Team 11: Nuclear receptors and prostate diseases

“Lipids, nuclear receptors and male disorders”

The primary goal of our group is to understand and discriminate the respective roles of the lipid related nuclear receptors (namely LXR, FXR and SHP) in the control of the endocrine activity in males. For that purpose we use complementary as well as parallel approaches to answer these questions: new or already available mouse models and various cell models. The research project is focused on two complementary topics: 1) Control of the lipid homeostasis in the reproductive functions by studying the physiologic role of LXRs in the testis and the impact of bile acids on male reproductive functions. 2) Impact of lipids on prostate physiology and pathology (benign prostate hyperplasia and prostate cancer).

Research

 Projet de l'équipe de L. Morel

Research thematics

People

Last Name First Name Position Contact
Anthony ALIOUI profile picture ALIOUI Anthony Ph.D Student
Silvere BARON profile picture BARON Silvere Principal Investigator
Laura BOUSSET profile picture BOUSSET Laura Ph.D Student
Sandra CARLET-DOLLET profile picture CARLET-DOLLET Sandra Research Technician
Olivier CELHAY profile picture CELHAY Olivier Ph.D Student
Cyrille DE JOUSSINEAU profile picture DE JOUSSINEAU Cyrille Associate Professor
Allan FOUACHE profile picture FOUACHE Allan Ph.D Student
Jean-Marc LOBACCARO profile picture LOBACCARO Jean-Marc Professor
Laurent MOREL profile picture MOREL Laurent Professor
Zangbewende Guy OUEDRAOGO profile picture OUEDRAOGO Zangbewende Guy Post-doctoral Fellow
Amandine RAMBUR profile picture RAMBUR Amandine Ph.D Student
Jean-Paul SARU profile picture SARU Jean-Paul Technical Assistant
Amalia TROUSSON profile picture TROUSSON Amalia Associate Professor

