Christophe TATOUT

Professor in Genetics


Christophe TATOUTprofile picture
  • 2013: Professor of Genetics, Principal Investigator
  • 2009: Professor of Genetics, Blaise Pascal University, (S. Tourmente's Team)
  • 1997-2009: Group leader of the maize genetics and genomics team at Biogemma, France.
  • 1999-2007: Member of the maize genetics and genomics team at Biogemma, France.
  • 1997-1999:  Postdoc, UMR CNRS 6457, Pr  Jean-Marc Deragon's team
  • 1994-1997: Postdoc, Department of Zoology and Animal Biology, Geneva, Dr Vincenzo Pirrotta's team 
  • 1990-1993: PhD, URA360, Blaise Pascal University, France, Pr Hubert Pinon's team



We have developed an ImageJ plugin called NucleusJ dedicated to researchers interested in nuclear shape and chromatin organization.

Starting from image stacks, the nuclear boundary as well as nuclear bodies are segmented. As output, NucleusJ automatically measures 15 parameters including shape and size of nuclei as well as intra-nuclear objects and the positioning of the objects within the nuclear volume. The plugin contains several methods to process and analyze 8 grey level image stacks of nuclei. For each method two versions are available, one version to analyze one image at a time and another for processing in batch mode.

NucleusJ and dependency Plugins and documentation available at:

Dataset of 77 nuclei from two genetic bakgrounds + results available at: /media/



Martinant JP., Tatout C. (2011) Method for modifying the blooming date of a plant. PCT/EP2011/053908WO 2011/113839.

Murigneux A., Martinant JP., Tatout C. and Grezes-Besset B. (2009) Maize with increased tolerance to fungal diseases. PCT/EP2008/065850, WO 2009/065863

Murigneux A., Martinant JP and Tatout C. (2009) Maize having improved digestibility. PCT/EP2008/059909, WO 2009/016166.

Murigneux A., Tatout C., Martinant JP. and Grezes-Besset B. (2008) Maize with good digestibility and disease resistance. PCT/EP2007/061373,WO 2008/049849.

Tatout C., Grezes-Besset B. and P. George (2008) Maize with enhanced tolerance to fungal pathogens. PCT/EP2007/061372, WO 2008/049848.

Perez, P., Consonni, G., Paul, W., Giulini, A., Tatout, C., Dal PRa, M. (2007)      EMP4 gene. PCT/EP2006/068464, WO 2007/057402.

Murigneux A., Martinant JP and Tatout C. (2006) Maize having an improved digestibility. PCT/EP2005/054885, WO 2006/035045.


