News
Inauguration du Centre de Recherche BioClinique de l’Université Clermont Auvergne
Depuis l’été 2018, les équipes du GReD sont hébergées au CRBC, Centre de Recherche BioClinique.
Ce nouveau bâtiment a été inauguré le lundi 10 décembre dernier en présence de M. Mathias BERNARD, président de l’Université Clermont Auvergne, M. Jean-Pierre BRENNAS, conseiller régional Auvergne-Rhône-Alpes, M. Jean-Marc MORVAN, vice-président de Clermont Auvergne Métropole, Mme Claire GIRY, présidente par intérim de l’Inserm, M. Hervé Moreau, représentant de l’Institut des Sciences biologiques du CNRS, M Clavelou, Doyen de la faculté de médecine de Clermont-Ferrand, Mme Chantal VAURY, directrice du GReD et de Mme Anne-Françoise JUMEAU, architecte à l’agence PERIPHERIQUES.
Outre le GReD , dont les équipes sont réparties sur 4 étages du bâtiment, le CRBC accueille, en rez de chaussée, un pôle enseignement avec des salles de cours et 2 amphithéâtres et, au premier étage, un pôle valorisation, géré par l’UCA accélérateur Biotech.
Les stagiaires de 3iéme à la découverte du GReD.
Du 17 au 21 décembre 2018, six collégiens, tous désireux de découvrir les métiers de la recherche, ont rejoint le GReD. Les activés menées tant dans les équipes d’accueil qu' en commun ont permis à Natacha & Noa (Collège Henri-Pourrat, Ceyrat); Lucas (Collège La Ribeyre, Cournon d’Auvergne); Sam (Collège Françoise Sagan, Bornel, Oise); Florian (Collège Louisa Paulin, Réalmont, Haute-Garonne) et Swann (Collège Emile Beaussire, Luçon, Vendée) de découvrir l’ensemble des métiers pratiqués au GReD, les services offerts par les plateformes et les services communs et de réaliser diverses approches expérimentales. Sans conteste ce sont ces dernières qui ont eu leur préférence ! Parmi ce qui les a le plus surpris : « Le nombre de métiers au sein d’un laboratoire » ; « La taille et le prix des microscopes ! » « …que l’on puisse travailler sur des mouches » ; « qu’il y ait autant de bureaux dans un laboratoire de recherche » ou encore « rien ». Et pour tous, cette semaine passée au GReD les a confortés dans leur désir de travailler plus tard dans la recherche " ...car on peut faire des découvertes tous les jours, voir ses résultats tous les jours, en plus c'est fabuleux de travailler ici car on a toujours envie d'y aller et on a l'impression que le temps défile à toute allure."…what else ?!
Adrenal differentiation: a key role for the epigenetic factor EZH2
The adrenal gland produces glucocorticoid and mineralocorticoid hormones that are essential for life. This hormone production depends on a complex process of recruitment and differentiation of progenitor cells. Using a mouse model of gene ablation, the team “Molecular Pathophysiology of Adrenal & Endocrine Tissues” has shown that the epigenetic factor EZH2 is essential to allow differentiation of progenitor cells into cells capable of hormone synthesis. EZH2 ablation results in primary adrenal glucocorticoid deficiency, suggesting that EZH2 alterations may be involved in the aetiology of these potentially lethal diseases in patients.
This study has been published in PNAS (Mathieu et al., 2018).
La recherche contre le cancer au GReD : De la paillasse… à la Courstache !
L’équipe NuReP mise en lumière dans un article de La Montagne de l’édition du Vendredi 2 Novembre dans le cadre du mois « MOVEMBER » de soutien aux patients atteints de cancers masculins (testicules et prostate).