Publications

  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
    • S. Ducheix, N. Podechard, F. Lasserre, A. Polizzi, A. Pommier, S. Murzilli, C. Di Lisio, S. D'Amore, J. Bertrand-Michel, A. Montagner, T. Pineau, N. Loiseau, JM. Lobaccaro, P. Martin and H. Guillou, “A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPARalpha.”, Biochimie, vol. 95 (3) , pp. 556–67, 2012.
    • M. Baptissart, A. Vega, JM. Lobaccaro and D. Volle, “Vitamin E: potential therapeutical approach for prevention of liver cancer development.”, Chinese clinical oncology, vol. 1 (1) , pp. 6, 2012.
    • M. Baptissart, A. Vega, S. Maqdasy, F. Caira, S. Baron, JM. Lobaccaro and DH. Volle, “Bile acids: from digestion to cancers.”, Biochimie, vol. 95 (3) , pp. 504–17, 2012.
    • S. Maqdasy, M. Baptissart, A. Vega, S. Baron, JM. Lobaccaro and DH. Volle, “Cholesterol and male fertility: what about orphans and adopted?”, Molecular and cellular endocrinology, vol. 368 (1-2) , pp. 30–46, 2012.
    • J. Dufour, E. Viennois, H. De Boussac, S. Baron and JM. Lobaccaro, “Oxysterol receptors, AKT and prostate cancer.”, Curr Opin Pharmacol, vol. 12 (6) , pp. 724–8, 2012.
    • K. Mouzat, S. Baron, G. Marceau, F. Caira, V. Sapin, DH. Volle, S. Lumbroso and JM. Lobaccaro, “Emerging roles for LXRs and LRH-1 in female reproduction.”, Molecular and cellular endocrinology, vol. 368 (1-2) , pp. 47–58, 2012.
    • E. Viennois, T. Esposito, J. Dufour, A. Pommier, S. Fabre, J. Kemeny, L. Guy, L. Morel, JM. Lobaccaro and S. Baron, “Lxralpha regulates the androgen response in prostate epithelium.”, Endocrinology, vol. 153 (7) , pp. 3211–23, 2012.
    • L. Eloy, A. Jarrousse, M. Teyssot, A. Gautier, L. Morel, C. Jolivalt, T. Cresteil and S. Roland, “Anticancer activity of silver-N-heterocyclic carbene complexes: caspase-independent induction of apoptosis via mitochondrial apoptosis-inducing factor (AIF).”, ChemMedChem, vol. 7 (5) , pp. 805–14, 2012.
    • A. Vega, M. Baptissart, F. Caira, F. Brugnon, JM. Lobaccaro and DH. Volle, “Epigenetic: a molecular link between testicular cancer and environmental exposures.”, Frontiers in endocrinology, vol. 3 , pp. 150, 2012.
  • 2011
    • E. Viennois, K. Mouzat, J. Dufour, L. Morel, JM. Lobaccaro and S. Baron, “Selective liver X receptor modulators (SLiMs): what use in human health?”, Molecular and cellular endocrinology, vol. 351 (2) , pp. 129–41, 2011.
    • L. Leotoing, F. Chereau, S. Baron, F. Hube, H. Valencia, D. Bordereaux, J. Demmers, J. Strouboulis and V. Baud, “A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity.”, J. biol. chem., vol. 286 (37) , pp. 32277–88, 2011.
    • G. Alves, L. Morel, M. El-Ghozzi, D. Avignant, B. Legeret, L. Nauton, F. Cisnetti and A. Gautier, “A platinum Chugaev carbene complex as a potent anticancer agent.”, Chemical communications (Cambridge, England), vol. 47 (27) , pp. 7830–2, 2011.
    • S. Ducheix, JM. Lobaccaro, P. Martin and H. Guillou, “Liver X Receptor: an oxysterol sensor and a major player in the control of lipogenesis.”, Chem. Phys. Lipids, vol. 164 (6) , pp. 500–14, 2011.
    • J. Makoukji, G. Shackleford, D. Meffre, J. Grenier, P. Liere, JM. Lobaccaro, M. Schumacher and C. Massaad, “Interplay between LXR and Wnt/beta-catenin signaling in the negative regulation of peripheral myelin genes by oxysterols.”, J. Neurosci., vol. 31 (26) , pp. 9620–9, 2011.
    • M. Tawk, J. Makoukji, M. Belle, C. Fonte, A. Trousson, T. Hawkins, H. Li, S. Ghandour, M. Schumacher and C. Massaad, “Wnt/beta-catenin signaling is an essential and direct driver of myelin gene expression and myelinogenesis.”, J. Neurosci., vol. 31 (10) , pp. 3729–42, 2011.
    • F. El-Hajjaji, A. Oumeddour, A. Pommier, A. Ouvrier, E. Viennois, J. Dufour, F. Caira, J. Drevet, DH. Volle, S. Baron, F. Saez and JM. Lobaccaro, “Liver X receptors, lipids and their reproductive secrets in the male.”, Biochim. Biophys. Acta, vol. 1812 (8) , pp. 974–81, 2011.
    • E. Viennois, A. Pommier, K. Mouzat, A. Oumeddour, F. El Hajjaji, J. Dufour, F. Caira, DH. Volle, S. Baron and JM. Lobaccaro, “Targeting liver X receptors in human health: deadlock or promising trail?”, Expert Opin. Ther. Targets, vol. 15 (2) , pp. 219–32, 2011.
    • A. Ouvrier, G. Alves, C. Damon-Soubeyrand, G. Marceau, R. Cadet, L. Janny, F. Brugnon, A. Kocer, A. Pommier, JM. Lobaccaro, J. Drevet and F. Saez, “Dietary cholesterol-induced post-testicular infertility.”, PLoS ONE, vol. 6 (11) , pp. e26966, 2011.