  • 2019
    • T. Dumur, S. Duncan, K. Graumann, S. Desset, R. Randall, O. Scheid, D. Prodanov, C. Tatout and C. Baroux, “Probing the 3D architecture of the plant nucleus with microscopy approaches: challenges and solutions.”, Nucleus, vol. 10 (1) , pp. 181–212, 2019.
    • S. Le Goff, B. Nur Keceli, H. Jerabkova, S. Heckmann, T. Rutten, S. Cotterell, V. Schubert, E. Roitinger, K. Mechtler, F. Franklin, C. Tatout, A. Houben, D. Geelen, A. Probst and I. Lermontova, “The H3 histone chaperone NASP(SIM) (3) escorts CenH3 in Arabidopsis.”, Plant J., 2019.
  • 2018
    • S. Kemeny, C. Tatout, G. Salaun, C. Pebrel-Richard, C. Goumy, N. Ollier, E. Maurin, B. Pereira, P. Vago and L. Gouas, “Spatial organization of chromosome territories in the interphase nucleus of trisomy 21 cells.”, Chromosoma, vol. 127 (2) , pp. 247–259, 2018.
    • M. Benoit, L. Simon, S. Desset, C. Duc, S. Cotterell, A. Poulet, S. Le Goff, C. Tatout and A. Probst, “Replication-coupled histone H3.1 deposition determines nucleosome composition and heterochromatin dynamics during Arabidopsis seedling development.”, The New phytologist, 2018.
    • G. Parry, A. Probst, C. Baroux and C. Tatout, “Meeting report - INDEPTH kick-off meeting.”, Journal of cell science, vol. 131 (12) , 2018.
    • L. Simon, F. Rabanal, T. Dubos, C. Oliver, D. Lauber, A. Poulet, A. Vogt, A. Mandlbauer, S. Le Goff, A. Sommer, H. Duborjal, C. Tatout and A. Probst, “Genetic and epigenetic variation in 5S ribosomal RNA genes reveals genome dynamics in Arabidopsis thaliana.”, Nucleic Acids Res., 2018.
    • S. Desset, A. Poulet and C. Tatout, “Quantitative 3D Analysis of Nuclear Morphology and Heterochromatin Organization from Whole-Mount Plant Tissue Using NucleusJ.”, Meth. Mol. Biol., vol. 1675 , pp. 615–632, 2018.
    • A. Poulet, X. Zhou, K. Tamura, I. Meier, C. Tatout, K. Graumann and D. Evans, “Computational Methods for Studying the Plant Nucleus.”, Meth. Mol. Biol., vol. 1840 , pp. 205–219, 2018.
    • M. Voisin, E. Vanrobays and C. Tatout, “Investigation of Nuclear Periphery Protein Interactions in Plants Using the Membrane Yeast Two-Hybrid (MbY2H) System.”, Meth. Mol. Biol., vol. 1840 , pp. 221–235, 2018.
  • 2017
  • 2016
  • 2015
  • 2014
    • K. Graumann, E. Vanrobays, S. Tutois, A. Probst, D. Evans and C. Tatout, “Characterization of two distinct subfamilies of SUN-domain proteins in Arabidopsis and their interactions with the novel KASH-domain protein AtTIK.”, J. Exp. Bot., vol. 65 (22) , pp. 6499–512, 2014.
    • A. Poulet, I. Arganda-Carreras, D. Legland, A. Probst, P. Andrey and C. Tatout, “NucleusJ: an ImageJ plugin for quantifying 3D images of interphase nuclei.”, Bioinformatics (Oxford, England), 2014.
    • C. Tatout, D. Evans, E. Vanrobays, A. Probst and K. Graumann, “The plant LINC complex at the nuclear envelope.”, Chromosome Res., 2014.
    • M. Thomas, L. Pingault, A. Poulet, J. Duarte, M. Throude, S. Faure, J. Pichon, E. Paux, A. Probst and C. Tatout, “Evolutionary history of Methyltransferase 1 genes in hexaploid wheat.”, BMC genomics, vol. 15 , pp. 922, 2014.
  • 2011
    • B. Tamasloukht, M. Wong Quai Lam, Y. Martinez, K. Tozo, O. Barbier, C. Jourda, A. Jauneau, G. Borderies, S. Balzergue, J. Renou, S. Huguet, J. Martinant, C. Tatout, C. Lapierre, Y. Barriere, D. Goffner and M. Pichon, “Characterization of a cinnamoyl-CoA reductase 1 (CCR1) mutant in maize: effects on lignification, fibre development, and global gene expression.”, J. Exp. Bot., vol. 62 (11) , pp. 3837–48, 2011.
  • 2009
    • Y. Barriere, V. Mechin, F. Lafargette, D. Manicacci, F. Guillon, H. Wang, D. Lauressergues, M. Pichon, M. Bosio and C. Tatout, “Towards the discovery of maize cell wall genes involved in silage quality and capacity to biofuel production”, Maydica, pp. 161–198, 2009.