Toujours dans le cadre de "MOVEMBER" les membres de l’équipe NuReP ont également participé à la course caritative « La Courstache » édition #2 qui a eu lieu à Aubière le samedi 3 Novembre.
sRNAPipe: a Galaxy-based pipeline for bioinformatic in-depth exploration of small RNAseq data
Les recherches menées au cours de cette dernière décennie ont révélé que la quasi-totalité des génomes est transcrite et que la plupart des molécules d’ARN ainsi produites correspondent à de multiples classes de petits ARN non codants. Malgré l'importance de ces découvertes, aucun outil bioinformatique, simple d’utilisation, n’a été développé à ce jour pour analyser des données de séquençage ciblant ces petits ARNs ("small RNA-Seq"). Dans cette étude, publiée dans mobile DNA (Pogorelcnik et al., 2018), l'équipe de C. Vaury et E. Brasset présente précisément un nouveau pipeline qui permet une analyse rapide de données de small RNA-Seq. Pour faciliter son utilisation par les biologistes, le pipeline a été intégré avec une interface conviviale à un portail Galaxy.
Les donateurs AFM-Téléthon à la rencontre des équipes de recherche du GReD
Le 8 octobre dernier le GReD organisait une journée Portes ouvertes aux donateurs de l’Association Française contre les Myopathies (AFM-Téléthon).
A key developmental stage for the targeting of transposable elements by piRNAs.
In few germline cells located at the anterior pole of the Drosophila ovariole, Piwi expression is weakened. This short time of germline development has been called the Piwiless pocket or Pilp (Dufourt et al. 2014).
In its last sudy, pubilshed in NAR (Théron et al., ) , the C. Vaury and E. Brasset team evidenced that Pilp is a key developmental stage for amplifying and specifying the piRNA repertoire targeting transposable elements.
GH1-HMGA1 : une protéine chromatinienne impliquée dans la stabilité des télomères et la réparation des cassures double brin de l’ADN
De par leur nature linéaire, les chromosomes des eucaryotes ont dû développer des mécanismes de protection de leurs extrémités appelés télomères. Si ces mécanismes sont défaillant, les télomères sont reconnus par la cellule comme des cassures de l’ADN et vont donc être « réparés » de façon abusive et engendrer des dommages génomiques dramatiques pour la cellule. Chez l’homme, l’ADN télomérique est remodelé par un complexe protéique spécifique, qui constituent une « coiffe » qui a pour rôle principal d’assurer la protection du génome. Malgré d’intenses recherches, très peu de protéines impliquées dans l'homéostasie des télomères ont été identifiées chez les plantes.
Dans sa dernière étude (Charbonnel et al.), le groupe de Charles White décrit le rôle de la protéine GH1-HMGA1 dans l’homéostasie télomérique ainsi que dans la réparation de l’ADN chez la plante Arabidopsis thaliana.
When the liver controls male puberty....
Puberty is a key event for the development of male reproductive functions. It depends on the increase of testosterone produced by the testis, under the control of the activity of ...
Read moreGReD's PhD students stimulate scientific career interest at Exposciences
From May 25th to May 28th, PhD students from the GReD lab held a booth at Polydôme (Clermont-Ferrand) to present their work to children and young adults.
Read moreHDR defence: Isabelle VAILLANT
On wednesday, November 8th, Isabelle VAILLANT will defend her HDR entitled:"Contrôle épigénétique des séquences répétées chez Arabidopsis et de l'expression des ...
Read moreConference: "The unique mechanisms for the nuclear dynamics in Arabidopsis" Dr. Tamura - Kyoto University, Japan
"The unique mechanisms for the nuclear dynamics in Arabidopsis"
By Dr. Kentaro Tamura, from Kyoto University, Japan
Friday the 3rd of February. 2:30pm
Meeting room, Vegetal Biology Building- Campus ...
Read moreConférence: "Biomechanics of Muscle Morphogenesis "- Friday 5th of may
SVSAE doctoral School conference
‘Biomechanics of Muscle Morphogenesis’
Franck Schnorrer, IBDM (Institut de Biologie du Développement) - Marseille
Friday, 5th of May; 2:30pm
Meeting room, Vegetal Biology Building- Campus ...
Read moreConference: "Revisiting cell lineage specification during male sex determination with single cell RNA sequencing ", Serge NEF, University of Geneva
SVSAE doctoral School conference
"Revisiting cell lineage specification during male sex determination with single cell RNA sequencing ", Serge NEF, University of Geneva, Medical School
Friday, 14th of April; 2pm
Meeting ...
