News

How does a begnihn tumor become cancerous?

 How does a begnihn tumor become cancerous?

While the evolution of cancer towards its most aggressive phases is largely studied, the mechanisms by which a benign tumour can become malignant remain poorly understood. Based on this observation, the "Nuclear Receptors and Prostate Diseases" team has developed a new model to study these early phases in Drosophila. Their work highlights the crucial role of growth factors in the transformation of the tumour. These results are published in Nature Communications (Rambur et al., 2020).

Relationship between transposable elements and their host genome: It is neither all black or all white...

Relationship between transposable elements and their host genome:  It is neither all black or all white...

In its last review article (Maupetit-Méhouas & Vaury), published in Cells,  the team " Genetic instabilities and control by the host genome"  presents the latest knwoledges on Germline reactivation of Transposable ...

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Focus sur le Groupe Cancer Clermont Auvergne

Focus sur le Groupe Cancer Clermont Auvergne

Focus sur le Groupe Cancer Clermont Auvergne dans le LAB#7 de l’UCA.

Retrouvez ici l’interview de Silvere Baron ( équipe : Récepteurs nucléaires et maladies de la ...

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Post-doc position available "Environment-Metabolism-Spermatogenesis-Pathophysiology-&-Inheritance”.

Post-doc position available  "Environment-Metabolism-Spermatogenesis-Pathophysiology-&-Inheritance”.

A 2 to 3 years post-doc position, funded by the Plan Cancer-3R call, is available in the Volle’s team

In order to explore the questions of Testicular Germ Cell tumor (TGCT) biology and their sensitivity to chemo-drugs, the team has started...

The GReD , a player of the research to fight prostate cancer

The GReD , a player of the research to fight prostate cancer

Le projet collaboratif TransCAP réunit depuis 2014 les acteurs Auvergnats de la recherche sur le cancer de la prostate, dont l'équipe "Récepteurs nucléaires et maladies de la prostate".  Cette collaboration fructueuse a abouti à la création d’une biobanque inédite en France, dont les détail sont à retrouver dans cet article de la Montagne

 

1st Spermatogenesis Conference. Male germ cells: from stem cells to diseases

1st Spermatogenesis Conference. Male germ cells: from stem cells to diseases

For the organizing committee, the GReD institute invite you to attend the first Spermatogenesis Conference. Male germ cells: from stem cells to diseases in Lisbon (Portugal) from July 16  to 19th, 2021.

https://www.fusion-conferences.com/conference/129

Muscular dystrophy and cardiac defects: the calcium lead

Muscular dystrophy and cardiac defects: the calcium lead

The majority of patients suffering from Myotonic Dystrophy Type I (DM1) exhibit cardiac conduction disturbance, reducing their life expectancy and causing sometimes sudden death. In their last study (Auxerre-Plantié et al., 2019), the team “Diversification of muscle and heart cells in normal and pathological conditions” used the fruitfly as a model system to reveal that this cardiac conduction defects are linked to gene expression alteration in cellular calcium regulation pathways, offering a new therapeutic lead for DM1 cardiac involvement.

The journey of a thousand piRNAs begins with a single Dot

The journey of a thousand piRNAs begins with a single Dot

Among the several kinds of non-coding small RNAs, piRNAs (Piwi-interacting RNAs) are the ‘transposon-silencers’. They occur within the gonads of animals, protecting the cellular genome from transposable elements. One of ...

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When the liver controls male puberty....

When the liver controls male puberty....

Puberty is a key event for the development of male reproductive functions. It depends on the increase of testosterone produced by the testis, under the control of the activity of ...

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Epigénétique: the revenge of Lamarck?

Epigénétique: the revenge of Lamarck?

The next  "Mercredis de la Science" ”, organized by the university Blaise Pascal, will be dedicated to the Epigenetics. All are welcome to listen our two researchers, Aline Probst and Christophe ...

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Le GReD soutient la création du Groupe Cancer Clermont Auvergne

Le GReD soutient la création du Groupe Cancer Clermont Auvergne

 

Plusieurs équipes du GReD sont partie prenante dans ce réseau, dont l’une des premières actions a été l’organisation de la 1ére Automnale du Groupe Cancer Clermont Auvergne, le 26 novembre dernier. Dans la lignée du succès de cette première rencontre, la création du groupe a fait l’objet de plusieurs retombées dans la presse.

Article dans la Montagne

Article dans 7 jours à Clermont

A focus on sperm DNA oxidative damage : a putative new trail to improve some male infertile situations

A focus on sperm DNA oxidative damage : a putative new trail to improve some male infertile situations

Oxidative alterations of the sperm nucleus are causative of reproductive failures and increase the risk of transmitting paternal inherited mutations to the next generation. With the goal to explore new ...

