News

CALL for a NEW RESEARCH GROUP LEADER

CALL for  a  NEW RESEARCH GROUP LEADER

The GReD wishes to recruit a new independent leader to form a group within the scientific spectrum of the GReD. The GReD will provide laboratory space (50m2) and free access to state-of-the-art technological platforms (cell/tissue culture, FACS, imaging/live imaging, histology). The successful candidates will have full access to transgenic plant and animal (mouse, drosophila, Arabidopsis) and bioinformatics facilities and will benefit of administrative support. Facilities for high-throughput sequencing, mass spectrometry, proteomics, electron microscopy and radiobiology are available on the multidisciplinary Medical School campus.

Appel à candidature pour la future direction du GReD

Appel à candidature pour la future direction du GReD

Le GReD lance un appel à candidature pour recruter sa future directrice ou futur directeur, pour une prise de fonction en janvier 2021

PhD Defense: Cristiana DONDI

PhD Defense: Cristiana DONDI

Cristiana DONDI  (Team “Diversification of muscle and heart cells in normal and pathological conditions”) will defend her thesis entitled:

"Molecular and functional analysis of cardiac diversification by cell specific translatomic approaches in Drosophila melanogaster"

Friday  the 8th of June 2018  at 1.30 pm

Amphi 2A , Medical School

Les Mardis du GRed - Juin 2018

Les Mardis du GRed - Juin 2018

12H45 – 13H45
Faculté de médecine
Amphi limagne (CRBC RdC)

DNA methylation : a new actor in CML biology

DNA methylation : a new actor in CML biology

Chronic myeloid leukemia (CML), a cancer of the white blood cell, results from a translocation event that ultimately leads to the production of BCR-ABL1, a chimeric oncoprotein that promotes CML by aberrantly phosphorylating target proteins. Nonetheless, this event on its own, cannot account for an increasing number of clinical observation suggesting the involvement of other pathways, among which DNA methylation alteration emerges as a relevant candidate.

On that basis the teams of Marc BERGER (CHU, Clermont-Ferrand) and Philippe ARNAUD have characterized  for the first  time the DNA methylation patterns of CML cell subsets (immature and mature cells) isolated form the same clone during the early stage of the disease, before any treatment    (Maupetit-Méhouas, Court, Bourgne et al.,). Altogether, this collaborative study demonstrated that DNA methylation abnormalities exist at early stages of CML and can affect the transcriptional landscape of malignant cells. These observations paved the way for new therapeutic strategies based on epigenetic drugs.

CNET 2018: Registration is open

CNET 2018: Registration   is open

The 21st annual meeting organized by the French research community working on transposable elements (CNET 2018), organized this year by the GReD,  will be held in  Clermont-Ferrand   on 2-4 July ...

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EMBO Workshop "Plant Genome Stability and Change"

EMBO  Workshop "Plant Genome Stability and Change"

This EMBO workshop represents the sixth International Meeting on molecular and cellular mechanisms underlying stability, variability and modification of plant genomes. It will be held at the IPK Gatersleben, Germany ...

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GENOME PLASTICITY: EXAMPLE OF 5S RIBOSOMAL RNA GENES

GENOME PLASTICITY: EXAMPLE OF 5S RIBOSOMAL RNA GENES

The genes coding 5S ribosomal RNAs (critical components of the ribosomes, the cellular machineries translating mRNA into proteins) are highly repeated in the genome, which allows the production of large quantities of these rRNAs.  

In their last study (Simon et al., 2018), the team of Aline Probst and Christophe Tatout revealed an important variation in number and expression of 5S rRNA genes between different ecotypes of Arabidopsis thaliana.

GReD Symposium : "Les surpises du Vivant"

GReD Symposium :  "Les surpises du Vivant"

the wednesday 16th of May, the GReD organizes its symposium

"Les surprises du vivant".

Amphitheater Limagne, CRBC Building , Faculté de Médecine

To the  Programm click on "read more "....