Read moreConference: "Ontogeny and function of muscle interstitial progenitor cells" Sigmar Stricker -Freie Universitaet of Berlin
"Ontogeny and function of muscle interstitial progenitor cells" Sigmar Stricker - Freie Universitaet of Berlin
Friday the 27th of January. 3pm
Meeting room, Vegetal Biology Building- Campus des Cézeaux
Contact ...
Read moreA focus on sperm DNA oxidative damage : a putative new trail to improve some male infertile situations
Oxidative alterations of the sperm nucleus are causative of reproductive failures and increase the risk of transmitting paternal inherited mutations to the next generation. With the goal to explore new ...
Read moreEpigénétique: the revenge of Lamarck?
The next "Mercredis de la Science" ”, organized by the university Blaise Pascal, will be dedicated to the Epigenetics. All are welcome to listen our two researchers, Aline Probst and Christophe ...
Read moreWhen it comes to DNA methylation, 1 + 1 = 3.
Variation in DNA methylation, which decorates DNA of most living organisms, can impact gene transcription, just like does DNA sequence. How distinct DNA methylation states of genes and transposons, called ...
Read moreBenjamin Bertin : prix du Jury des JED 2016
Benjamin BERTIN, doctorant dans l'équipe de Krzysztof Jagla , a reçu le prix du Jury lors des 'Journées de l'Ecole Doctorale 2016".
Read moreEZH2, a novel therapeutic target in Adrenal Cortex Cancer
Adrenal cortex Cancer is one of the most aggressive cancers, for which there is no effective therapeutic approach. Research supervised by Pierre VAL at GReD laboratories, identified overexpression of EZH2 ...
Read moreAxel POULET thesis works highlighted on the Oxford Brooke University website.
The 6th of June, Axel Poulet, student in Christophe Tatout and Aline Probst’s team, successfully defended his thesis performed under a co-tutelle arrangement between Oxford Brooked and Blaise ...
Read moreA new recognition for the GReD research againts cancer
The EDC-CaP project- Environmental chemical disrupter and metastasic potential of prostate cancer- leads by Jean-Marc Lobacarro et Sylvére Baron is among the 8 selected projects from the national call ...
Read morePhd Defense : Marjorie WHITFIELD
Marjorie WHITFIELD ( Team "Mechanisms of mammalian post-testicular infertility" ) will defend her thesis
"Modèle murin invalidé pour les LXRs : dyslipidémie et impact sur la maturation post-testiculaire des gamètes ...
Read moreRecombination machinery compensates telomere loss in the absence of telomerase.
The chromosomes of most eukaryotic species are linear, consisting of a single DNA double-helix running from one end to the other. Each chromosome thus has two ends and these are ...
Read moreTRAINING SCHOOL 3D-FisH & IMAGE ANALYSIS
October 15-19th, 2018
The Probst-Tatout’team organizes a training school in "3D-FiSH and Image Analysis" in the frame of INDEPTH. This first training school will also be supported at the local scale by the University Clermont Auvergne), the Wide Open to the World (WOW!) Program from the CAP20-25 project and by the GReD laboratory through its Confocal Imaging Platform.
PhD defense: Typhanie DUMONTET
On Friday, july 7th, in the CRBC Amphi "Volcan", Thyphanie DUMONTET will defend her thesis entitled:"Rôle de la signalisation PKA dans la zonation de la glande surrénale ...
Read moreLINE fishing... with the new bioinformatics tool CLIFinder
Repeated elements represent 45% of the human genome. However, due to their large number and their high sequence homology, the contribution of those elements to the human genome transcriptome remains ...
Read moreNutrition and Cancer Congress - June 22 -23, 2017
The 4th International Congress of Translational Research in Human Nutrition – Theme: Nutrition and Cancer , will be held in Clermont-Ferrand on 22 and 23 of june.
To know more about ...
Read moreCALL for a NEW RESEARCH GROUP LEADER
The GReD wishes to recruit a new independent leader to form a group within the scientific spectrum of the GReD. The GReD will provide laboratory space (50m2) and free ...
