Franck COURT


Franck COURTprofile picture

2016-              Chargé de recherche CNRS au GReD équipe P. Arnaud, Université Clermont d’Auvergne, CNRS UMR6293, Inserm UMR1103.

 « Etude des mécanismes épigénétiques en lien avec le destin cellulaire. »

2013-2016      Stage postdoctoral au GReD équipe P. Arnaud, Université Clermont d’Auvergne, CNRS UMR6293, Inserm UMR1103.

 « Caractérisation des altérations épigénétiques dans le cancer. »

2011-2013      Stage postdoctoral à l’IDIBELL/PEBC équipe D Monk, Barcelone, Espagne

 «Etude de l’empreinte génomique  parentale et de son altération dans les syndromes humains.»

2006-2010      Doctorat à l’GMM équipe T Forné CNRS UMR 5535, Montpellier

 « Organisation supérieure de la chromatine chez les mammifères : dynamique fondamentale et interactions spécifiques. »




  • 2021
    • E. L. Boiteux, F. Court, P. Guichet, C. Vaurs-Barri{`{e}}re, I. Vaillant, E. Chautard, P. Verrelle, B. M. Costa, L. Karayan-Tapon, A. Fogli and P. Arnaud, “Widespread overexpression from the four DNA hypermethylated HOX clusters in aggressive ( IDH wt) glioma is associated with H3K27me3 depletion and alternative promoter usage”, Molecular Oncology, 2021.
    • E. Le Boiteux, F. Court, P. Guichet, C. Vaurs-Barriere, I. Vaillant, E. Chautard, P. Verrelle, B. Costa, L. Karayan-Tapon, A. Fogli and P. Arnaud, “Widespread overexpression from the four DNA hypermethylated HOX clusters in aggressive (IDHwt) glioma is associated with H3K27me3 depletion and alternative promoter usage.”, Molecular oncology, 2021.
  • 2020
  • 2019
    • F. Court, E. Le Boiteux, A. Fogli, M. Muller-Barthelemy, C. Vaurs-Barriere, E. Chautard, B. Pereira, J. Biau, J. Kemeny, T. Khalil, L. Karayan-Tapon, P. Verrelle and P. Arnaud, “Transcriptional alterations in glioma result primarily from DNA methylation-independent mechanisms.”, Genome Res., vol. 29 (10) , pp. 1605–1621, 2019.
  • 2018
    • M. Baudement, A. Cournac, F. Court, M. Seveno, H. Parrinello, C. Reynes, R. Sabatier, T. Bouschet, Z. Yi, S. Sallis, M. Tancelin, C. Rebouissou, G. Cathala, A. Lesne, J. Mozziconacci, L. Journot and T. Forne, “High-salt-recovered sequences are associated with the active chromosomal compartment and with large ribonucleoprotein complexes including nuclear bodies.”, Genome Res., vol. 28 (11) , pp. 1733–1746, 2018.
    • S. Maupetit-Mehouas, F. Court, C. Bourgne, A. Guerci-Bresler, P. Cony-Makhoul, H. Johnson, G. Etienne, P. Rousselot, D. Guyotat, A. Janel, E. Hermet, S. Saugues, J. Berger, P. Arnaud and M. Berger, “DNA methylation profiling reveals a pathological signature that contributes to transcriptional defects of CD34(+) CD15(-) cells in early chronic-phase chronic myeloid leukemia.”, Molecular oncology, vol. 12 (6) , pp. 814–829, 2018.
    • M. Pinson, R. Pogorelcnik, F. Court, P. Arnaud and C. Vaurs-Barriere, “CLIFinder: identification of LINE-1 chimeric transcripts in RNA-seq data.”, Bioinformatics (Oxford, England), vol. 34 (4) , pp. 688–690, 2018.
  • 2017
    • M. Alsina Casanova, A. Monteagudo-Sanchez, L. Rodiguez Guerineau, F. Court, I. Gazquez Serrano, L. Martorell, C. Rovira Zurriaga, G. Moore, M. Ishida, M. Castanon, E. Moliner Calderon, D. Monk and J. Moreno Hernando, “Maternal mutations of FOXF1 cause alveolar capillary dysplasia despite not being imprinted.”, Hum. Mutat., vol. 38 (6) , pp. 615–620, 2017.
    • F. Court and P. Arnaud, “An annotated list of bivalent chromatin regions in human ES cells: a new tool for cancer epigenetic research.”, Oncotarget, vol. 8 (3) , pp. 4110–4124, 2017.
  • 2016
