Olivier BARDOT

Associate Professor in Biochemistry IUT d'Auvergne

Resume

Olivier BARDOTprofile picture

I am Associate Professor in the Biology Department of the University Institute of Technology (Auvergne) since 1995 on the Campus Cezeaux, Aubiere. I am teaching biochemistry and molecular biology.
I mainly studied morphogenesis during development in the Drosophila melanogaster model organism. I have developed for this work, approaches based on genetics, molecular biology and microscopy.

I am currently working on mechanisms that control the size and shape of the cells during development.

Research

I am currently working on mechanisms to control the size and shape of the cells during development. These two parameters must be coordinated during growth and epithelial differentiation, deregulation of coordination often leads to the formation of tumors, most cancer tumors having an epithelial origin. We use as a model ovarian follicular cells of Drosophila melanogaster. This somatic cell monolayer surrounding the germ cells that will grow up to give a fertilized egg by increasing size during its development. Follicular cells must follow the growth of tissue witout loosing their properties. For this work, the approaches used are primarily
genetic and confocal microscopy imaging.

A good analogy: When we are getting fat, how the skin "follows" the deformation without leaving holes and without leaving folds when we get slim.

Publications

  • 2018
  • 2014
    • C. Vachias, C. Fritsch, P. Pouchin, O. Bardot and V. Mirouse, “Tight coordination of growth and differentiation between germline and soma provides robustness for drosophila egg development.”, Cell Rep, vol. 9 (2) , pp. 531–41, 2014.
    • G. Borrel, N. Parisot, H. Harris, E. Peyretaillade, N. Gaci, W. Tottey, O. Bardot, K. Raymann, S. Gribaldo, P. Peyret, P. O'Toole and J. Brugere, “Comparative genomics highlights the unique biology of Methanomassiliicoccales, a Thermoplasmatales-related seventh order of methanogenic archaea that encodes pyrrolysine.”, BMC genomics, vol. 15 , pp. 679, 2014.
  • 2013
    • G. Borrel, H. Harris, N. Parisot, N. Gaci, W. Tottey, A. Mihajlovski, J. Deane, S. Gribaldo, O. Bardot, E. Peyretaillade, P. Peyret, P. O'Toole and J. Brugere, “Genome Sequence of "Candidatus Methanomassiliicoccus intestinalis" Issoire-Mx1, a Third Thermoplasmatales-Related Methanogenic Archaeon from Human Feces.”, Genome announcements, vol. 1 (4) , 2013.
  • 2011
  • 2005
    • M. Bringer, N. Barnich, A. Glasser, O. Bardot and A. Darfeuille-Michaud, “HtrA stress protein is involved in intramacrophagic replication of adherent and invasive Escherichia coli strain LF82 isolated from a patient with Crohn's disease.”, Infection and immunity, vol. 73 (2) , pp. 712–21, 2005.
  • 2003
    • C. Lours, O. Bardot, D. Godt, F. Laski and J. Couderc, “The Drosophila melanogaster BTB proteins bric a brac bind DNA through a composite DNA binding domain containing a pipsqueak and an AT-Hook motif.”, Nucleic Acids Res., vol. 31 (18) , pp. 5389–98, 2003.
  • 2002
    • O. Bardot, D. Godt, F. Laski and J. Couderc, “Expressing UAS-bab1 and UAS-bab2: a comparative study of gain-of-function effects and the potential to rescue the bric a brac mutant phenotype.”, Genesis (New York, N.Y. : 2000), vol. 34 (1-2) , pp. 66–70, 2002.
  • 1996
    • P. Passilly, C. Pacot, B. Jannin, M. Cherkaoui Malki, O. Bardot, F. Caira, M. Clemencet and N. Latruffe, “Toxicological evaluation of peroxisome proliferators. Further cellular and molecular aspects.”, Annals of the New York Academy of Sciences, vol. 804 , pp. 716–8, 1996.
  • 1995
    • O. Bardot, M. Clemencet, M. Cherkaoui Malki and N. Latruffe, “Delayed effects of ciprofibrate on rat liver peroxisomal properties and proto-oncogene expression.”, Biochemical pharmacology, vol. 50 (7) , pp. 1001–6, 1995.
    • F. Caira, C. Pacot, O. Bardot, M. Cherkaoui Malki and N. Latruffe, “Transcriptional and post-transcriptional analysis of peroxisomal protein encoding genes from rat treated with an hypolipemic agent, ciprofibrate. Effect of an intermittent treatment and influence of obesity.”, Biochemical pharmacology, vol. 49 (5) , pp. 611–9, 1995.
    • O. Bardot, M. Clemencet, P. Passilly and N. Latruffe, “The analysis of modified peroxisome proliferator responsive elements of the peroxisomal bifunctional enzyme in transfected HepG2 cells reveals two regulatory motifs.”, FEBS Lett., vol. 360 (2) , pp. 183–6, 1995.
  • 1993
    • O. Bardot, T. Aldridge, N. Latruffe and S. Green, “PPAR-RXR heterodimer activates a peroxisome proliferator response element upstream of the bifunctional enzyme gene.”, Biochemical and biophysical research communications, vol. 192 (1) , pp. 37–45, 1993.
  • 1991
    • J. Berrez, O. Bardot, M. Thiard, F. Alvarez and N. Latruffe, “Molecular analysis of a human liver mitochondrial ornithine transcarbamylase deficiency.”, J. Inherit. Metab. Dis., vol. 14 (1) , pp. 29–36, 1991.
    • M. Cherkaoui Malki, L. Assaka, C. Pacot, O. Bardot and N. Latruffe, “Effect of different hypolipemic agents on rat liver peroxisomal and mitochondrial functions and biogenesis.”, Cellular and molecular biology, vol. 37 (7) , pp. 723–33, 1991.
  • 1990
    • M. Cherkaoui Malki, O. Bardot, J. Lhuguenot and N. Latruffe, “Expression of liver peroxisomal proteins as compared to other organelle marker enzymes in rats treated with hypolipidemic agents.”, Biology of the cell / under the auspices of the European Cell Biology Organization, vol. 69 (2) , pp. 83–92, 1990.