Cymbopogon citratus and cancer: when citronella is a repellent not only for mosquitoes…

Cymbopogon citratus and cancer: when citronella is a repellent not only for mosquitoes…

Through a real bilateral collaboration, Drs. Silvère BARON’s et and Jean-Marc LOBACCARO’s team Nuclear Receptor and Prostate diseases and Pr. Jacques SIMPORE’s team (Laboratoire de Biologie Moléculaire et de Génétique, Université de Ouagadougou, Burkina Faso), have identified medicinal plants of the Burkina Faso pharmacopeia that could be used in the future in cancer treatment (Bayala et al., 2018).

 

Recombination machinery compensates telomere loss in the absence of telomerase.

Recombination machinery compensates telomere loss in the absence of telomerase.

The chromosomes of most eukaryotic species are linear, consisting of a single DNA double-helix running from one end to the other. Each chromosome thus has two ends and these are protected by specialized DNA-protein structures named telomeres. The importance of telomere structure is readily observed in the severe genetic instability and cell death that result from its absence.

In its last study ( Olivier et al., 2018), the team of Charles White and Maria Gallego unveiled mechanisms by which recombination machinery contributes to protect the telomeres from replicative failure, ensuring  their stability.

How to turn a football into a rugby ball?

How to turn a football into a rugby ball?

Tissue elongation is part of the repertoire of processes that allow an organ to acquire its shape (morphogenesis). In the last years, the elongation of the ovarian follicle of Drosophila has emerged as a model of choice for the study of tissue elongation mechanisms. During its development the initially spherical follicle becomes ovoid and this elongation is controlled by the epithelial cells surrounding each follicle. However, so far, all studies on the subject have focused on the basal domain of these cells.

In its last study (Alegot et al.,) , the group of Vincent Mirouse has shown that the apical domain of the epithelial cells also contributed to this elongation.

LINE fishing... with the new bioinformatics tool CLIFinder

LINE fishing... with the new bioinformatics tool CLIFinder

Repeated elements represent 45% of the human genome. However, due to their large number and their high sequence homology, the contribution of those elements to the human genome transcriptome remains difficult to study. Particularly, implication of recent LINE-1 (L1) elements to the transcriptional expression profile of cells and tissues is probably under-evaluated. Indeed, those L1 elements possess, in addition to their sense promoter, an antisense promoter (ASP) which allow the transcription of their adjacent sequences (which may include genes) in the form of LINE-1 chimeric transcripts (LCTs). Such LCTs have been already described in literature bur the question remains of the pangenomic extent of this transcriptional activity.

In a study conducted by Catherine Barrière (Pinson, Pogorelcnik et al., 2017), Philippe Arnaud’s team has developed and validated CLIFinder (Chimeric Line Finder), a new software dedicated to the identification of LCTs from stranded paired-end RNA-seq data. Thus, CLIFinder take advantage of the strong potential of next generation sequencing to unravel the complete transcriptome composition and allow the “fishing”, among all the transcriptome’s sequences, of numerous LCTs comprising a L1 sequence and a unique sequence of the genome. The CLIFinder tool is today available for the scientific community to realize extensive analyses in normal and pathological tissues. Indeed, many LCTs have been identified specifically in tumors and are supposed to play a functional role in tumorigenesis.

This software has been published in Bioinformatics (Pinson, Pogorelcnik et al., 2017)

A new recognition for the GReD research againts cancer

A new recognition for the GReD  research againts cancer

The EDC-CaP project- Environmental chemical disrupter and metastasic potential of prostate cancer- leads by Jean-Marc Lobacarro et Sylvére Baron is among the 8 selected projects from the national call ...

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When the liver controls male puberty....

When the liver controls male puberty....

Puberty is a key event for the development of male reproductive functions. It depends on the increase of testosterone produced by the testis, under the control of the activity of ...

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GReD's PhD students stimulate scientific career interest at Exposciences

GReD's PhD students stimulate scientific career interest at Exposciences

From May 25th to May 28th, PhD students from the GReD lab held a booth at Polydôme (Clermont-Ferrand) to present their work  to children and young adults.

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EZH2, a novel therapeutic target in Adrenal Cortex Cancer

EZH2, a novel therapeutic target in Adrenal Cortex Cancer

Adrenal cortex Cancer is one of the most aggressive cancers, for which there is no effective therapeutic approach. Research supervised by Pierre VAL at GReD laboratories, identified overexpression of EZH2 ...