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Les stagiaires de 3iéme à la découverte du GReD.

Les stagiaires de 3iéme à la découverte du GReD.

Du 17 au 21 décembre 2018, six collégiens, tous désireux de découvrir les métiers de la recherche, ont rejoint le GReD.  Les activés men ...

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When it comes to DNA methylation, 1 + 1 = 3.

 When it comes to DNA methylation, 1 + 1 = 3.

Variation in DNA methylation, which decorates DNA of most living organisms, can impact gene transcription, just like does DNA sequence. How distinct DNA methylation states of genes and transposons, called ...

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Benjamin Bertin : prix du Jury des JED 2016

Benjamin Bertin :  prix du Jury des JED 2016

Benjamin BERTIN, doctorant dans l'équipe de Krzysztof Jagla , a reçu le prix du Jury lors  des 'Journées de l'Ecole Doctorale 2016".

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Axel POULET thesis works highlighted on the Oxford Brooke University website.

 Axel POULET thesis works highlighted on the Oxford Brooke University website.

The 6th of June, Axel Poulet, student in Christophe Tatout and Aline Probst’s team,   successfully defended his thesis performed under a co-tutelle arrangement between Oxford Brooked and Blaise ...

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Stress & SUMO : le poids de SUMO dans la glande surrénale

Stress & SUMO : le poids de SUMO dans la glande surrénale

La SUMOylation est un processus de modification post-traductionnelle conservé chez les eucaryotes, indispensable au maintien de l’intégrité des génomes, à la régulation des gènes et à la ...

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GH1-HMGA1 : une protéine chromatinienne impliquée dans la stabilité des télomères et la réparation des cassures double brin de l’ADN

GH1-HMGA1 : une protéine chromatinienne impliquée dans la stabilité des télomères et la réparation des cassures double brin de l’ADN

De par leur nature linéaire, les chromosomes des eucaryotes ont dû développer des mécanismes de protection de leurs extrémités appelés télomères. Si ...

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Weapons exchange in the battle between transposable elements and their host

Weapons exchange in the battle between transposable elements and their host

The inactivation of transposable elements within genomes is insured by multiple epigenetic mechanisms. Olivier Mathieu's team has identified two genes required for repressing many transposable elements through a new ...

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Adrenal differentiation: a key role for the epigenetic factor EZH2

Adrenal differentiation: a key role for the epigenetic factor EZH2

The adrenal gland produces glucocorticoid and mineralocorticoid hormones that are essential for life. This hormone production depends on a complex process of recruitment and differentiation of progenitor cells. Using a ...

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A key developmental stage for the targeting of transposable elements by piRNAs.

A key developmental stage for the targeting of transposable elements by piRNAs.

In few germline cells located at the anterior pole of the Drosophila ovariole, Piwi expression is weakened. This short time of germline development has been called the Piwiless pocket or ...

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Les donateurs AFM-Téléthon à la rencontre des équipes de recherche du GReD

Les donateurs AFM-Téléthon à la rencontre des équipes de recherche du GReD

Le 8 octobre dernier le GReD organisait une journée Portes ouvertes aux donateurs de l’Association Française contre les Myopathies (AFM-Téléthon).

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Chaperoning histones and controlling genome function

Chaperoning histones and controlling genome function

Histone proteins are critical components of chromatin and the incorporation of different histone variants modulates nucleosome stability. Deposition of histones at the right time and the correct place in the ...

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Recombination machinery compensates telomere loss in the absence of telomerase.

Recombination machinery compensates telomere loss in the absence of telomerase.

The chromosomes of most eukaryotic species are linear, consisting of a single DNA double-helix running from one end to the other. Each chromosome thus has two ends and these are ...

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Male infertility, toward new molecular causes .

Male infertility, toward new molecular causes .

Bile acids are molecules with endocrine activities controlling several physiological functions such as immunity and glucose homeostasis. Recently, they have also been shown to be involved in testicular physiology and ...

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GENOME PLASTICITY: EXAMPLE OF 5S RIBOSOMAL RNA GENES

GENOME PLASTICITY: EXAMPLE OF 5S RIBOSOMAL RNA GENES

The genes coding 5S ribosomal RNAs (critical components of the ribosomes, the cellular machineries translating mRNA into proteins) are highly repeated in the genome, which allows the production of large ...

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LINE fishing... with the new bioinformatics tool CLIFinder

LINE fishing... with the new bioinformatics tool CLIFinder

Repeated elements represent 45% of the human genome. However, due to their large number and their high sequence homology, the contribution of those elements to the human genome transcriptome remains ...

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EZH2, a novel therapeutic target in Adrenal Cortex Cancer

EZH2, a novel therapeutic target in Adrenal Cortex Cancer

Adrenal cortex Cancer is one of the most aggressive cancers, for which there is no effective therapeutic approach. Research supervised by Pierre VAL at GReD laboratories, identified overexpression of EZH2 ...

