News

CALL for NEW RESEARCH GROUP LEADERS

CALL for NEW RESEARCH GROUP LEADERS

The GReD wishes to recruit a new independent leader to establish a group within the scientific spectrum of the GReD. The project must be focused on the scientific field covered by the UCA CAP 20-25 project – challenge 3: « Personalized human mobility for a better health » (Muscle development, metabolic response to exercise, impact of nutrition on mobility, pathologies affecting locomotion...  see annexe).

As part of the CAP20-25 initiative, the successful candidate will benefit from a start-up package of €300,000 to €340,000 (salaries and operating budget for 24 to 30 months).

What if honeybees could help fighting prostate cancer?

What if honeybees could help fighting prostate cancer?

Prostate cancer is one of the most frequent and deadly tumors in man for which it is necessary to expand the portfolio of therapeutic strategies.

Based on an ethnobotany screening, the teams of J.M Lobaccaro/S. Baron & V. Sapin/L. Blanchon have developed a collaborative study with Jijel and Oum El Bouaghi Universities (Algeria) and the  CHU Clermont-Ferrand, to evaluate the effects of ethanolic extract of propolis from Jijel  (Algeria) on human prostate cancer cells.

This work, published in the Journal of Steroid Biochemistry and Molecular Biology shows for the first time that propolis reduces the survival of LNCaP cells with high efficacy by the induction of the apoptosis as well as blocking the cell cycle.

Portes ouvertes aux étudiants de Licence et Master 1 et 2; Jeudi 14 mars 2019

 Portes ouvertes aux étudiants de Licence et Master 1 et 2; Jeudi  14 mars 2019

Le jeudi 14 mars 2019 le GReD organise une journée portes ouvertes spécialement dédiée aux étudiants de Licence et Master 1 et 2.

Ce sera l’occasion de rencontrer des membres du GReD (étudiants, post-docs, chercheurs, enseignants-chercheurs, ingénieurs...), d’échanger autour d’un café sur leurs thématiques de recherche et leurs expériences mais aussi de découvrir nos nouveaux locaux.

Accueil sans interruption de 10h à 17h salle 002 (RDC) du bâtiment CRBC, sur le campus de la faculté de médecine.

Les Mardis du GRed - March 2019

Les Mardis du GRed - March 2019

12H45 – 13H45
Faculté de médecine
Amphi Limagne (CRBC RdC)

Inauguration du Centre de Recherche BioClinique de l’Université Clermont Auvergne

Inauguration du Centre de Recherche BioClinique de l’Université Clermont Auvergne

Depuis l’été 2018, les équipes du GReD sont hébergées au CRBC, Centre de Recherche BioClinique.

Ce nouveau bâtiment a été inauguré le lundi 10 décembre dernier en présence de M. Mathias BERNARD, président de l’Université Clermont Auvergne, M. Jean-Pierre BRENNAS, conseiller régional Auvergne-Rhône-Alpes, M. Jean-Marc MORVAN, vice-président de Clermont Auvergne Métropole, Mme Claire GIRY, présidente par intérim de l’Inserm, M. Hervé Moreau, représentant  de l’Institut des Sciences biologiques du CNRS, M Pierre Clavelou, Doyen de la faculté de médecine de Clermont-Ferrand,   Mme Chantal VAURY, directrice du GReD et de Mme Anne-Françoise JUMEAU, architecte à l’agence PERIPHERIQUES.

Outre le GReD , dont les équipes sont  réparties sur 4 étages du bâtiment, le CRBC accueille, en rez de chaussée, un pôle enseignement avec des salles de cours et 2 amphithéâtres et, au premier étage,  un pôle valorisation, géré par l’UCA accélérateur Biotech.

Les stagiaires de 3iéme à la découverte du GReD.

Les stagiaires de 3iéme à la découverte du GReD.

