), le groupe de Charles White décrit le rôle de la protéine GH1-HMGA1 dans l’homéostasie télomérique ainsi que dans la réparation de l’ADN chez la plante Arabidopsis thaliana.
PhD Thesis defense : Cecilia BASSALERT
Cecilia BASSALERT (Team “Molecular mechanisms of cell lineage differentiation in the early mouse embryo") will defend her thesis entitled:
"Influence des voies de signalisation IGF et MAPK sur la spécification des lignages de l'embryon de souris préimplantatoire."
Friday the 7th of September 2018 at 2 pm
Amphi 6B , Medical School
DNA methylation : a new actor in CML biology
Chronic myeloid leukemia (CML), a cancer of the white blood cell, results from a translocation event that ultimately leads to the production of BCR-ABL1, a chimeric oncoprotein that promotes CML by aberrantly phosphorylating target proteins. Nonetheless, this event on its own, cannot account for an increasing number of clinical observation suggesting the involvement of other pathways, among which DNA methylation alteration emerges as a relevant candidate.
On that basis the teams of Marc BERGER (CHU, Clermont-Ferrand) and Philippe ARNAUD have characterized for the first time the DNA methylation patterns of CML cell subsets (immature and mature cells) isolated form the same clone during the early stage of the disease, before any treatment (Maupetit-Méhouas, Court, Bourgne et al.,). Altogether, this collaborative study demonstrated that DNA methylation abnormalities exist at early stages of CML and can affect the transcriptional landscape of malignant cells. These observations paved the way for new therapeutic strategies based on epigenetic drugs.
GENOME PLASTICITY: EXAMPLE OF 5S RIBOSOMAL RNA GENES
The genes coding 5S ribosomal RNAs (critical components of the ribosomes, the cellular machineries translating mRNA into proteins) are highly repeated in the genome, which allows the production of large quantities of these rRNAs.
In their last study (Simon et al., 2018), the team of Aline Probst and Christophe Tatout revealed an important variation in number and expression of 5S rRNA genes between different ecotypes of Arabidopsis thaliana.
Cymbopogon citratus and cancer: when citronella is a repellent not only for mosquitoes…
Through a real bilateral collaboration, Drs. Silvère BARON’s et and Jean-Marc LOBACCARO’s team Nuclear Receptor and Prostate diseases and Pr. Jacques SIMPORE’s team (Laboratoire de Biologie Moléculaire et de Génétique, Université de Ouagadougou, Burkina Faso), have identified medicinal plants of the Burkina Faso pharmacopeia that could be used in the future in cancer treatment (Bayala et al., 2018).
Recombination machinery compensates telomere loss in the absence of telomerase.
The chromosomes of most eukaryotic species are linear, consisting of a single DNA double-helix running from one end to the other. Each chromosome thus has two ends and these are protected by specialized DNA-protein structures named telomeres. The importance of telomere structure is readily observed in the severe genetic instability and cell death that result from its absence.
In its last study ( Olivier et al., 2018), the team of Charles White and Maria Gallego unveiled mechanisms by which recombination machinery contributes to protect the telomeres from replicative failure, ensuring their stability.
How to turn a football into a rugby ball?
Tissue elongation is part of the repertoire of processes that allow an organ to acquire its shape (morphogenesis). In the last years, the elongation of the ovarian follicle of Drosophila has emerged as a model of choice for the study of tissue elongation mechanisms. During its development the initially spherical follicle becomes ovoid and this elongation is controlled by the epithelial cells surrounding each follicle. However, so far, all studies on the subject have focused on the basal domain of these cells.
In its last study (Alegot et al.,) , the group of Vincent Mirouse has shown that the apical domain of the epithelial cells also contributed to this elongation.
LINE fishing... with the new bioinformatics tool CLIFinder
Repeated elements represent 45% of the human genome. However, due to their large number and their high sequence homology, the contribution of those elements to the human genome transcriptome remains difficult to study. Particularly, implication of recent LINE-1 (L1) elements to the transcriptional expression profile of cells and tissues is probably under-evaluated. Indeed, those L1 elements possess, in addition to their sense promoter, an antisense promoter (ASP) which allow the transcription of their adjacent sequences (which may include genes) in the form of LINE-1 chimeric transcripts (LCTs). Such LCTs have been already described in literature bur the question remains of the pangenomic extent of this transcriptional activity.