Read moreCALL for NEW RESEARCH GROUP LEADERS
We are opening two distinct calls for new research group leaders. We encourage both young and already established outstanding researchers to apply. The deadline for applications is July 1st 2017 ...
Read morePhD defense: Marie-Elisa PINSON
Marie-Elisa Pinson (Team “Genomic Imprinting and the epigenetic control of cell fate determination”) will defend her thesis entitled:
"Etude de l'impact de la dérégulation transcriptionnelle liée ...
Read moreWeapons exchange in the battle between transposable elements and their host
The inactivation of transposable elements within genomes is insured by multiple epigenetic mechanisms. Olivier Mathieu's team has identified two genes required for repressing many transposable elements through a new ...
Read moreMarie-Elisa PINSON won the prize for the best poster at the Auvergne-Rhône-Alpes forum on cancer research
Marie-Elisa PINSON won the prize for the best poster, section "Bioinformatics and modelisation" at the Auvergne-Rhône-Alpes forum on cancer research.
To know more, the awarded poster can be uploaded ...
Read moreChaperoning histones and controlling genome function
Histone proteins are critical components of chromatin and the incorporation of different histone variants modulates nucleosome stability. Deposition of histones at the right time and the correct place in the ...
Read moreINDEPTH : The GReD, in collaboration with LIMOS laboratory, holds the first COST-Action coordinated by Clermont Auvergne University (UCA)
GReD and LIMOS laboratories are happy to inform you that their COST-action project entitled «Impact of Nuclear Domains on Gene Expression and Plant Traits » (INDEPTH) has been awarded. This pan-european ...
Read moreSoutenance de thése : Benjamin BERTIN
Benjamin BERTIN (Equipe « Diversification des cellules musculaires et cardiaques en conditions normales et pathologiques ») soutiendra sa thèse intitulée :
"Analyses moléculaires et fonctionnelles de la diversification musculaire par ...
Read moreAdrenal gland differentiation: positive antagonism
Endocrine activity of the adrenal glands is essential for body homeostasis and depends on the differentiation of two concentric cellular zones. Using transgenic mouse models, Pierre Val’s team has ...
Read moreConference: " Chromatin alterations in cancers "
"Chromatin alterations in cancers"
Raphaël Margueron- Institut Curie Paris
Friday 23rd of March; 11am
Amphi 6A- Medical School- Main Building R3 3rd floor
Contact :pierre.val@uca.fr
Read moreMale infertility, toward new molecular causes .
Bile acids are molecules with endocrine activities controlling several physiological functions such as immunity and glucose homeostasis. Recently, they have also been shown to be involved in testicular physiology and ...
Read moreAmandine RAMBUR won the prize for the best poster at the 26th ARTP annual meeting
Amandine RAMBUR (Team "Nuclear receptor and prostate diseases") won the prize for the best poster at the ARTP (Asociation for research on prostate tumors) 26th annual meeting.
To know more ...
Read moreGENOME PLASTICITY: EXAMPLE OF 5S RIBOSOMAL RNA GENES
The genes coding 5S ribosomal RNAs (critical components of the ribosomes, the cellular machineries translating mRNA into proteins) are highly repeated in the genome, which allows the production of large ...
Read morePhD Defense: Mickael MATHIEU
Mickael MATHIEU ( équipe : "Pathophysiologie moléculaire des tissus surrénaux et endocriniens") will defend his thesis entitled:
"Rôle de EZH2 et du complexe PRC2 dans l'homéostasie du ...
Read moreA new research group has joined the GReD
The team « Epigenetic Regulation and Hematopoiesis », headed by Lucas Waltzer, has joined the GReD.
The team: Manon Boulet ( PhD Student)- Lucas Waltzer (DR2 CNRS, Team leader)- Laurence Vandel (DR2 CNRS ...
Read moreConference: « From fitness comparison to spatial constrains : the many roads of cell competition »
By Romain levayer, Institut Pasteur, Paris.
Thursday the 11th of january. 11:00 am
Meeting room 003, CRBC Building- Medical school campus
Contact: Vincent MIROUSE (vincent.mirouse@uca.fr)
Read moreThe LINC complex contributes to heterochromatin organisation and transcriptional gene silencing in plants
The linker of nucleoskeleton and cytoskeleton (LINC) complex is an evolutionarily well-conserved protein bridge connecting the cytoplasmic and nuclear compartments across the nuclear membrane. Recent investigations have highlighted its function ...