Du 17 au 21 décembre 2018, six collégiens, tous désireux de découvrir les métiers de la recherche, ont rejoint le GReD.  Les activés menées tant dans  les équipes d’accueil qu' en commun ont permis à Natacha & Noa (Collège Henri-Pourrat, Ceyrat); Lucas (Collège La Ribeyre, Cournon d’Auvergne); Sam (Collège Françoise Sagan, Bornel, Oise); Florian (Collège Louisa Paulin, Réalmont, Haute-Garonne) et  Swann (Collège Emile Beaussire, Luçon, Vendée) de découvrir l’ensemble des métiers pratiqués au GReD, les services offerts par les plateformes et les services communs et de réaliser diverses approches expérimentales. Sans conteste ce sont ces dernières qui ont eu leur préférence ! Parmi ce qui les a le plus surpris : « Le nombre de métiers au sein d’un laboratoire » ; «  La taille et le prix des microscopes ! » «  …que l’on puisse travailler sur des mouches » ; «  qu’il y ait autant de bureaux dans un laboratoire de recherche » ou encore « rien ». Et pour tous, cette semaine passée au GReD les a confortés dans leur désir de travailler plus tard dans la recherche " ...car on peut faire des découvertes tous les jours, voir ses résultats tous les jours,  en plus c'est fabuleux de travailler ici car on a toujours envie d'y aller et on a l'impression que le temps défile à toute allure."…what else ?!

Adrenal differentiation: a key role for the epigenetic factor EZH2

Adrenal differentiation: a key role for the epigenetic factor EZH2

The adrenal gland produces glucocorticoid and mineralocorticoid hormones that are essential for life. This hormone production depends on a complex process of recruitment and differentiation of progenitor cells. Using a mouse model of gene ablation, the team “Molecular Pathophysiology of Adrenal & Endocrine Tissues” has shown that the epigenetic factor EZH2 is essential to allow differentiation of progenitor cells into cells capable of hormone synthesis. EZH2 ablation results in primary adrenal glucocorticoid deficiency, suggesting that EZH2 alterations may be involved in the aetiology of these potentially lethal diseases in patients.

This study has been published in PNAS (Mathieu et al., 2018).

 

La recherche contre le cancer au GReD : De la paillasse… à la Courstache !

La recherche contre le cancer au GReD : De la paillasse… à la Courstache !

L’équipe NuReP mise en lumière dans un article de La Montagne de l’édition du Vendredi 2 Novembre dans le cadre du mois « MOVEMBER » de soutien aux patients atteints de cancers masculins (testicules et prostate).

Toujours dans le cadre de "MOVEMBER"  les membres de l’équipe NuReP ont également participé à la course caritative « La Courstache » édition #2 qui  a eu lieu à  Aubière  le samedi 3 Novembre.

sRNAPipe: a Galaxy-based pipeline for bioinformatic in-depth exploration of small RNAseq data

sRNAPipe: a Galaxy-based pipeline for bioinformatic in-depth exploration of small RNAseq data

Les recherches menées au cours de cette dernière décennie ont révélé que la quasi-totalité des génomes est transcrite et que la plupart des molécules d’ARN ainsi produites correspondent à de multiples classes de petits ARN non codants. Malgré l'importance de ces découvertes, aucun outil bioinformatique, simple d’utilisation, n’a été développé à ce jour pour analyser des données de séquençage ciblant ces petits ARNs ("small RNA-Seq"). Dans cette étude, publiée dans  mobile DNA (Pogorelcnik et al., 2018), l'équipe de C. Vaury et E. Brasset  présente précisément  un nouveau  pipeline qui permet une analyse rapide de données de small RNA-Seq. Pour faciliter son utilisation par les biologistes, le pipeline a été intégré avec une interface conviviale à un portail Galaxy.

Les donateurs AFM-Téléthon à la rencontre des équipes de recherche du GReD

Les donateurs AFM-Téléthon à la rencontre des équipes de recherche du GReD

Le 8 octobre dernier le GReD organisait une journée Portes ouvertes aux donateurs de l’Association Française contre les Myopathies (AFM-Téléthon).

A key developmental stage for the targeting of transposable elements by piRNAs.

A key developmental stage for the targeting of transposable elements by piRNAs.

In few germline cells located at the anterior pole of the Drosophila ovariole, Piwi expression is weakened. This short time of germline development has been called the Piwiless pocket or Pilp (Dufourt et al. 2014).

In its last sudy, pubilshed in NAR (Théron et al., ) , the C. Vaury and E. Brasset team evidenced that Pilp is  a key developmental stage for amplifying and specifying the piRNA repertoire targeting transposable elements.