In a study conducted by Catherine Barrière (Pinson, Pogorelcnik et al., 2017), Philippe Arnaud’s team has developed and validated CLIFinder (Chimeric Line Finder), a new software dedicated to the identification of LCTs from stranded paired-end RNA-seq data. Thus, CLIFinder take advantage of the strong potential of next generation sequencing to unravel the complete transcriptome composition and allow the “fishing”, among all the transcriptome’s sequences, of numerous LCTs comprising a L1 sequence and a unique sequence of the genome. The CLIFinder tool is today available for the scientific community to realize extensive analyses in normal and pathological tissues. Indeed, many LCTs have been identified specifically in tumors and are supposed to play a functional role in tumorigenesis.
This software has been published in Bioinformatics (Pinson, Pogorelcnik et al., 2017)
A new recognition for the GReD research againts cancer
The EDC-CaP project- Environmental chemical disrupter and metastasic potential of prostate cancer- leads by Jean-Marc Lobacarro et Sylvére Baron is among the 8 selected projects from the national call ...
Read moreWhen the liver controls male puberty....
Puberty is a key event for the development of male reproductive functions. It depends on the increase of testosterone produced by the testis, under the control of the activity of ...
Read moreGReD's PhD students stimulate scientific career interest at Exposciences
From May 25th to May 28th, PhD students from the GReD lab held a booth at Polydôme (Clermont-Ferrand) to present their work to children and young adults.
Read moreEZH2, a novel therapeutic target in Adrenal Cortex Cancer
Adrenal cortex Cancer is one of the most aggressive cancers, for which there is no effective therapeutic approach. Research supervised by Pierre VAL at GReD laboratories, identified overexpression of EZH2 ...
Read morePhD Defense: Alexandre CHAMPROUX
Alexandre CHAMPROUX ( team : "Mechanisms of mammalian post-testicular infertility") will defend his thesis entitled:
"L'impact du stress oxydant sur l'épigénome spermatique murin. "
Wednesday the 11 of April 2018 ...
Read moreConference: "Epigenetic regulatory complexes in development and cancer. "
SVSAE doctoral School conference
‘Epigenetic regulatory complexes in development and cancer’.
Peter MULLIGAN - Centre de Recherche en Cancérologie de Lyon (CRCL)- Centre Léon Bérard, Lyon
Friday, 12th ...
Read morePint of Science "Le Gras c'est la vie !" par L. Bousset & S. Baron-Lundi 15 mai
Et si on démystifiait la recherche scientifique autour d’une petite bière…
LE GRAS C’EST LA VIE !
Mon médecin m’a dit : « Trop de cholestérol ...
Read moreSoutenance de thése : Benjamin BERTIN
Benjamin BERTIN (Equipe « Diversification des cellules musculaires et cardiaques en conditions normales et pathologiques ») soutiendra sa thèse intitulée :
"Analyses moléculaires et fonctionnelles de la diversification musculaire par ...
Read morePhD Defense: Lilia Laddada
Lilia LADDADA (Team “Diversification of muscle and heart cells in normal and pathological conditions”) will defend her thesis entitled:
"Étude du développement des tendons et de leur interaction avec ...
Read moreConference: "Hematopoiesis and immune response: insight from Drosophila "
Hematopoiesis and immune response: insight from Drosophila
Michèle Crozatier (CBD Toulouse)
Friday Sept 29 at 11h, CBRC room 003
Contact: christophe.jagla@udamail.fr
Read more
Claire CHAZAUD received the VAN BENEDEN prize.
This prize is awarded every three years by the Royal Academy of Sciences, Letters and Fine Arts of Belgium to acknowledge a pioneer work in embryology or cytology .
Claire Chazaud ...
Read morePhD defense: Typhanie DUMONTET
On Friday, july 7th, in the CRBC Amphi "Volcan", Thyphanie DUMONTET will defend her thesis entitled:"Rôle de la signalisation PKA dans la zonation de la glande surrénale ...