  • 2007
    • J. Gutierrez-Marcos, M. Dal Pra, A. Giulini, L. Costa, G. Gavazzi, S. Cordelier, O. Sellam, C. Tatout, W. Paul, P. Perez, H. Dickinson and G. Consonni, “empty pericarp4 encodes a mitochondrion-targeted pentatricopeptide repeat protein necessary for seed development and plant growth in maize.”, Plant Cell, vol. 19 (1) , pp. 196–210, 2007.
  • 2006
    • A. Martin, J. Lee, T. Kichey, D. Gerentes, M. Zivy, C. Tatout, F. Dubois, T. Balliau, B. Valot, M. Davanture, T. Terce-Laforgue, I. Quillere, M. Coque, A. Gallais, M. Gonzalez-Moro, L. Bethencourt, D. Habash, P. Lea, A. Charcosset, P. Perez, A. Murigneux, H. Sakakibara, K. Edwards and B. Hirel, “Two cytosolic glutamine synthetase isoforms of maize are specifically involved in the control of grain production.”, Plant Cell, vol. 18 (11) , pp. 3252–74, 2006.
  • 2005
    • A. Karkonen, A. Murigneux, J. Martinant, E. Pepey, C. Tatout, B. Dudley and S. Fry, “UDP-glucose dehydrogenases of maize: a role in cell wall pentose biosynthesis.”, The Biochemical journal, vol. 391 (Pt 2) , pp. 409–15, 2005.
  • 2002
    • T. Pelissier, C. Tatout, J. Lavige, I. Busseau, A. Bucheton and J. Deragon, “Utilization of the IR hybrid dysgenesis system in Drosophila to test in vivo mobilization of synthetic SINEs sharing 3' homology with the I factor.”, Gene, vol. 285 (1-2) , pp. 239–45, 2002.
    • G. Dellino, C. Tatout and V. Pirrotta, “Extensive conservation of sequences and chromatin structures in the bxd polycomb response element among Drosophilid species.”, The International journal of developmental biology, vol. 46 (1) , pp. 133–41, 2002.
  • 2001
    • A. Tikhonov, L. Lavie, C. Tatout, J. Bennetzen, Z. Avramova and J. Deragon, “Target sites for SINE integration in Brassica genomes display nuclear matrix binding activity.”, Chromosome Res., vol. 9 (4) , pp. 325–37, 2001.
  • 2000
    • E. Gauthier, C. Tatout and H. Pinon, “Artificial and epigenetic regulation of the I factor, a nonviral retrotransposon of Drosophila melanogaster.”, Genetics, vol. 156 (4) , pp. 1867–78, 2000.
    • B. Horard, C. Tatout, S. Poux and V. Pirrotta, “Structure of a polycomb response element and in vitro binding of polycomb group complexes containing GAGA factor.”, Molecular and cellular biology, vol. 20 (9) , pp. 3187–97, 2000.
    • M. Delattre, C. Tatout and D. Coen, “P-element transposition in Drosophila melanogaster: influence of size and arrangement in pairs.”, Molecular & general genetics : MGG, vol. 263 (3) , pp. 445–54, 2000.
  • 1999
    • C. Goubely, P. Arnaud, C. Tatout, J. Heslop-Harrison and J. Deragon, “S1 SINE retroposons are methylated at symmetrical and non-symmetrical positions in Brassica napus: identification of a preferred target site for asymmetrical methylation.”, Plant molecular biology, vol. 39 (2) , pp. 243–55, 1999.
  • 1998
    • C. Tatout, E. Gauthier and H. Pinon, “Rapid evaluation in Escherichia coli of antisense RNAs and ribozymes.”, Letters in applied microbiology, vol. 27 (5) , pp. 297–301, 1998.
    • C. Tatout, L. Lavie and J. Deragon, “Similar target site selection occurs in integration of plant and mammalian retroposons.”, Journal of molecular evolution, vol. 47 (4) , pp. 463–70, 1998.
  • 1994
    • C. Tatout, M. Docquier, P. Lachaume, M. Mesure, P. Lecher and H. Pinon, “Germ-line expression of a functional LINE from Drosophila melanogaster: fine characterization allows for potential investigations of trans-regulators.”, The International journal of developmental biology, vol. 38 (1) , pp. 27–33, 1994.