We are opening two distinct calls for new research group leaders. We encourage both young and already established outstanding researchers to apply. The deadline for applications is July 1st 2017. Selected applicants will be interviewed in October 2017.
The team "Nuclear receptors and protate diseases" is recruiting a post-doctoral researcher.
Project: “Effects of environmental disrupting chemicals in metastatic development of prostate cancer and evolution in castration resistant cancer”
Key words: Prostate cancer, environmental disrupting chemicals, nuclear receptors, metastasis, castration resistant prostate cancer.
The 4th International Congress of Translational Research in Human Nutrition – Theme: Nutrition and Cancer , will be held in Clermont-Ferrand on 22 and 23 of june.
To know more about ...Read more
Marie-Elisa PINSON won the prize for the best poster at the Auvergne-Rhône-Alpes forum on cancer research
12H30 – 13H30
Faculté de médecine
Amphi 1 (1èR étage, R1)
04 Avril !!! AMPHI 3 !!! (5ème R1) : Mubeen GOOLAM
University of Cambridge, Department of Physiology, Development & Neuroscience, UK
Identification of Novel Molecular Regulators of Cell Fate during Mouse Preimplantation Development.
11 Avril : Pas de séminaire
18 Avril : Lauriane SEDES
GReD, INSERM U1103, CNRS 6293, UCA
FXRalpha as a new sensor of environmental molecules.
25 Avril : Marc PIECHACZYK
UMR5535, Institut de Génétique Moléculaire Montpellier (IGMM)
The ROS/SUMO axis in chemosensitivity versus chemoresistance of acute myeloid leukemia (and other transcriptional studies).
Bile acids are molecules with endocrine activities controlling several physiological functions such as immunity and glucose homeostasis. Recently, they have also been shown to be involved in testicular physiology and as a cause of male fertility in experimental models. By the mean of mouse models and pharmacological approaches, the team of David Volle revealed the unexpected presence of alternative pathways, involving the Nuclear Receptor CAR (Constitutive-Androstane-Receptor ; NR1I3), to mediate bile acid functions in testis.
This study is published in Scientific Reports (Martinot et al., 2017).
The LINC complex contributes to heterochromatin organisation and transcriptional gene silencing in plants
The linker of nucleoskeleton and cytoskeleton (LINC) complex is an evolutionarily well-conserved protein bridge connecting the cytoplasmic and nuclear compartments across the nuclear membrane. Recent investigations have highlighted its function in nuclear morphology and meiosis. The new study performed by the team of Aline Probst and Christophe Tatout brings new insights into LINC complex function in plants. Using 3D imaging and molecular techniques the authors reveal that plants carrying mutations in this complex show release of transcriptional silencing as well as a decompaction of heterochromatic sequences. Therefore, the plant LINC complex contributes to proper heterochromatin organisation and positioning at the nuclear periphery, illustrating the important function of the nuclear envelope in the regulation of genome expression.
This study has been published in Journal of Cell Science (Poulet et al., 2017)
Among the several kinds of non-coding small RNAs, piRNAs (Piwi-interacting RNAs) are the ‘transposon-silencers’. They occur within the gonads of animals, protecting the cellular genome from transposable elements. One of the most mysterious question is how piRNAs are transcribed and processed inside the cell. Now Chantal Vaury’s lab brings new data into the biosynthesis of piRNAs. Their study, published recently in Nature Comm (Dennis & al., Nat Commun, 2016 Dec 8;7:13739. doi: 10.1038/ncomms13739), shows that the precursor transcripts of piRNAs are exported out of the nucleus by specific exporter proteins-Nxt1,Nxf1 and that the export itself directs the assembly of Yb bodies which are the cytoplasmic maturation centres of piRNAs. Chantal’s lab has been actively studying piRNA production for the past years, using the ovarian tissue of the fruit fly Drosophila melanogaster as a model. In 2013, they discovered ‘Dot COM’ – a single bright spot within the nuclei of ovarian follicular cells where piRNA precursor transcripts accumulate before to be processed. This year their new study has revealed that the precursors travel away from the site of transcription in the DNA to DOT COM, with the help of exportins and exon-junction complex (EJC) proteins. The study opens new possibilities of research in the piRNA and transposable element regulation fields.
Endocrine activity of the adrenal glands is essential for body homeostasis and depends on the differentiation of two concentric cellular zones. Using transgenic mouse models, Pierre Val’s team has shown that this zonal differentiation relies on a double antagonistic interaction between two signalling pathways. They further show that this antagonism inhibits development of aggressive tumours in mouse models and patients. This study is published in Nature Communications (Drelon et al., 2016) .
Adrenal cortex Cancer is one of the most aggressive cancers, for which there is no effective therapeutic approach. Research supervised by Pierre VAL at GReD laboratories, identified overexpression of EZH2 as a novel alteration involved in malignant progression of this cancer. These data show that targeting EZH2 with pharmacological inhibitors blocks proliferation of cancer cells and induces cell death. This suggests that EZH2 could be an interesting target for treatment of adrenal cancer. This article is published in Human Molecular Genetics (Drelon et al., 2016)
From May 25th to May 28th, PhD students from the GReD lab held a booth at Polydôme (Clermont-Ferrand) to present their work to children and young adults.