GH1-HMGA1 : une protéine chromatinienne impliquée dans la stabilité des télomères et la réparation des cassures double brin de l’ADN

GH1-HMGA1 : une protéine chromatinienne impliquée dans la stabilité des télomères et la réparation des cassures double brin de l’ADN

De par leur nature linéaire, les chromosomes des eucaryotes ont dû développer des mécanismes de protection de leurs extrémités appelés télomères. Si ces mécanismes sont défaillant, les télomères sont reconnus par la cellule comme des cassures de l’ADN et vont donc être « réparés » de façon abusive et engendrer des dommages génomiques dramatiques pour la cellule. Chez l’homme, l’ADN télomérique est remodelé par un complexe protéique spécifique, qui constituent une « coiffe » qui a pour rôle principal d’assurer la protection du génome. Malgré d’intenses recherches, très peu de protéines impliquées dans l'homéostasie des télomères ont été identifiées chez les plantes.

Dans sa dernière étude (Charbonnel et al.), le groupe de Charles White décrit le rôle de la protéine GH1-HMGA1 dans l’homéostasie télomérique ainsi que dans la réparation de l’ADN chez la plante Arabidopsis thaliana.

Benjamin Bertin : prix du Jury des JED 2016

Benjamin Bertin :  prix du Jury des JED 2016

Benjamin BERTIN, doctorant dans l'équipe de Krzysztof Jagla , a reçu le prix du Jury lors  des 'Journées de l'Ecole Doctorale 2016".

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Axel POULET thesis works highlighted on the Oxford Brooke University website.

 Axel POULET thesis works highlighted on the Oxford Brooke University website.

The 6th of June, Axel Poulet, student in Christophe Tatout and Aline Probst’s team,   successfully defended his thesis performed under a co-tutelle arrangement between Oxford Brooked and Blaise ...

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A new recognition for the GReD research againts cancer

A new recognition for the GReD  research againts cancer

The EDC-CaP project- Environmental chemical disrupter and metastasic potential of prostate cancer- leads by Jean-Marc Lobacarro et Sylvére Baron is among the 8 selected projects from the national call ...

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Nutrition and Cancer Congress - June 22 -23, 2017

Nutrition and Cancer Congress - June 22 -23, 2017

The 4th  International Congress of Translational Research in Human Nutrition – Theme: Nutrition and Cancer , will be held in Clermont-Ferrand  on 22 and 23 of june.

To know more about ...

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Weapons exchange in the battle between transposable elements and their host

Weapons exchange in the battle between transposable elements and their host

The inactivation of transposable elements within genomes is insured by multiple epigenetic mechanisms. Olivier Mathieu's team has identified two genes required for repressing many transposable elements through a new ...

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Marie-Elisa PINSON won the prize for the best poster at the Auvergne-Rhône-Alpes forum on cancer research

Marie-Elisa PINSON won the prize for the best poster at the Auvergne-Rhône-Alpes forum on cancer research

Marie-Elisa PINSON won the prize for the best poster, section "Bioinformatics and modelisation" at the Auvergne-Rhône-Alpes forum on cancer research.

To know more, the awarded poster can be uploaded ...

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Chaperoning histones and controlling genome function

Chaperoning histones and controlling genome function

Histone proteins are critical components of chromatin and the incorporation of different histone variants modulates nucleosome stability. Deposition of histones at the right time and the correct place in the ...

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Recombination machinery compensates telomere loss in the absence of telomerase.

Recombination machinery compensates telomere loss in the absence of telomerase.

The chromosomes of most eukaryotic species are linear, consisting of a single DNA double-helix running from one end to the other. Each chromosome thus has two ends and these are ...

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Male infertility, toward new molecular causes .

Male infertility, toward new molecular causes .

Bile acids are molecules with endocrine activities controlling several physiological functions such as immunity and glucose homeostasis. Recently, they have also been shown to be involved in testicular physiology and ...

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Amandine RAMBUR won the prize for the best poster at the 26th ARTP annual meeting

Amandine RAMBUR won the prize for the best poster at the 26th ARTP annual meeting

 Amandine RAMBUR (Team "Nuclear receptor and prostate diseases") won the prize for the best poster at the  ARTP (Asociation for research on prostate tumors) 26th annual meeting.

To know more ...