Read moreGReD meets Johan Swinnen during its 2400 km run for cancer patients
From the 21st of Auguts our colleague Johan Swinnen undertook a journey of a lifetime: running from Leuven to Santiago de Compostela with a backpack filled with hundreds of letters ...
Read moreFXRα a new actor of germinal stem cells fate.
The FXRα nuclear receptor (Farnesoid-X-Receptor alpha) is a key factor controlling the male sex hormone synthesis within the testis. However, its roles in male germ cell homeostasis have not yet ...
Read moreConference: " Multi-scale mathematical model of Epi/PrE specification. "
Multi-scale mathematical model of Epi/PrE specification.
Alen TOSENBERGER- Unit of Theoretical Chronobiology, ULB, Brussels
Tuesday September 26th at 12h45, amphi LIMAGNE (Ground floor CRBC building)
Contact : claire.chazaud@uca ...
Read moreConference: "Hematopoiesis and immune response: insight from Drosophila "
Hematopoiesis and immune response: insight from Drosophila
Michèle Crozatier (CBD Toulouse)
Friday Sept 29 at 11h, CBRC room 003
Contact: christophe.jagla@udamail.fr
Read more
PhD defense: Stéphanie HERMITTE
Stéphanie HERMITTE (Team “Molecular mechanisms of cell lineage differentiation in the early mouse embryo”) will defend her thesis entitled:
"Caractérisation de la différenciation de l'endoderme primitif ...
Read moreWorkshop "Mechanobiology and Physics of Life"
After Lyon (2016) and Grenoble (2017), we are pleased to welcome you to the third workshop in Mechanobiology and Physics of Life to be held in Clermont-Ferrand on Tuesday January ...
Read moreMeeting: “Impact of Nuclear Domains in Gene Expression and Plant Traits” (INDEPTH)
We are pleased to announce the first main meeting of the COST-Action CA16212 “Impact of Nuclear Domains in Gene Expression and Plant Traits” (INDEPTH). The meeting will take place from ...
Read morePhD defense: Margaux OLIVIER
Margaux OLIVIER (Team “Recombination and Maintenance of Genome Integrity”) (will defend her thesis
" Rôle des protéines de la recombinaison dans le maintien des télomères."
Monday 2 ...
Read morePhD Defense: Alexandre CHAMPROUX
Alexandre CHAMPROUX ( team : "Mechanisms of mammalian post-testicular infertility") will defend his thesis entitled:
"L'impact du stress oxydant sur l'épigénome spermatique murin. "
Wednesday the 11 of April 2018 ...
Read morePhD defense: Gunjita SINGH
Gunjita SINGH (Team “Recombination and Maintenance of Genome Integrity”) will defend her thesis entitled:
" Role of recombination protein in cross-over formation, pairing and synapsis in Arabidopsis meiosis"
Monday 9th ...
Read moreLes Doctorants du GReD à l’honneur lors des JED 2017.
Houda TABBAL, doctorante dans l’équipe « Pathophysiologie moléculaire des tissus surrénaux et endocriniens » et Alexandre CHAMPROUX, doctorant dans l’équipe « Mécanismes de l'infertilité mâle post-testiculaire ...
Read morePhD Defense: Cristiana DONDI
Cristiana DONDI (Team “Diversification of muscle and heart cells in normal and pathological conditions”) will defend her thesis entitled:
"Molecular and functional analysis of cardiac diversification by cell specific translatomic ...
Read moreClaire CHAZAUD received the VAN BENEDEN prize.
This prize is awarded every three years by the Royal Academy of Sciences, Letters and Fine Arts of Belgium to acknowledge a pioneer work in embryology or cytology .
Claire Chazaud ...
Read moreDNA methylation : a new actor in CML biology
Chronic myeloid leukemia (CML), a cancer of the white blood cell, results from a translocation event that ultimately leads to the production of BCR-ABL1, a chimeric oncoprotein that promotes CML by aberrantly phosphorylating target proteins. Nonetheless, this event on its own, cannot account for an increasing number of clinical observation suggesting the involvement of other pathways, among which DNA methylation alteration emerges as a relevant candidate.
