News
CALL for a NEW RESEARCH GROUP LEADER,
The GReD Institute opens a position of Independent Group Leader in human mobility related fields.
As part of the CAP20-25 initiative , the successful candidate will benefit from a 400 k€ start-up package and the GReD Institute will provide office, appropriate lab space and access to in-house facilities.
The final deadline for applications is noon, January 31st 2021.
For more details and apply , it's here
Replicate to repress
Heterochromatin, which states for highly condensed genomics regions, is mainly constituted of transcriptionally repressed repeated elements. In its last study, published in Genome Biology (Bourguet et al., 2020), the SILENT team shows that DNA polymerase epsilon, which is involved in DNA replication, plays a crucial role in maintaining both the structure and the function of heterochromatin.
Post-doc available : “Identification of natural extracts targeting LXR nuclear receptors activity involved in skin wound healing”
A 2 years post-doc position, shared between the GRed and GREENTECH company, is available in the "Nuclear receptors and prostate diseases" from august 2021
For more details and to apply ...
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Post-doc available to valorize a treatment Strategy by sevoflurane of the Acute Respiratory Distress Syndrome COVID-19
A 30 months post-doc position is available in the "Translational approach to epithelial injury and repair" team to work on the ASTRA project: "Biomedical and industrial valorization of a Treatment ...
Read moreThree new young CNRS/INSERM researchers at the GReD in 2020...what else ?!
2020 Competitive Examinations for CNRS and INSERM Researchers has been a great vintage for the GReD as all its three candidates have been appointed.
We are thus happy and proud ...
Read more4ème Colloque Recherche de la filière FIRENDO
Le 4ème Colloque Recherche de la filière FIRENDO , co-organisé par l'équipe "Pathophysiologie moléculaire des tissus surrénaux et endocriniens", aura lieu le Mardi 8 décembre ...
Read moreLes Doctorantes du GReD s’illustrent lors des JED 2020.
Amy HESKETH (Equipe “SILENT”), Marianne YOTH (Equipe “Instabilités génétiques et contrôle par le génome hôte”) et Manon BOULET (“Régulation épigénétique et ...
Read moreA new research group has joined the GReD
Awarded in 2020 by the FRM "Young Investigator " programm, Antoine Molaro has joined the GRed this summer to develop its thematic on Evolutionary Epigenomics and Genetic Conflicts.
He his supported in this journey by Marine Fraisse and both they can count on their trusty companions "Steeve" and "Brian" .
To know more, it's here
Discovering how plant adapt to climate changes : INDEPTH meets the challenge!
A better understanding of the mechanisms whereby 3D organisation of chromatin would influence plant growth is a prerequisite to discover how plant can adapt to climate changes.
The COST-Action INDEPTH ...
Read moreEverything you wanted to know on the impact of nuclear organization on plant traits....
The Team "Histone variants and the nuclear envelope in heterochromatin dynamics" have co-edited the Special issue of the Journal of Experimental Botany on 'Impact of Chromatin Domains on Plant Phenotypes' in collaboration with the Society of Experimental Biology and the COST Action CA16212.
The team contributed a review article (Probst et al,) presenting up-to-date knowledge on histone variants that you can access here.
1st Spermatogenesis Conference. Male germ cells: from stem cells to diseases
For the organizing committee, the GReD institute invite you to attend the first Spermatogenesis Conference. Male germ cells: from stem cells to diseases in Lisbon (Portugal) from July 16 to 19th, 2021.
https://www.fusion-conferences.com/conference/129
When the liver controls male puberty....
Puberty is a key event for the development of male reproductive functions. It depends on the increase of testosterone produced by the testis, under the control of the activity of ...
Read moreLes piARNs contre attaquent
Dans sa dernière étude, publiée dans Genome Biology (Duc, Yoth et al., 2019) , l’équipe « Instabilités génétiques et contrôle par le génome h ...
Read moreLe GReD soutient la création du Groupe Cancer Clermont Auvergne
Plusieurs équipes du GReD sont partie prenante dans ce réseau, dont l’une des premières actions a été l’organisation de la 1ére Automnale du Groupe Cancer ...
Read moreEpigénétique: the revenge of Lamarck?
The next "Mercredis de la Science" ”, organized by the university Blaise Pascal, will be dedicated to the Epigenetics. All are welcome to listen our two researchers, Aline Probst and Christophe ...
Read moreA focus on sperm DNA oxidative damage : a putative new trail to improve some male infertile situations
Oxidative alterations of the sperm nucleus are causative of reproductive failures and increase the risk of transmitting paternal inherited mutations to the next generation. With the goal to explore new ...
Read moreLes stagiaires de 3iéme à la découverte du GReD.
Du 17 au 21 décembre 2018, six collégiens, tous désireux de découvrir les métiers de la recherche, ont rejoint le GReD. Les activés men ...
