News
PhD defense: Elisa LE BOITEUX
Elisa Le Boiteux (Team “Genomic Imprinting and the epigenetic control of cell fate determination”) will defend her thesis entitled:
"Altération du contrôle de H3K27me3 et dérégulation transcriptionnelle dans les gliomes : Etude des clusters HOX"
Tuesday the 3rd of December 2019 at 1:30 pm
Salle des Thése, Medical School
Viva examiners : Mary CALLANAN (CHU, Dijon), Marie-Pierre JUNIER (IBPS, Paris), Samir MERABET (IGFL, Lyon) ; Pierre VERRELLE (Institut Curie, Paris & UCA), Anne Fogli (GReD), Philippe ARNAUD (GReD)
Recrutement chargé(e) de mission scientifique
La filière Maladies Rares Endocriniennes (FIRENDO http://www.firendo.fr/accueil-filiere-firendo/) recherche :
Un(e) chargé(e) de mission scientifique, affecté(e) à l'équipe "Pathophysiologie moléculaire des tissus surrénaux et endocriniens" au GReD
CDD de 1 an renouvelable
Missions: accompagner, conseiller, soutenir et coordonner les acteurs recherche de la filière dans le but de recenser, faciliter et optimiser la mise en place des projets de recherche.
Diplômes: minimum BAC+5 scientifique ou ingénierie des systèmes de santé ou Bac+8 Doctorat en Biologie. Une formation en recherche clinique est un plus, mais n’est pas indispensable.
Contact: Antoine Martinez email: antoine.martinez@uca.fr
Le profil détaillé du poste est disponible ici
1ere Automnale du Groupe Cancer Clermont Auvergne
Le mardi 26 Novembre, de 9h à 17h, se tiendra la 1éreAutomnale du Groupe Cancer Clermont Auvergne
Cette journée permettra d’avoir un panorama de la recherche en cancérologie du site, alliant ses aspects fondamentaux (biologiques et sciences humaines), translationnelles et cliniques.
International congress on transposable elements (ICTE)
For the organizing committee, the GReD institute invite you to attend the next international congress on transposable elements (ICTE) in Saint Malo from April 25 to 29th, 2020.
Read moreLooking for pERK !
In its last study, published in Development (Azami et al., ), the team "Molecular mechanisms of cell lineage differentiation in the early mouse embryo" identified the phosporylation of ERK as a key event in the specification of epiblast (Epi) and Primitive Endoderm (PrE).
Transcriptional alterations in Glioma: DNA methylation is the tip of the “epigenetic” iceberg
In cancer cells, aberrant DNA methylation is commonly associated with transcriptional alterations, including silencing of tumor suppressor genes. However, multiple epigenetic mechanisms, including polycomb repressive marks, contribute to gene deregulation in cancer. In its last study (Court et al., 2019) the team " Genomic Imprinting and the epigenetic control of cell fate determination" used glioma, one the most widespread type of brain tumor, to evaluate for the first time the relative contribution of DNA methylation-independent mechanisms on transcriptional alteration at CpG-island (CGI)/promoter-associated genes in cancer cells. They found that most transcriptional alterations in tumor samples were DNA methylation-independent. Instead, altered histone H3 trimethylation at lysine 27 (H3K27me3) was the predominant molecular defect at deregulated genes.
Les Chercheurs du GReD accueillent les malades
Sous l''égide de l'INSERM, le GReD et M2iSH accueillent les malades sur le théme "Santé et environnement" , le mercredi 13 novembre .
Au programme (13h30-16h30, salle de réunion 003, batiment CRBC):
- La Recherche à l'Inserm avec et pour les Associations de Malades : C. Lemercier, Inserm
- Présentation générale des deux laboratoires GReD et M2ISH
- Effets des perturbateurs endocriniens sur la reproduction, le cancer : D. Volle, Inserm U1103
- Environnement, Microbiote Intestinal, Inflammation : N. Barnich, directeur du laboratoire M2ISH.·
- Visite du GReD
Pour en savoir plus cliquez ici
Sewing workshop in GReD
Everyone has been involved, from the doctoral students to the director, to contribute to the "Pink October" and to make "heart cushions" for patients who have had breast cancer. They were given to the Jean Perrin Center in Clermont-Ferrand on October 22, 2019
GReD goes green...