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PhD Defense: Alexandre CHAMPROUX

PhD Defense: Alexandre CHAMPROUX

Alexandre CHAMPROUX  ( team : "Mechanisms of mammalian post-testicular infertility") will defend his thesis entitled:

"L'impact du stress oxydant sur l'épigénome spermatique murin. "

Wednesday the 11 of April  2018 ...

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Conference: "Epigenetic regulatory complexes in development and cancer. "

SVSAE doctoral School conference

‘Epigenetic regulatory complexes in development and cancer’. 

Peter MULLIGAN - Centre de Recherche en Cancérologie de Lyon (CRCL)- Centre Léon Bérard, Lyon

Friday, 12th ...

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Pint of Science "Le Gras c'est la vie !" par L. Bousset & S. Baron-Lundi 15 mai

Pint of Science "Le Gras c'est la vie !"  par L. Bousset & S. Baron-Lundi 15 mai

Et si on démystifiait la recherche scientifique autour d’une petite bière…

LE GRAS C’EST LA VIE !

Mon médecin m’a dit : « Trop de cholestérol ...

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Les Mardis du GRed - Avril 2018

Les Mardis du GRed - Avril 2018

12H45 – 13H45
Faculté de médecine
Amphi limagne (CRBC RdC)

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Les mardis du GReD: Mars 2018

Les mardis du GReD: Mars 2018

12H45 – 13H45
Faculté de médecine
CRBC Amphi Limagne (CRBC R
dC)

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Soutenance de thése : Benjamin BERTIN

Soutenance de thése : Benjamin BERTIN

Benjamin BERTIN  (Equipe « Diversification des cellules musculaires et cardiaques en conditions normales et pathologiques »)  soutiendra sa thèse intitulée :

"Analyses moléculaires et fonctionnelles de la diversification musculaire par ...

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PhD Defense: Lilia Laddada

PhD Defense: Lilia Laddada

Lilia LADDADA  (Team “Diversification of muscle and heart cells in normal and pathological conditions”) will defend her thesis entitled:

"Étude du développement des tendons et de leur interaction avec ...

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Conference: "Hematopoiesis and immune response: insight from Drosophila "

Conference: "Hematopoiesis  and immune response: insight from Drosophila  "

Hematopoiesis  and immune response: insight from Drosophila

Michèle Crozatier (CBD Toulouse)

Friday  Sept 29 at 11h, CBRC room 003

Contact: christophe.jagla@udamail.fr

 

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Claire CHAZAUD received the VAN BENEDEN prize.

Claire CHAZAUD received the VAN BENEDEN prize.

This prize is awarded every three years by the Royal Academy of Sciences, Letters and Fine Arts of Belgium  to acknowledge a pioneer work in embryology or cytology .

 

Claire Chazaud ...

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PhD defense: Typhanie DUMONTET

On Friday, july 7th, in the CRBC Amphi "Volcan", Thyphanie DUMONTET will defend her thesis entitled:"Rôle de la signalisation PKA dans la zonation de la glande surrénale ...

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Les Mardis du GRed - Juin 2017

Les Mardis du GRed - Juin 2017

12H30 – 13H30
Faculté de médecine
Amphi 1 (1èR étage, R1)

06 Juin :     Damien BOUVIER GReD, INSERM U1103, CNRS 6293, UCA

Biomarkers of Fetal Alcohol Syndrome in amniotic fluid ...

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Conference: « From fitness comparison to spatial constrains : the many roads of cell competition »

Conference: « From fitness comparison to spatial constrains : the many roads of cell competition »

By Romain levayer, Institut Pasteur, Paris.

Thursday the 11th of january. 11:00 am

Meeting room 003, CRBC  Building- Medical school campus

Contact: Vincent MIROUSE (vincent.mirouse@uca.fr)

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GReD meets Johan Swinnen during its 2400 km run for cancer patients

GReD meets Johan Swinnen during its 2400 km run for cancer patients

From the 21st of Auguts our colleague Johan Swinnen undertook  a journey of a lifetime: running from Leuven to Santiago de Compostela with a backpack filled with hundreds of letters ...