Read moreWhen it comes to DNA methylation, 1 + 1 = 3.
Variation in DNA methylation, which decorates DNA of most living organisms, can impact gene transcription, just like does DNA sequence. How distinct DNA methylation states of genes and transposons, called ...
Read moreBenjamin Bertin : prix du Jury des JED 2016
Benjamin BERTIN, doctorant dans l'équipe de Krzysztof Jagla , a reçu le prix du Jury lors des 'Journées de l'Ecole Doctorale 2016".
Read moreAxel POULET thesis works highlighted on the Oxford Brooke University website.
The 6th of June, Axel Poulet, student in Christophe Tatout and Aline Probst’s team, successfully defended his thesis performed under a co-tutelle arrangement between Oxford Brooked and Blaise ...
Read moreStress & SUMO : le poids de SUMO dans la glande surrénale
La SUMOylation est un processus de modification post-traductionnelle conservé chez les eucaryotes, indispensable au maintien de l’intégrité des génomes, à la régulation des gènes et à la ...
Read moreGH1-HMGA1 : une protéine chromatinienne impliquée dans la stabilité des télomères et la réparation des cassures double brin de l’ADN
De par leur nature linéaire, les chromosomes des eucaryotes ont dû développer des mécanismes de protection de leurs extrémités appelés télomères. Si ...
Read moreWeapons exchange in the battle between transposable elements and their host
The inactivation of transposable elements within genomes is insured by multiple epigenetic mechanisms. Olivier Mathieu's team has identified two genes required for repressing many transposable elements through a new ...
Read moreAdrenal differentiation: a key role for the epigenetic factor EZH2
The adrenal gland produces glucocorticoid and mineralocorticoid hormones that are essential for life. This hormone production depends on a complex process of recruitment and differentiation of progenitor cells. Using a ...
Read moreA key developmental stage for the targeting of transposable elements by piRNAs.
In few germline cells located at the anterior pole of the Drosophila ovariole, Piwi expression is weakened. This short time of germline development has been called the Piwiless pocket or ...
Read moreLes donateurs AFM-Téléthon à la rencontre des équipes de recherche du GReD
Le 8 octobre dernier le GReD organisait une journée Portes ouvertes aux donateurs de l’Association Française contre les Myopathies (AFM-Téléthon).
Read moreChaperoning histones and controlling genome function
Histone proteins are critical components of chromatin and the incorporation of different histone variants modulates nucleosome stability. Deposition of histones at the right time and the correct place in the ...
Read moreINDEPTH : The GReD, in collaboration with LIMOS laboratory, holds the first COST-Action coordinated by Clermont Auvergne University (UCA)
GReD and LIMOS laboratories are happy to inform you that their COST-action project entitled «Impact of Nuclear Domains on Gene Expression and Plant Traits » (INDEPTH) has been awarded. This pan-european ...
Read moreRecombination machinery compensates telomere loss in the absence of telomerase.
The chromosomes of most eukaryotic species are linear, consisting of a single DNA double-helix running from one end to the other. Each chromosome thus has two ends and these are ...
Read moreMale infertility, toward new molecular causes .
Bile acids are molecules with endocrine activities controlling several physiological functions such as immunity and glucose homeostasis. Recently, they have also been shown to be involved in testicular physiology and ...
Read moreGENOME PLASTICITY: EXAMPLE OF 5S RIBOSOMAL RNA GENES
The genes coding 5S ribosomal RNAs (critical components of the ribosomes, the cellular machineries translating mRNA into proteins) are highly repeated in the genome, which allows the production of large ...
Read moreLINE fishing... with the new bioinformatics tool CLIFinder
Repeated elements represent 45% of the human genome. However, due to their large number and their high sequence homology, the contribution of those elements to the human genome transcriptome remains ...
Read moreEZH2, a novel therapeutic target in Adrenal Cortex Cancer
Adrenal cortex Cancer is one of the most aggressive cancers, for which there is no effective therapeutic approach. Research supervised by Pierre VAL at GReD laboratories, identified overexpression of EZH2 ...
Read moreThe LINC complex contributes to heterochromatin organisation and transcriptional gene silencing in plants
The linker of nucleoskeleton and cytoskeleton (LINC) complex is an evolutionarily well-conserved protein bridge connecting the cytoplasmic and nuclear compartments across the nuclear membrane. Recent investigations have highlighted its function ...
Read moreAdrenal gland differentiation: positive antagonism
Endocrine activity of the adrenal glands is essential for body homeostasis and depends on the differentiation of two concentric cellular zones. Using transgenic mouse models, Pierre Val’s team has ...
Read moreGReD meets Johan Swinnen during its 2400 km run for cancer patients
From the 21st of Auguts our colleague Johan Swinnen undertook a journey of a lifetime: running from Leuven to Santiago de Compostela with a backpack filled with hundreds of letters ...