GReD days 2019 (10th and 11th of october) will be held at the holiday village of Parent , near Clermont.
In the programme (here) : Science sand recreation...Quoi de plus ?!
Les piARNs contre attaquent
Dans sa dernière étude, publiée dans Genome Biology (Duc, Yoth et al., 2019) , l’équipe « Instabilités génétiques et contrôle par le génome hôte » montre qu’à la suite d’une réactivation d’un élément transposable (ET = séquence d’ADN mobile) dans un tissu adjacent aux cellules germinales, cet élément est capable d’infecter et d’envahir le génome de la lignée germinale comme le ferait un virus. En retour, la lignée germinale apprend à se défendre de cette attaque en piégeant cet élément dans son ADN de façon à garder la mémoire de cette infection. Une « auto-immunisation » du génome se met ainsi en place et « vaccine » la lignée germinale de l’individu et de sa descendance contre des futures invasions.
Les experts mondiaux des maladies de la surrénale se sont réunis au GReD
Sous l’impulsion de l’équipe « Pathophysiologie moléculaire des tissus surrénaux et endocriniens », les maladies rares de la surrénale ont été à l’honneur du 25 au 28 ...
Read morePhD defense: Quentin Laurichesse
Quentin LAURICHESSE (Team “ Diversification of muscle and heart cells in normal and pathological conditions”) will defend his thesis entitled:
" Caractérisation génétique des précurseurs de tendons appendiculaires ...
Read moreWhen the liver controls male puberty....
Puberty is a key event for the development of male reproductive functions. It depends on the increase of testosterone produced by the testis, under the control of the activity of ...
Read moreConference : " The connection between nervous and immune system in Drosophila melanogaster "
The connection between nervous and immune system in Drosophila melanogaster
Angela Giangrande- IGBMC à Strasbourg
Frdiday 10th of may, 11 am
Amphi Limagne. CRBC Building - Medical school
Read more
Conference: "The unique mechanisms for the nuclear dynamics in Arabidopsis" Dr. Tamura - Kyoto University, Japan
"The unique mechanisms for the nuclear dynamics in Arabidopsis"
By Dr. Kentaro Tamura, from Kyoto University, Japan
Friday the 3rd of February. 2:30pm
Meeting room, Vegetal Biology Building- Campus ...
Read moreA focus on sperm DNA oxidative damage : a putative new trail to improve some male infertile situations
Oxidative alterations of the sperm nucleus are causative of reproductive failures and increase the risk of transmitting paternal inherited mutations to the next generation. With the goal to explore new ...
Read moreEpigénétique: the revenge of Lamarck?
The next "Mercredis de la Science" ”, organized by the university Blaise Pascal, will be dedicated to the Epigenetics. All are welcome to listen our two researchers, Aline Probst and Christophe ...
Read moreLes stagiaires de 3iéme à la découverte du GReD.
Du 17 au 21 décembre 2018, six collégiens, tous désireux de découvrir les métiers de la recherche, ont rejoint le GReD. Les activés men ...
Read moreWhen it comes to DNA methylation, 1 + 1 = 3.
Variation in DNA methylation, which decorates DNA of most living organisms, can impact gene transcription, just like does DNA sequence. How distinct DNA methylation states of genes and transposons, called ...
Read moreBenjamin Bertin : prix du Jury des JED 2016
Benjamin BERTIN, doctorant dans l'équipe de Krzysztof Jagla , a reçu le prix du Jury lors des 'Journées de l'Ecole Doctorale 2016".
Read moreAxel POULET thesis works highlighted on the Oxford Brooke University website.
The 6th of June, Axel Poulet, student in Christophe Tatout and Aline Probst’s team, successfully defended his thesis performed under a co-tutelle arrangement between Oxford Brooked and Blaise ...