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Amandine RAMBUR won the prize for the best poster at the 26th ARTP annual meeting

Amandine RAMBUR won the prize for the best poster at the 26th ARTP annual meeting

 Amandine RAMBUR (Team "Nuclear receptor and prostate diseases") won the prize for the best poster at the  ARTP (Asociation for research on prostate tumors) 26th annual meeting.

To know more ...

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Nutrition and Cancer Congress - June 22 -23, 2017

Nutrition and Cancer Congress - June 22 -23, 2017

The 4th  International Congress of Translational Research in Human Nutrition – Theme: Nutrition and Cancer , will be held in Clermont-Ferrand  on 22 and 23 of june.

To know more about ...

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HDR defence: Isabelle VAILLANT

HDR defence: Isabelle VAILLANT

On wednesday, November 8th, Isabelle VAILLANT  will defend her HDR  entitled:"Contrôle épigénétique des séquences répétées chez Arabidopsis et de l'expression des ...

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Workshop "Mechanobiology and Physics of Life"

Workshop "Mechanobiology and Physics of Life"

After Lyon (2016) and Grenoble (2017), we are pleased to welcome you to the third workshop in Mechanobiology and Physics of Life to be held in Clermont-Ferrand on Tuesday January ...

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The LINC complex contributes to heterochromatin organisation and transcriptional gene silencing in plants

The LINC complex contributes to heterochromatin organisation and transcriptional gene silencing in plants

The linker of nucleoskeleton and cytoskeleton (LINC) complex is an evolutionarily well-conserved protein bridge connecting the cytoplasmic and nuclear compartments across the nuclear membrane. Recent investigations have highlighted its function ...

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Meeting: “Impact of Nuclear Domains in Gene Expression and Plant Traits” (INDEPTH)

Meeting: “Impact of Nuclear Domains in Gene Expression and Plant Traits” (INDEPTH)

We are pleased to announce the first main meeting of the COST-Action CA16212 “Impact of Nuclear Domains in Gene Expression and Plant Traits” (INDEPTH). The meeting will take place from ...

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Marie-Elisa PINSON won the prize for the best poster at the Auvergne-Rhône-Alpes forum on cancer research

Marie-Elisa PINSON won the prize for the best poster at the Auvergne-Rhône-Alpes forum on cancer research

Marie-Elisa PINSON won the prize for the best poster, section "Bioinformatics and modelisation" at the Auvergne-Rhône-Alpes forum on cancer research.

To know more, the awarded poster can be uploaded ...

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Chaperoning histones and controlling genome function

Chaperoning histones and controlling genome function

Histone proteins are critical components of chromatin and the incorporation of different histone variants modulates nucleosome stability. Deposition of histones at the right time and the correct place in the ...

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FXRα a new actor of germinal stem cells fate.

FXRα  a new actor  of germinal stem cells fate.

The FXRα nuclear receptor (Farnesoid-X-Receptor alpha) is a key factor controlling the male sex hormone synthesis within the testis. However, its roles in male germ cell homeostasis have not yet ...

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Conférence: "Biomechanics of Muscle Morphogenesis "- Friday 5th of may

Conférence: "Biomechanics of Muscle Morphogenesis "- Friday 5th of may

SVSAE doctoral School conference

‘Biomechanics of Muscle Morphogenesis’

Franck Schnorrer, IBDM (Institut de Biologie du Développement) - Marseille

Friday, 5th of May; 2:30pm

Meeting room, Vegetal Biology Building- Campus ...

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Weapons exchange in the battle between transposable elements and their host

Weapons exchange in the battle between transposable elements and their host

The inactivation of transposable elements within genomes is insured by multiple epigenetic mechanisms. Olivier Mathieu's team has identified two genes required for repressing many transposable elements through a new ...

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PhD defense: Marie-Elisa PINSON

PhD defense: Marie-Elisa PINSON

Marie-Elisa Pinson (Team “Genomic Imprinting and the epigenetic control of cell fate determination”) will defend her thesis entitled:

"Etude de l'impact de la dérégulation transcriptionnelle liée ...