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A new research group has joined the GReD

The team « Epigenetic Regulation and Hematopoiesis », headed by Lucas Waltzer, has joined the GReD.

The team: Manon Boulet ( PhD Student)- Lucas Waltzer (DR2 CNRS, Team leader)- Laurence Vandel (DR2 CNRS ...

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The LINC complex contributes to heterochromatin organisation and transcriptional gene silencing in plants

The LINC complex contributes to heterochromatin organisation and transcriptional gene silencing in plants

The linker of nucleoskeleton and cytoskeleton (LINC) complex is an evolutionarily well-conserved protein bridge connecting the cytoplasmic and nuclear compartments across the nuclear membrane. Recent investigations have highlighted its function ...

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Adrenal gland differentiation: positive antagonism

Adrenal gland differentiation: positive antagonism

Endocrine activity of the adrenal glands is essential for body homeostasis and depends on the differentiation of two concentric cellular zones. Using transgenic mouse models, Pierre Val’s team has ...

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GReD meets Johan Swinnen during its 2400 km run for cancer patients

GReD meets Johan Swinnen during its 2400 km run for cancer patients

From the 21st of Auguts our colleague Johan Swinnen undertook  a journey of a lifetime: running from Leuven to Santiago de Compostela with a backpack filled with hundreds of letters ...

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FXRα a new actor of germinal stem cells fate.

FXRα  a new actor  of germinal stem cells fate.

The FXRα nuclear receptor (Farnesoid-X-Receptor alpha) is a key factor controlling the male sex hormone synthesis within the testis. However, its roles in male germ cell homeostasis have not yet ...

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What if honeybees could help fighting prostate cancer?

What if honeybees could help fighting prostate cancer?

Prostate cancer is one of the most frequent and deadly tumors in man for which it is necessary to expand the portfolio of therapeutic strategies.

Based on an ethnobotany screening ...

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Recrutement chargé(e) de mission scientifique

Recrutement chargé(e) de mission scientifique

La filière Maladies Rares Endocriniennes (FIRENDO http://www.firendo.fr/accueil-filiere-firendo/) recherche :

Un(e) chargé(e) de mission scientifique, affecté(e)  à l'équipe  "Pathophysiologie moléculaire des tissus surrénaux et endocriniens" au GReD

CDD de 1 an renouvelable 

Missions: accompagner, conseiller, soutenir et coordonner les acteurs recherche de la filière dans le but de recenser, faciliter et optimiser la mise en place des projets de recherche.

Diplômes: minimum BAC+5 scientifique ou ingénierie des systèmes de santé ou Bac+8 Doctorat en Biologie. Une formation en recherche clinique est un plus, mais n’est pas indispensable.

Contact: Antoine Martinez   email: antoine.martinez@uca.fr

Le profil détaillé du poste est disponible ici

Workshop "Mechanobiology and Physics of Life"

Workshop "Mechanobiology and Physics of Life"

After Lyon (2016) and Grenoble (2017), we are pleased to welcome you to the third workshop in Mechanobiology and Physics of Life to be held in Clermont-Ferrand on Tuesday January ...

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Inauguration du Centre de Recherche BioClinique de l’Université Clermont Auvergne

Inauguration du Centre de Recherche BioClinique de l’Université Clermont Auvergne

Depuis l’été 2018, les équipes du GReD sont hébergées au CRBC, Centre de Recherche BioClinique.

Ce nouveau bâtiment a été inauguré le lundi 10 décembre ...

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Même confiné le GReD reste actif et solidaire

Même confiné le GReD reste actif et solidaire

Solidaire tout d’abord de nos membres aussi praticiens hospitaliers, ainsi que de nos collègues clermontois, qui sont directement impliqués dans la lutte contre le virus : courage  à vous ...

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How to turn a football into a rugby ball?

How to turn a football into a rugby ball?

Tissue elongation is part of the repertoire of processes that allow an organ to acquire its shape (morphogenesis). In the last years, the elongation of the ovarian follicle of Drosophila ...

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GReD Symposium : "Les surpises du Vivant"

GReD Symposium :  "Les surpises du Vivant"

the wednesday 16th of May, the GReD organizes its symposium

"Les surprises du vivant".

Amphitheater Limagne, CRBC Building , Faculté de Médecine

To the  Programm click on "read more "....

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sRNAPipe: a Galaxy-based pipeline for bioinformatic in-depth exploration of small RNAseq data

sRNAPipe: a Galaxy-based pipeline for bioinformatic in-depth exploration of small RNAseq data

Les recherches menées au cours de cette dernière décennie ont révélé que la quasi-totalité des génomes est transcrite et que la plupart des mol ...