Read moreStress & SUMO : le poids de SUMO dans la glande surrénale
La SUMOylation est un processus de modification post-traductionnelle conservé chez les eucaryotes, indispensable au maintien de l’intégrité des génomes, à la régulation des gènes et à la ...
Read moreGH1-HMGA1 : une protéine chromatinienne impliquée dans la stabilité des télomères et la réparation des cassures double brin de l’ADN
De par leur nature linéaire, les chromosomes des eucaryotes ont dû développer des mécanismes de protection de leurs extrémités appelés télomères. Si ...
Read moreA new recognition for the GReD research againts cancer
The EDC-CaP project- Environmental chemical disrupter and metastasic potential of prostate cancer- leads by Jean-Marc Lobacarro et Sylvére Baron is among the 8 selected projects from the national call ...
Read moreNutrition and Cancer Congress - June 22 -23, 2017
The 4th International Congress of Translational Research in Human Nutrition – Theme: Nutrition and Cancer , will be held in Clermont-Ferrand on 22 and 23 of june.
To know more about ...
Read moreWeapons exchange in the battle between transposable elements and their host
The inactivation of transposable elements within genomes is insured by multiple epigenetic mechanisms. Olivier Mathieu's team has identified two genes required for repressing many transposable elements through a new ...
Read moreAdrenal differentiation: a key role for the epigenetic factor EZH2
The adrenal gland produces glucocorticoid and mineralocorticoid hormones that are essential for life. This hormone production depends on a complex process of recruitment and differentiation of progenitor cells. Using a ...
Read moreMarie-Elisa PINSON won the prize for the best poster at the Auvergne-Rhône-Alpes forum on cancer research
Marie-Elisa PINSON won the prize for the best poster, section "Bioinformatics and modelisation" at the Auvergne-Rhône-Alpes forum on cancer research.
To know more, the awarded poster can be uploaded ...
Read moreA key developmental stage for the targeting of transposable elements by piRNAs.
In few germline cells located at the anterior pole of the Drosophila ovariole, Piwi expression is weakened. This short time of germline development has been called the Piwiless pocket or ...
Read moreLes donateurs AFM-Téléthon à la rencontre des équipes de recherche du GReD
Le 8 octobre dernier le GReD organisait une journée Portes ouvertes aux donateurs de l’Association Française contre les Myopathies (AFM-Téléthon).
Read moreChaperoning histones and controlling genome function
Histone proteins are critical components of chromatin and the incorporation of different histone variants modulates nucleosome stability. Deposition of histones at the right time and the correct place in the ...
Read moreINDEPTH : The GReD, in collaboration with LIMOS laboratory, holds the first COST-Action coordinated by Clermont Auvergne University (UCA)
GReD and LIMOS laboratories are happy to inform you that their COST-action project entitled «Impact of Nuclear Domains on Gene Expression and Plant Traits » (INDEPTH) has been awarded. This pan-european ...
Read moreRecombination machinery compensates telomere loss in the absence of telomerase.
The chromosomes of most eukaryotic species are linear, consisting of a single DNA double-helix running from one end to the other. Each chromosome thus has two ends and these are ...
Read moreMale infertility, toward new molecular causes .
Bile acids are molecules with endocrine activities controlling several physiological functions such as immunity and glucose homeostasis. Recently, they have also been shown to be involved in testicular physiology and ...
Read moreAmandine RAMBUR won the prize for the best poster at the 26th ARTP annual meeting
Amandine RAMBUR (Team "Nuclear receptor and prostate diseases") won the prize for the best poster at the ARTP (Asociation for research on prostate tumors) 26th annual meeting.
To know more ...
Read moreGENOME PLASTICITY: EXAMPLE OF 5S RIBOSOMAL RNA GENES
The genes coding 5S ribosomal RNAs (critical components of the ribosomes, the cellular machineries translating mRNA into proteins) are highly repeated in the genome, which allows the production of large ...