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GENOME PLASTICITY: EXAMPLE OF 5S RIBOSOMAL RNA GENES

GENOME PLASTICITY: EXAMPLE OF 5S RIBOSOMAL RNA GENES

The genes coding 5S ribosomal RNAs (critical components of the ribosomes, the cellular machineries translating mRNA into proteins) are highly repeated in the genome, which allows the production of large ...

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LINE fishing... with the new bioinformatics tool CLIFinder

LINE fishing... with the new bioinformatics tool CLIFinder

Repeated elements represent 45% of the human genome. However, due to their large number and their high sequence homology, the contribution of those elements to the human genome transcriptome remains ...

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EZH2, a novel therapeutic target in Adrenal Cortex Cancer

EZH2, a novel therapeutic target in Adrenal Cortex Cancer

Adrenal cortex Cancer is one of the most aggressive cancers, for which there is no effective therapeutic approach. Research supervised by Pierre VAL at GReD laboratories, identified overexpression of EZH2 ...

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A new research group has joined the GReD

The team « Epigenetic Regulation and Hematopoiesis », headed by Lucas Waltzer, has joined the GReD.

The team: Manon Boulet ( PhD Student)- Lucas Waltzer (DR2 CNRS, Team leader)- Laurence Vandel (DR2 CNRS ...

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The LINC complex contributes to heterochromatin organisation and transcriptional gene silencing in plants

The LINC complex contributes to heterochromatin organisation and transcriptional gene silencing in plants

The linker of nucleoskeleton and cytoskeleton (LINC) complex is an evolutionarily well-conserved protein bridge connecting the cytoplasmic and nuclear compartments across the nuclear membrane. Recent investigations have highlighted its function ...

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Adrenal gland differentiation: positive antagonism

Adrenal gland differentiation: positive antagonism

Endocrine activity of the adrenal glands is essential for body homeostasis and depends on the differentiation of two concentric cellular zones. Using transgenic mouse models, Pierre Val’s team has ...

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GReD meets Johan Swinnen during its 2400 km run for cancer patients

GReD meets Johan Swinnen during its 2400 km run for cancer patients

From the 21st of Auguts our colleague Johan Swinnen undertook  a journey of a lifetime: running from Leuven to Santiago de Compostela with a backpack filled with hundreds of letters ...

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FXRα a new actor of germinal stem cells fate.

FXRα  a new actor  of germinal stem cells fate.

The FXRα nuclear receptor (Farnesoid-X-Receptor alpha) is a key factor controlling the male sex hormone synthesis within the testis. However, its roles in male germ cell homeostasis have not yet ...

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Workshop "Mechanobiology and Physics of Life"

Workshop "Mechanobiology and Physics of Life"

After Lyon (2016) and Grenoble (2017), we are pleased to welcome you to the third workshop in Mechanobiology and Physics of Life to be held in Clermont-Ferrand on Tuesday January ...

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Conference: "Epigenetic regulatory complexes in development and cancer. "

SVSAE doctoral School conference

‘Epigenetic regulatory complexes in development and cancer’. 

Peter MULLIGAN - Centre de Recherche en Cancérologie de Lyon (CRCL)- Centre Léon Bérard, Lyon

Friday, 12th ...

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Budding Researchers

Budding Researchers

The pupils ,aged 6 years old, of the school Nestor Perret in Clermont-Ferrand spent Tuesday, May 30th, morning together with the researchers of the GReD in a real course ...

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GReD internal meeting 2017

The GReD internal meeting 2017 will be held thursday the 9th and friday the 10th of february  at "amplhi de Physique" on Cézeaux Campus.

Please,click  here to download ...

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Pint of Science "Le Gras c'est la vie !" par L. Bousset & S. Baron-Lundi 15 mai

Pint of Science "Le Gras c'est la vie !"  par L. Bousset & S. Baron-Lundi 15 mai

Et si on démystifiait la recherche scientifique autour d’une petite bière…

LE GRAS C’EST LA VIE !

Mon médecin m’a dit : « Trop de cholestérol ...

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The journey of a thousand piRNAs begins with a single Dot

The journey of a thousand piRNAs begins with a single Dot

Among the several kinds of non-coding small RNAs, piRNAs (Piwi-interacting RNAs) are the ‘transposon-silencers’. They occur within the gonads of animals, protecting the cellular genome from transposable elements. One of ...

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When the liver controls male puberty....

When the liver controls male puberty....