Read moreFXRα a new actor of germinal stem cells fate.
The FXRα nuclear receptor (Farnesoid-X-Receptor alpha) is a key factor controlling the male sex hormone synthesis within the testis. However, its roles in male germ cell homeostasis have not yet ...
Read moreRecrutement chargé(e) de mission scientifique
La filière Maladies Rares Endocriniennes (FIRENDO http://www.firendo.fr/accueil-filiere-firendo/) recherche :
Un(e) chargé(e) de mission scientifique, affecté(e) à l'équipe "Pathophysiologie moléculaire des tissus surr ...
Read moreWhat if honeybees could help fighting prostate cancer?
Prostate cancer is one of the most frequent and deadly tumors in man for which it is necessary to expand the portfolio of therapeutic strategies.
Based on an ethnobotany screening ...
Read moreWorkshop "Mechanobiology and Physics of Life"
After Lyon (2016) and Grenoble (2017), we are pleased to welcome you to the third workshop in Mechanobiology and Physics of Life to be held in Clermont-Ferrand on Tuesday January ...
Read moreInauguration du Centre de Recherche BioClinique de l’Université Clermont Auvergne
Depuis l’été 2018, les équipes du GReD sont hébergées au CRBC, Centre de Recherche BioClinique.
Ce nouveau bâtiment a été inauguré le lundi 10 décembre ...
Read moreLes Doctorants du GReD à l’honneur lors des JED 2017.
Houda TABBAL, doctorante dans l’équipe « Pathophysiologie moléculaire des tissus surrénaux et endocriniens » et Alexandre CHAMPROUX, doctorant dans l’équipe « Mécanismes de l'infertilité mâle post-testiculaire ...
Read moreMême confiné le GReD reste actif et solidaire
Solidaire tout d’abord de nos membres aussi praticiens hospitaliers, ainsi que de nos collègues clermontois, qui sont directement impliqués dans la lutte contre le virus : courage à vous ...
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How to turn a football into a rugby ball?
Tissue elongation is part of the repertoire of processes that allow an organ to acquire its shape (morphogenesis). In the last years, the elongation of the ovarian follicle of Drosophila ...
Read moreGReD Symposium : "Les surpises du Vivant"
the wednesday 16th of May, the GReD organizes its symposium
"Les surprises du vivant".
Amphitheater Limagne, CRBC Building , Faculté de Médecine
To the Programm click on "read more "....
Read moreCymbopogon citratus and cancer: when citronella is a repellent not only for mosquitoes…
Through a real bilateral collaboration, Drs. Silvère BARON’s et and Jean-Marc LOBACCARO’s team Nuclear Receptor and Prostate diseases and Pr. Jacques SIMPORE’s team (Laboratoire de Biologie ...
Read moreLe GReD partie prenante dans le projet VitAbeilles
Quatre laboratoires de l’Université Clermont Auvergne, dont le GReD, viennent de mettre en évidence un extrait végétal capable de soigner la nosémose, une maladie qui d ...
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Souvenirs ( pas si lointain) d'un GReD confiné
La mosaique du GReD confiné, en attendant le 22 juin, date à laquelle nous pourrons enfin tous nous retrouver dans nos locaux,tout en respectant les gestes barriéres.
Les d ...
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Muscular dystrophy and cardiac defects: the calcium lead
The majority of patients suffering from Myotonic Dystrophy Type I (DM1) exhibit cardiac conduction disturbance, reducing their life expectancy and causing sometimes sudden death. In their last study (Auxerre-Plantié et ...
Read moreLa recherche contre les myopathies au GReD : La drosophile un modéle précieux
Grâce aux dons du téléthon, L' AFM soutient deux équipes de recherche au GReD.
En tirant partie du modéle drosophile, les équipes "Diversification des cellules musculaires ...
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Transcriptional alterations in Glioma: DNA methylation is the tip of the “epigenetic” iceberg
In cancer cells, aberrant DNA methylation is commonly associated with transcriptional alterations, including silencing of tumor suppressor genes. However, multiple epigenetic mechanisms, including polycomb repressive marks, contribute to gene deregulation ...
Read moreLes polyphénols, l’alternative « gagnant/gagnant » aux pesticides pour protéger à la fois les plantes et les abeilles.
Dans les cinquante dernières années, la protection des espèces végétales a consisté à utiliser massivement les produits phytopharmaceutiques ou pesticides. Cependant, ces composés de synthèse sont devenus délétères pour l’ensemble des organismes vivants dont les abeilles.
Une étude impliquant quatre unités clermontoises, LMGE-PIAF-SIGMA et le GReD, fait précisément émerger un nouveau concept technologique consistant à extraire les polyphénols des plantes et les réintroduire dans l’environnement pour protéger les plantes et les abeilles. Ce procédé phytosanitaire a fait l’objet d’un dépôt de brevet.