Read moreLes Mardis du GRed - Juin 2017
12H30 – 13H30
Faculté de médecine
Amphi 1 (1èR étage, R1)
06 Juin : Damien BOUVIER GReD, INSERM U1103, CNRS 6293, UCA
Biomarkers of Fetal Alcohol Syndrome in amniotic fluid ...
Read moreConference: « From fitness comparison to spatial constrains : the many roads of cell competition »
By Romain levayer, Institut Pasteur, Paris.
Thursday the 11th of january. 11:00 am
Meeting room 003, CRBC Building- Medical school campus
Contact: Vincent MIROUSE (vincent.mirouse@uca.fr)
Read moreGReD meets Johan Swinnen during its 2400 km run for cancer patients
From the 21st of Auguts our colleague Johan Swinnen undertook a journey of a lifetime: running from Leuven to Santiago de Compostela with a backpack filled with hundreds of letters ...
Read moreAmandine RAMBUR won the prize for the best poster at the 26th ARTP annual meeting
Amandine RAMBUR (Team "Nuclear receptor and prostate diseases") won the prize for the best poster at the ARTP (Asociation for research on prostate tumors) 26th annual meeting.
To know more ...
Read moreNutrition and Cancer Congress - June 22 -23, 2017
The 4th International Congress of Translational Research in Human Nutrition – Theme: Nutrition and Cancer , will be held in Clermont-Ferrand on 22 and 23 of june.
To know more about ...
Read moreHDR defence: Isabelle VAILLANT
On wednesday, November 8th, Isabelle VAILLANT will defend her HDR entitled:"Contrôle épigénétique des séquences répétées chez Arabidopsis et de l'expression des ...
Read moreWorkshop "Mechanobiology and Physics of Life"
After Lyon (2016) and Grenoble (2017), we are pleased to welcome you to the third workshop in Mechanobiology and Physics of Life to be held in Clermont-Ferrand on Tuesday January ...
Read moreThe LINC complex contributes to heterochromatin organisation and transcriptional gene silencing in plants
The linker of nucleoskeleton and cytoskeleton (LINC) complex is an evolutionarily well-conserved protein bridge connecting the cytoplasmic and nuclear compartments across the nuclear membrane. Recent investigations have highlighted its function ...
Read moreMeeting: “Impact of Nuclear Domains in Gene Expression and Plant Traits” (INDEPTH)
We are pleased to announce the first main meeting of the COST-Action CA16212 “Impact of Nuclear Domains in Gene Expression and Plant Traits” (INDEPTH). The meeting will take place from ...
Read moreMarie-Elisa PINSON won the prize for the best poster at the Auvergne-Rhône-Alpes forum on cancer research
Marie-Elisa PINSON won the prize for the best poster, section "Bioinformatics and modelisation" at the Auvergne-Rhône-Alpes forum on cancer research.
To know more, the awarded poster can be uploaded ...
Read moreChaperoning histones and controlling genome function
Histone proteins are critical components of chromatin and the incorporation of different histone variants modulates nucleosome stability. Deposition of histones at the right time and the correct place in the ...
Read moreFXRα a new actor of germinal stem cells fate.
The FXRα nuclear receptor (Farnesoid-X-Receptor alpha) is a key factor controlling the male sex hormone synthesis within the testis. However, its roles in male germ cell homeostasis have not yet ...
Read moreINDEPTH : The GReD, in collaboration with LIMOS laboratory, holds the first COST-Action coordinated by Clermont Auvergne University (UCA)
GReD and LIMOS laboratories are happy to inform you that their COST-action project entitled «Impact of Nuclear Domains on Gene Expression and Plant Traits » (INDEPTH) has been awarded. This pan-european ...
Read moreConférence: "Biomechanics of Muscle Morphogenesis "- Friday 5th of may
SVSAE doctoral School conference
‘Biomechanics of Muscle Morphogenesis’
Franck Schnorrer, IBDM (Institut de Biologie du Développement) - Marseille
Friday, 5th of May; 2:30pm
Meeting room, Vegetal Biology Building- Campus ...
Read moreWeapons exchange in the battle between transposable elements and their host
The inactivation of transposable elements within genomes is insured by multiple epigenetic mechanisms. Olivier Mathieu's team has identified two genes required for repressing many transposable elements through a new ...