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CALL for NEW RESEARCH GROUP LEADERS

CALL for NEW RESEARCH GROUP LEADERS

We are opening  two distinct calls for new research group leaders. We encourage both young and already established outstanding researchers to apply. The deadline for applications is July 1st 2017 ...

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Conference: " Multi-scale mathematical model of Epi/PrE specification. "

Conference: " Multi-scale mathematical model of Epi/PrE specification.  "

Multi-scale mathematical model of Epi/PrE specification.

Alen TOSENBERGER- Unit of Theoretical Chronobiology, ULB, Brussels

Tuesday September 26th at 12h45, amphi LIMAGNE (Ground floor CRBC building)

Contact : claire.chazaud@uca ...

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Male infertility, toward new molecular causes .

Male infertility, toward new molecular causes .

Bile acids are molecules with endocrine activities controlling several physiological functions such as immunity and glucose homeostasis. Recently, they have also been shown to be involved in testicular physiology and ...

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Adrenal gland differentiation: positive antagonism

Adrenal gland differentiation: positive antagonism

Endocrine activity of the adrenal glands is essential for body homeostasis and depends on the differentiation of two concentric cellular zones. Using transgenic mouse models, Pierre Val’s team has ...

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The journey of a thousand piRNAs begins with a single Dot

The journey of a thousand piRNAs begins with a single Dot

Among the several kinds of non-coding small RNAs, piRNAs (Piwi-interacting RNAs) are the ‘transposon-silencers’. They occur within the gonads of animals, protecting the cellular genome from transposable elements. One of ...

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A new research group has joined the GReD

The team « Epigenetic Regulation and Hematopoiesis », headed by Lucas Waltzer, has joined the GReD.

The team: Manon Boulet ( PhD Student)- Lucas Waltzer (DR2 CNRS, Team leader)- Laurence Vandel (DR2 CNRS ...

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PhD defense: Gunjita SINGH

PhD defense: Gunjita SINGH

Gunjita SINGH  (Team “Recombination and Maintenance of Genome Integrity”) will defend her thesis entitled:

" Role of recombination protein in cross-over formation, pairing and synapsis in Arabidopsis meiosis"

Monday  9th ...

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PhD defense: Stéphanie HERMITTE

PhD defense: Stéphanie HERMITTE

Stéphanie HERMITTE  (Team “Molecular mechanisms of cell lineage differentiation in the early mouse embryo”) will defend her thesis entitled:

"Caractérisation de la différenciation de l'endoderme primitif ...

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PhD defense: Margaux OLIVIER

PhD defense: Margaux OLIVIER

Margaux  OLIVIER  (Team “Recombination and Maintenance of Genome Integrity”) (will defend her thesis

" Rôle des protéines de la recombinaison dans le maintien des télomères."

Monday  2 ...

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PhD defense: Maxime VOISIN

PhD defense: Maxime VOISIN

Maxime Voisin  (TeamHistone variants and the nuclear envelope in heterochromatin organization”) will defend his thesis entitled:

"Fonction des protéines de l’enveloppe et de la périphérie ...

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PhD Defense: Mickael MATHIEU

PhD Defense: Mickael MATHIEU

Mickael MATHIEU ( équipe : "Pathophysiologie moléculaire des tissus surrénaux et endocriniens") will defend his thesis entitled:

"Rôle de EZH2 et du complexe PRC2 dans l'homéostasie du ...

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Les Mardis du GRed - Mars 2017

Les Mardis du GRed - Mars 2017

12H30 – 13H30
Faculté de médecine
Amphi 1 (1er étage, R1)

07 Mars  :               Séminaires Etudiants M2R GReD

DOUET Jérémie               Étude du rôle des protéines TRBs ...

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Conference: " Chromatin alterations in cancers "

Conference: " Chromatin alterations in cancers "

"Chromatin alterations in cancers"

Raphaël Margueron- Institut Curie Paris

Friday 23rd of  March; 11am
Amphi 6A- Medical School-  Main Building R3 3rd floor

Contact :pierre.val@uca.fr

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Budding Researchers

Budding Researchers

The pupils ,aged 6 years old, of the school Nestor Perret in Clermont-Ferrand spent Tuesday, May 30th, morning together with the researchers of the GReD in a real course ...