Pour en savoir plus, retrouvez ici l’article dédié sur le site de la minute recherche de l’UCA.
Contact au GReD : Ayhan Kocer
A new research group has joined the GReD (2017)
The team « Epigenetic Regulation and Hematopoiesis », headed by Lucas Waltzer, has joined the GReD.
The team: Manon Boulet ( PhD Student)- Lucas Waltzer (DR2 CNRS, Team leader)- Laurence Vandel (DR2 CNRS ...
Read moreL'Art s'affiche au GReD
Dans le cadre de la fête de la science l'artiste peinte /plasticien Lionel Chantillon (http://lionel.chantillon.overblog.com/page/2) expose une partie de ses oeuvres dans ...
Read moreRelationship between transposable elements and their host genome: It is neither all black or all white...
In its last review article (Maupetit-Méhouas & Vaury), published in Cells, the team " Genetic instabilities and control by the host genome" presents the latest knwoledges on Germline reactivation of Transposable ...
Read moreThe GReD , a player of the research to fight prostate cancer
Le projet collaboratif TransCAP réunit depuis 2014 les acteurs Auvergnats de la recherche sur le cancer de la prostate, dont l'équipe "Récepteurs nucléaires et maladies de ...
Read moreHow does a begnin tumor become cancerous?
While the evolution of cancer towards its most aggressive phases is largely studied, the mechanisms by which a benign tumour can become malignant remain poorly understood. Based on this observation, the "Nuclear Receptors and Prostate Diseases" team has developed a new model to study these early phases in Drosophila. Their work highlights the crucial role of growth factors in the transformation of the tumour. These results are published in Nature Communications (Rambur et al., 2020).
Looking for pERK !
In its last study, published in Development (Azami et al., ), the team "Molecular mechanisms of cell lineage differentiation in the early mouse embryo" identified the phosporylation of ERK as a ...
Read moresRNAPipe: a Galaxy-based pipeline for bioinformatic in-depth exploration of small RNAseq data
Les recherches menées au cours de cette dernière décennie ont révélé que la quasi-totalité des génomes est transcrite et que la plupart des mol ...
Read moreImaris Open Day
Georgia Golfis, de Bitplane, viendra présenter le logiciel Imaris le 11 février 2014.
Cette présentation sera suivie d'une formation pratique l'après-midi.
The conserved yeast telomeric CST complex also functions in the regulation of RNA polymerase II transcription
The telomeric CST complex contributes to maintain genome stability through chromosome end protection and telomere length regulation. In its last study conducted on the yeast model (Calvo, Grandin et al ...
Read moreDNA methylation : a new actor in CML biology
Chronic myeloid leukemia (CML), a cancer of the white blood cell, results from a translocation event that ultimately leads to the production of BCR-ABL1, a chimeric oncoprotein that promotes CML ...
Read more1ere Automnale du Groupe Cancer Clermont Auvergne
Le mardi 26 Novembre, de 9h à 17h, se tiendra la 1éreAutomnale du Groupe Cancer Clermont Auvergne
Cette journée permettra d’avoir un panorama de la recherche en ...
Read moreFocus sur le Groupe Cancer Clermont Auvergne
Focus sur le Groupe Cancer Clermont Auvergne dans le LAB#7 de l’UCA.
Retrouvez ici l’interview de Silvere Baron ( équipe : Récepteurs nucléaires et maladies de la ...
Read moreBudding Researchers
The pupils ,aged 6 years old, of the school Nestor Perret in Clermont-Ferrand spent Tuesday, May 30th, morning together with the researchers of the GReD in a real course ...
Read moreLes experts mondiaux des maladies de la surrénale se sont réunis au GReD
Sous l’impulsion de l’équipe « Pathophysiologie moléculaire des tissus surrénaux et endocriniens », les maladies rares de la surrénale ont été à l’honneur du 25 au 28 ...
Read moreLes Doctorants du GReD à l’honneur lors des JED 2019.
Laura BOUSSET, doctorante dans l’équipe « Récepteurs nucléaires et maladies de la prostate» et Laura THIROUARD, doctorante dans l’équipe « Environnement, spermatogénèse, pathophysiologie et hér ...
Read moreThe journey of a thousand piRNAs begins with a single Dot
Among the several kinds of non-coding small RNAs, piRNAs (Piwi-interacting RNAs) are the ‘transposon-silencers’. They occur within the gonads of animals, protecting the cellular genome from transposable elements. One of ...
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GRED’s people in the spotlight
Heidi Serra received the young researcher award 2015 from the Bettencourt-Schueller foundation.
Read moreCeremony for the foundation stone of the new building CRBC (Centre for Research in Clinical Biology).
Spring 2017 is going to be a landmark for the GReD with the Research Unit being united in the brand-new building CRBC.
This large research facility is part of the ...
