Lucie PICCHIO

Ph.D in developmental biology and genetics

Resume

Lucie PICCHIOprofile picture
  • Complete my research work started during my PhD, GReD, Clermont-Ferrand, 2014
  • Master and PhD in developmental biology and genetics, GReD, Clermont-Ferrand, 2009-2013 

https://www.researchgate.net/profile/Lucie_Picchio/

Research

During my PhD, I set up a new Drosophila model of Dystrophy Myotonic type 1(DM1), an autosomic dominant neuromuscular disorder affecting 1/8000 people worldwide. This model is inducible and reproduces different states of severity of the disease. I focused on describing larval somatic muscles phenotypes as well as adult heart physiologic phenotypes. I used genome-wide approaches in order to assess the involvement of splicing factors (MBNL1 and CUGBP1) mis-expressed in DM1 and conserved with the fruit fly.

Currently, I am trying to understand the role of CUGBP1 orthologue in both diseased and healthy muscles.

Publications

  • 2018
    • L. Picchio, V. Legagneux, S. Deschamps, Y. Renaud, S. Chauveau, L. Paillard and K. Jagla, “Bruno-3 regulates sarcomere component expression and contributes to muscle phenotypes of myotonic dystrophy type 1.”, Disease models & mechanisms, vol. 11 (5) , 2018.
  • 2013
    • L. Picchio, E. Plantie, Y. Renaud, P. Poovthumkadavil and K. Jagla, “Novel Drosophila model of myotonic dystrophy type 1: phenotypic characterization and genome-wide view of altered gene expression.”, Hum. Mol. Genet., vol. 22 (14) , pp. 2795–810, 2013.
  • 2010
    • M. Daczewska, L. Picchio, T. Jagla, N. Figeac and K. Jagla, “Muscle development and regeneration in normal and pathological conditions: learning from Drosophila.”, Curr. Pharm. Des., vol. 16 (8) , pp. 929–41, 2010.