On that basis the teams of Marc BERGER (CHU, Clermont-Ferrand) and Philippe ARNAUD have characterized for the first time the DNA methylation patterns of CML cell subsets (immature and mature cells) isolated form the same clone during the early stage of the disease, before any treatment (Maupetit-Méhouas, Court, Bourgne et al.,). Altogether, this collaborative study demonstrated that DNA methylation abnormalities exist at early stages of CML and can affect the transcriptional landscape of malignant cells. These observations paved the way for new therapeutic strategies based on epigenetic drugs.
Conference: "Epigenetic regulatory complexes in development and cancer. "
SVSAE doctoral School conference
‘Epigenetic regulatory complexes in development and cancer’.
Peter MULLIGAN - Centre de Recherche en Cancérologie de Lyon (CRCL)- Centre Léon Bérard, Lyon
Friday, 12th ...
Read morePhD defense: Maxime VOISIN
Maxime Voisin (Team “Histone variants and the nuclear envelope in heterochromatin organization”) will defend his thesis entitled:
"Fonction des protéines de l’enveloppe et de la périphérie ...
Read moreBudding Researchers
The pupils ,aged 6 years old, of the school Nestor Perret in Clermont-Ferrand spent Tuesday, May 30th, morning together with the researchers of the GReD in a real course ...
Read more
Pint of Science "Le Gras c'est la vie !" par L. Bousset & S. Baron-Lundi 15 mai
Et si on démystifiait la recherche scientifique autour d’une petite bière…
LE GRAS C’EST LA VIE !
Mon médecin m’a dit : « Trop de cholestérol ...
Read moreThe journey of a thousand piRNAs begins with a single Dot
Among the several kinds of non-coding small RNAs, piRNAs (Piwi-interacting RNAs) are the ‘transposon-silencers’. They occur within the gonads of animals, protecting the cellular genome from transposable elements. One of ...
Read moreEMBO Workshop "Plant Genome Stability and Change"
This EMBO workshop represents the sixth International Meeting on molecular and cellular mechanisms underlying stability, variability and modification of plant genomes. It will be held at the IPK Gatersleben, Germany ...
Read moreGReD Symposium : "Les surpises du Vivant"
the wednesday 16th of May, the GReD organizes its symposium
"Les surprises du vivant".
Amphitheater Limagne, CRBC Building , Faculté de Médecine
To the Programm click on "read more "....
Read moreCymbopogon citratus and cancer: when citronella is a repellent not only for mosquitoes…
Through a real bilateral collaboration, Drs. Silvère BARON’s et and Jean-Marc LOBACCARO’s team Nuclear Receptor and Prostate diseases and Pr. Jacques SIMPORE’s team (Laboratoire de Biologie ...
Read moreHow to turn a football into a rugby ball?
Tissue elongation is part of the repertoire of processes that allow an organ to acquire its shape (morphogenesis). In the last years, the elongation of the ovarian follicle of Drosophila has emerged as a model of choice for the study of tissue elongation mechanisms. During its development the initially spherical follicle becomes ovoid and this elongation is controlled by the epithelial cells surrounding each follicle. However, so far, all studies on the subject have focused on the basal domain of these cells.
In its last study (Alegot et al.,) , the group of Vincent Mirouse has shown that the apical domain of the epithelial cells also contributed to this elongation.
PhD Defense: Lilia Laddada
Lilia LADDADA (Team “Diversification of muscle and heart cells in normal and pathological conditions”) will defend her thesis entitled:
"Étude du développement des tendons et de leur interaction avec ...
Read moreGRED’s people in the spotlight
Heidi Serra received the young researcher award 2015 from the Bettencourt-Schueller foundation.
Read moreCeremony for the foundation stone of the new building CRBC (Centre for Research in Clinical Biology).
Spring 2017 is going to be a landmark for the GReD with the Research Unit being united in the brand-new building CRBC.
This large research facility is part of the ...