Read morePhD defense: Marie-Elisa PINSON
Marie-Elisa Pinson (Team “Genomic Imprinting and the epigenetic control of cell fate determination”) will defend her thesis entitled:
"Etude de l'impact de la dérégulation transcriptionnelle liée ...
Read moreCALL for NEW RESEARCH GROUP LEADERS
We are opening two distinct calls for new research group leaders. We encourage both young and already established outstanding researchers to apply. The deadline for applications is July 1st 2017 ...
Read moreConference: " Multi-scale mathematical model of Epi/PrE specification. "
Multi-scale mathematical model of Epi/PrE specification.
Alen TOSENBERGER- Unit of Theoretical Chronobiology, ULB, Brussels
Tuesday September 26th at 12h45, amphi LIMAGNE (Ground floor CRBC building)
Contact : claire.chazaud@uca ...
Read moreAdrenal gland differentiation: positive antagonism
Endocrine activity of the adrenal glands is essential for body homeostasis and depends on the differentiation of two concentric cellular zones. Using transgenic mouse models, Pierre Val’s team has ...
Read moreThe journey of a thousand piRNAs begins with a single Dot
Among the several kinds of non-coding small RNAs, piRNAs (Piwi-interacting RNAs) are the ‘transposon-silencers’. They occur within the gonads of animals, protecting the cellular genome from transposable elements. One of ...
Read moreLes Doctorants du GReD à l’honneur lors des JED 2017.
Houda TABBAL, doctorante dans l’équipe « Pathophysiologie moléculaire des tissus surrénaux et endocriniens » et Alexandre CHAMPROUX, doctorant dans l’équipe « Mécanismes de l'infertilité mâle post-testiculaire ...
Read moreA new research group has joined the GReD
The team « Epigenetic Regulation and Hematopoiesis », headed by Lucas Waltzer, has joined the GReD.
The team: Manon Boulet ( PhD Student)- Lucas Waltzer (DR2 CNRS, Team leader)- Laurence Vandel (DR2 CNRS ...
Read morePhD defense: Gunjita SINGH
Gunjita SINGH (Team “Recombination and Maintenance of Genome Integrity”) will defend her thesis entitled:
" Role of recombination protein in cross-over formation, pairing and synapsis in Arabidopsis meiosis"
Monday 9th ...
Read morePhD defense: Stéphanie HERMITTE
Stéphanie HERMITTE (Team “Molecular mechanisms of cell lineage differentiation in the early mouse embryo”) will defend her thesis entitled:
"Caractérisation de la différenciation de l'endoderme primitif ...
Read morePhD defense: Margaux OLIVIER
Margaux OLIVIER (Team “Recombination and Maintenance of Genome Integrity”) (will defend her thesis
" Rôle des protéines de la recombinaison dans le maintien des télomères."
Monday 2 ...
Read morePhD defense: Maxime VOISIN
Maxime Voisin (Team “Histone variants and the nuclear envelope in heterochromatin organization”) will defend his thesis entitled:
"Fonction des protéines de l’enveloppe et de la périphérie ...
Read moreConference: " Chromatin alterations in cancers "
"Chromatin alterations in cancers"
Raphaël Margueron- Institut Curie Paris
Friday 23rd of March; 11am
Amphi 6A- Medical School- Main Building R3 3rd floor
Contact :pierre.val@uca.fr
Read morePhD Defense: Mickael MATHIEU
Mickael MATHIEU ( équipe : "Pathophysiologie moléculaire des tissus surrénaux et endocriniens") will defend his thesis entitled:
"Rôle de EZH2 et du complexe PRC2 dans l'homéostasie du ...
Read moreLes Mardis du GRed - Mars 2017
12H30 – 13H30
Faculté de médecine
Amphi 1 (1er étage, R1)
07 Mars : Séminaires Etudiants M2R GReD
DOUET Jérémie Étude du rôle des protéines TRBs ...
Read morePhD Defense: Cristiana DONDI
Cristiana DONDI (Team “Diversification of muscle and heart cells in normal and pathological conditions”) will defend her thesis entitled:
"Molecular and functional analysis of cardiac diversification by cell specific translatomic approaches in Drosophila melanogaster"
Friday the 8th of June 2018 at 1.30 pm
Amphi 2A , Medical School
EMBO Workshop "Plant Genome Stability and Change"
This EMBO workshop represents the sixth International Meeting on molecular and cellular mechanisms underlying stability, variability and modification of plant genomes. It will be held at the IPK Gatersleben, Germany ...