Read moreLINE fishing... with the new bioinformatics tool CLIFinder
Repeated elements represent 45% of the human genome. However, due to their large number and their high sequence homology, the contribution of those elements to the human genome transcriptome remains ...
Read moreEZH2, a novel therapeutic target in Adrenal Cortex Cancer
Adrenal cortex Cancer is one of the most aggressive cancers, for which there is no effective therapeutic approach. Research supervised by Pierre VAL at GReD laboratories, identified overexpression of EZH2 ...
Read moreA new research group has joined the GReD
The team « Epigenetic Regulation and Hematopoiesis », headed by Lucas Waltzer, has joined the GReD.
The team: Manon Boulet ( PhD Student)- Lucas Waltzer (DR2 CNRS, Team leader)- Laurence Vandel (DR2 CNRS ...
Read moreThe LINC complex contributes to heterochromatin organisation and transcriptional gene silencing in plants
The linker of nucleoskeleton and cytoskeleton (LINC) complex is an evolutionarily well-conserved protein bridge connecting the cytoplasmic and nuclear compartments across the nuclear membrane. Recent investigations have highlighted its function ...
Read moreAdrenal gland differentiation: positive antagonism
Endocrine activity of the adrenal glands is essential for body homeostasis and depends on the differentiation of two concentric cellular zones. Using transgenic mouse models, Pierre Val’s team has ...
Read moreGReD meets Johan Swinnen during its 2400 km run for cancer patients
From the 21st of Auguts our colleague Johan Swinnen undertook a journey of a lifetime: running from Leuven to Santiago de Compostela with a backpack filled with hundreds of letters ...
Read moreFXRα a new actor of germinal stem cells fate.
The FXRα nuclear receptor (Farnesoid-X-Receptor alpha) is a key factor controlling the male sex hormone synthesis within the testis. However, its roles in male germ cell homeostasis have not yet ...
Read morePhD defense: Colin Niarfeix
Colin NIARFEIX (Team “ Epithelial Growth and Morphogenesis”) will defend his thesis entitled:
"Impact des signaux germinaux sur la croissance et la prolifération des cellules somatiques et leurs cellules souches ...
Read moreWhat if honeybees could help fighting prostate cancer?
Prostate cancer is one of the most frequent and deadly tumors in man for which it is necessary to expand the portfolio of therapeutic strategies.
Based on an ethnobotany screening ...
Read moreWorkshop "Mechanobiology and Physics of Life"
After Lyon (2016) and Grenoble (2017), we are pleased to welcome you to the third workshop in Mechanobiology and Physics of Life to be held in Clermont-Ferrand on Tuesday January ...
Read moreInauguration du Centre de Recherche BioClinique de l’Université Clermont Auvergne
Depuis l’été 2018, les équipes du GReD sont hébergées au CRBC, Centre de Recherche BioClinique.
Ce nouveau bâtiment a été inauguré le lundi 10 décembre ...
Read moreCymbopogon citratus and cancer: when citronella is a repellent not only for mosquitoes…
Through a real bilateral collaboration, Drs. Silvère BARON’s et and Jean-Marc LOBACCARO’s team Nuclear Receptor and Prostate diseases and Pr. Jacques SIMPORE’s team (Laboratoire de Biologie ...
Read moreConference : " Interaction of light and circadian clock signaling networks in Arabidopsis "
Laszlo Kozma-Bogna ,
Institute of Plant Biology, Szeged, Hungary
Frdiay 12th of april, 11 am
Amphi 2B Medical School, R1 4th floor
Contact : Aline Probst (aline.probst@uca.fr)
The conserved yeast telomeric CST complex also functions in the regulation of RNA polymerase II transcription
The telomeric CST complex contributes to maintain genome stability through chromosome end protection and telomere length regulation. In its last study conducted on the yeast model (Calvo, Grandin et al ...
Read moreDNA methylation : a new actor in CML biology
Chronic myeloid leukemia (CML), a cancer of the white blood cell, results from a translocation event that ultimately leads to the production of BCR-ABL1, a chimeric oncoprotein that promotes CML ...
