We are opening two distinct calls for new research group leaders. We encourage both young and already established outstanding researchers to apply. The deadline for applications is July 1st 2017. Selected applicants will be interviewed in October 2017.
The GReD internal meeting 2017 will be held thursday the 9th and friday the 10th of february at "amplhi de Physique" on Cézeaux Campus.
Please,click here to download the program.
12H30 – 13H30
Faculté de médecine
Amphi 1 (1èR étage, R1)
07 Février : Pas de séminaire - Journées du GReD - 9-10 Février - Amphi Physique Cézeaux
14 Février : Julien MAUPETIT, Président, co-fondateur de TailorDev SAS
Contact : email@example.com
OPEN SCIENCE 101
Depuis quelques années, grâce au développement d'Internet mais également des réseaux sociaux, le mouvement Open Science a pris de l'ampleur. Je vous propose une définition de ce que regroupe le terme Open Science, une présentation des outils du moment facilitant l'ouverture de vos travaux de recherche et un échange pragmatico-pratique sur la réalité du terrain et les questions que soulève l'adoption de ces pratiques dans votre recherche.
21 Février : Pas de séminaire
28 Février : Romain GUIEZE, EA CHELTER UCA
Genomic basis of resistance to BCL2 inhibition in lymphoid malignancies
Among the several kinds of non-coding small RNAs, piRNAs (Piwi-interacting RNAs) are the ‘transposon-silencers’. They occur within the gonads of animals, protecting the cellular genome from transposable elements. One of the most mysterious question is how piRNAs are transcribed and processed inside the cell. Now Chantal Vaury’s lab brings new data into the biosynthesis of piRNAs. Their study, published recently in Nature Comm (Dennis & al., Nat Commun, 2016 Dec 8;7:13739. doi: 10.1038/ncomms13739), shows that the precursor transcripts of piRNAs are exported out of the nucleus by specific exporter proteins-Nxt1,Nxf1 and that the export itself directs the assembly of Yb bodies which are the cytoplasmic maturation centres of piRNAs. Chantal’s lab has been actively studying piRNA production for the past years, using the ovarian tissue of the fruit fly Drosophila melanogaster as a model. In 2013, they discovered ‘Dot COM’ – a single bright spot within the nuclei of ovarian follicular cells where piRNA precursor transcripts accumulate before to be processed. This year their new study has revealed that the precursors travel away from the site of transcription in the DNA to DOT COM, with the help of exportins and exon-junction complex (EJC) proteins. The study opens new possibilities of research in the piRNA and transposable element regulation fields.
Endocrine activity of the adrenal glands is essential for body homeostasis and depends on the differentiation of two concentric cellular zones. Using transgenic mouse models, Pierre Val’s team has shown that this zonal differentiation relies on a double antagonistic interaction between two signalling pathways. They further show that this antagonism inhibits development of aggressive tumours in mouse models and patients. This study is published in Nature Communications (Drelon et al., 2016) .
The EDC-CaP project- Environmental chemical disrupter and metastasic potential of prostate cancer- leads by Jean-Marc Lobacarro et Sylvére Baron is among the 8 selected projects from the national call "effects of the exposure to environmental risk factors on cancer". This success highlights the capabilities of the GReD teams to design and coordinate demanding and original research projects to fight cancer.
A focus on sperm DNA oxidative damage : a putative new trail to improve some male infertile situations
Oxidative alterations of the sperm nucleus are causative of reproductive failures and increase the risk of transmitting paternal inherited mutations to the next generation. With the goal to explore new ...Read more
Variation in DNA methylation, which decorates DNA of most living organisms, can impact gene transcription, just like does DNA sequence. How distinct DNA methylation states of genes and transposons, called ...Read more
12H30 – 13H30
Faculté de médecine
Amphi 1 (1èR étage, R1)
10 Janvier : Frédérick ARNAUD, UMR 754 - IVPC - Infections Virales et Pathologie Comparée, Lyon
Contact : chantal ...
From May 25th to May 28th, PhD students from the GReD lab held a booth at Polydôme (Clermont-Ferrand) to present their work to children and young adults.
Benjamin BERTIN, doctorant dans l'équipe de Krzysztof Jagla , a reçu le prix du Jury lors des 'Journées de l'Ecole Doctorale 2016".Read more
The 6th of June, Axel Poulet, student in Christophe Tatout and Aline Probst’s team, successfully defended his thesis performed under a co-tutelle arrangement between Oxford Brooked and Blaise ...Read more
Adrenal cortex Cancer is one of the most aggressive cancers, for which there is no effective therapeutic approach. Research supervised by Pierre VAL at GReD laboratories, identified overexpression of EZH2 as a novel alteration involved in malignant progression of this cancer. These data show that targeting EZH2 with pharmacological inhibitors blocks proliferation of cancer cells and induces cell death. This suggests that EZH2 could be an interesting target for treatment of adrenal cancer. This article is published in Human Molecular Genetics (Drelon et al., 2016)
Puberty is a key event for the development of male reproductive functions. It depends on the increase of testosterone produced by the testis, under the control of the activity of the hypothalamic-pituitary axis. Ultimately, this leads to the maturation of secondary sexual characteristics, to the establishment and maintenance of spermatogenesis and fertility. In a study published in Oncotarget (Baptisard et al., 2016), David Volle and Coll. reveal that he nuclear receptor for bile acids, FXRa, play a key role in this process.
The pupils ,aged 6 years old, of the school Nestor Perret in Clermont-Ferrand spent Tuesday, May 30th, morning together with the researchers of the GReD in a real course ...Read more
The GReD joins to the Science fair 2016: Worshops to present the researcher's bench life to pupills ( IUT , Campus des Cézeaux) and particpation to the exhibition "Climate and ...Read more
Conference: "Ontogeny and function of muscle interstitial progenitor cells" Sigmar Stricker -Freie Universitaet of Berlin
"Ontogeny and function of muscle interstitial progenitor cells" Sigmar Stricker - Freie Universitaet of Berlin
Friday the 27th of January. 3pm
Meeting room, Vegetal Biology Building- Campus des Cézeaux
Contact ...Read more
Conference: "The unique mechanisms for the nuclear dynamics in Arabidopsis" Dr. Tamura - Kyoto University, Japan
"The unique mechanisms for the nuclear dynamics in Arabidopsis"
By Dr. Kentaro Tamura, from Kyoto University, Japan
Friday the 3rd of February. 2:30pm
Meeting room, Vegetal Biology Building- Campus ...Read more
Ceremony for the foundation stone of the new building CRBC (Centre for Research in Clinical Biology).
Spring 2017 is going to be a landmark for the GReD with the Research Unit being united in the brand-new building CRBC.
This large research facility is part of the ...
Heidi Serra received the young researcher award 2015 from the Bettencourt-Schueller foundation.Read more