Read moreGReD Symposium : "Les surpises du Vivant"
the wednesday 16th of May, the GReD organizes its symposium
"Les surprises du vivant".
Amphitheater Limagne, CRBC Building , Faculté de Médecine
To the Programm click on "read more "....
PhD Thesis defense : Fabiana CERQUEIRA CAMPOS
Fabiana CERQUEIRA CAMPOS (Team “Epithelial Growth and Morphogenesis") will defend her thesis entitled:
''Etude du rôle du complexe Dystrophine-Dystroglycan au cours de l'élongation tissulaire du follicule ovarien chez ...
Read moreMale infertility, toward new molecular causes .
Bile acids are molecules with endocrine activities controlling several physiological functions such as immunity and glucose homeostasis. Recently, they have also been shown to be involved in testicular physiology and ...
Read moreBudding Researchers
The pupils ,aged 6 years old, of the school Nestor Perret in Clermont-Ferrand spent Tuesday, May 30th, morning together with the researchers of the GReD in a real course ...
Read moreA focus on sperm DNA oxidative damage : a putative new trail to improve some male infertile situations
Oxidative alterations of the sperm nucleus are causative of reproductive failures and increase the risk of transmitting paternal inherited mutations to the next generation. With the goal to explore new ...
Read moreConference: "Revisiting cell lineage specification during male sex determination with single cell RNA sequencing ", Serge NEF, University of Geneva
SVSAE doctoral School conference
"Revisiting cell lineage specification during male sex determination with single cell RNA sequencing ", Serge NEF, University of Geneva, Medical School
Friday, 14th of April; 2pm
Meeting ...
Read moreWhen it comes to DNA methylation, 1 + 1 = 3.
Variation in DNA methylation, which decorates DNA of most living organisms, can impact gene transcription, just like does DNA sequence. How distinct DNA methylation states of genes and transposons, called ...
Read morePhd Defense : Marjorie WHITFIELD
Marjorie WHITFIELD ( Team "Mechanisms of mammalian post-testicular infertility" ) will defend her thesis
"Modèle murin invalidé pour les LXRs : dyslipidémie et impact sur la maturation post-testiculaire des gamètes ...
Read moreBenjamin Bertin : prix du Jury des JED 2016
Benjamin BERTIN, doctorant dans l'équipe de Krzysztof Jagla , a reçu le prix du Jury lors des 'Journées de l'Ecole Doctorale 2016".
Read moreAxel POULET thesis works highlighted on the Oxford Brooke University website.
The 6th of June, Axel Poulet, student in Christophe Tatout and Aline Probst’s team, successfully defended his thesis performed under a co-tutelle arrangement between Oxford Brooked and Blaise ...
Read moreConference: "The unique mechanisms for the nuclear dynamics in Arabidopsis" Dr. Tamura - Kyoto University, Japan
"The unique mechanisms for the nuclear dynamics in Arabidopsis"
By Dr. Kentaro Tamura, from Kyoto University, Japan
Friday the 3rd of February. 2:30pm
Meeting room, Vegetal Biology Building- Campus ...
Read moreEpigénétique: the revenge of Lamarck?
The next "Mercredis de la Science" ”, organized by the university Blaise Pascal, will be dedicated to the Epigenetics. All are welcome to listen our two researchers, Aline Probst and Christophe ...
Read moreConference: "Ontogeny and function of muscle interstitial progenitor cells" Sigmar Stricker -Freie Universitaet of Berlin
"Ontogeny and function of muscle interstitial progenitor cells" Sigmar Stricker - Freie Universitaet of Berlin
Friday the 27th of January. 3pm
Meeting room, Vegetal Biology Building- Campus des Cézeaux
Contact ...
Read moreCeremony for the foundation stone of the new building CRBC (Centre for Research in Clinical Biology).
Spring 2017 is going to be a landmark for the GReD with the Research Unit being united in the brand-new building CRBC.
This large research facility is part of the ...
GRED’s people in the spotlight
Heidi Serra received the young researcher award 2015 from the Bettencourt-Schueller foundation.
Read more