Read moreConference: "Epigenetic regulatory complexes in development and cancer. "
SVSAE doctoral School conference
‘Epigenetic regulatory complexes in development and cancer’.
Peter MULLIGAN - Centre de Recherche en Cancérologie de Lyon (CRCL)- Centre Léon Bérard, Lyon
Friday, 12th ...
Read moreBudding Researchers
The pupils ,aged 6 years old, of the school Nestor Perret in Clermont-Ferrand spent Tuesday, May 30th, morning together with the researchers of the GReD in a real course ...
Read moreLes Doctorants du GReD à l’honneur lors des JED 2019.
Laura BOUSSET, doctorante dans l’équipe « Récepteurs nucléaires et maladies de la prostate» et Laura THIROUARD, doctorante dans l’équipe « Environnement, spermatogénèse, pathophysiologie et hér ...
Read more
Pint of Science "Le Gras c'est la vie !" par L. Bousset & S. Baron-Lundi 15 mai
Et si on démystifiait la recherche scientifique autour d’une petite bière…
LE GRAS C’EST LA VIE !
Mon médecin m’a dit : « Trop de cholestérol ...
Read moreConference : "Preserving Heart Function despite Obesity, Aging and Parental Diet"
"Preserving Heart Function despite Obesity, Aging and Parental Diet"
Rolf Bodmer (Sanford Burnham Prebys, San-Diego)
Monday 24th of June, 2pm
Amphi Volcan. CRBC Building - Medical school
Contact : Krzysztof JAGLA (christophe ...
Read moreThe journey of a thousand piRNAs begins with a single Dot
Among the several kinds of non-coding small RNAs, piRNAs (Piwi-interacting RNAs) are the ‘transposon-silencers’. They occur within the gonads of animals, protecting the cellular genome from transposable elements. One of ...
Read moreEMBO Workshop "Plant Genome Stability and Change"
This EMBO workshop represents the sixth International Meeting on molecular and cellular mechanisms underlying stability, variability and modification of plant genomes. It will be held at the IPK Gatersleben, Germany ...
Read moreGReD Symposium : "Les surpises du Vivant"
the wednesday 16th of May, the GReD organizes its symposium
"Les surprises du vivant".
Amphitheater Limagne, CRBC Building , Faculté de Médecine
To the Programm click on "read more "....
Read moreLe GReD partie prenante dans le projet VitAbeilles
Quatre laboratoires de l’Université Clermont Auvergne, dont le GReD, viennent de mettre en évidence un extrait végétal capable de soigner la nosémose, une maladie qui d ...
Read moreLes Doctorants du GReD à l’honneur lors des JED 2017.
Houda TABBAL, doctorante dans l’équipe « Pathophysiologie moléculaire des tissus surrénaux et endocriniens » et Alexandre CHAMPROUX, doctorant dans l’équipe « Mécanismes de l'infertilité mâle post-testiculaire ...
Read moresRNAPipe: a Galaxy-based pipeline for bioinformatic in-depth exploration of small RNAseq data
Les recherches menées au cours de cette dernière décennie ont révélé que la quasi-totalité des génomes est transcrite et que la plupart des mol ...
Read moreHow to turn a football into a rugby ball?
Tissue elongation is part of the repertoire of processes that allow an organ to acquire its shape (morphogenesis). In the last years, the elongation of the ovarian follicle of Drosophila ...
Read morePhD defense: Marilyne LAVERGNE
Marilyne LAVERGNE (Team “Translational approach to epithelial injury and repair”) will defend her thesis entitled:
" Rôle des protéines NLRP dans la physiopathologie des membranes fœtales humaines ...
Read moreGRED’s people in the spotlight
Heidi Serra received the young researcher award 2015 from the Bettencourt-Schueller foundation.
Read moreCeremony for the foundation stone of the new building CRBC (Centre for Research in Clinical Biology).
Spring 2017 is going to be a landmark for the GReD with the Research Unit being united in the brand-new building CRBC.
This large research facility is part of the ...