Benjamin BERTIN, doctorant dans l'équipe de Krzysztof Jagla , a reçu le prix du Jury lors des 'Journées de l'Ecole Doctorale 2016".Read more
Conference: "The unique mechanisms for the nuclear dynamics in Arabidopsis" Dr. Tamura - Kyoto University, Japan
"The unique mechanisms for the nuclear dynamics in Arabidopsis"
By Dr. Kentaro Tamura, from Kyoto University, Japan
Friday the 3rd of February. 2:30pm
Meeting room, Vegetal Biology Building- Campus ...Read more
The EDC-CaP project- Environmental chemical disrupter and metastasic potential of prostate cancer- leads by Jean-Marc Lobacarro et Sylvére Baron is among the 8 selected projects from the national call "effects of the exposure to environmental risk factors on cancer". This success highlights the capabilities of the GReD teams to design and coordinate demanding and original research projects to fight cancer.
The GReD internal meeting 2017 will be held thursday the 9th and friday the 10th of february at "amplhi de Physique" on Cézeaux Campus.
Please,click here to download the program.
Puberty is a key event for the development of male reproductive functions. It depends on the increase of testosterone produced by the testis, under the control of the activity of the hypothalamic-pituitary axis. Ultimately, this leads to the maturation of secondary sexual characteristics, to the establishment and maintenance of spermatogenesis and fertility. In a study published in Oncotarget (Baptisard et al., 2016), David Volle and Coll. reveal that he nuclear receptor for bile acids, FXRa, play a key role in this process.
The pupils ,aged 6 years old, of the school Nestor Perret in Clermont-Ferrand spent Tuesday, May 30th, morning together with the researchers of the GReD in a real course ...Read more
Conference: "Revisiting cell lineage specification during male sex determination with single cell RNA sequencing ", Serge NEF, University of Geneva
SVSAE doctoral School conference
"Revisiting cell lineage specification during male sex determination with single cell RNA sequencing ", Serge NEF, University of Geneva, Medical School
Friday, 14th of April; 2pm
Meeting room, Vegetal Biology Building- Campus des Cézeaux
Contact: Antoine Martinez (Antoine.MARTINEZ@uca.fr)
Conference: "Ontogeny and function of muscle interstitial progenitor cells" Sigmar Stricker -Freie Universitaet of Berlin
"Ontogeny and function of muscle interstitial progenitor cells" Sigmar Stricker - Freie Universitaet of Berlin
Friday the 27th of January. 3pm
Meeting room, Vegetal Biology Building- Campus des Cézeaux
Contact ...Read more
A focus on sperm DNA oxidative damage : a putative new trail to improve some male infertile situations
Oxidative alterations of the sperm nucleus are causative of reproductive failures and increase the risk of transmitting paternal inherited mutations to the next generation. With the goal to explore new ...Read more
Variation in DNA methylation, which decorates DNA of most living organisms, can impact gene transcription, just like does DNA sequence. How distinct DNA methylation states of genes and transposons, called ...Read more
Marjorie WHITFIELD ( Team "Mechanisms of mammalian post-testicular infertility" ) will defend her thesis
"Modèle murin invalidé pour les LXRs : dyslipidémie et impact sur la maturation post-testiculaire des gamètes ...Read more
12H30 – 13H30
Faculté de médecine
Amphi 1 (1er étage, R1)
07 Mars : Séminaires Etudiants M2R GReD
DOUET Jérémie Étude du rôle des protéines TRBs dans la protection télomérique.
HESKETH Amy Origins and consequences of DNA hypermethylation in Pol epsilon-depleted plants.
THIROUARD Laura Etude du rôle de TGR5 dans l'altération de la spermatogenèse induite par le busulfan.
14 Mars : Séminaires Etudiants M2R GReD
EXCEPTIONNELLEMENT !!! AMPHI 3 !!! (5ème R1)
BAUDET Laura Régulation épigénétique des éléments transposables dans la lignée germinale.
FOURNET Marianne Régulation par RAGE de l'activation macrophagique via l'inflammasome NLRP3 au cours de l'agression alvéolaire aiguë.
21 Mars : Denis TAGU, Gaël LE TRIONNAIRE & Fabrice LEGEAI
INRA Rennes, UMR Igepp (Institut de Génétique, Environnement et Protection des Plantes), & INRIA Rennes, Irisa
Contact : email@example.com
Integrative genomics and gene networks for studying phenotypic plasticity in the pea aphid.
28 Mars : Séminaires Etudiants M2R GReD
LELONG Emeline Etude et caractérisation du mutant related to VRN1 (rtv1) et de ses partenaires chez Arabidopsis thaliana.
SAINTE-CATHERINE David Rôle du complexe PRC2 dans la physiopathologie surrénalienne.
GARCIA Manon Caractérisation des rôles de FXRα dans l'initiation et le développement des cancers germino-testiculaires.
The 6th of June, Axel Poulet, student in Christophe Tatout and Aline Probst’s team, successfully defended his thesis performed under a co-tutelle arrangement between Oxford Brooked and Blaise ...Read more
Heidi Serra received the young researcher award 2015 from the Bettencourt-Schueller foundation.Read more
Ceremony for the foundation stone of the new building CRBC (Centre for Research in Clinical Biology).
Spring 2017 is going to be a landmark for the GReD with the Research Unit being united in the brand-new building CRBC.
This large research facility is part of the ...