    • K. Mouzat, E. Mercier, A. Polge, A. Evrard, S. Baron, J. Balducchi, J. Brouillet, S. Lumbroso and J. Gris, “A common polymorphism in NR1H2 (LXRbeta) is associated with preeclampsia.”, BMC medical genetics, vol. 12 , pp. 145, 2011.
  • 2010
    • C. Macari, C. Teyssier, V. Tribollet, K. Mouzat, C. Forcet, B. Horard, JM. Lobaccaro and J. Vanacker, “Estrogens repress PGC1-alpha expression in the uterus.”, Molecular and cellular endocrinology, vol. 330 (1-2) , pp. 33–40, 2010.
    • K. Gauthier, C. Billon, M. Bissler, M. Beylot, JM. Lobaccaro, J. Vanacker and J. Samarut, “Thyroid hormone receptor beta (TRbeta) and liver X receptor (LXR) regulate carbohydrate-response element-binding protein (ChREBP) expression in a tissue-selective manner.”, J. biol. chem., vol. 285 (36) , pp. 28156–63, 2010.
    • J. Talvas, C. Caris-Veyrat, L. Guy, M. Rambeau, B. Lyan, R. Minet-Quinard, JM. Lobaccaro, M. Vasson, S. George, A. Mazur and E. Rock, “Differential effects of lycopene consumed in tomato paste and lycopene in the form of a purified extract on target genes of cancer prostatic cells.”, The American journal of clinical nutrition, vol. 91 (6) , pp. 1716–24, 2010.
    • A. Pommier, G. Alves, E. Viennois, S. Bernard, Y. Communal, B. Sion, G. Marceau, C. Damon, K. Mouzat, F. Caira, S. Baron and JM. Lobaccaro, “Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells.”, Oncogene, vol. 29 (18) , pp. 2712–23, 2010.
    • E. Chautard, G. Loubeau, A. Tchirkov, J. Chassagne, C. Vermot-Desroches, L. Morel and P. Verrelle, “Akt signaling pathway: a target for radiosensitizing human malignant glioma.”, Neuro-oncology, vol. 12 (5) , pp. 434–43, 2010.
  • 2009
    • C. Rebe, M. Raveneau, A. Chevriaux, D. Lakomy, A. Sberna, A. Costa, G. Bessede, A. Athias, E. Steinmetz, JM. Lobaccaro, G. Alves, A. Menicacci, S. Vachenc, E. Solary, P. Gambert and D. Masson, “Induction of transglutaminase 2 by a liver X receptor/retinoic acid receptor alpha pathway increases the clearance of apoptotic cells by human macrophages.”, Circulation research, vol. 105 (4) , pp. 393–401, 2009.
    • M. Teyssot, A. Jarrousse, M. Manin, A. Chevry, S. Roche, F. Norre, C. Beaudoin, L. Morel, D. Boyer, R. Mahiou and A. Gautier, “Metal-NHC complexes: a survey of anti-cancer properties.”, Dalton trans., pp. 6894–902, 2009.
    • A. Trousson, S. Bernard, P. Petit, P. Liere, A. Pianos, K. El Hadri, JM. Lobaccaro, M. Ghandour, M. Raymondjean, M. Schumacher and C. Massaad, “25-hydroxycholesterol provokes oligodendrocyte cell line apoptosis and stimulates the secreted phospholipase A2 type IIA via LXR beta and PXR.”, Journal of neurochemistry, vol. 109 (4) , pp. 945–58, 2009.
    • A. Ouvrier, R. Cadet, P. Vernet, B. Laillet, J. Chardigny, JM. Lobaccaro, J. Drevet and F. Saez, “LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell-specific manner.”, J. Lipid Res., vol. 50 (9) , pp. 1766–75, 2009.
    • K. Mouzat, F. Volat, S. Baron, G. Alves, A. Pommier, DH. Volle, G. Marceau, A. DeHaze, P. Dechelotte, R. Duggavathi, F. Caira and JM. Lobaccaro, “Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice.”, Endocrinology, vol. 150 (7) , pp. 3369–75, 2009.
    • K. Mouzat, G. Alves, A. Pommier, E. Viennois, T. Pihen, F. Caira and S. a. A. L. J. Baron, “[Nuclear liver X receptors are involved in the biology of reproduction].”, Med Sci (Paris), vol. 25 (2) , pp. 141–4, 2009.
    • A. Ouvrier, R. Cadet, JM. Lobaccaro, J. Drevet and F. Saez, “LXR regulate cholesterol homeostasis in the proximal mouse epididymis.”, Folia Histochem. Cytobiol., vol. 47 (5) , pp. S75–9, 2009.
    • M. Teyssot, A. Jarrousse, A. Chevry, A. De Haze, C. Beaudoin, M. Manin, S. Nolan, S. Diez-Gonzalez, L. Morel and A. Gautier, “Toxicity of copper(I)-NHC complexes against human tumor cells: induction of cell cycle arrest, apoptosis, and DNA cleavage.”, Chemistry (Weinheim an der Bergstrasse, Germany), vol. 15 (2) , pp. 314–8, 2009.
    • C. Beaudoin, S. Maquaire, L. Leotoing, J. Allemand, C. Lours-Calet, G. Veyssiere, M. Manin and L. Morel, “[NPM: a new player in prostate cancer?].”, Med Sci (Paris), vol. 25 (1) , pp. 19–21, 2009.
  • 2008
    • N. Dejeans, S. Auclair, J. Henry-Berger, JM. Lobaccaro and A. Mazur, “A specialized cDNA microarray (Mouse Lipid Chip) reveals hepatic overexpression of serum amyloid a in high-fat diet-fed mice.”, Horm. Metab. Res., vol. 40 (3) , pp. 228–30, 2008.
    • J. Henry-Berger, K. Mouzat, S. Baron, C. Bernabeu, G. Marceau, J. Saru, V. Sapin, JM. Lobaccaro and F. Caira, “Endoglin (CD105) expression is regulated by the liver X receptor alpha (NR1H3) in human trophoblast cell line JAR.”, Biol Reprod, vol. 78 (6) , pp. 968–75, 2008.