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GReD confined : The mosaic ....team 1

GReD confined :  The mosaic ....team 1

Team 1: Behind the screen...each has its own containment

more details : here

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La recherche contre les myopathies au GReD : La drosophile un modéle précieux

La recherche contre les myopathies au GReD : La drosophile un modéle précieux

Grâce aux dons du téléthon, L' AFM soutient deux équipes de recherche au GReD.

En tirant partie du modéle drosophile, les équipes "Diversification des cellules musculaires ...

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Transcriptional alterations in Glioma: DNA methylation is the tip of the “epigenetic” iceberg

Transcriptional alterations in Glioma:  DNA methylation is the tip of the “epigenetic” iceberg

In cancer cells, aberrant DNA methylation is commonly associated with transcriptional alterations, including silencing of tumor suppressor genes. However, multiple epigenetic mechanisms, including polycomb repressive marks, contribute to gene deregulation in cancer. In its last study  (Court et al.,  2019) the team " Genomic Imprinting and the epigenetic control of cell fate determination" used glioma, one the most widespread type of brain tumor, to evaluate for the first time the relative contribution of DNA methylation-independent mechanisms on transcriptional alteration at CpG-island (CGI)/promoter-associated genes in cancer cells. They found that most transcriptional alterations in tumor samples were DNA methylation-independent. Instead, altered histone H3 trimethylation at lysine 27 (H3K27me3) was the predominant molecular defect at deregulated genes.

Imaris Open Day

Imaris Open Day

Georgia Golfis, de Bitplane, viendra présenter le logiciel Imaris le 11 février 2014.
Cette présentation sera suivie d'une formation pratique l'après-midi.

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The conserved yeast telomeric CST complex also functions in the regulation of RNA polymerase II transcription

The conserved yeast telomeric CST complex also functions in the regulation of RNA polymerase II transcription

The telomeric CST complex contributes to maintain genome stability through chromosome end protection and telomere length regulation. In its last study conducted on the yeast model (Calvo, Grandin et al ...

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DNA methylation : a new actor in CML biology

DNA methylation : a new actor in CML biology

Chronic myeloid leukemia (CML), a cancer of the white blood cell, results from a translocation event that ultimately leads to the production of BCR-ABL1, a chimeric oncoprotein that promotes CML ...

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1ere Automnale du Groupe Cancer Clermont Auvergne

1ere Automnale du Groupe Cancer Clermont Auvergne

Le mardi 26 Novembre, de 9h à 17h, se tiendra la 1éreAutomnale du Groupe Cancer Clermont Auvergne

Cette journée permettra d’avoir un panorama de la recherche en ...

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Budding Researchers

Budding Researchers

The pupils ,aged 6 years old, of the school Nestor Perret in Clermont-Ferrand spent Tuesday, May 30th, morning together with the researchers of the GReD in a real course ...

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Les experts mondiaux des maladies de la surrénale se sont réunis au GReD

 Les experts mondiaux des maladies de la surrénale se sont réunis au GReD

Sous l’impulsion de l’équipe « Pathophysiologie moléculaire des tissus surrénaux et endocriniens », les maladies rares de la surrénale ont été à l’honneur du 25 au 28 ...

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GReD internal meeting 2017

The GReD internal meeting 2017 will be held thursday the 9th and friday the 10th of february  at "amplhi de Physique" on Cézeaux Campus.

Please,click  here to download ...

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Looking for pERK !

Looking for pERK !

In its last study, published in Development (Azami et al., ),   the team "Molecular mechanisms of cell lineage differentiation in the early mouse embryo" identified the phosporylation of ERK as a key event in the specification of epiblast (Epi) and Primitive Endoderm (PrE).

Le GReD partie prenante dans le projet VitAbeilles

 Le GReD partie prenante dans le projet VitAbeilles

Quatre laboratoires de l’Université Clermont Auvergne, dont le GReD, viennent de mettre en évidence un extrait végétal capable de soigner la nosémose, une maladie qui d ...

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GReD confiné : La mosaïque .... Team Nurep

GReD confiné :  La mosaïque .... Team Nurep

Team NuReP: "COVID or not COVID? This is not the question… show must go on :)"

More here

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GRED’s people in the spotlight

GRED’s people in the spotlight

 

Heidi Serra received the young researcher award 2015 from the Bettencourt-Schueller foundation.

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Ceremony for the foundation stone of the new building CRBC (Centre for Research in Clinical Biology).

Ceremony for the foundation stone of the new building CRBC (Centre for Research in Clinical Biology).

Spring 2017 is going to be a landmark for the GReD with the Research Unit being united in the brand-new building CRBC.
This large research facility is part of the ...

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Les Journées du Gred 2015 en images

Les Journées du Gred 2015 en images

Pour prolonger les journées du GReD 2015...

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