    • D. Monk, J. Morales, J. den Dunnen, S. Russo, F. Court, D. Prawitt, T. Eggermann, J. Beygo, K. Buiting and Z. Tumer, “Recommendations for a nomenclature system for reporting methylation aberrations in imprinted domains.”, Epigenetics, pp. 0, 2016.
    • M. Sanchez-Delgado, F. Court, E. Vidal, J. Medrano, A. Monteagudo-Sanchez, A. Martin-Trujillo, C. Tayama, I. Iglesias-Platas, I. Kondova, R. Bontrop, M. Poo-Llanillo, T. Marques-Bonet, K. Nakabayashi, C. Simon and D. Monk, “Human Oocyte-Derived Methylation Differences Persist in the Placenta Revealing Widespread Transient Imprinting.”, PLoS Genet., vol. 12 (11) , pp. e1006427, 2016.
    • J. Huertas-Martinez, F. Court, S. Rello-Varona, D. Herrero-Martin, O. Almacellas-Rabaiget, M. Sainz-Jaspeado, S. Garcia-Monclus, L. Lagares-Tena, R. Buj, L. Hontecillas-Prieto, A. Sastre, D. Azorin, X. Sanjuan, R. Lopez-Alemany, S. Moran, J. Roma, S. Gallego, J. Mora, X. Garcia Del Muro, P. Giangrande, M. Peinado, J. Alonso, E. de Alava, D. Monk, M. Esteller and O. Tirado, “DNA methylation profiling identifies PTRF/Cavin-1 as a novel tumor suppressor in Ewing sarcoma when co-expressed with Caveolin-1.”, Cancer letters, 2016.
    • S. Maupetit-Mehouas, B. Montibus, D. Nury, C. Tayama, M. Wassef, S. Kota, A. Fogli, F. Cerqueira Campos, K. Hata, R. Feil, R. Magueron, K. Nakabayashi, F. Court and P. Arnaud, “Imprinting control regions (ICRs) are marked by mono-allelic bivalent chromatin when transcriptionally inactive.”, Nucleic Acids Res., vol. 44 (2) , pp. 621-635, 2016.
    • A. Fogli, E. Chautard, C. Vaurs-Barriere, B. Pereira, M. Muller-Barthelemy, F. Court, J. Biau, A. Almeida Pinto, J. Kemeny, T. Khalil, L. Karayan-Tapon, P. Verrelle, B. Costa and P. Arnaud, “The tumoral A genotype of the MGMT rs34180180 single-nucleotide polymorphism in aggressive gliomas is associated with shorter patients' survival.”, Carcinogenesis, vol. 37 (2) , pp. 169-176, 2016.
  • 2015
    • V. Ea, F. Court and T. Forne, “Quantitative Analysis of Intra-chromosomal Contacts: The 3C-qPCR Method.”, Meth. Mol. Biol., 2015.
  • 2014
    • V. Romanelli, K. Nakabayashi, M. Vizoso, S. Moran, I. Iglesias-Platas, N. Sugahara, C. Simon, K. Hata, M. Esteller, F. Court and D. Monk, “Variable maternal methylation overlapping the nc886/vtRNA2-1 locus is locked between hypermethylated repeats and is frequently altered in cancer.”, Epigenetics, vol. 9 (5) , pp. 783–90, 2014.
    • F. Court, C. Tayama, V. Romanelli, A. Martin-Trujillo, I. Iglesias-Platas, K. Okamura, N. Sugahara, C. Simon, H. Moore, J. Harness, H. Keirstead, J. Sanchez-Mut, E. Kaneki, P. Lapunzina, H. Soejima, N. Wake, M. Esteller, T. Ogata, K. Hata, K. Nakabayashi and D. Monk, “Genome-wide parent-of-origin DNA methylation analysis reveals the intricacies of human imprinting and suggests a germline methylation-independent mechanism of establishment.”, Genome Res., vol. 24 (4) , pp. 554–69, 2014.
    • F. Court, C. Camprubi, C. Garcia, A. Guillaumet-Adkins, A. Sparago, D. Seruggia, J. Sandoval, M. Esteller, A. Martin-Trujillo, A. Riccio, L. Montoliu and D. Monk, “The PEG13-DMR and brain-specific enhancers dictate imprinted expression within the 8q24 intellectual disability risk locus.”, Epigenetics & chromatin, vol. 7 (1) , pp. 5, 2014.
    • J. Liang, L. Lacroix, A. Gamot, S. Cuddapah, S. Queille, P. Lhoumaud, P. Lepetit, P. Martin, J. Vogelmann, F. Court, M. Hennion, G. Micas, S. Urbach, O. Bouchez, M. Nollmann, K. Zhao, E. Emberly and O. Cuvier, “Chromatin immunoprecipitation indirect peaks highlight long-range interactions of insulator proteins and Pol II pausing.”, Molecular cell, vol. 53 (4) , pp. 672–81, 2014.