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A focus on sperm DNA oxidative damage : a putative new trail to improve some male infertile situations

A focus on sperm DNA oxidative damage : a putative new trail to improve some male infertile situations

Oxidative alterations of the sperm nucleus are causative of reproductive failures and increase the risk of transmitting paternal inherited mutations to the next generation. With the goal to explore new ...

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Conference: "Revisiting cell lineage specification during male sex determination with single cell RNA sequencing ", Serge NEF, University of Geneva

Conference: "Revisiting cell lineage specification during  male sex determination with single cell RNA sequencing ", Serge NEF,  University of Geneva

SVSAE doctoral School conference

"Revisiting cell lineage specification during  male sex determination with single cell RNA sequencing ", Serge NEF,  University of Geneva, Medical School

Friday, 14th of April; 2pm

Meeting ...

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When it comes to DNA methylation, 1 + 1 = 3.

 When it comes to DNA methylation, 1 + 1 = 3.

Variation in DNA methylation, which decorates DNA of most living organisms, can impact gene transcription, just like does DNA sequence. How distinct DNA methylation states of genes and transposons, called ...

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Phd Defense : Marjorie WHITFIELD

Marjorie WHITFIELD ( Team  "Mechanisms of mammalian post-testicular infertility" ) will defend her thesis

"Modèle murin invalidé pour les LXRs : dyslipidémie et impact sur la maturation post-testiculaire des gamètes ...

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Benjamin Bertin : prix du Jury des JED 2016

Benjamin Bertin :  prix du Jury des JED 2016

Benjamin BERTIN, doctorant dans l'équipe de Krzysztof Jagla , a reçu le prix du Jury lors  des 'Journées de l'Ecole Doctorale 2016".

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Axel POULET thesis works highlighted on the Oxford Brooke University website.

 Axel POULET thesis works highlighted on the Oxford Brooke University website.

The 6th of June, Axel Poulet, student in Christophe Tatout and Aline Probst’s team,   successfully defended his thesis performed under a co-tutelle arrangement between Oxford Brooked and Blaise ...

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GReD internal meeting 2017

The GReD internal meeting 2017 will be held thursday the 9th and friday the 10th of february  at "amplhi de Physique" on Cézeaux Campus.

Please,click  here to download ...

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Conference: "The unique mechanisms for the nuclear dynamics in Arabidopsis" Dr. Tamura - Kyoto University, Japan

"The unique mechanisms for the nuclear dynamics in Arabidopsis"

By Dr. Kentaro Tamura, from Kyoto University, Japan

Friday the 3rd of February. 2:30pm

Meeting room, Vegetal Biology Building- Campus ...

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Epigénétique: the revenge of Lamarck?

Epigénétique: the revenge of Lamarck?

The next  "Mercredis de la Science" ”, organized by the university Blaise Pascal, will be dedicated to the Epigenetics. All are welcome to listen our two researchers, Aline Probst and Christophe ...

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Conference: "Ontogeny and function of muscle interstitial progenitor cells" Sigmar Stricker -Freie Universitaet of Berlin

"Ontogeny and function of muscle interstitial progenitor cells" Sigmar Stricker - Freie Universitaet of Berlin

Friday the 27th of January. 3pm

Meeting room, Vegetal Biology Building- Campus des Cézeaux

Contact ...

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Ceremony for the foundation stone of the new building CRBC (Centre for Research in Clinical Biology).

Ceremony for the foundation stone of the new building CRBC (Centre for Research in Clinical Biology).

Spring 2017 is going to be a landmark for the GReD with the Research Unit being united in the brand-new building CRBC.
This large research facility is part of the ...

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GRED’s people in the spotlight

GRED’s people in the spotlight

 

Heidi Serra received the young researcher award 2015 from the Bettencourt-Schueller foundation.

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Les Journées du Gred 2015 en images

Les Journées du Gred 2015 en images

Pour prolonger les journées du GReD 2015...

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