Team 10: Translational approach to epithelial injury and repair

Retinoids (active derivatives of vitamin A) are fundamental morphogens for the harmonious development of mammals.  We previously initiated the study of the implications of retinoids during the normal and pathological development of two human tissues (amniotic membranes and the lung) by establishing the functionality of the metabolic and molecular cascades of retinoids.

Research

The purpose of our project is to identify new tissue, cellular, and molecular sequences regulated by retinoids. The dysregulation of these sequences could be one of the pathophysiological mechanisms that explain the abnormal development of the lung and the amniotic membranes. A definition of the retinoid target genes is established for this purpose using a transcriptomic approach combined with bioinformatic analysis. The integration of target genes in large physiological cascades will provide a more complete picture of the involvement of retinoids in these two tissues. An epigenetic approach will complement this approach. In the long term, the data obtained will make it possible to improve the diagnosis and treatment of lung development disorders (diaphragmatic congenital hernia) and amniotic membrane pathologies (rupture of the membranes).

Research thematics

People

Last Name First Name Position Contact
Corinne BELVILLE profile picture BELVILLE Corinne Research Engineer
Loic BLANCHON profile picture BLANCHON Loic Associate Professor
Raiko BLONDONNET profile picture BLONDONNET Raiko Ph.D Student
Damien BOUVIER profile picture BOUVIER Damien Clinician
Frederic CHIAMBARETTA profile picture CHIAMBARETTA Frederic Professor - Clinician
Jean-Michel CONSTANTIN profile picture CONSTANTIN Jean-Michel Professor - Clinician
Karen COSTE profile picture COSTE Karen Associate Professor - Clinician
Amelie DELABAERE profile picture DELABAERE Amelie Ph.D Student
Marianne FOURNET profile picture FOURNET Marianne Intern
Emmanuel FUTIER profile picture FUTIER Emmanuel Professor - Clinician
Denis GALLOT profile picture GALLOT Denis Professor - Clinician
Christelle GROSS profile picture GROSS Christelle Ph.D Student
Matthieu JABAUDON profile picture JABAUDON Matthieu Associate Professor - Clinician
sarah LAVERGNE profile picture LAVERGNE Sarah Ph.D Student
Geoffroy MARCEAU profile picture MARCEAU Geoffroy Associate Professor - Clinician
Regine MINET-QUINARD profile picture MINET-QUINARD Regine Associate Professor - Clinician
Laurence ROSZYK profile picture ROSZYK Laurence Clinician
Vincent SAPIN profile picture SAPIN Vincent Principal Investigator

Publications

  • 2016
  • 2014
    • F. Dutheil, G. Walther, R. Chapier, G. Mnatzaganian, B. Lesourd, G. Naughton, J. Verney, A. Fogli, V. Sapin, M. Duclos, A. Vinet, P. Obert, D. Courteix and G. Lac, “Atherogenic subfractions of lipoproteins in the treatment of metabolic syndrome by physical activity and diet - the RESOLVE trial.”, Lipids in health and disease, vol. 13 , pp. 112, 2014.
  • 2013
    • JM. Lobaccaro, D. Gallot, S. Lumbroso and K. Mouzat, “Liver X Receptors and female reproduction: when cholesterol meets fertility!”, Journal of endocrinological investigation, vol. 36 (1) , pp. 55–60, 2013.
  • 2012
  • 2010
    • A. Albert, M. Gaume, S. Ughetto, V. Sapin and A. Fogli, “[Coupling proteinemia and serum protein electrophoresis: evaluation of the capillary technique (Capillarys 2, Sebia), experience from Clermont-Ferrand].”, Ann. Biol. Clin. (Paris), vol. 68 (6) , pp. 657–67, 2010.
    • I. Sahut-Barnola, C. de Joussineau, P. Val, S. Lambert-Langlais, C. Damon, A. Lefrancois-Martinez, J. Pointud, G. Marceau, V. Sapin, F. Tissier, B. Ragazzon, J. Bertherat, L. Kirschner, C. Stratakis and A. Martinez, “Cushing's syndrome and fetal features resurgence in adrenal cortex-specific Prkar1a knockout mice.”, PLoS Genet., vol. 6 (6) , pp. e1000980, 2010.
    • J. Talvas, C. Caris-Veyrat, L. Guy, M. Rambeau, B. Lyan, R. Minet-Quinard, JM. Lobaccaro, M. Vasson, S. George, A. Mazur and E. Rock, “Differential effects of lycopene consumed in tomato paste and lycopene in the form of a purified extract on target genes of cancer prostatic cells.”, The American journal of clinical nutrition, vol. 91 (6) , pp. 1716–24, 2010.
    • C. Goumy, L. Gouas, G. Marceau, K. Coste, L. Veronese, D. Gallot, V. Sapin, P. Vago and A. Tchirkov, “Retinoid pathway and congenital diaphragmatic hernia: hypothesis from the analysis of chromosomal abnormalities.”, Fetal. Diagn. Ther., vol. 28 (3) , pp. 129–39, 2010.
    • C. Goumy, K. Coste, G. Marceau, L. Gouas, A. Tchirkov, P. Vago, D. Gallot and V. Sapin, “Fetal skin fibroblasts: a cell model for studying the retinoid pathway in congenital diaphragmatic hernia.”, Birth Defects Res. Part A Clin. Mol. Teratol., vol. 88 (3) , pp. 195–200, 2010.
  • 2009
    • I. Sahut-Barnola, C. De Joussineau, P. Val, S. Lambert-Langlais, A. Lefrancois-Martinez, J. Pointud, G. Marceau, V. Sapin, B. Ragazzon, J. Bertherat, L. Kirschner, C. Stratakis and A. Martinez, “Mouse model for bilateral adrenal hyperplasia.”, Annales d'endocrinologie, vol. 70 (3) , pp. 194, 2009.
    • C. Belville, J. Marechal, S. Pennetier, P. Carmillo, L. Masgrau, L. Messika-Zeitoun, J. Galey, G. Machado, D. Treton, J. Gonzales, J. Picard, N. Josso, R. Cate and N. di Clemente, “Natural mutations of the anti-Mullerian hormone type II receptor found in persistent Mullerian duct syndrome affect ligand binding, signal transduction and cellular transport.”, Hum. Mol. Genet., vol. 18 (16) , pp. 3002–13, 2009.
  • 2008