Puberty is a key event for the development of male reproductive functions. It depends on the increase of testosterone produced by the testis, under the control of the activity of ...

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Conference: "The unique mechanisms for the nuclear dynamics in Arabidopsis" Dr. Tamura - Kyoto University, Japan

"The unique mechanisms for the nuclear dynamics in Arabidopsis"

By Dr. Kentaro Tamura, from Kyoto University, Japan

Friday the 3rd of February. 2:30pm

Meeting room, Vegetal Biology Building- Campus ...

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A focus on sperm DNA oxidative damage : a putative new trail to improve some male infertile situations

A focus on sperm DNA oxidative damage : a putative new trail to improve some male infertile situations

Oxidative alterations of the sperm nucleus are causative of reproductive failures and increase the risk of transmitting paternal inherited mutations to the next generation. With the goal to explore new ...

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Epigénétique: the revenge of Lamarck?

Epigénétique: the revenge of Lamarck?

The next  "Mercredis de la Science" ”, organized by the university Blaise Pascal, will be dedicated to the Epigenetics. All are welcome to listen our two researchers, Aline Probst and Christophe ...

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When it comes to DNA methylation, 1 + 1 = 3.

 When it comes to DNA methylation, 1 + 1 = 3.

Variation in DNA methylation, which decorates DNA of most living organisms, can impact gene transcription, just like does DNA sequence. How distinct DNA methylation states of genes and transposons, called ...

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EMBO Workshop "Plant Genome Stability and Change"

EMBO  Workshop "Plant Genome Stability and Change"

This EMBO workshop represents the sixth International Meeting on molecular and cellular mechanisms underlying stability, variability and modification of plant genomes. It will be held at the IPK Gatersleben, Germany ...

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GReD Symposium : "Les surpises du Vivant"

GReD Symposium :  "Les surpises du Vivant"

the wednesday 16th of May, the GReD organizes its symposium

"Les surprises du vivant".

Amphitheater Limagne, CRBC Building , Faculté de Médecine

To the  Programm click on "read more "....

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DNA methylation : a new actor in CML biology

DNA methylation : a new actor in CML biology

Chronic myeloid leukemia (CML), a cancer of the white blood cell, results from a translocation event that ultimately leads to the production of BCR-ABL1, a chimeric oncoprotein that promotes CML by aberrantly phosphorylating target proteins. Nonetheless, this event on its own, cannot account for an increasing number of clinical observation suggesting the involvement of other pathways, among which DNA methylation alteration emerges as a relevant candidate.

On that basis the teams of Marc BERGER (CHU, Clermont-Ferrand) and Philippe ARNAUD have characterized  for the first  time the DNA methylation patterns of CML cell subsets (immature and mature cells) isolated form the same clone during the early stage of the disease, before any treatment    (Maupetit-Méhouas, Court, Bourgne et al.,). Altogether, this collaborative study demonstrated that DNA methylation abnormalities exist at early stages of CML and can affect the transcriptional landscape of malignant cells. These observations paved the way for new therapeutic strategies based on epigenetic drugs.

How to turn a football into a rugby ball?

How to turn a football into a rugby ball?

Tissue elongation is part of the repertoire of processes that allow an organ to acquire its shape (morphogenesis). In the last years, the elongation of the ovarian follicle of Drosophila has emerged as a model of choice for the study of tissue elongation mechanisms. During its development the initially spherical follicle becomes ovoid and this elongation is controlled by the epithelial cells surrounding each follicle. However, so far, all studies on the subject have focused on the basal domain of these cells.

In its last study (Alegot et al.,) , the group of Vincent Mirouse has shown that the apical domain of the epithelial cells also contributed to this elongation.

GRED’s people in the spotlight

GRED’s people in the spotlight

 

Heidi Serra received the young researcher award 2015 from the Bettencourt-Schueller foundation.

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Ceremony for the foundation stone of the new building CRBC (Centre for Research in Clinical Biology).

Ceremony for the foundation stone of the new building CRBC (Centre for Research in Clinical Biology).

Spring 2017 is going to be a landmark for the GReD with the Research Unit being united in the brand-new building CRBC.
This large research facility is part of the ...

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Les Journées du Gred 2015 en images

Les Journées du Gred 2015 en images

Pour prolonger les journées du GReD 2015...

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