    • A. Guillaumet-Adkins, J. Richter, M. Odero, J. Sandoval, X. Agirre, A. Catala, M. Esteller, F. Prosper, M. Calasanz, I. Buno, M. Kwon, F. Court, R. Siebert and D. Monk, “Hypermethylation of the alternative AWT1 promoter in hematological malignancies is a highly specific marker for acute myeloid leukemias despite high expression levels.”, Journal of hematology & oncology, vol. 7 , pp. 4, 2014.
  • 2013
    • T. Salem, T. Gomard, F. Court, G. Moquet-Torcy, F. Brockly, T. Forne and M. Piechaczyk, “Chromatin loop organization of the junb locus in mouse dendritic cells.”, Nucleic Acids Res., vol. 41 (19) , pp. 8908–25, 2013.
    • C. Camprubi, I. Iglesias-Platas, A. Martin-Trujillo, C. Salvador-Alarcon, M. Rodriguez, D. Barredo, F. Court and D. Monk, “Stability of genomic imprinting and gestational-age dynamic methylation in complicated pregnancies conceived following assisted reproductive technologies.”, Biol Reprod, vol. 89 (3) , pp. 50, 2013.
    • F. Court, A. Martin-Trujillo, V. Romanelli, I. Garin, I. Iglesias-Platas, I. Salafsky, M. Guitart, G. Perez de Nanclares, P. Lapunzina and D. Monk, “Genome-wide allelic methylation analysis reveals disease-specific susceptibility to multiple methylation defects in imprinting syndromes.”, Hum. Mutat., vol. 34 (4) , pp. 595–602, 2013.
    • M. Borensztein, P. Monnier, F. Court, Y. Louault, M. Ripoche, L. Tiret, Z. Yao, S. Tapscott, T. Forne, D. Montarras and L. Dandolo, “Myod and H19-Igf2 locus interactions are required for diaphragm formation in the mouse.”, Development, vol. 140 (6) , pp. 1231–9, 2013.
    • I. Iglesias-Platas, F. Court, C. Camprubi, A. Sparago, A. Guillaumet-Adkins, A. Martin-Trujillo, A. Riccio, G. Moore and D. Monk, “Imprinting at the PLAGL1 domain is contained within a 70-kb CTCF/cohesin-mediated non-allelic chromatin loop.”, Nucleic Acids Res., vol. 41 (4) , pp. 2171–9, 2013.
  • 2012
    • I. Iglesias-Platas, A. Martin-Trujillo, D. Cirillo, F. Court, A. Guillaumet-Adkins, C. Camprubi, D. Bourc'his, K. Hata, R. Feil, G. Tartaglia, P. Arnaud and D. Monk, “Characterization of novel paternal ncRNAs at the Plagl1 locus, including Hymai, predicted to interact with regulators of active chromatin.”, PLoS ONE, vol. 7 (6) , pp. e38907, 2012.
    • C. Hippert, S. Ibanes, N. Serratrice, F. Court, F. Malecaze, E. Kremer and V. Kalatzis, “Corneal transduction by intra-stromal injection of AAV vectors in vivo in the mouse and ex vivo in human explants.”, PLoS ONE, vol. 7 (4) , pp. e35318, 2012.
    • V. Tran, F. Court, A. Duputie, E. Antoine, N. Aptel, L. Milligan, F. Carbonell, M. Lelay-Taha, J. Piette, M. Weber, D. Montarras, C. Pinset, L. Dandolo, T. Forne and G. Cathala, “H19 antisense RNA can up-regulate Igf2 transcription by activation of a novel promoter in mouse myoblasts.”, PLoS ONE, vol. 7 (5) , pp. e37923, 2012.
  • 2011
    • F. Court, M. Baniol, H. Hagege, J. Petit, M. Lelay-Taha, F. Carbonell, M. Weber, G. Cathala and T. Forne, “Long-range chromatin interactions at the mouse Igf2/H19 locus reveal a novel paternally expressed long non-coding RNA.”, Nucleic Acids Res., vol. 39 (14) , pp. 5893–906, 2011.
    • F. Court, J. Miro, C. Braem, M. Lelay-Taha, A. Brisebarre, F. Atger, T. Gostan, M. Weber, G. Cathala and T. Forne, “Modulated contact frequencies at gene-rich loci support a statistical helix model for mammalian chromatin organization.”, Genome biology, vol. 12 (5) , pp. R42, 2011.
  • 2007
    • E. Brasset, F. Bantignies, F. Court, S. Cheresiz, C. Conte and C. Vaury, “Idefix insulator activity can be modulated by nearby regulatory elements.”, Nucleic Acids Res., vol. 35 (8) , pp. 2661–70, 2007.